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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Formation and causes of NO_x pollution on the east side of the Taihang Mountains in China显示文摘Tropospheric column amounts of NO 2 from OMI/Aura products were applied to investigate the seasonal variation of NO x on the east side of the Taihang Mountains (ESTM) in China. The NO 2 concentration varied seasonally, with winter maxima and summer minima. To explore the causes of the heavy NO 2 pollution in this region, wind field simulations were conducted by using the Fifth-Generation NCAR/Penn State Mesoscale Model (MM5). MM5 simulations showed that wind directions in the ESTM region were dominated by northeasterly and northwesterly winds throughout the year and to a lesser degree by southwesterlies. Elevated NO 2 concentrations (higher than 50×10 15 molec/cm 2 ) occurred in three meteorological situations: convergent wind fields (5 days), northeasterly winds (2 days), and calm days (1 day) in January. Although the local anthropogenic NO x emission strength was not so high as that in other developed areas, the calms and frequent occurrence of convergent wind fields, as well as unfavorable terrains for diffusion, resulted in the accumulation of atmospheric pollutants and hence heavy NO x pollution. Furthermore, long-distance NO x transportation from the Beijing-Tianjin-Tangshan region to the ESTM area could be seen when the wind was from a northeasterly direction, especially under high wind speeds. | TIAN HeZhong WANG Yan ZHAO Dan CHAI FaHe XING ZiShan CHENG Ke | 2011 | Chinese Science Bulletin2011，56，19： | 6 |
| 3 | Enhanced photocatalytic N2 fixation by promoting N2 adsorption with a co-catalyst显示文摘Photocatalytic N2 fixation involves a nitrogen reduction reaction on the surface of the photocatalyst to convert N2 into ammonia.Currently,the adsorption of N2 is the limiting step for the N2 reduction reaction on the surface of the catalyst.Based on the concept of photocatalytic water splitting,the photocatalytic efficiency can be greatly enhanced by introducing a co-catalyst.In this report,we proposed a new strategy,namely,the loading of a NiS co-catalyst on CdS nanorods for photocatalytic N2 fixation.Theoretical calculation results indicated that N2 was effectively adsorbed onto the NiS/CdS surface.Temperature programmed desorption studies confirmed that the N2 molecules preferred to adsorb onto the NiS/CdS surface.Linear sweep voltammetry results revealed that the overpotential of the N2 reduction reaction was reduced by loading NiS.Furthermore,transient photocurrent and electrochemical impedance spectroscopy indicated that the charge separation was enhanced by introducing NiS.Photocatalytic N2 fixation was carried out in the presence of the catalyst dispersed in water without any sacrificial agent.As a result,1.0 wt% NiS/CdS achieved an ammonia production rate of 2.8 and 1.7 mg L-1 for the first hour under full spectrum and visible light(λ>420 nm),respectively.The catalyst demonstrated apparent quantum efficiencies of 0.76%,0.39% and 0.09% at 420,475 and 520 nm,res pectively.This study provides a new method to promote the photocatalytic efficiency of N2 fixation. | Xiang Gao Li An Dan Qu Wenshuai Jiang Yanxiao Chai Shaorui Sun Xingyuan Liu Zaicheng Sun | 2019 | Science Bulletin2019，64，13： | 6 |
| 4 | Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)显示文摘一系列 1-(1H-1,2,4-triazole-1-yl )-2-(2,4-difluorophenyl)-3-(N-isoproyl-N-substituted-amino)-2-propanols 根据 lanosterol 14a-demethylase (CYP51 ) 的活跃地点被设计了并且综合。他们的结构被 MS 和 1 H NMR。在 vitro,这些综合混合物的抗真菌的活动与八人的病原的真菌被作比较。结果证明所有标题混合物对测试到某程度的真菌展出了活动。混合物 3c, 3d, 7a, 7b 和 7c 展出了更多的有势力对将近除了曲霉属菌 fumigatus,真菌比 fluconazole 测试了的所有的抗真菌的活动。 | Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu | 2009 | Chinese Chemical Letters2009，20，8： | 5 |
| 5 | Effect of bio-column composed of aged refuse on methane abatement-A novel configuration of biological oxidation in refuse landfill显示文摘An experimental bio-column composed of aged refuse was installed around the exhaust pipe as a new way to mitigate methane in refuse landfill.One of the objectives of this work was to assess the effect of aged refuse thickness in bio-column on reducing CH 4 emissions.Over the study period,methane oxidation was observed at various thicknesses,5 cm (small size),10 cm (middle size) and 15 cm (large size),representing one to three times of pipeline diameters.The middle and large size both showed over 90% methane conversion,and the highest methane conversion rate of above 95% occurred in the middle-size column cell.Michaelis-Menten equation addressed the methanotrophs diffusion in different layers of the bio-columns.Maximum methanotrophic activity (V max) measured at the three thicknesses ranged from 6.4 × 10 3 to 15.6 × 10 3 units,and the half-saturation value (K M) ranged from 0.85% to 1.67%.Both the highest V max and K M were observed at the middle-size of the bio-column,as well as the largest methanotrophs population,suggesting a significant efficiency of methane mitigation happened in the optimum zone with greatest affinity and methanotrophic bacteria activities.Therefore,bio-column is a potential style for methane abatement in landfill,and the aged refuse both naturally formed and artificially placed in the column plays a critical role in CH 4 emission. | Dan Han Youcai Zhao Binjie Xue Xiaoli Chai | 2010 | Journal of Environmental Sciences2010，22，5： | 4 |
| 6 | Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis显示文摘Ischemic heart diseases(IHDs)cause great morbidity and mortality worldwide,necessitating effective treatment.Salvianic acid A sodium(SAAS)is an active compound derived from the well-known herbal medicine Danshen,which has been widely used for clinical treatment of cardiovascular diseases in China.This study aimed to confirm the cardioprotective effects of SAAS in rats with myocardial infarction and to investigate the underlying molecular mechanisms based on proteome and transcriptome profiling of myocardial tissue.The results showed that SAAS effectively protected against myocardial injury and improved cardiac function.The differentially expressed proteins and genes included important structural molecules,receptors,transcription factors,and cofactors.Functional enrichment analysis indicated that SAAS participated in the regulation of actin cytoskeleton,phagosome,focal adhesion,tight junction,apoptosis,MAPK signaling,and Wnt signaling pathways,which are closely related to cardiovascular diseases.SAAS may exert its cardioprotective effect by targeting multiple pathways at both the proteome and transcriptome levels.This study has provided not only new insights into the pathogenesis of myocardial infarction but also a road map of the cardioprotective molecular mechanisms of SAAS,which may provide pharmacological evidence to aid in its clinical application. | Dan Jia Cheng-zhong Zhang Yan Qiu Xiao-fei Chen Lin Jia Alex F.Chen Yi-feng Chai Zhen-yu Zhu Jin Huang Chuan Zhang | 2019 | Acta Pharmacologica Sinica2019，40，12： | 4 |
| 7 | Monitoring of SiC MOSFET Junction Temperature with On-state Voltage at High Currents显示文摘A junction temperature monitoring method has been presented based on the on-state voltage at high currents.With a simplified physical model,this method mapped the relationship between junction temperature and on-state voltage.The tough calibration and signal sensing issues are solved.Verified by body-diode voltage detecting method,the presented method shows a good performance and high accuracy,in the meantime,it would not change the modulation strategy and topology of the converter. | Dan Zheng Yuhui Kang Han Cao Xiaoguang Chai Tao Fan Puqi Ning | 2020 | Chinese Journal of Electrical Engineering2020，6，3： | 3 |
| 8 | Role of tetraspanin CD151–α3/α6 integrin complex: Implication in angiogenesis显示文摘 | Wei-Feng Liu Hou-Juan Zuo Bo-lan Chai Dan Peng Yu-Jie Fei Jing-Yang Lin Xiao-Hui Yu Dao-Wen Wang Zheng-Xiang Liu | 2011 | International Journal of Biochemistry and Cell Biology2011，，4： | 3 |
| 9 | Structural engineering of cathodes for improved Zn-ion batteries显示文摘Aqueous zinc-ion batteries(ZIBs) are attracting considerable attention because of their low cost,high safety and abundant anode material resources.However,the major challenge faced by aqueous ZIBs is the lack of stable and high capacity cathode materials due to their complicated reaction mechanism and slow Zn-ion transport kinetics.This study reports a unique 3 D ’flower-like’ zinc cobaltite(ZnCo_(2)O_(4-x)) with enriched oxygen vacancies as a new cathode material for aqueous ZIBs.Computational calculations reveal that the presence of oxygen vacancies significantly enhances the electronic conductivity and accelerates Zn^(2+) diffusion by providing enlarged channels.The as-fabricated batteries present an impressive specific capacity of 148.3 mAh g^(-1) at the current density of 0.05 A g^(-1),high energy(2.8 Wh kg^(-1)) and power densities(27.2 W kg^(-1)) based on the whole device,which outperform most of the reported aqueous ZIBs.Moreover,a flexible solid-state pouch cell was demonstrated,which delivers an extremely stable capacity under bending states.This work demonstrates that the performance of Zn-ion storage can be effectively enhanced by tailoring the atomic structure of cathode materials,guiding the development of low-cost and eco-friendly energy storage materials. | Jiajia Huang Yuying Li Ruikuan Xie Jianwei Li Zhihong Tian Guoliang Chai Yanwu Zhang Feili Lai Guanjie He Chuntai Liu Tianxi Liu Dan J.L.Brett | 2021 | Journal of Energy Chemistry2021，30，7： | 3 |
| 10 | Efficacy of Sijunzi decoction(四君子汤) on limb weakness in spleen Qi deficiency model rats through adenosine monophosphate-activated protein kinase/unc-51 like autophagy activating kinase 1 signaling显示文摘OBJECTIVE:To investigate the efficacy of Sijunzi decoction(四君子汤)on limb weakness in a rat model of spleen Qi deficiency(SQD),and to study its effect on mitophagy in skeletal muscle through adenosine monophosphate-activated protein kinase(AMPK)/unc-51 like autophagy activating kinase 1(ULK1)signaling.METHODS:SQD model rats were produced by fasting combined with forced swimming method for15 d.After model assessment,rats were randomly divided into four groups of 10[low/middle/high(L/M/H)Sijunzi decoction dose groups and a normal saline(S)group].Limb holding power(HP)and body mass(BM)were measured after 2 weeks of treatment.Following euthanasia,quadriceps femoris were dissected and myofiber and mitochondrial morphology were observed by transmission electron microscopy(TEM).Mitochondrial membrane potential(MMP),adenosine triphosphatase(ATP)and reactive oxygen species(ROS)levels were determined using colorimetric methods,and immunoblot analysis of Microtubule-associated protein light chain 3(LC3)and Sequestosome 1(p62)was performed to monitor mitophagy and AMPK/ULK1 signaling.RESULTS:Compared with control(C)group rats,in the S group,HP was reduced,the myofiber Z line was disordered,mitochondria were scattered,and numerous vacuoles and mitophagy were observed.MMP and ATP levels were reduced,ROS levels were elevated,and LC3B expression,and p-AMPKα(Thr172)/AMPKα,p-ULK1(Ser555)/ULK1,and p-Raptor(Ser792)/Raptor ratios were increased,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were decreased.After treatment,compared with the S group,HP was improved in M and H groups but not in the L group.Mitophagy was reduced in M,H and L groups but the Z line was disordered and vacuolization remained in the L group.ATP levels were elevated in M,H and L groups,and MMPs were elevated in M and H groups but not in the L group.ROS levels were decreased in M,H and L groups,as were LC3B expression and p-Raptor(Ser792)/Raptor ratios,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were increased in M and H groups but not in the L group.p-AMPKα(Thr172)/AMPKαand p-ULK1(Ser555)/ULK1 ratios were decreased in M,H and L groups.CONCLUSIONS:Sijunzi decoction improved HP,possibly by inhibiting mitophagy via suppression of AMPK/ULK1 signaling.This restored mitochondrial morphology and improved oxidative phosphorylation,which contributed to recovery of limb weakness in SQD model rats. | LIU Wenjun XU Xinzhu DUAN Zhiyuan LIANG Xicai MA Dan LI Gege XIE Xin CHAI Jiyan CHEN Jing SHAN Dehong | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 2 |
| 11 | Regeneration of hair cells in the mammalian vestibular system显示文摘毛细胞在整个非哺乳动物的脊椎动物的一生再生,允许这些动物从听觉恢复并且平衡赤字。如此的新生不在人和另外的哺乳动物高效地发生。因此,平衡赤字变得永久并且是在整个世界的普通感觉混乱。后来前进并且 Warchol 在成熟哺乳动物在 gentamicininduced 损坏以后发现了门厅的毛细胞的有限自发的新生,重要努力被施加了在毛细胞损失以后在哺乳动物跟踪有限门厅的新生的起源。而且,最近,许多策略被开发了支持毛细胞新生和门厅的系统的随后的功能的恢复包括操作 Wnt,槽口和 Atoh1。这篇文章在哺乳动物的门厅的 epithelia 在毛细胞新生提供最近的进展的概述。而且,这评论加亮毛细胞新生的当前的限制并且提供可能的答案改革功能的毛细胞并且部分恢复门厅的功能。 | Wenyan Li Dan You Yan Chen Renjie Chai Huawei Li | 2016 | Frontiers of Medicine2016，10，2： | 2 |
| 12 | A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications. | Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 13 | Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation显示文摘Studies have shown that downregulation of nuclear-enriched autosomal transcript 1(Neat1)may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice.Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear.Therefore,the effects of Neat1 on neuronal apoptosis were observed.C57 BL/6 primary neurons were obtained from the cortices of newborn mice and cultured in vitro,and an oxygen and glucose deprivation cell model was established to simulate the secondary brain injury that occurs after traumatic brain injury in vitro.The level of Neat1 expression in neuronal cells was regulated by constructing a recombinant adenovirus to infect neurons,and the effects of Neat1 expression on neuronal apoptosis after oxygen and glucose deprivation were observed.The experiment was divided into four groups:the control group,without any treatment,received normal culture;the oxygen and glucose deprivation group were subjected to the oxygen and glucose deprivation model protocol;the Neat1 overexpression and Neat1 downregulation groups were treated with Neat1 expression intervention techniques and were subjected to the in oxygen and glucose deprivation protocol.The protein expression levels of neurons p53-induced death domain protein 1(PIDD1,a pro-apoptotic protein),caspase-2(an apoptotic priming protein),cytochrome C(a pro-apoptotic protein),and cleaved caspase-3(an apoptotic executive protein)were measured in each group using the western blot assay.To observe changes in the intracellular distribution of cytochrome C,the expression levels of cytochrome C in the cytoplasm and mitochondria of neurons from each group were detected by western blot assay.Differences in the cell viability and apoptosis rate between groups were detected by cell-counting kit 8 assay and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay,respectively.The results showed that the apoptosis rate,PIDD1,caspase-2,and cleaved caspase-3 expression levels significantly decreased,and cell viability significantly improved in the Neat1 overexpression group compared with the oxygen and glucose deprivation group;however,Neat1 downregulation reversed these changes.Compared with the Neat1 downregulation group,the cytosolic cytochrome C level in the Neat1 overexpression group significantly decreased,and the mitochondrial cytochrome C level significantly increased.These data indicate that Neat1 upregulation can reduce the release of cytochrome C from the mitochondria to the cytoplasm by inhibiting the PIDD1-caspase-2 pathway,reducing the activation of caspase-3,and preventing neuronal apoptosis after oxygen and glucose deprivation,which might reduce secondary brain injury after traumatic brain injury.All experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Chongqing Medical University,China,on December 19,2020(approval No.2020-895). | Wei-Na Chai Yi-Fan Wu Zhi-Min Wu Yan-Feng Xie Quan-Hong Shi Wei Dan Yan Zhan Jian-Jun Zhong Wei Tang Xiao-Chuan Sun Li Jiang | 2022 | Neural Regeneration Research2022，17，1： | 1 |
| 14 | Effect and mechanism of persulfate activated by different methods for PAHs removal in soil显示文摘 | Dan Zhao Xiaoyong Liao Xiulan Yan Scott G. Huling Tuanyao Chai Huan Tao | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 15 | An explorato- ry study on understanding the technological dimension in disruptive innovation 显示文摘 | HANG CHANG CHIEH YU DAN CHAI KAH HIN | 2007 | The 5th International Symposium on Management of Technology2007，，17： | 1 |
| 16 | Cadmium-induced oxidative stress and response of the ascorbate–glutathione cycle in Bechmeria nivea (L.) Gaud显示文摘 | Yunguo Liu Xin Wang Guangming Zeng Dan Qu Jiajia Gu Ming Zhou Liyuan Chai | 2007 | Chemosphere2007，，1： | 1 |
| 17 | Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance显示文摘As a major class of medicine for treating the lethal type of castration-resistant prostate cancer(PCa),long-term use of androgen receptor(AR)antagonists commonly leads to antiandrogen resistance.When AR signaling pathway is blocked by AR-targeted therapy,glucocorticoid receptor(GR)could compensate for AR function especially at the late stage of PCa.AR-GR dual antagonist is expected to be a good solution for this situation.Nevertheless,no effective non-steroidal AR-GR dual antagonist has been reported so far.In this study,an AR-GR dual binder H18 was first discovered by combining structure-based virtual screening and biological evaluation.Then with the aid of computationally guided design,the AR-GR dual antagonist HD57 was finally identified with antagonistic activity towards both AR(IC_(50)=0.394μM)and GR(IC_(50)=17.81μM).Moreover,HD57 could effectively antagonize various clinically relevant AR mutants.Further molecular dynamics simulation provided more atomic insights into the mode of action of HD57.Our research presents an efficient and rational strategy for discovering novel AR-GR dual antagonists,and the new scaffold provides important clues for the development of novel therapeutics for castration-resistant PCa. | Xin Chai Xue-ping Hu Xin-yue Wang Hua-ting Wang Jin-ping Pang Wen-fang Zhou Jia-ning Liao Lu-hu Shan Xiao-hong Xu Lei Xu Hong-guang Xia Ting-jun Hou Dan Li | 2023 | Acta Pharmacologica Sinica2023，44，7： | 1 |
| 18 | Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays显示文摘Androgen receptor(AR),a ligand-activated transcription factor,is a master regulator in the development and progress of prostate cancer(PCa).A major challenge for the clinically used AR antagonists is the rapid emergence of resistance induced by the mutations at AR ligand binding domain(LBD),and therefore the discovery of novel anti-AR therapeutics that can combat mutation-induced resistance is quite demanding.Therein,blocking the interaction between AR and DNA represents an innovative strategy.However,the hits confirmed targeting on it so far are all structurally based on a sole chemical scaffold.In this study,an integrated docking-based virtual screening(VS)strategy based on the crystal structure of the DNA binding domain(DBD)of AR was conducted to search for novel AR antagonists with new scaffolds and 2-(2-butyl-1,3-dioxoisoindoline-5-carboxamido)−4,5-dimethoxybenzoicacid(Cpd39)was identified as a potential hit,which was competent to block the binding of AR DBD to DNA and showed decent potency against AR transcriptional activity.Furthermore,Cpd39 was safe and capable of effectively inhibiting the proliferation of PCa cell lines(i.e.,LNCaP,PC3,DU145,and 22RV1)and reducing the expression of the genes regulated by not only the full-length AR but also the splice variant AR-V7.The novel AR DBD-ARE blocker Cpd39 could serve as a starting point for the development of new therapeutics for castration-resistant PCa. | Jin-ping Pang Chao Shen Wen-fang Zhou Yun-xia Wang Lu-hu Shan Xin Chai Ying Shao Xue-ping Hu Feng Zhu Dan-yan Zhu Li Xiao Lei Xu Xiao-hong Xu Dan Li Ting-jun Hou | 2022 | Acta Pharmacologica Sinica2022，43，1： | 1 |
| 19 | Effect and mechanism of persulfate activated by different methods for PAHs removal in soil显示文摘 | Dan Zhao Xiaoyong Liao Xiulan Yan Scott G. Huling Tuanyao Chai Huan Tao | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 20 | Liquid biopsy:Precise diagnosis and therapy for cholangiocarcinoma显示文摘The following letter to the editor highlights the review titled“Liquid biopsy in cholangiocarcinoma:Current status and future perspective”in World J Gastrointest Oncol 2021;13:332-350.It is necessary to realize individualized therapy to improve the clinical prognosis of patients with cholangiocarcinoma. | Si-Qin Wang Chu-Xing Chai Bi-Rong Wang Feng Zhu Dan Shang Min Li | 2022 | World Journal of Gastrointestinal Oncology2022，14，1： | 1 |
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