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| 1 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 2 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 3 | Calycosin-7-O-β-D-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways显示文摘The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the osteogenic effects of CG and its underlying mechanism in ST2 cells. The results show that exposure of cells to CG in osteogenic differentiation medium increases ALP activity, osteocalcin(Ocal) m RNA expression and the osteoblastic mineralization process. Mechanistically, CG treatment increased the expression of bone morphogenetic protein 2(BMP-2), p-Smad 1/5/8, β-catenin and Runx2, all of which are regulators of the BMP- or wingless-type MMTV integration site family(WNT)/β-catenin-signaling pathways. Moreover, the osteogenic effects of CG were inhibited by Noggin and DKK-1 which are classical inhibitors of the BMP and WNT/β-catenin-signaling pathways, respectively. Taken together, the results indicate that CG promotes the osteoblastic differentiation of ST2 cells through regulating the BMP/WNT signaling pathways. On this basis, CG may be a useful lead compound for improving the treatment of bone-decreasing diseases and enhancing bone regeneration. | Jing Jian Lijuan Sun Xun Cheng Xiaofang Hu Jichao Liang Yong Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，5： | 16 |
| 4 | Yolk-shell structured Co-C/Void/Co9S8 composites with a tunable cavity for ultrabroadband and efficient low- frequency microwave absorption显示文摘 | Xiaofang Liu Chengcheng Hao Lihua He Cheng Yang Yubin Chen Chengbao Jiang Ronghai Yu | 2018 | Nano Research2018，11，8： | 10 |
| 5 | Optical analysis of a hybrid solar concentrating Photovoltaic /Thermal (CPV/T) system with beam splitting technique显示文摘A novel hybrid solar concentrating Photovoltaic/Thermal (CPV/T) system with beam splitting technique is presented. In this system, a beam splitter is used to separate the concentrated solar radiation into two parts: one for the PV power generation and the other for thermal utility. The solar concentrator is a flat Fresnel-type concentrator with glass mirror reflectors. It can concentrate solar radiation onto solar cells with high uniformity, which is beneficial to improving the efficiency of solar cells. The thermal receiver is separated to the solar cells, and therefore, the thermal fluid can be heated to a relatively high temperature and does not affect the performance of solar cells. A dimensionless model was developed for the performance analysis of the concentrating system. The effects of the main parameters on the performance of the concentrator were analyzed. The beam splitter with coating materials Nb2O3 /SiO2 was designed by using the needle optimization technique, which can reflect about 71% of the undesired radiation for silicon cell(1.1m < 3m) to the thermal receiver for thermal utility. The performance of this CPV/T system was also theoretically analyzed. | HU Peng ZHANG Qian LIU Yang SHENG ChunChen CHENG XiaoFang CHEN ZeShao | 2013 | Science China(Technological Sciences)2013，56，6： | 10 |
| 6 | Xuanbai Chengqi decoction(宣白承气汤) plus Western Medicine in treatment of severe pneumonia with symptom pattern of phlegm-heat obstructing lung:a Meta-analysis显示文摘OBJECTIVE: To evaluate the effectiveness and safety of Xuanbai Chengqi decoction(宣白承气汤, XBCQD) plus Western Medicine(WM) in treatment of severe pneumonia with symptom pattern of phlegm-heat obstructing lung.METHODS: Randomized controlled trials(RCTs) investigating the effect of XBCQD on severe pneumonia with symptom pattern of phlegm-heat obstructing lung, were included in this study. Seven electronic databases were searched up to March 2019.Meta-analysis was conducted by Review Manager5.3 software. Risk ratio(RR) and mean difference(MD) with 95% confidence interval(CI) were used as effect estimation.RESULTS: Eleven RCTs were included, involving992 participants. Meta-analysis showed that XBCQD combined with WM achieved better effectiveness than WM alone in terms of total effective rate[RR = 1.23, 95%CI(1.16, 1.30)], clinical pulmonary infection score [CPIS, MD =-2.02, 95%CI(-2.42,-1.63)], acute physiology and chronic health evaluation Ⅱ [APACHE Ⅱ, MD =-6.81, 95% CI(-8.26,5.37)], mechanical ventilation time [MD =-101.41,95%CI(-140.47,-62.34)], and lactic acid content in arterial blood [MD =-2.41, 95%CI(-2.64,-2.18)].CONCLUSION: XBCQD combined with WM had better benefit than WM alone to the patients of severe pneumonia with the symptom pattern of phlegm-heat obstructing lung. However, due to low quality of the included studies, more rigorously designed studies were required to further evaluate the effectiveness and safety of XBCQD in the treatment of severe pneumonia with symptom pattern of phlegm-heat obstructing lung. | YIN Xiaofang CHENG Ningchang ZHU Jia | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 5 |
| 7 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 8 | Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk:a case-control study of a Chinese Han population显示文摘Peroxisome proliferator-activated receptor (PPAR-γ),which is mainly involved in adipocyte differentiation, has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis. We investigated the frequencies of two common tagging polymorphisms of the PPAR-γ gene and two of PPAR-α with minor allele frequency (MAF)≥ 0.05 in the Chinese Han population and analyzed the correlation between the different genotypes and the risk of type 2 diabetes mellitus (T2DM). TaqMan assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal controls (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs17817276GG, rs3856806CT and rs3856806CT/TT of PPAR-γ were associated with T2DM, P = 0.023,0.037 and 0.018, respectively. Furthermore, the prevalence of haplotype GT in PPAR-γ was less frequent in the case subjects (0.3%) than in the controls (1.9%) [P < 0.001,OR(95%CI)=0.13 (0.06-0.31)]. Patients with genotype TT of rs3856806 had a higher serum level of adiponectin than those with the genotype CC and CT (P = 0.031 and 0.038, respectively). There was no statistically significant difference between patients and controls in genotype distribution of rs6537944 and rs1045570 of the RXR-α gene. The present study suggests that the variant genotypes in the PPAR-γ gene could decrease the risk for the development of T2DM in the Chinese Han population. | Juan Du Hui Shi Ying Lu Wencong Du Yuanyuan Cao Qian Li Jianhua Ma Xinhua Ye Jinluo Cheng Xiaofang Yu Yanqin Gao Ling Zhou | 2011 | The Journal of Biomedical Research2011，25，1： | 3 |
| 9 | Application of the back-error propagation artificial neural network(BPANN) on genetic variants in the PPAR-γ and RXR-α gene and risk of metabolic syndrome in a Chinese Han population显示文摘This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propagation artificial neural network(BPANN).We established the model based on data gathered from metabolic syndrome patients(n = 1012) and normal controls(n = 1069) by BPANN.Mean impact value(MIV) for each input variable was calculated and the sequence of factors was sorted according to their absolute MIVs.Generalized multifactor dimensionality reduction(GMDR) confirmed a joint effect of PPAR-γ and RXR-α based on the results from BPANN.By BPANN analysis,the sequences according to the importance of metabolic syndrome risk factors were in the order of body mass index(BMI).serum adiponectin,rs4240711,gender,rs4842194,family history of type 2 diabetes,rs2920502,physical activity,alcohol drinking,rs3856806,family history of hypertension,rsl045570,rs6537944,age,rsl7817276,family history of hyperlipidemia,smoking,rs1801282 and rs3132291.However,no polymorphism was statistically significant in multiple logistic regression analysis.After controlling for environmental factors,A_1,A_2,B_1 and B_2(rs4240711,rs4842194,rs2920502 and rs3856806) models were the best models(cross-validation consistency 10/10,P = 0.0107) with the GMDR method.In conclusion,the interaction of the PPAR-γ and RXR-α gene could play a role in susceptibility to metabolic syndrome.A more realistic model is obtained by using BPANN to screen out determinants of diseases of multiple etiologies like metabolic syndrome. | Xu Zhao Kang Xu Hui Shi Jinluo Cheng Jianhua Ma Yanqin Gao Qian Li Xinhua Ye Ying Lu Xiaofang Yu Juan Du Wencong Du Qing Ye Ling Zhou | 2014 | The Journal of Biomedical Research2014，28，2： | 3 |
| 10 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 11 | The principle of primary spectrum pyrometry显示文摘In this paper, for the measured surface with the characteristics of continuous radiation, we put forward the general model of the spectral emissivity with non- dimensional wavelength. In the analysis process, based on the Taylor series expansion, we theoretically discuss the applicable conditions of the model. Further, introducing the concept of the non-correlative spectrum functions in colourometry, the principle of primary spectrum pyrometry is established. And the application of primary spectrum pyrometer is illustrated in a specific example. | CHENG Xiaofang FU Tairan FAN Xueliang | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 2 |
| 12 | A cohort study of adolescents with depression in China:tracking multidimensional outcomes and early biomarkers for intervention显示文摘Background Depression in adolescents is recognised as a global public health concern,but little is known about the trajectory of its clinical symptoms and pathogenesis.Understanding the nature of adolescents with depression and identifying earlybiomarkers can facilitatepersonalised intervention andreducediseaseburden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis,as well as response to treatment,prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression(sBEAD).We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years.Multidimensional clinical presentations and objective indicators are collected at baseline,weeks 4,8,12 and 24,and years 1,2,3,4 and 5.Conclusions To the best of our knowledge,this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression.This study aims at providing early individualised interventions for young,depressed patients to reduce the burden of disease. | Xiaofei Zhang Yanling Zhou Jiaqi Sun Ruilan Yang Jianshan Chen Xiaofang Cheng Zezhi Li Xinlei Chen Chanjuan Yang Xinhong Zhu Liping Cao | 2022 | General Psychiatry2022，35，4： | 2 |
| 13 | Chemica studies on antioxidant mechanism of tea catechins : analysis of radical reaction products of catechin and epicatechinwith 2, 2 - Diphenyl - 1 - picrylhydrazyl 显示文摘 | Shengmin Sang Xiaofang Cheng Ruth E | 2002 | Bioorganic&medicinal chemistry2002，10，7： | 1 |
| 14 | Effects of melamineon the Maillard reaction between lactose and phenylalanine显示文摘 | MA Jinyu PENG Xiaofang CHENG K W | 2010 | Food Chemistry2010，，： | 1 |
| 15 | Iridoid glycosides from the leaves of Morinda citrifolia 显示文摘 | Sang Shengmin Cheng Xiaofang | 2001 | J Nat Prod2001，64，： | 1 |
| 16 | The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer’s disease显示文摘 | Xiaofang Cheng Jian Wu Miao Geng Jiaxiang Xiong | 2013 | Neurobiology of Aging2013，，： | 1 |
| 17 | Flavonol glycosides and novel iridoid glycoside from the leaves of Morinda citrifolia显示文摘 | Sang Shengmin Cheng Xiaofang | 2001 | J Agric Food Chem2001，49，： | 1 |
| 18 | The analysis of se- ries resistance and P-T characteristic of solar cell 显示文摘 | DING Jinlei CHENG Xiaofang FU Tairan | 2005 | Vacuum2005，77，2： | 1 |
| 19 | The measurement coordinates for multi -band pyrometry显示文摘 | Fu Tairan Cheng Xiaofang Wu Bo | 2006 | Measurement Science & Technology2006，17，： | 1 |
| 20 | Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts 显示文摘 | Peng Xiaofang Cheng Ka-Wing Ma Jinyu | 2008 | J Agric Food Chem2008，56，6： | 1 |
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