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| 1 | A novel bioremediation strategy for petroleum hydrocarbon pollutants using salt tolerant Corynebacterium variabile HRJ4 and biochar显示文摘The present work aimed to develop a novel strategy to bioremediate the petroleum hydrocarbon contaminants in the environment.Salt tolerant bacterium was isolated from Dagang oilfield,China and identified as Corynebacterium variabile HRJ4 based on 16 S r RNA gene sequence analysis.The bacterium had a high salt tolerant capability and biochar was developed as carrier for the bacterium.The bacteria with biochar were most effective in degradation of n-alkanes(C16,C18,C19,C26,C28) and polycyclic aromatic hydrocarbons(NAP,PYR) mixture.The result demonstrated that immobilization of C.variabile HRJ4 with biochar showed higher degradation of total petroleum hydrocarbons(THPs) up to 78.9%after 7-day of incubation as compared to the free leaving bacteria.The approach of this study will be helpful in clean-up of petroleum-contamination in the environments through bioremediation process using eco-friendly and cost effective materials like biochar. | Hairong Zhang Jingchun Tang Lin Wang Juncheng Liu Ranjit Gajanan Gurav Kejing Sun | 2016 | Journal of Environmental Sciences2016，28，9： | 25 |
| 2 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 3 | Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors显示文摘功能的网膜的颜料上皮(RPE ) 的产生具有到再生药的地的大治疗学的兴趣并且可以为网膜的退化疾病提供可能的痊愈,包括年龄相关的有斑点的退化(AMD ) 。尽管 RPE 房间能从胚胎的干细胞被生产或导致了 pluripotent 干细胞,决定系的抄写因素驾驶的直接房间 reprogramming 提供一条立即的线路给他们的产生。由监视人的 RPE 特定的 Best1::GFP 记者,我们报导进 RPE 系使用的人的成纤维细胞的变换定义抄写因素的集合。我们发现 Best1::GFP 积极房间形成了殖民地并且展出了早阶段 RPE 房间的词法、分子的特征。而且,他们能在 Retinoic 酸(RA ) 和表明小径的声音的刺猬(嘘) 的激活之上获得色素沉着。我们的学习不仅建立了一个理想的平台调查调整 RPE 房间命运决心的 transcriptional 网络,而且提供了其他的策略产生为疾病建模,屏蔽的药,和网膜的退化的房间治疗补充 pluripotent 干细胞的使用的功能的 RPE 房间。 | Kejing Zhang Guang-Hui Liu Fei Yi Nuria Montserrat Tomoaki Hishida Concepcion Rodriguez Esteban Juan Carlos Izpisua Belmonte] | 2014 | Protein & Cell2014，5，1： | 6 |
| 4 | Influencing factors of disinfection byproducts formation during chloramination of Cyclops metabolite solutions显示文摘Effects of reaction time, chlorine dosage, pH and temperature on the formation of disinfection byproducts(DBPs), were investigated during the chloramination of Cyclops metabolite solutions. The results showed that some species of DBPs like trichloromethane(TCM), dichloroacetic acid(DCAA) and trichloroacetic acid(TCAA) could accumulate to their respective stable values with a progressive elevation in reaction time and monochloramine concentration. And 1,1,1-2-trichloropropanone(1,1,1-TCP) content decreased correspondingly with a continuous increase of reaction time. The amounts of chloral hydrate(CH), chloropicrin(TCNM), 1,1,1-TCP and DCAA firstly increased and then decreased with increasing monochloramine doses. Higher temperature resulted in a decrease of CH, dichloroacetonitrile(DCAN), 1,1-dichloropropanone(1,1-DCP), 1,1,1-TCP, DCAA and TCAA concentration. pH affected the formation of the different DBPs distinctly. TCM accumulateded with the increase of pH under 9, and DCAA, TCAA, CH and 1,1-DCP decreased continuously with increasing pH from 5 to 10, and other DBPs had the maximum concentrations at pH 6–7. | Xingbin Sun Lei Sun Ying Lu Jing Zhang Kejing Wang | 2014 | Journal of Environmental Sciences2014，26，3： | 5 |
| 5 | An Outbreak of the SARS-CoV-2 Omicron Variant BA.1—Zhuhai City,Guangdong Province,China,January 13,2022显示文摘On January 13,2022,Zhuhai CDC received a notification that a coronavirus disease 2019(COVID-19)case was found in the fever clinic in nearby Zhongshan City.Zhuhai CDC promptly carried out large-scale population screening in three nearby counties.A total of 4 COVID-19 cases were found in Nanping County.34 cases were screened from close contacts,and 2 cases were reported from close contacts in other cities of Guangdong Province.The 20 cases were sequenced by Guangdong CDC and identified as the variant of concern(VOC)/Omicron variant BA.1.Since January 14,Zhuhai has carried out 8 rounds of nucleic acid screening for COVID-19 in the county where the cases occurred.Four large-scale nucleic acid screening tests for COVID-19 were conducted across the city,and no new community cases were reported after January 15. | Feng Ruan Xuebao Zhang Songjian Xiao Xihe Ni Xiling Yin Zhongwen Ye Guorong Chen Tingting Zhu Zeling Chen Gang Yao Long Chen Sichen Huang Huitao Huang Yi Zhou Heyan Wu Hui Huang Kejing Zhu Shanzi Huang Xiaoou Tang Min Kang Bosheng Li Wenhua Mei | 2022 | China CDC weekly2022，4，30： | 2 |
| 6 | Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: a meta‐analysis of randomized control trials显示文摘 | Wencheng Nie Yanru Liu Jian Ye Liuhong Shi Fangchun Shao Kejing Ying Ruifeng Zhang | 2014 | The Clinical Respiratory Journal2014，，3： | 1 |
| 7 | Diagnostic value of the soluble triggering receptor expressed on myeloid cells‐1 in lower respiratory tract infections: A meta‐analysis显示文摘 | Wu Ye Yanjie Hu Ruifeng Zhang Kejing Ying | 2014 | Respirology2014，，4： | 1 |
| 8 | Different mechanism of LPS-induced calcium increase in human lung epithelial cell and microvascular endothelial cell: a cell culture study in a model for ARDS显示文摘 | Zhang Kejing Wang Ping Huang Shuaishuai | 2014 | Molecular biology reports2014，41，7： | 1 |
| 9 | Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway显示文摘 | Kejing Tao Lin Du Xueqian Sun Menghao Cai Tianjiao Zhu Xiangshan Zhou Qianqun Gu Yuanxing Zhang | 2008 | Tetrahedron Letters2008，，9： | 1 |
| 10 | Reactive distillation columns with a top-bottom external recycle显示文摘 | CHEN Haisheng HUANG Kejing ZHANG Liang | 2012 | Industrial&Engineering Chemistry Research2012，51，14： | 1 |
| 11 | Nonlinear characterization and performance optimization for broadband bistable energy harvester显示文摘As two crucial indicators of bistable energy harvesting performance,band width and power amplitude are simultaneously investigated for obtaining the synergy effect.Toward this goal,a nonlinear electromechanical-coupled distributed-parameter model of the bistable piezoelectric energy harvester is established.Based on the electromechanical decoupled method,approximate higher-order analytical solutions of the beam displacement,harvested power and effective bandwidth are derived.The cubic-function discriminant of the analytical solution is introduced to determine the nonlinear excitation-frequency boundaries of multiple solutions and power peak.The stability of the multiple solutions is analyzed through Jacobi matrix of the modulation equation.Superharmonic resonance is notified.Upward and downward sweep experiments and numerical solutions of time history curves,phase portraits and power spectra confirm the analytical findings.To realize optimized broadband energy harvesting,the parametric study on the coefficients of the linear and cubic elastic external forces with the corresponding optimal load resistance is performed.For the nonlinear hardening case,more positive linear coefficient is preferred.For the nonlinear softening case,the cubic coefficient slightly larger than its optimal value is recommended at each given linear coefficient.By tuning the load resistance and linear and cubic coefficients of the external force,broadband bistable energy harvesting with optimized power is realized. | Ting Tan Zhimiao Yan Kejing Ma Fengrui Liu Linchuan Zhao Wenming Zhang | 2020 | Acta Mechanica Sinica2020，36，3： | 1 |
| 12 | Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal lymph node staging of lung cancer: A meta-analysis显示文摘 | Ruifeng Zhang Kejing Ying Liuhong Shi Lianfeng Zhang Lin Zhou | 2013 | European Journal of Cancer2013，，8： | 1 |
| 13 | Transplantation Therapy of Cats with Chronic Renal Failure显示文摘Dialysis therapy is not a radical cure of chronic renal failure in cats,while renal transplantation is the cure method.Renal transplanta-tion requires rigorous examination of donor and receptor,and the procedure is strictly sterile.The main points of renal transplantation are:renal artery and vein sutured to abdominal aorta and posterior vena cava,respectively;ureter sutured to bladder;minimizing the time of thermal ischemia.Cats should be given immunosuppressant before the operation,and the drug should be administered throughout the life.Various indicators should be monitored regularly to prevent the occurrence of immunological rejection. | Zuo Kejing Huang Mian Tang Xiaojun Chen Xuanjiao Wen Yan Chen Tanzipeng Sa Jiaqi Liang Yuzhen Zhang Malong Peng Shiming Zhi Guanglin Wu Qirui | 2018 | Animal Husbandry and Feed Science2018，10，2： | 1 |
| 14 | In-plane epitaxial growth of 2D CoSe-WSe2 metalsemiconductor lateral heterostructures with improved WSe2 transistors performance显示文摘The two-dimensional(2D)in-plane(lateral)heterostructures have attracted increasing interest for potential applications in the atomically thin electronics and optoelectronics.While most studies focus on semiconductorsemiconductor lateral heterostructures with highly similar lattice structures between the constituent components,the synthesis of metal-semiconductor lateral heterostructures is much less explored and usually more challenging due to more distinct lattice structures or chemical properties.Herein,a vapor phase epitaxy growth method of high-quality metal-semiconductor lateral heterostructures between tetragonal CoSe and hexagonal WSe2 is reported.The 2D CoSe can selectively nucleate at the edge of pre-grown WSe2 nanosheets to form CoSe-WSe2 metal-semiconductor lateral heterostructures.Optical microscopy(OM),scanning electron microscopy(SEM),and atomic force microscopy(AFM)studies reveal distinct contrast across the heterostructure interface.High-resolution transmission electron microscopy(HRTEM)and selected area electron diffraction(SAED)studies further confirm the microstructure modulation across the heterostructure interface.The field-effect transistors(FETs)of CoSe-WSe2 lateral heterostructures show satisfactory Ohmic contacts and considerably better FET performance over those with deposited Cr/Au contacts,suggesting the in-plane metal-semiconductor junctions may function as improved contacts for the atomically thin electronics. | Huifang Ma Kejing Huang Ruixia Wu Zhengwei Zhang Jia Li Bei Zhao Chen Dai Ziwei Huang Hongmei Zhang Xiangdong Yang BoLi Yuan Liu Xiangfeng Duan Xidong Duan | 2021 | InfoMat2021，3，2： | 1 |
| 15 | Experimental evidence of the thickness- and electric-field-dependent topological phase transitions intopological crystalline insulator SnTe(111) thin films显示文摘Using in situ angle-resolved photoemission spectroscopy, we systematicallystudied molecular-beam-epitaxy-grown topological crystalline insulator SnTe(111 )thin films with varied thicknesses and substrate conditions. An oscillation in theband gap size with an increase in thickness was observed to depend on theelectric field perpendicular to the films. The observations are consistent withthe theoretically predicted thickness- and electric-field-dependent topologicalphase transitions between the normal insulator and the quantum spin Hallinsulator phases in SnTe(111) films and demonstrate them to be an excellentand electrically tunable quantum spin Hall system. | Yan Gong Kejing Zhu Zhe Li Yunyi Zang Xiao Feng Ding Zhang Canli Song Lili Wang Wei Li Xi Chen Xu-Cun Ma Qi-Kun Xue Yong Xu Ke He | 2018 | Nano Research2018，11，11： | 1 |
| 16 | A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer显示文摘Objective:DNA methylation alterations are early events in carcinogenesis and immune signalling in lung cancer.This study aimed to develop a model based on short stature homeobox 2 gene (SHOX2)/prostaglandin E receptor 4gene (PTGER4) DNA methylation in plasma,appearance subtype of pulmonary nodules (PNs) and low-dose computed tomography (LDCT) images to distinguish early-stage lung cancers.Methods:We developed a multimodal prediction model with a training set of 257 individuals.The performance of the multimodal prediction model was further validated in an independent validation set of 42 subjects.In addition,we explored the association between SHOX2/PTGER4 DNA methylation and driver gene mutations in lung cancer based on data from The Cancer Genome Atlas (TCGA) portal.Results:There were significant differences between the early-stage lung cancers and benign groups in the methylation levels.The area under a receiver operator characteristic curve (AUC) of SHOX2 in patients with solid nodules,mixed ground-glass opacity nodules and pure ground-glass opacity nodules were 0.693,0.497 and 0.864,respectively,while the AUCs of PTGER4 were 0.559,0.739 and 0.619,respectively.With the highest AUC of0.894,the novel multimodal prediction model outperformed the Mayo Clinic model (0.519) and LDCT-based deep learning model (0.842) in the independent validation set.Database analysis demonstrated that patients with SHOX2/PTGER4 DNA hypermethylation were enriched in TP53 mutations.Conclusions:The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs.A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis. | Jing Zhang Haohua Yao Chunliu Lai Xue Sun Xiujuan Yang Shurong Li Yubiao Guo Junhang Luo Zhihua Wen Kejing Tang | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 17 | Vertebro-basilar Ischemia and Sleep Related Breathing Disorders (Abstract)显示文摘 Introduction The relationship between cerebrovascular diseases (CVD) and sleep-related breathing disorders (SRBD) has attracted people's attention more and more in the past years. However,the subtentorial ischemic attacks - vertibrobasilar ischemia (VBI) has not been reported yet. This study is to show the interaction between VBI and SRBD.
…… | You Guoxiong Yang Hongjun Zhu Shixiu Zhang Kejing | 2000 | 中国临床神经科学2000，8，z1： | 0 |
| 18 | Human neuromuscular junction three-dimensional organoid models and the insight in motor disorders显示文摘The neuromuscular junction(NMJ),a peripheral synaptic connection between motoneurons and skeletal muscle fibers,controls movement.Dysregulation of NMJs has been implicated in various motor disorders.Because of their large size and easy accessibility,NMJs have been extensively investigated in the neuroscience field and have greatly contributed to our understanding of the fundamental principles of synapses in the central nervous system.Researchers have tried multiple ways to develop models to recreate NMJs.Rapid progress in the research and development of tissue-like organoids has made it possible to produce human NMJ three-dimensional(3D)models in vitro,providing an additional powerful strategy to study NMJs.Here,we introduce the most recent advances of human embryonic stem cell-or induced pluripotent stem cell-derived organoids to model 3D NMJs. | Kejing Zhang Lei Bai Wentao Xu Chengyong Shen | 2021 | Journal of Molecular Cell Biology2021，13，11： | 0 |
| 19 | C9orf72 poly-GA proteins impair neuromuscular transmission显示文摘Amyotrophic lateral sclerosis(ALS) is a devastating motoneuron disease,in which lower motoneurons lose control of skeletal muscles.Degeneration of neuromuscular junctions(NMJs) occurs at the initial stage of ALS.Dipeptide repeat proteins(DPRs) from G4C2repeat-associated non-ATG(RAN) translation are known to cause C9orf72-associated ALS(C9-ALS).However,DPR inclusion burdens are weakly correlated with neurodegenerative areas in C9-ALS patients,indicating that DPRs may exert cell non-autonomous effects,in addition to the known intracellular pathological mechanisms.Here,we report that poly-GA,the most abundant form of DPR in C9-ALS,is released from cells.Local administration of poly-GA proteins in peripheral synaptic regions causes muscle weakness and impaired neuromuscular transmission in vivo.The NMJ structure cannot be maintained,as evidenced by the fragmentation of postsynaptic acetylcholine receptor(AChR) clusters and distortion of presynaptic nerve terminals.Mechanistic study demonstrated that extracellular poly-GA sequesters soluble Agrin ligands and inhibits Agrin-MuSK signaling.Our findings provide a novel cell non-autonomous mechanism by which poly-GA impairs NMJs in C9-ALS.Thus,targeting NMJs could be an early therapeutic intervention for C9-ALS. | Wen-Yo Tu Wentao Xu Jianmin Zhang Shuyuan Qi Lei Bai Chengyong Shen Kejing Zhang | 2023 | Zoological Research2023，44，2： | 0 |
| 20 | Electroacupuncture stimulating Zusanli(ST36),Sanyinjiao(SP6)in mice with collagen-induced arthritis leads to adenosine A2A receptor-mediated alteration of p38αmitogen-activated protein kinase signaling and inhibition of osteoclastogenesis显示文摘OBJECTIVE:To observe the effect of electroacupuncture(EA)stimulating Zusanli(ST36),Sanyinjiao(SP6)on inhibition of osteoclastogenesis and the role of the adenosine A2A receptor(A2AR)and the p38αMitogen-Activated Protein Kinase(MAPK)signaling pathway in mediating this effect.METHODS:Mice with collagen induced arthritis(CIA)received different treatments.Immunohistochemistry and western blotting were used to determine the levels of multiple signaling molecules in these joints[receptor activator of nuclear transcription factor-κB(NF-κB)ligand(RANKL),receptor activator of NF-κB(RANK),tumor necrosis factor receptor associated factor 6(TRAF6),p38α,NF-κB,and nuclear factor of activated T cells C1(NFATc1)].Osteoclasts were identified using tartrate-resistant acid phosphatase(TRAP)staining.RESULTS:The immunohistochemistry results indicated upregulation of p38α,NF-κB,and NFATc1 in the CIA-control and CIA-EA-SCH58261 groups,but reduced levels in the CIA-EA group.Western blotting indicated upregulation of RANKL,RANK,TRAF6,p38α,NF-κB,and NFATc1 in the CIA-control and CIA-EA-SCH58261 groups,but reduced expression in the CIA-EA group.Osteoclasts were more abundant in the CIA-control and CIA-EA-SCH58261 groups than in the CIA-EA group.CONCLUSIONS:EA treatment enhanced the A2AR activity and inhibited osteoclast formation by inhibition of RANKL,RANK,TRAF6,p38α,NF-κB,and NFATc1.SCH58261 reversed the effect of EA.These results suggest that EA regulated p38α-MAPK signaling by increasing A2AR activity,which inhibited osteoclastogenesis. | DU Zhongheng CONG Wenjie TANG Kejing ZHENG Qiqi SONG Zhiwei CHEN Yong YANG Su ZHANG Chunwu YE Tianshen | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
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