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| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | SPECIAL ISSUE: MIGRANT WORKERS IN THE COURSE OF URBANIZATON Wages for migrant workers in the Pearl River Delta: determining factors显示文摘本文通过对珠江三角洲农民工问卷调查资料的回归分析,试图检验在市场转型下的企业制度和社会环境对农民工工资的影响。研究发现,人力资本中的教育年限、本企业工龄等变量对农民工工资有显著的正向影响,年龄和性别也有显著影响;企业制度中的工种对工资有显著影响,表现出明显的等级性。企业所属行业、规模和企业性质对工资没有显著影响,是否签订劳动合同和缺工情况同样如此。社会资本变量和社会环境变量对农民工工资水平没有显著影响。文章由此认为,农民工的工资是处于分割的二元劳动力市场一端,是高度市场化的,缺乏企业内部劳动力市场或晋升机制,也少受劳动力市场用工情况变化影响,没有地区性差异,是一个实实在在的、刚性的低工资。 | Liu Linping Zhang Chunni | 2008 | Social Sciences in China2008，29，3： | 6 |
| 3 | Phase coupling synchronization of FHN neurons connected by a Josephson junction显示文摘Avariety of nonlinear circuits can be tamed to reproduce the main dynamical properties in neural activities for biological neurons while designing reliable artificial synapses for connecting these neural circuits becomes a challenge.In this paper,a Josephson junction is used to build coupling channel for connecting two FitzHugh-Nagumo neural circuits driven by periodical voltage source.The hybrid synapse is designed by using a linear resistor paralleled with a Josephson junction,which can estimate the effect of external magnetic field by generating additive phase error between the junction.Indeed,it activates nonlinear coupling due to phase diversity in the Josephson junction.The coupled circuits are estimated in dimensionless dynamical systems by applying scale transformation on the variables and parameters in neural circuits.In fact,the intrinsic parameters of coupling channel are adjusted to detect the occurrence of synchronization.Bifurcation analysis is calculated to predict and confirm the occurrence of synchronization between two neural circuits.It is found that synchronization can be stabilized between two FHN neural circuits by selecting appropriate values for parameters in the Josephson junction involved in the coupling channel.It gives useful guidance for implementing artificial synapse for signal processing in neural circuits. | ZHANG Yin WANG ChunNi TANG Jun MA Jun REN GuoDong | 2020 | Science China(Technological Sciences)2020，63，11： | 6 |
| 4 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 3 |
| 5 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer显示文摘 | Liu Rui Chen Xi Du Yiqi Yao Weiyan Shen Lin Wang Cheng Hu Zhibin Zhuang Rui Ning Guang Zhang Chunni Yuan Yaozong Li Zhaoshen Zen Ke Ba Yi Zhang Chen-Yu | 2012 | Clinical Chemistry2012，，3： | 2 |
| 6 | Inhibitory effects of Rosa roxburghii Tratt juice on in vitro oxidative modification of low density lipoprotein and on the macrophage growth and cellular cholesteryl ester accumulation induced by oxidized low density lipoprotein 显示文摘 | ZHANG Chunni LIU Xiaozhuan QIANG Hongjuan | 2001 | Clin Chim Acta2001，313，2： | 1 |
| 7 | Expression Profile of MieroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma显示文摘 | Chunni Zhang Cheng Wang Xi Chen | 2010 | Clinical Chemistry2010，56，18： | 1 |
| 8 | Effect of hypoalbuminemia on the increased serum cholesteryl ester transfer protein concentration in children with idiopathic nephrotic syndrome 显示文摘 | Chunni Zhang Min Yao Xiangdong Wang | 2007 | Clin Biochem2007，40，12： | 1 |
| 9 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 1 |
| 10 | Inhibitory effects of rosa roxburghii tratt juice on in vitro oxidative modification of low density lipoprotein and on the macrophage growth and cellular cholesteryl ester accumulation induced by oxidized low density lipoprotein显示文摘 | Chunni Zhang Xiaozhuan Liu Hongduan Qiang | 2001 | Clinica Chimica Acta2001，313，1： | 1 |
| 11 | Characterization of EGFR family gene aberrations in cholangiocarcinoma显示文摘 | Xiaoqing Yang Weishan Wang Chunni Wang Lin Wang Muyi Yang Mei Qi Hong Su Xiubin Sun Zhiyan Liu Juan Zhang Xiaomin Qin Bo Han | 2014 | Oncology Reports2014，，2： | 1 |
| 12 | Saikosaponin aand its epimer Saikosaponin d exhibit anti-inflammatory activityby suppressing activation of NF- k B signaling pathway 显示文摘 | LU Chunni YUAN Ziguo ZHANG Xiaoli | 2012 | Inter-national Immunopharmacology2012，14，1： | 1 |
| 13 | Relationship between endogenous concentrations and serum cholesteryl ester transfer protein concentrations in Chinese women 显示文摘 | Zhuang Yiyi Qiang Hongjuan | 2001 | Clin Chim Acta2001，314，12： | 1 |
| 14 | ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cells显示文摘 | Lin Wang Yanjiang Li Xiaoqing Yang Huiqing Yuan Xiangzhi Li Mei Qi Yannicca W.Y. Chang Chunni Wang WeiWei Fu Muyi Yang Juan Zhang Bo Han | 2014 | Prostate2014，，6： | 1 |
| 15 | Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects显示文摘 | Jia Wu Jiaxi Song Cheng Wang Dongmei Niu Hanqing Li Yuxiu Liu Lijuan Ma Ruijie Yu Xi Chen Ke Zen Qi Yang Chunni Zhang Chen-Yu Zhang Junjun Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 16 | Does the school cutoff date cause the disadvantage for children born in July and August?显示文摘Compulsory education systems usually specify a cutoff date regulating the precise age for entry into primary school.Existing literature from the USA and Europe has demonstrated that children born just before the cutoff date are disadvantaged in academic performance and has formalized this phenomenon as the“age position effect.”A recent study by Liu and Li(Sociol Stud 6:169-245,2015)reported similar findings for China.Our study,however,challenges Liu and Li’s conclusion by examining the long-term effects of birth month on socioeconomic attainment and the compliance rate regarding the cutoff date.Using the 20051%Mini-census Survey and the 1992 National Sample Survey of the Living Situation of Chinese Children,we found a significant variation in socioeconomic achievement by birth month in adulthood in ways that differ from those reported by Liu and Li.In addition,we found compliance to be affected by both birth month and parental characteristics.In conclusion,our article proposes parental self-selection as an alternative explanation for the cutoff date effect. | Chunni Zhang Yu Xie | 2018 | The Journal of Chinese Sociology2018，5，1： | 0 |
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