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| 1 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 2 | Secondary non-resectable liver tumors:A single-center living-donor and deceased-donor liver transplantation case series显示文摘Background: During the last decades, deceased-donor liver transplantation (DDLT) has gained a place in the therapeutic algorithm of well-selected patients harbouring non-resectable secondary liver tumors. Living-donor LT (LDLT) might represent a valuable means to further expand this indication for LT. Methods: Between 1985 and 2016, twenty-two adults were transplanted because of neuroendocrine ( n = 18, 82%) and colorectal metastases ( n = 4, 18%);50% received DDLT and 50% LDLT. In LDLT, 4 (36%) right and 7 (64%) left grafts were used;the median graft-to-recipient-weight ratios (GRWR) were 1.03%(IQR 0.86%- 1.30%) and 0.59%(IQR 0.51%- 0.91%), respectively. Median post-LT follow-up was 64 months (IQR 17–107) in the DDLT group and 40 months (IQR 35–116) in the LDLT group. DDLT and LDLT recipients were compared in terms of overall survival, graft survival, postoperative complications and recurrence. Results: The 1- and 5-year actuarial patient survivals were 82% and 55% after DDLT, 100% and 100% after LDLT, respectively ( P < 0.01). One- and 5-year actuarial graft survivals were 73% and 36% after DDLT, 91% and 91% after LDLT ( P < 0.01). The outcomes of right or left LDLT were comparable. Donor hepatectomy proved safe, and one donor experienced a Clavien IIIb complication. Bilirubin peak was significantly lower after left hepatectomy compared with that after right hepatectomy [1.3 (IQR 1.2–2.2) vs. 3.3 (IQR 2.3–5.2) mg/dL;P = 0.02]. Conclusions: The more recent LDLT series compared favorably to our DDLT series in the treatment of secondary liver malignancies. The absence of portal hypertension and the use of smaller left grafts make recipient and donor surgeries safe. The safety of the procedures and lack of interference with the scarce allograft pool are expected to lead to a more frequent use of LDLT in the field of transplant oncology. | Jan Lerut Samuele Iesari Gaetan Vandeplas Tiziana Fabbrizio Kevin Ackenine Milton Eduardo Inostroza Nunez Mina Komuta Laurent Coubeau Olga Ciccarelli Eliano Bonaccorsi-Riani | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 2 |
| 3 | A meta-analytic overview of thrombectomy during primary angioplasty显示文摘 | Giuseppe De Luca Eliano Pio Navarese Harry Suryapranata | 2013 | International Journal of Cardiology2013，，3： | 2 |
| 4 | Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction显示文摘 | Iwona Swiatkiewicz Marek Kozinski Przemyslaw Magielski Joanna Gierach Tomasz Fabiszak Aldona Kubica Adam Sukiennik Eliano Navarese Grazyna Odrowaz-Sypniewska Jacek Kubica | 2012 | Inflammation Research2012，，7： | 1 |
| 5 | Adenosine improves post-procedural coronary flow but not clinical outcomes in patients with acute coronary syndrome: A meta-analysis of randomized trials显示文摘 | Eliano Pio Navarese Antonino Buffon Felicita Andreotti Paul Alfred Gurbel Marek Kozinski Aldona Kubica Giuseppe Musumeci Alberto Cremonesi Luigi Tavazzi Jacek Kubica Fausto Castriota | 2011 | Atherosclerosis2011，，1： | 1 |
| 6 | Tacrolimus Monotherapy in Liver Transplantation: One-Year Results of a Prospective, Randomized, Double-Blind, Placebo-Controlled Study显示文摘 | Jan Lerut Jules Mathys Catherine Verbaandert Stéphanie Talpe Olga Ciccarelli Julien Lemaire Eliano Bonaccorsi-Riani Vincent Vanthuyne Nathalie Hetsch Francine Roggen Chantal D. E. Reyck Pierre Goffette Dominique Latinne Giuseppe Orlando Jacques Rahier Chr | 2008 | Annals of Surgery2008，，6： | 1 |
| 7 | Meta-analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus显示文摘 | Eliano Pio Navarese Antonino Buffon Felicita Andreotti Marek Kozinski Nicky Welton Tomasz Fabiszak Salvatore Caputo Grzegorz Grzesk Aldona Kubica Iwona Swiatkiewicz Adam Sukiennik Malte Kelm Stefano De Servi Jacek Kubica | 2012 | The American Journal of Cardiology2012，，： | 1 |
| 8 | Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation显示文摘AIM: To determine the impact of red blood cell distribution width on outcome in anemic patients undergoing transcatheter aortic valve implantation(TAVI).METHODS: In a retrospective single center cohort study we determined the impact of baseline red cell distribution width(RDW) and anemia on outcome in 376 patients with aortic stenosis undergoing TAVI. All patients were discussed in the institutional heart team and declined for surgical aortic valve replacement due to high operative risk. Collected data included patient characteristics, imaging findings, periprocedural in hospital data, laboratory results and follow up data. Blood samples for hematology and biochemistry analysis were taken from every patient before and at fixed intervals up to 72 h after TAVI including blood count and creatinine. Descriptive statistics were used for patient's characteristics. KaplanMeier survival curves were used for time to event outcomes. A recursive partitioning regression and classification was used to investigate the association between potential risk factors and outcome variables.RESULTS: Mean age in our study population was 81 ± 6.1 years. Anemia was prevalent in 63.6%(n = 239) of our patients. Age and creatinine were identified as risk factors for anemia. In our study population, anemia per se did influence 30-d mortality but did not predict longterm mortality. In contrast, a RDW > 14% showed to be highly predictable for a reduced short- and longterm survival in patients with aortic valve disease after TAVI procedure.CONCLUSION: Age and kidney function determine the degree of anemia. The anisocytosis of red blood cells in anemic patients supplements prognostic information in addition to that derived from the WHO-based definition of anemia. | Katharina Hellhammer Tobias Zeus Pablo E Verde Verena Veulemanns Lisa Kahlstadt Georg Wolff Ralf Erkens Ralf Westenfeld Eliano P Navarese Marc W Merx Tienush Rassaf Malte Kelm | 2016 | World Journal of Cardiology2016，8，2： | 0 |
| 9 | Artspy:网络是终止行为艺术的死神?显示文摘网络视频会扼杀行为艺术吗?——《纽约时报》在一篇报道中提出了这个问题,这篇报道称YouTube与其它社交媒介上传的记录行为艺术的视频击败了行为艺术本身的震撼效果。人物传记《WhenMarinaAbramovicDies》的作者Jameswestcott就写到:“数字影像以及好奇心的普遍存在在当前看来是行为艺术力量被盗走的一个原因。 | Liza Eliano 陈颖 | 2011 | 东方艺术2011，，21： | 0 |
| 10 | Delivery of genetic load during ex situ liver machine perfusion with potential for CRISPR-Cas9 gene editing:An innovative strategy for graft treatment显示文摘To the Editor:Over the years,the shortage of suitable donor organs has challenged the transplant community in performing life-saving liver transplantation(LT).Recent reports from European and American liver transplant registries show persistently high waitlist mortality rates ranging between 10%and 18%[1,2]. | Eliano Bonaccorsi-Riani Andrew Gillooly Isabel M.A.Brüggenwirth Paulo N.Martins | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 0 |
| 11 | What is the Optimal Duration of Dual Antiplatelet Therapy After Stenting?显示文摘The optimal duration of dual antiplatelet therapy(DAPT)of aspirin and a P2Y12 receptor blocker after stenting is still being debated.The current recommendations for DAPT duration are signifi cantly focused on reducing stent thrombosis;a less frequent event with later than earlier generation drug eluting stents(DES).A persistent occurrence of late and very late stent thrombosis with first generation DES supported extended use of DAPT beyond one year.However,recent studies have demonstrated that extended duration DAPT is associated with increased bleeding;an independent predictor for poor outcomes,including long-term mortality.Second-generation DES are associated with less late and very late stent thrombosis.Some recent studies have supported a shorter duration of DAPT for second generation DES.However,these studies were inadequately powered to assess signifi cant differences in stent thrombosis.Furthermore,extended duration DAPT has been associated with a reduced risk of thrombotic events in non-culprit vessels in addition to stent thrombosis in patients with acute coronary syndromes(ACS).The higher risk of bleeding associated with extended DAPT therapy provides a strong rationale for personalized DAPT based on patient risk factors(e.g.ACS vs.non-ACS),type of stents,and cost-benefit analyses. | Udaya S.Tantry Eliano P.Navarese Paul A.Gurbel | 2016 | Cardiovascular Innovations and Applications2016，，B05： | 0 |
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