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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 3 | FourierCam:a camera for video spectrum acquisition in a single shot显示文摘The novel camera architecture facilitates the development of machine vision. Instead of capturing frame sequences in the temporal domain as traditional video cameras, Fourier Cam directly measures the pixel-wise temporal spectrum of the video in a single shot through optical coding. Compared to the classic video cameras and timefrequency transformation pipeline, this programmable frequency-domain sampling strategy has an attractive combination of characteristics for low detection bandwidth, low computational burden, and low data volume.Based on the various temporal filter kernel designed by Fourier Cam, we demonstrated a series of exciting machine vision functions, such as video compression, background subtraction, object extraction, and trajectory tracking. | CHENGYANG HU HONGHAO HUANG MINGHUA CHEN SIGANG YANG HONGWEI CHEN | 2021 | Photonics Research2021，9，5： | 3 |
| 4 | Effects of design parameters on rooftop photovoltaic economics in the urban environment:A case study in Melbourne,Australia显示文摘Many researchers found high potential of adopting building photovoltaic(PV)systems in urban areas,especially on building rooftop,to improve the sustainability of urban environment.However,the optimal energy output performance and economic benefit of the PV system are affected by the usable roof area,PV array layout,and shading effect considering high city density.This study aims to understand the effects of these design parameters in the urban environment of rooftop PV's economic performance.This study carries out a case study in the urban area of Melbourne with 90 PV designs under three shading conditions to generate 270 scenarios.Through a lifecycle cost-benefit analysis,including net present value(NPV),NPV per kW,internal return rate(IRR),and payback year,the results can help in developing a comprehensive understanding of the economic performance of rooftop PV designs that cover most of the urban areas of Melbourne.The optimal PV design scenarios for the urban environment are identified,thereby providing investors and industry professionals with useful information on value-for-money PV design.Meanwhile,the maximum shading loss that makes the PV systems financially unfeasible is investigated,and design scenarios with greatest ability to sustain the shading effect are identified.This research can also support the policy makers'decision on the development and deployment of the roof PV systems in urban planning. | Hongying ZHAO Chaohong YANG W.M·Pabasara U.WIJERATNE Chengyang LIU Xiaolong XUE Nishara ABDEEN | 2019 | Frontiers of Engineering Management2019，6，3： | 2 |
| 5 | Single-shot 3D tracking based on polarization multiplexed Fourier-phase camera显示文摘For moving objects,3D mapping and tracking has found important applications in the 3D reconstruction for vision odometry or simultaneous localization and mapping.This paper presents a novel camera architecture to locate the fast-moving objects in four-dimensional(4D)space(x,y,z,t)through a single-shot image.Our 3D tracking system records two orthogonal fields-of-view(FoVs)with different polarization states on one polarization sensor.An optical spatial modulator is applied to build up temporal Fourier-phase coding channels,and the integration is performed in the corresponding CMOS pixels during the exposure time.With the 8 bit grayscale modulation,each coding channel can achieve 256 times temporal resolution improvement.A fast single-shot 3D tracking system with 0.78 ms temporal resolution in 200 ms exposure is experimentally demonstrated.Furthermore,it provides a new image format,Fourier-phase map,which has a compact data volume.The latent spatio-temporal information in one 2D image can be efficiently reconstructed at relatively low computation cost through the straightforward phase matching algorithm.Cooperated with scene-driven exposure as well as reasonable Fourier-phase prediction,one could acquire 4D data(x,y,z,t)of the moving objects,segment 3D motion based on temporal cues,and track targets in a complicated environment. | JIAJIE TENG CHENGYANG HU HONGHAO HUANG MINGHUA CHEN SIGANG YANG HONGWEI CHEN | 2021 | Photonics Research2021，9，10： | 2 |
| 6 | How Do We Design CoMP to Achieve Promised Potential 显示文摘 | Chengyang Yang Shengqian Han Xueying Hou | 2013 | IEEE Wireless Com- munications2013，，2： | 1 |
| 7 | Preparation and structure analysis of nano-iron/mesocarbon microbead composites made from a coal tar pitch with addition of ferrocene 显示文摘 | Yang Yishuang Wang Chengyang Chen Mingming | 2009 | Journal of Physics and Chemistry of Solids2009，70，： | 1 |
| 8 | CoB and BN composites enabling integrated adsorption/catalysis to polysulfides for inhibiting shuttle-effect in Li-S batteries显示文摘Lithium-sulfur(Li-S)batteries are hampered by the infamous shuttle effect and slow redox kinetics,resulting in rapid capacity decay.Herein,a bifunctional catalysis CoB/BN@rGO with integrated structure and synergy effect between adsorption and catalysis is proposed to solve the above problems.The integrated CoB and BN are simultaneously and uniformly introduced on the rGO substrate through a one-step calcination strategy,applied to modify the cathode side of PP separator.The transition metal borides can catalyze the conversion of lithium polysulfides(Li_(2)Sn,n≥4),whereas the bond of B-S is too weak to absorb LPS.Thus BN introduced can effectively restrict the diffusion of polysulfides via strong chemisorption with LiSnLi+…N,while the rGO substrate ensures smooth electron transfer for redox reaction.Therefore,through the integrated adsorption/catalysis,the shuttle effect is suppressed,the kinetics of redox reaction is enhanced,and the capacity decay is reduced.Using CoB/BN@rGO modified PP separator,the Li-S batteries with high initial capacity(1450 mAh g^(-1)at 0.35 mA cm^(-2))and long-cycle stability(700 cycles at 1.74 mA cm^(-2)with a decay rate of 0.032%per cycle)are achieved.This work provides a novel insight for the preparation of bifunctional catalysis with integrated structure for long-life Li-S batteries. | Tianli Wu Ting Yang Jizong Zhang Xuewen Zheng Kunlin Liu Chengyang Wang Mingming Chen | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 9 | Preparation and structure analysis of nano-iron/mesocarbon microbead composites made from a coal tar pitch with addition of ferrocene 显示文摘 | Yang Yishuang Wang Chengyang Chen Mingming | 2009 | Journal of Physics and Chemistry of Solids2009，70，： | 1 |
| 10 | Screening of Bacillus subtilis HAAS01 and Its Biocontrol Effect on Fusarium wilt in Sweet Potato显示文摘Fusarium wilt,a disease caused by Fusarium oxysporum f.sp batatas(Fob)is an important disease in sweet potato production.Using endophytic bacteria for biological control of sweet potato diseases is one of the important ways.A Bacillus subtilis with antagonistic effect on Fusarium wilt of sweet potato was isolated from soil by confrontation culture.According to the biological characteristics,16S rDNA sequence analysis,and physiological and biochemical analysis,the Bacillus subtilis HAAS01 was named.A pot experiment was conducted for the biological control experiment of strain HAAS01,and the endogenous hormone content,antioxidant enzyme activity,soluble protein content,and related gene expressions of sweet potato plants were detected.The results showed that the HAAS01 strain could promote the production of endogenous hormones and resist the infection of plant diseases together with defensive enzymes and upregulation of related gene expressions.In summary,Bacillus subtilis HAAS01 was effective in controlling Fusarium wilt of sweet potato and has potential for application and development. | Chengyang Li Lianjun Wang Shasha Chai Yinghua Xu Chong Wang Yi Liu Jian Lei Xiaojie Jin Xianliang Cheng Yuanyuan Yang Xinsun Yang Wenying Zhang | 2022 | Phyton-International Journal of Experimental Botany2022，91，8： | 0 |
| 11 | Understanding the Development of the 2018/19 Central Pacific El Niño显示文摘A central Pacific(CP)El Niño event occurred in 2018/19.Previous studies have shown that different mechanisms are responsible for different subtypes of CP El Niño events(CP-I El Niño and CP-II El Niño).By comparing the evolutions of surface winds,ocean temperatures,and heat budgets of the CP-I El Niño,CP-II El Niño,and 2018/19 El Niño,it is illustrated that the subtropical westerly anomalies in the North Pacific,which led to anomalous convergence of Ekman flow and surface warming in the central equatorial Pacific,played an important role in the 2018/19 El Niño event as well as in the CP-II El Niño.Although the off-equatorial forcing played a vital role,it is found that the equatorial forcing acted as a driving(damping)term in boreal spring(summer)of the 2018/19 El Niño.The 2018/19 El Niño provides a timely and vivid example that helps illustrate the proposed mechanism of the CP El Niño,which could be leveraged to improve El Niño predictability. | Chengyang GUAN Xin WANG Haijun YANG | 2023 | Advances in Atmospheric Sciences2023，40，1： | 0 |
| 12 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Isolation and comparative proteomic analysis of mitochondria from the pulp of ripening citrus fruit显示文摘Mitochondria are crucial for the production of primary and secondary metabolites,which largely determine the quality of fruit.However,a method for isolating high-quality mitochondria is currently not available in citrus fruit,preventing high-throughput characterization of mitochondrial functions.Here,based on differential and discontinuous Percoll density gradient centrifugation,we devised a universal protocol for isolating mitochondria from the pulp of four major citrus species,including satsuma mandarin,ponkan mandarin,sweet orange,and pummelo.Western blot analysis and microscopy confirmed the high purity and intactness of the isolated mitochondria.By using this protocol coupled with a label-free proteomic approach,a total of 3353 nonredundant proteins were identified.Comparison of the four mitochondrial proteomes revealed that the proteins commonly detected in all proteomes participate in several typical metabolic pathways(such as tricarboxylic acid cycle,pyruvate metabolism,and oxidative phosphorylation)and pathways closely related to fruit quality(such asγ-aminobutyric acid(GABA)shunt,ascorbate metabolism,and biosynthesis of secondary metabolites).In addition,differentially abundant proteins(DAPs)between different types of species were also identified;these were found to be mainly involved in fatty acid and amino acid metabolism and were further confirmed to be localized to the mitochondria by subcellular localization analysis.In summary,the proposed protocol for the isolation of highly pure mitochondria from different citrus fruits may be used to obtain high-coverage mitochondrial proteomes,which can help to establish the association between mitochondrial metabolism and fruit storability or quality characteristics of different species and lay the foundation for discovering novel functions of mitochondria in plants. | Xin Li Yingfang Chai Hongbin Yang Zhen Tian Chengyang Li Rangwei Xu Chunmei Shi Feng Zhu Yunliu Zeng Xiuxin Deng Pengwei Wang Yunjiang Cheng | 2021 | Horticulture Research2021，8，1： | 0 |
| 14 | Variability of urban fractional vegetation cover and its driving factors in 328 cities in China显示文摘Urban green space promotes the health of urban residents,enhances urban ecosystem biodiversity,mitigates environmental pollution,and attenuates urban heat island effect.However,urban vegetation cover is highly heterogeneous and difficult to quantify.In this study,the variation of urban fractional vegetation cover(FVC)in 328 cities in China from 1990 to2022 was quantified based on Landsat satellite data at a 30-m resolution.It was found that from 1990 to 2005,due to increases in building density and impervious surfaces in cities,the national mean urban vegetation cover decreased from 0.38 to 0.35.After2005,urban vegetation cover began to reverse,reaching 0.45 in 2022.This increasing trend was most pronounced in newly built urban districts.The decrease in average urban vegetation cover before 2005 was mainly due to the expansion of low vegetation cover areas,while the increase in urban vegetation cover after 2005 manifested as the expansion of high vegetation cover areas.The reversal in the trend of urban vegetation cover change after 2004 is related to the gradual implementation of national policies requiring increased urban green space coverage.The urban gross domestic product(GDP)showed the highest correlation with changes in urban vegetation cover.For large and medium-sized cities,the top three factors influencing vegetation cover were GDP,urban population,and temperature.However,for cities in arid/semi-arid regions,changes in vegetation cover were more sensitive to climatic factors(such as precipitation).Although the urban vegetation cover in China has substantially increased in recent years,the urban green space in small-sized cities and in the old urban districts of large-sized cities still have room to improve. | Fei FENG Xin YANG Baoquan JIA Xiaoting LI Xianwen LI Chengyang XU Kaicun WANG | 2024 | Science China Earth Sciences2024，67，2： | 0 |
| 15 | Structural Changes of Activated Carbon Electrodes for EDLCs in the Manufacturing Process显示文摘Supercapacitors,or electric double-layer capacitors(EDLCs),are the new generation of energy storage devices to store electrical charges and provide high power densities and long cyclic life compared to other storage devices.EDLC mainly consists of activated carbon electrodes and an electrolyte,and the performance of EDLC depends on the activated carbon electrodes.In this work,the structural changes of activated carbon electrodes are analyzed using commercial 2.7 V/9500F EDLCs in its manufacturing process.It is found that there is no significant change in morphology and crystal structure of the activated carbon,but its specific surface area(SSA)reduced greatly.The SSA of activated carbon was decreased by 23%after they were manufactured or converted into electrodes and finally retained only 40%of SSA after the capacitance test.Besides,the SSA of the positive electrodes was found to decrease critically than that of the negative electrodes.The SSA of the external positive electrodes is only 14.3%after fl oating test at 65℃. | Bin Yang Dianbo Ruan Yang Zhang Chengyang Wang Zhijun Qiao | 2020 | Transactions of Tianjin University2020，26，5： | 0 |
| 16 | Genetic differentiation and diversity of SARS-CoV-2 Omicron variant in its early outbreak显示文摘The recently emerged Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)has quickly spread around the world.Although many consensus mutations of the Omicron variant have been recognized,little is known about its genetic variation during its transmission in the population.Here,we comprehensively analyzed the genetic differentiation and diversity of the Omicron variant during its early outbreak.We found that Omicron achieved more structural variations,especially deletions,on the SARS‐CoV‐2 genome than the other four variants of concern(Alpha,Beta,Gamma,and Delta)in the same timescale.In addition,the Omicron variant acquired,except for 50 consensus mutations,seven great new non‐synonymous nucleotide substitutions during its spread.Three of them are on the S protein,including S_A701V,S_L1081V,and S_R346K,which belong to the receptor‐binding domain(RBD).The Omicron BA.1 branch could be divided into five divergent groups spreading across different countries and regions based on these seven novel mutations.Furthermore,we found that the Omicron variant possesses more mutations related to a faster transmission rate than the other SARS‐CoV‐2 variants by assessing the relationship between the genetic diversity and transmission rate.The findings indicated that more attention should be paid to the significant genetic differentiation and diversity of the Omicron variant for better disease prevention and control. | Shenghui Weng Jingzhe Shang Yexiao Cheng Hangyu Zhou Chengyang Ji Rong Yang Aiping Wu | 2022 | Biosafety and Health2022，4，3： | 0 |
| 17 | LOEN:Lensless opto-electronic neural network empowered machine vision显示文摘Machine vision faces bottlenecks in computing power consumption and large amounts of data.Although opto-electronic hybrid neural networks can provide assistance,they usually have complex structures and are highly dependent on a coherent light source;therefore,they are not suitable for natural lighting environment applications.In this paper,we propose a novel lensless opto-electronic neural network architecture for machine vision applications.The architecture optimizes a passive optical mask by means of a task-oriented neural network design,performs the optical convolution calculation operation using the lensless architecture,and reduces the device size and amount of calculation required.We demonstrate the performance of handwritten digit classification tasks with a multiple-kernel mask in which accuracies of as much as 97.21%were achieved.Furthermore,we optimize a large-kernel mask to perform optical encryption for privacy-protecting face recognition,thereby obtaining the same recognition accuracy performance as no-encryption methods.Compared with the random MLS pattern,the recognition accuracy is improved by more than 6%. | Wanxin Shi Zheng Huang Honghao Huang Chengyang Hu Minghua Chen Sigang Yang Hongwei Chen | 2022 | Light(Science & Applications)2022，11，6： | 0 |
| 18 | Single-shot 3D tracking based on polarization multiplexed Fourier-phase camera:erratum显示文摘Figures 5(b)and 5(c)in the original article[1]are not consistent with their captions.Correct images are shown as follows.The article[1]was corrected online on 29 March 2022. | JIAJIE TENG CHENGYANG HU HONGHAO HUANG MINGHUA CHEN SIGANG YANG HONGWEI CHEN | 2022 | Photonics Research2022，10，5： | 0 |
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