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| 1 | Buoyance-driven hydrocarbon accumulation depth and its implication for unconventional resource prediction显示文摘The discovery of unconventional hydrocarbon resources since the late 20th century changed geologists’understanding of hydrocarbon migration and accumulations and provides a solution to energy shortage.In 2016,unconventional oil production in the USA accounted for 41%of the total oil production;and unconventional natural gas production in China accounted for 35%of total gas production,showing strong growth momentum of unconventional hydrocarbons explorations.Unconventional hydrocarbons generally coexist with conventional petroleum resources;they sometimes distribute in a separate system,not coexisting with a conventional system.Identification and prediction of unconventional resources and their potentials are prominent challenges for geologists.This study analyzed the results of 12,237 drilling wells in six representative petroliferous basins in China and studied the correlations and differences between conventional and unconventional hydrocarbons by comparing their geological features.Migration and accumulation of conventional hydrocarbon are caused dominantly by buoyance.Wepropose a concept of buoyance-driven hydrocarbon accumulation depth to describe the deepest hydrocarbon accumulation depth driven dominantly by buoyance;beyond this depth the buoyance becomes unimportant for hydrocarbon accumulation.We found that the buoyance-driven hydrocarbon accumulation depth in petroliferous basins controls the different oil/gas reservoirs distribution and resource potentials.Hydrocarbon migration and accumulations above this depth is dominated by buoyancy,forming conventional reservoirs in traps with high porosity and permeability,while hydrocarbon migration and accumulation below this depth is dominated by non-buoyancy forces(mainly refers to capillary force,hydrocarbon volumeexpansion force,etc.),forming unconventional reservoirs in tight layers.The buoyance-driven hydrocarbon accumulation depths in six basins in China range from 1200mto 4200 m,which become shallowerwith increasing geothermal gradient,decreasing particle size of sandstone reservoir layers,or an uplift in the whole petroliferous basin.The predicted unconventional resource potential belowthe buoyance-driven hydrocarbon accumulation depth in six basins in China is more than 15.71×10^(9) t oil equivalent,among them 4.71×10^(9) t reserves have been proved.Worldwide,94%of 52,926 oil and gas reservoirs in 1186 basins are conventional reservoirs and only 6%of them are unconventional reservoirs.These 94%conventional reservoirs show promising exploration prospects in the deep area below buoyance-driven hydrocarbon accumulation depth. | Xiongqi Pang Chengzao Jia Wenyang Wang Zhangxin Chen Maowen Li Fujie Jiang Tao Hu Ke Wang Yingxun Wang | 2021 | Geoscience Frontiers2021，12，4： | 9 |
| 2 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 3 | Effect of Sophora flavescens alkaloid on aerobic vaginitis in gel form for local treatment显示文摘OBJECTIVE: To investigate the effect of Sophora flavescens alkaloid(SFA) in gel form on aerobic vaginitis(AV) and the possible mechanism underlying the effects.METHODS: AV rat models were prepared by intravaginal inoculation of Escherichia coli and Staphylococcus aureus. SFA gel and placebo gel were intravaginally administered. In vivo antibacterial effects,vaginal microenvironment, vaginal smears, pathological tissues of vaginas, and retention of gel in the vaginal cavity were investigated.RESULTS: SFA gel had much higher antibacterial effect than placebo gel. SFA gel protected the vaginal mucosa from erosion of bacteria. At the same time,they inhibited the inflammatory responses, exhibiting little leukocytes and parabasal cells. Furthermore, the number of vaginal Lactobacilli remarkably increased following administration of SFA gel.However, the vaginal p H did not recover to thehealthy acidic levels after treatment due to the buffering effect of gel. The gel of a fluorescent agent,Cyanine 7, showed very long retention time in the vaginal cavity, up to more than 24 h, much longer than the solutions.CONCLUSION: The SFA gel is a promising medicine for local treatment of AV with the advantages of anti-bacteria, protection of vaginal mucosa, increase of Lactobacilli, and long retention time in the vaginal cavity. | Wang Xiu Li Jianchun Hu Yuzhen Chen Wenyang Jin Yiguang | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 7 |
| 4 | Side Wall Effects on the Hydrodynamics of a Floating Body by ImageGreen Function Based on TEBEM显示文摘A novel numerical model based on the image Green function and first-order Taylor expansion boundary element method(TEBEM), which can improve the accuracy of the hydrodynamic simulation for the non-smooth body, was developed to calculate the side wall effects on first-order motion responses and second-order drift loads upon offshore structures in the wave tank. This model was confirmed by comparing it to the results from experiments on hydrodynamic coefficients, namely the first-order motion response and second-order drift load upon a hemisphere, prolate spheroid, and box-shaped barge in the wave tank. Then,the hydrodynamics of the KVLCC2 model were also calculated in two wave tanks with different widths. It was concluded that this model can predict the hydrodynamics for offshore structures effectively, and the side wall has a significant impact on the firstorder quantities and second-order drift loads, which satisfied the resonant rule. | Jikang Chen Lijia Wang Wenyang Duan | 2018 | Journal of Marine Science and Application2018，17，3： | 3 |
| 5 | Adenine Phosphoribosyl Transferase 1 is a Key Enzyme Catalyzing Cytokinin Conversion from Nucleobases to Nucleotides in Arabidopsis显示文摘在植物,细胞激动素包括细胞激动素生合成,互变现象, inactivation,和降级,新陈代谢的进程在细胞激动素动态平衡和植物开发的规定起关键作用。嘌呤新陈代谢的酶被暗示了在以前的工作催化细胞激动素互变现象。在这研究,我们报导腺嘌 Phosphoribosyl Transferase 1 (APT1 ) 是高剂量的细胞激动素抵抗的异种的原因的基因。APT1 从免费的底催化细胞激动素变换到核苷酸,并且在 Arabidopsis 腺嘌 Phosphoribosyl Transferase 家庭的五个成员之中是机能上地占优势的。在工厂的 APT1 活动的损失导致细胞激动素底的过量累积,因此唤起无数调整细胞激动素的回答例如推迟的叶老朽, anthocyanin 累积,和下游的基因表示。因此,我们的学习把 APT1 定义为由 phosphoribosylation 参予细胞激动素 inactivation 的关键新陈代谢的酶。 | Xinyan Zhang Yutao Chen Xin Lin Xinyu Hong Ying Zhu Wenyang Li Wenrong He Fengying An Hongwei Guo | 2013 | Molecular Plant2013，6，5： | 2 |
| 6 | Notes The distribution of planktonic Ostracoda between the source Of Kuroshio and west of Taiwan Strait显示文摘NotesThedistributionofplanktonicOstracodabetweenthesourceofKuroshioandwestofTaiwanStrait￥ChenRuixiang;LinJinghong(TI!rdinstit... | Chen Ruixiang Lin Jinghong Zeng Wenyang | 1994 | Acta Oceanologica Sinica1994，13，3： | 1 |
| 7 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 8 | Gravity waves with effect of surface tension and fluid viscosity 显示文摘 | CHEN X B DUAN Wenyang LU Dongqiang | 2006 | Journal of Hydrodynamics Ser B2006，18，3： | 1 |
| 9 | Diel dynamics of multi-omics in elkhorn fern provide new insights into weak CAM photosynthesis显示文摘Crassulacean acid metabolism(CAM)has high water-use efficiency(WUE)and is widely recognized to have evolved from C3 photosynthesis.Different plant lineages have convergently evolved CAM,but the molecular mechanism that underlies C3-to-CAM evolution remains to be clarified.Platycerium bifurcatum(elkhorn fern)provides an opportunity to study the molecular changes underlying the transition from C3 to CAM photosynthesis because both modes of photosynthesis occur in this species,with sporotrophophyll leaves(SLs)and cover leaves(CLs)performing C3 and weak CAM photosynthesis,respectively.Here,we report that the physiological and biochemical attributes of CAM in weak CAM-performing CLs differed from those in strong CAM species.We investigated the diel dynamics of the metabolome,proteome,and transcriptome in these dimorphic leaves within the same genetic background and under identical environmental conditions.We found that multi-omic diel dynamics in P.bifurcatum exhibit both tissue and diel effects.Our analysis revealed temporal rewiring of biochemistry relevant to the energy-producing pathway(TCA cycle),CAM pathway,and stomatal movement in CLs compared with SLs.We also confirmed that PHOSPHOENOLPYRUVATE CARBOXYLASE KINASE(PPCK)exhibits convergence in gene expression among highly divergent CAM lineages.Gene regulatory network analysis identified candidate transcription factors regulating the CAM pathway and stomatal movement.Taken together,our results provide new insights into weak CAM photosynthesis and new avenues for CAM bioengineering. | Cheng Li Wenjie Huang Xiaoxu Han Guohua Zhao Wenyang Zhang Weijun He Bao Nie Xufeng Chen Taijie Zhang Wenhui Bai Xiaopeng Zhang Jingjing He Cheng Zhao Alisdair RFernie Timothy JTschaplinski Xiaohan Yang Shijuan Yan Li Wang | 2023 | Plant Communications2023，4，5： | 0 |
| 10 | Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer显示文摘Propofol,a common intravenous anesthetic used in clinical,has been shown to regulate cells proliferation,inflammation,angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer.However,the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown.The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer(CRC).Scratches assay,Transwell assay were used to detect colon cells migration and invasion.Realtime Quantitative Polymerase Chain Reaction(RT-qPCR),Western blotting were utilized to detect the expression of related molecules.Dual-luciferase assay was performed to identify transcriptional activity of target genes,RNA pulldown assay was used to confirm the interactions of RNAs.Results indicated that propofol inhibited cell migration and invasion through suppressing lactic acid production in CRC.Moreover,propofol reduced lactic acid production by down-regulating the expression of hypoxia inducible factor-1α(HIF-1α)and monocarboxylate transporter 4(MCT4).In addition,propofol inhibited the expression of HIF-1αand cells migration/invasion via suppressing the interaction of HOX transcript antisense RNA(HOTAIR)with miR-93.The present study indicated that propofol inhibited colon cancer cell migration and invasion by reducing lactic acid production and the expression of HIF-1αand MCT4 via HOTAIR/miR-93 axis.These data may provide potential metabolic targets for CRC treatment. | RUONAN GU WENJING GUO WENYANG WANG GUIHUAN LI XIAOJU LAI ZHIBIN HUANG WANLU ZHAO ZHICONGWU HUA CHEN WENYANG LUO FANGYIN ZENG FAN DENG | 2021 | BIOCELL2021，45，6： | 0 |
| 11 | Reduced ABO blood group antibody titers in patients after CD19 CAR-T cell therapy显示文摘1.INTRODUCTION With rapid developments in genetic engineering,tumor immunology,and cellular engineering,chimeric antigen receptor T cell(CAR-T)cell therapy has become a novel immunotherapy for oncology and other medical fields.1 The promising results of CD19 CAR-T treating B-cell malignancies were reported.2,3 Simultaneously,there existed many adverse events,the most reported of which including B-cell aplasia,hematological toxicity,cytokine release syndrome(CRS),and immune effector-cell–associated neurotoxicity syndrome(ICANS),3,4 but there is still lack of reports demonstrating the impact of CD19 CAR-T on the ABO blood group potency of patient’s serum. | Qiang Li Zhihuan Yang Kuo Fang Shuning Wei Jiali Sun Wei Liu Xiaojuan Chen Wenyang Huang Guangji Zhang Yin Shi Yuntao Liu Xiaoyuan Gong Fang Liu Xueli Zhou Jianxiang Wang Ying Wang | 2023 | Blood Science2023，5，1： | 0 |
| 12 | Characterization on Modification and Biocompatibility of PCL Scaffold Prepared with Near-field Direct-writing Melt Electrospinning显示文摘In this study,orthogonal experiments were designed to explore the optimal process parameters for preparing polycaprolactone(PCL)scaffolds by the near-field direct-writing melt electrospinning(NFDWMES)technology.Based on the optimal process parameters,the PCL scaffolds with different thicknesses,gaps and structures were manufactured and the corresponding hydrophilicities were characterized.The PCL scaffolds were modified by chitosan(CS)and hyaluronic acid(HA)to improve biocompatibility and hydrophilicity.Both Fourier transform infrared spectroscopy(FTIR)analysis and antibacterial experimental results show that the chitosan and hyaluronic acid adhere to the surface of PCL scaffolds,suggesting that the modification plays a positive role in biocompatibility and antibacterial effect.The PCL scaffolds were then employed as a carrier to culture cells.The morphology and distribution of the cells observed by a fluorescence microscope demonstrate that the modified PCL scaffolds have good biocompatibility,and the porous structure of the scaffolds is conducive to adhesion and deep growth of cells. | CHEN Zhijun HAO Ming QIAN Xiaoming CHEN Wenyang ZENG Ming HUANG Juan LI Ruixin FAN Jintu LIU Yanbo | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 13 | Prediction of seawater pH by bidirectional gated recurrent neural network with attention under phase space reconstruction:case study of the coastal waters of Beihai,China显示文摘Marine life is very sensitive to changes in pH.Even slight changes can cause ecosystems to collapse.Therefore,understanding the future pH of seawater is of great significance for the protection of the marine environment.At present,the monitoring method of seawater pH has been matured.However,how to accurately predict future changes has been lacking effective solutions.Based on this,the model of bidirectional gated recurrent neural network with multi-headed self-attention based on improved complete ensemble empirical mode decomposition with adaptive noise combined with phase space reconstruction(ICPBGA)is proposed to achieve seawater pH prediction.To verify the validity of this model,pH data of two monitoring sites in the coastal sea area of Beihai,China are selected to verify the effect.At the same time,the ICPBGA model is compared with other excellent models for predicting chaotic time series,and root mean square error(RMSE),mean absolute error(MAE),mean absolute percentage error(MAPE),and coefficient of determination(R2)are used as performance evaluation indicators.The R2 of the ICPBGA model at Sites 1 and 2 are above 0.9,and the prediction errors are also the smallest.The results show that the ICPBGA model has a wide range of applicability and the most satisfactory prediction effect.The prediction method in this paper can be further expanded and used to predict other marine environmental indicators. | Chongxuan Xu Ying Chen Xueliang Zhao Wenyang Song Xiao Li | 2023 | Acta Oceanologica Sinica2023，42，10： | 0 |
| 14 | Research on aiming methods for small sample size shooting tests of two-dimensional trajectory correction fuse显示文摘The longitudinal dispersion of the projectile in shooting tests of two-dimensional trajectory corrections fused with fixed canards is extremely large that it sometimes exceeds the correction ability of the correction fuse actuator.The impact point easily deviates from the target,and thus the correction result cannot be readily evaluated.However,the cost of shooting tests is considerably high to conduct many tests for data collection.To address this issue,this study proposes an aiming method for shooting tests based on small sample size.The proposed method uses the Bootstrap method to expand the test data;repeatedly iterates and corrects the position of the simulated theoretical impact points through an improved compatibility test method;and dynamically adjusts the weight of the prior distribution of simulation results based on Kullback-Leibler divergence,which to some extent avoids the real data being'submerged'by the simulation data and achieves the fusion Bayesian estimation of the dispersion center.The experimental results show that when the simulation accuracy is sufficiently high,the proposed method yields a smaller mean-square deviation in estimating the dispersion center and higher shooting accuracy than those of the three comparison methods,which is more conducive to reflecting the effect of the control algorithm and facilitating test personnel to iterate their proposed structures and algorithms.;in addition,this study provides a knowledge base for further comprehensive studies in the future. | Chen Liang Qiang Shen Zilong Deng Hongyun Li Wenyang Pu Lingyun Tian Ziyang Lin | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
| 15 | Synthesis of Carbon dots from Biomass Chenpi for the Detection of Hg^(2+)显示文摘Biomass-derived carbon dots(C-dots)are considered a very important carbon material in metal ion detection of their small environmental impact,simple preparation process,and relatively low cost.A green approach for synthesizing biomass-derived C-dots from Chenpi using a hydrothermal method without further processing is proposed in the present study.The as-synthesized C-dots show excellent fluorescence properties,superior resistance to UV irradiation photobleaching,and high photostability in salt-containing solutions.The C-dots were used in the form of label-free fluorescent probes for sensitively detecting Hg^(2+)selectively.The outcome relationship behaved linearly and was established based on a given range between 10–300 nM concentration,with a detection limit of 7.0 nM.This green strategy obtains a high C-dot quantum yield of 10.8%and satisfactory results in detecting Hg^(2+)in actual water samples. | Jun Xiang Xiaoqing Chen Qi Liu Huihua Jing Tongqiang Chen Wanli Tang Wenyang Xu | 2023 | Journal of Renewable Materials2023，11，10： | 0 |
| 16 | Multi-domain Boundary Element Method with Dissipation显示文摘在漂浮的身体附近的波浪衍射和放射在相当完美的液体在线性潜在的理论的框架以内被考虑。液体域在水平方向无穷地延长了,但是被排除身体 waterplane 的免费表面的海床,身体壳,和部分限制,并且根据身体几何学被细分进二子域。二子域被控制表面在液体连接。在每子域,速度潜力被使用包含格林功能的平常的边界积分表示描述。边界积分方程然后被建立由令人满意边界条件和越过控制的潜力和正常推导的连续条件出现。这个多域边界元素方法(MDBEM ) 为有包括平常的 BEM 介绍奇特和数字结果的慢集中给的 moonpools 的一种壳形式的身体特别地有趣。MDBEM 的申请出现在 moonpools 学习水列的反响的运动 MDBEM 提供一个有效、可靠的预言方法。 | Xiaobo Chen (12) xiao-bo.chen@bureauveritas.com Wenyang Duan (3) | 2012 | Journal of Marine Science and Application2012，11，1： | 0 |
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