|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Two stages of immiscible liquid separation in the formation of Panzhihua-type Fe-Ti-V oxide deposits,SW China显示文摘在 260 妈 Emeishan 大火的省(ELIP ) 的 Magmatic 氧化物沉积物, SW 中国和北越南,是 Fe, Ti 和 V 的重要来源。一些巨大的 magmatic Fe-Ti-V 氧化物沉积物例如 Panzhihua, Hongge,和 Baima 沉积物,很好在文学被描述并且在 Panxi 区域在分层的 mafic-ultramafic 侵入被招待,中央 ELIP。ELIP 相关的沉积物的一样的类型也远发生到南方并且在红河差错地区包括 Anyi 沉积物, Panzhihua 的大约 130 km 南方,和 Mianhuadi 沉积物。Anyi 沉积物是相对小的,但是同样在分层的 mafic 侵入被招待。Mianhuadi 沉积物有 260 妈的锆石 U-Pb 年龄并且与 ELIP 因此是同时期的。这存款易变地在指责的 Indosinian 造山运动和红河期间被变形。组合地, Mianhuadi 存款的磁铁矿比另外的存款的包含 Ti 和 V 的更小的数量,对以后的变态可能可归因。氧化物矿石存款的分发不与 ELIP 的 domal 结构有关。在 ELIP 的所有氧化物存款的一个主要特征是忍受氧化物的 gabbroic 侵入,黑花岗石 plutons 和 high-Ti 洪水暗岩的空间协会。因此,我们建议从一根披风羽毛的岩浆是进他们被发展进液体 immiscibility 的域形成二硅酸盐液体的一个浅岩浆房间的 emplaced,与一极其 Fe-Ti-rich gabbroic 作文和另外的黑花岗石。不能混合的 Fe-Ti-(P) 氧化物融化然后可以与 mafic 岩浆分开形成氧化物存款。这些存款从形成了的父母岩浆是在作文的可能的 Fe-Ti-rich picritic 并且比生产了 ELIP 的忍受硫化物的侵入的岩浆在更大的深度从充实的 asthenospheric 披风被导出。 | Mei-Fu Zhou Wei Terry Chen Christina Yan Wang Stephen A.Prevec Patricia Pingping Liu Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 35 |
| 2 | A 1000-year chironomid-based salinity reconstruction from varved sediments of Sugan Lake,Qaidam Basin,arid Northwest China,and its palaeoclimatic significance显示文摘A 1000-year high-resolution(~10 years) chironomid record from varved sediments of Sugan Lake,Qaidam Basin on the northern Tibetan Plateau,is presented.The chironomid assemblages are mainly composed of the relatively high-saline-water taxa Psectrocladius barbimanus-type and Orthocladius/Cricotopus,and the relatively low-saline-water taxa Procladius and Psectrocladius sordidellus-type.Variations in the chironomid fauna and inferred salinities suggest that over the last millennium,the Sugan Lake catchment has alternated between contrasting climatic conditions,having a dry climate during the period 990―1550 AD,a relatively humid climate during the Little Ice Age(LIA)(1550―1840 AD),and a dry climate again from 1840 AD onwards.At the decadal to centennial scale,a wet event around 1200―1230 AD,interrupting the generally arid period(990―1550 AD),and a dry event around 1590―1700 AD,punctuating the generally humid period(1550―1840 AD),are clearly documented.Trends in the chironomid-based salinity time series indicate a highly unstable climate during the LIA when salinity fluctuations were of greater magnitude and higher frequency.The effective moisture evolution in the Sugan Lake catchment during the last millennium reconstructed by chironomid analysis is in broad agreement with previous palaeo-moisture data derived from other sites in arid Northwest China(ANC).The LIA,characterized by generally humid conditions over the west-erly-dominated ANC was distinctly different from that in monsoonal China,implying an 'out-of-phase' relationship between moisture evolution in these two regions during the past 1000 years. | CHEN JianHui CHEN FaHu ZHANG EnLou BROOKS Stephen J ZHOU AiFeng ZHANG JiaWu | 2009 | Chinese Science Bulletin2009，54，20： | 20 |
| 3 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 4 | Hydropower reservoirs on the upper Mekong River modify nutrient bioavailability downstream显示文摘Hydropower development is the key strategy in many developing countries for energy supply,climate-change mitigation and economic development.However,it is commonly assumed that river dams retain nutrients and therefore reduce downstream primary productivity and fishery catches,compromising food security and causing trans-boundary disputes.Contrary to expectation,here we found that a cascade of reservoirs along the upper Mekong River increased downstream bioavailability of nitrogen andphosphorus.The dams caused phytoplankton density to increase with hydraulic residence time and stratification of the stagnant reservoirs caused hypoxia at depth.This allowed the release of bioavailable phosphorus from the sediment and an increase in dissolved inorganic nitrogen as well as a shift in nitrogen species from nitrate to ammonium,which were transported downstream by the discharge of water from the base of the dam.Our findings provide a new perspective on the environmental impacts of river dams on nutrient cycling and ecosystem functioning,with potential implications for sustainable development of hydropower worldwide. | Qiuwen Chen Wenqing Shi Jef Huisman Stephen C.Maberly Jianyun Zhang Juhua Yu Yuchen Chen Daniele Tonina Qitao Yi | 2020 | National Science Review2020，7，9： | 15 |
| 5 | Multigene editing via CRISPR/Cas9 guided by a single-sgRNA seed in Arabidopsis显示文摘We report that a solo single-guide RNA(sg RNA) seed is capable of guiding Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/CRISPRàassociated 9(CRISRP/Cas_9) to simultaneously edit multiple genes At RPL_(10)A, At RPL_(10)B and At RPL_(10)C in Arabidopsis. Our results also demonstrate that it is possible to use CRISPR/Cas_9 technology to create At RPL_(10) triple mutants which otherwise cannot be generated by conventional genetic crossing. Compared to other conventional multiplex CRISPR/Cas systems, a single sg RNA seed has the advantage of reducing off-target gene-editing. Such a gene editing system might be also applicable to modify other homologous genes, or even less-homologous sequences for multiple gene-editing in plants and other organisms. | Zhiming Yu Qiyuan Chen Weiwei Chen Xian Zhang Fengling Mei Pengcheng Zhang Mei Zhao Xiaohong Wang Nongnong Shi Stephen Jackson Yiguo Hong | 2018 | Journal of Integrative Plant Biology2018，60，5： | 10 |
| 6 | Thermoelectric transport across graphene/hexagonal boron nitride/graphene heterostructures显示文摘我们越过 graphene/hexagonal 硼氮化物(h-BN ) 报导热电的运输大小 /graphene heterostructure 设备。用一种交流占据技术,我们能分开热电的贡献到这些重要设备结构的 IV 特征。温度坡度用拉曼光谱学光学地被测量,它使我们能探索在材料接口生产的热电的运输,越过就 12 nm 的长度规模。基于观察热电的电压(V) 和温度坡度(T) , 99.3 V/K 的一个 Seebeck 系数为 heterostructure 设备被查明。获得的 Seebeck 系数能为在新兴的 2D heterostructure 设备的跨飞机的 IV 行为理解热电的部件是有用的。这些结果提供一条途径给在二维的分层的 heterostructures 探查热电的精力变换。 | Chun-Chung Chen Zhen Li Li Shi Stephen B. Cronin | 2015 | Nano Research2015，8，2： | 8 |
| 7 | Gut Microbiota and Short Chain Fatty Acids:Influence on the Autonomic Nervous System显示文摘Reaching across multiple fields of focus,spanning from periodontistry to gastroenterology to neurobiology to behavior,interest in the influence of the microbiome in human physiology and pathology has risen over the past few decades.Microbiota co-exist in and on humans forming an evolutionarily symbiotic biological unit,a halobiont,in which disruptions in the relationship can occur through genomic alterations and mutations[1],The human microbiome consists of bacteria,viruses,fungi,and protozoans that contribute 450 times more genes to this relationship and slightly outnumber human host cells[2,3].The bacteria in the gastrointestinal(GI)tract are of the most interest and exist within five phyla:Bacteroidetes,Firmicutes,Pro-teobacteria,Actinobacteria,and Verrucomicrobi&.Within the Verrucomicrobia an interesting bacterium has emerged. | Jessica Bruning Andrew Chapp Gregory A.Kaurala Renjun Wang Stephen Techtmann Qing-Hui Chen | 2020 | Neuroscience Bulletin2020，36，1： | 7 |
| 8 | Efficient first-principles prediction of solid stability:Towards chemical accuracy显示文摘The question of material stability is of fundamental importance to any analysis of system properties in condensed matter physics and materials science.The ability to evaluate chemical stability,i.e.,whether a stoichiometry will persist in some chemical environment,and structure selection,i.e.what crystal structure a stoichiometry will adopt,is critical to the prediction of materials synthesis,reactivity and properties.Here,we demonstrate that density functional theory,with the recently developed strongly constrained and appropriately normed(SCAN)functional,has advanced to a point where both facets of the stability problem can be reliably and efficiently predicted for main group compounds,while transition metal compounds are improved but remain a challenge.SCAN therefore offers a robust model for a significant portion of the periodic table,presenting an opportunity for the development of novel materials and the study of fine phase transformations even in largely unexplored systems with little to no experimental data. | Yubo Zhang Daniil A.Kitchaev Julia Yang Tina Chen Stephen T.Dacek Rafael A.Sarmiento-Pérez Maguel A.L.Marques Haowei Peng Gerbrand Ceder John P.Perdew Jianwei Sun | 2018 | npj Computational Materials2018，，1： | 7 |
| 9 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 10 | 荧光多重实时PCR检测单纯疱疹病毒显示文摘目的建立单纯疱疹病毒的荧光多重实时PCR检测及分型技术,为生殖器疱疹的诊断及病毒分型提供快捷、敏感、特异的方法.方法以细胞培养法为对照,用Smart Cycler System作为实验平台,以DNA探针荧光标记技术建立荧光多重实时PCR,用于检测生殖器疱疹患者临床标本中的1型和2型单纯疱疹病毒(HSV1、HSV2)DNA.结果荧光多重实时PCR检测HSV1和HSV2 DNA的敏感性和特异性均为100%,可检测出低至1~5拷贝的HSV DNA,30 min左右即可完成整个检测过程,而细胞培养的敏感性和特异性分别为70.10%和100%.结论基于Smart Cycler System的荧光多重实时PCR是一种易于操作、扩增效率高、封闭式的核酸扩增技术,可用一次PCR反应就能快速、敏感、准确地对临床标本中的单纯疱疹病毒进行检测和分型. | 赖维 Cheng-Yen Chen 苏向阳 黄怀球 张玉清 Ron C Ballard Stephen A Morse | 2004 | 中华皮肤科杂志2004，37，5： | 6 |
| 11 | An overview on recent in vivo biological application of cerium oxide nanoparticles显示文摘Cerium oxide nanoparticles(CNPs)possess a great potential as therapeutic agents due to their ability to self-regenerate by reversibly switching between two valences+3 and+4.This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer’s disease,obesity,liver inflammation,cancer,sepsis,amyotrophic lateral sclerosis,acute kidney injury,radiation-induced tissue damage,hepatic ischemia reperfusion injury,retinal diseases and constipation.In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma,ovarian,breast and retinoblastoma cancer cell-induced mice,with their conjugation with folic acid,doxorubicin,CPM,or CXC receptor-4 antagonist ligand eliciting higher efficiency.After conjugation with triphenylphosphonium or magnetite nanoparticles,CNPs were shown to combat Alzheimer’s disease by reducing amyloid-β,glial fibrillary acidic protein,inflammatory and oxidative stress markers in mice.By improving muscle function and longevity,the citrate/EDTA-stabilized CNPs could ameliorate amyotrophic lateral sclerosis.Also,they could effectively reduce obesity in mice by scavenging ROS and reducing adipogenesis,triglyceride synthesis,GAPDH enzyme activity,leptin and insulin levels.In CCl4-induced rats,stress signaling pathways due to inflammatory cytokines,liver enzymes,oxidative and endoplasmic reticulum messengers could be attenuated by CNPs.Commercial CNPs showed protective effects on rats with hepatic ischemia reperfusion and peritonitis-induced hepatic/cardiac injuries by decreasing oxidative stress and hepatic/cardiac inflammation.The same CNPs could improve kidney function by diminishing renal superoxide,hyperglycemia and tubular damage in peritonitis-induced acute kidney injury in rats.Radiation-induced lung and testicular tissue damage could be alleviated in mice,with the former showing improvement in pulmonary distress and bronchoconstriction and the latter exhibiting restoration in spermatogenesis rate and spermatid/spermatocyte number.Through enhancement of gastrointestinal motility,the CNPs could alleviate constipation in both young and old rats.They could also protect rat from light-induced retinal damage by slowing down neurodegenerative process and microglial activation. | Baskaran Stephen Inbaraj Bing-Huei Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 6 |
| 12 | Combined transplantation of GDAs^(BMP) and hr-decorin in spinal cord contusion repair显示文摘Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, double-immunofluorescent histochemistry revealed that combined transplantation inhibited the early inflammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was secreted by transplanted cells, protected injured axons. The combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels. | Liang Wu Jianjun Li Liang Chen Hong Zhang Li Yuan Stephen JA Davies | 2013 | Neural Regeneration Research2013，8，24： | 6 |
| 13 | Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis显示文摘 | Remo Panaccione Subrata Ghosh Stephen Middleton Juan R. Márquez Boyd B. Scott Laurence Flint Hubert JF. van Hoogstraten Annie C. Chen Hanzhe Zheng Silvio Danese Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 14 | Risk factors for mortality at beginning of maintenance hemodialysis显示文摘Hemodialysis(HD)is a crucial renal replacement therapy for patients with end-stage renal disease.Despite improvements in dialysis technology,mortality for maintenance HD(MHD)patients remains high.To improve the quality of life among MHD patients,it is necessary to examine the risk factors associated with mortality.In this study,we retrospectively analyzed patients5 conditions at the beginning of dialysis and assessed the risk factors for mortality in MHD patients treated at the Center for Hemodialysis in West China Hospital,Sichuan University,China.The aim of this study was to identify significant risk factors to guide the treatment of MHD patients and targeted early preventions to improve prognosis. | Shao-Bin Yu Huai-Hong Yuan Stephen Salerno Shen-Ju Gou Wen-Wen Chen Hong-Liu Yang Yi Li Ping Fu | 2020 | Chinese Medical Journal2020，，7： | 5 |
| 15 | Statements from the Taormina expert meeting on occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Jean-Pierre Allain Maurizia R. Brunetto Marie-Annick Buendia Ding-Shinn Chen Massimo Colombo Antonio Craxì Francesco Donato Carlo Ferrari Giovanni B. Gaeta Wolfram H. Gerlich Massimo Levrero Stephen Locarnini Thomas Michalak Mario U. Mon | 2008 | Journal of Hepatology2008，，4： | 5 |
| 16 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 17 | 植物雌激素协同化疗药的抗白血病作用体外研究显示文摘异黄酮类的Genistein及daidzein和黄酮类的quercetin是天然的植物雌激素,具有抗癌特征。本研究探讨植物雌激素在急性和慢性粒细胞性白血病中的抗增殖作用及与化疗药的协同作用。用台盼蓝染色法分析genistein单独应用和与化疗药联合应用在NB4和HL-60白血病细胞中的抗增殖作用;用MTT法分析quercetin对K562及K562/A细胞的生长抑制作用;确定genistein与化疗药联合应用中同时及顺序给药的最佳作用次序;观察联合作用24、48、72小时后细胞的生长状态,研究genistein的凋亡诱导作用和细胞周期阻滞作用。结果表明:Genistein对NB4和HL-60白血病细胞有剂量、时间依赖性的增殖抑制作用,可诱导细胞凋亡和细胞周期阻滞。Genistein和化疗药联合应用对细胞生长有协同抑制作用,且与作用次序相关。Quercetin对白血病敏感株和耐药株均有明显的抑制作用。结论:本研究报道genistein和化疗药联合有协同抗白血病细胞增殖作用,具有作用次序相关性特性,这种联合应用有可能为白血病临床治疗提供新的思路。 | 沈晶 张伟京 Yan-Chin Tai Ching-Ho Stephen Wong Zhigang Xie Chien-Shing Chen | 2008 | 中国实验血液学杂志2008，16，2： | 5 |
| 18 | Hybrid speciation via inheritance of alternate alleles of parental isolating genes显示文摘It is increasingly realized that homoploid hybrid speciation(HHS),which involves no change in chromosome number,is an important mechanism of speciation.HHS will likely increase in frequency as ecological and geographical barriers between species are continuing to be disrupted by human activities.HHS requires the establishment of reproductive isolation between a hybrid and its parents,but the underlying genes and genetic mechanisms remain largely unknown.In this study,we reveal by integrated approaches that reproductive isolation originates in one homoploid hybrid plant species through the inheritance of altemate alleles at genes that determine parental premating isolation.The parent species of this hybrid species are reproductively isolated by differences in flowering time and survivorship on soils containing high concentrations of iron.We found that the hybrid species inherits alleles of parental isolating major genes related to flowering time from one parent and alleles of major genes related to iron tolerance from the other parent.In this way,it became reproductively isolated from one parent by the difference in flowering time and from the other by habitat adaptation(iron tolerance).These findings and further modeling results suggest that HHS may occur relatively easily via the inheritance of alternate parental premating isolating genes and barriers. | Zefu Wang Yuanzhong Jiang Hao Bi Zhiqiang Lu Yazhen Ma Xiaoyue Yang Ningning Chen Bin Tian Bingbing Liu Xingxing Mao Tao Ma Stephen P.DiFazio Quanjun Hu Richard J.Abbott Jianquan Liu | 2021 | Molecular Plant2021，14，2： | 4 |
| 19 | Polar interaction of polymer host-solvent enables stable solid electrolyte interphase in composite lithium metal anodes显示文摘The lithium(Li) metal anode is an integral component in an emerging high-energy-density rechargeable battery.A composite Li anode with a three-dimensional(3 D) host exhibits unique advantages in suppressing Li dendrites and maintaining dimensional stability.However,the fundamental understanding and regulation of solid electrolyte interphase(SEI),which directly dictates the behavior of Li plating/stripping,are rarely researched in composite Li metal anodes.Herein,the interaction between a polar polymer host and solvent molecules was proposed as an emerging but effective strategy to enable a stable SEI and a uniform Li deposition in a working battery.Fluoroethylene carbonate molecules in electrolytes are enriched in the vicinity of a polar polyacrylonitrile(PAN) host due to a strong dipole-dipole interaction,resulting in a LiF-rich SEI on Li metal to improve the uniformity of Li deposition.A composite Li anode with a PAN host delivers 145 cycles compared with 90 cycles when a non-polar host is employed.Moreover,60 cycles are demonstrated in a 1:0 Ah pouch cell without external pressure.This work provides a fresh guidance for designing practical composite Li anodes by unraveling the vital role of the synergy between a 3 D host and solvent molecules for regulating a robust SEI. | Peng Shi Ze-Yu Liu Xue-Qiang Zhang Xiang Chen Nan Yao Jin Xie Cheng-Bin Jin Ying-Xin Zhan Gang Ye Jia-Qi Huang Stephens IfanE L Titirici Maria-Magdalena Qiang Zhang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 20 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员