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| 1 | Perfecting and extending the near-infrared imaging window显示文摘In vivo fluorescence imaging in the second near-infrared window(NIR-II)has been considered as a promising technique for visualizing mammals.However,the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected.Herein,we simulate the photon propagation in the NIR region(to 2340 nm),confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm,where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions,respectively.Moreover,2080–2340 nm is newly proposed as the third near-infrared(NIR-III)window,which is believed to provide the best imaging quality.The wide-field fluorescence microscopy in the brain is performed around the NIRIIx region,with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date.We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging,using bright fluorophores with short emission wavelength. | Zhe Feng Tao Tang Tianxiang Wu Xiaoming Yu Yuhuang Zhang Meng Wang Junyan Zheng Yanyun Ying Siyi Chen Jing Zhou Xiaoxiao Fan Dan Zhang Shengliang Li Mingxi Zhang Jun Qian | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 2 | A current-mode RF transmitter for 6–9 GHz MB-OFDM UWB application显示文摘This paper presents a current-mode 6–9 GHz RF transmitter for MB-OFDM UWB systems. The proposed current-mode transmitter consists of current-mode IQ LPF, current mirror amplifier, IQ up-conversion mixer (up-mixer), differential power driver amplifier (PA) and high-speed divider with LO buffers for generating IQ LO signals. All circuits are designed to possess high linearity and wide bandwidth. The transmitter is fabricated in TSMC 0.13 μm 1P8M RF CMOS technology with a die area of 1.56 mm2. Measurement results show that a maximum output power of -0.7 dBm with an LO leakage/sideband rejection ratio (LOL/SB RR) around -33/ - 35 dBc is achieved, and that this transmitter excels the traditional voltage-mode counterpart in terms of high linearity (about +1 dBm output 1-dB compression point, +10 dBm output IP3 in average) with comparable power consumption (drawing 48 mA current from 1.2 V supply). | CHEN YunFeng FAN JinHan LI Wei LINing REN JunYan | 2011 | Science China(Information Sciences)2011，54，2： | 2 |
| 3 | Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway in perimenopausal rats显示文摘OBJECTIVE:To investigate the efficacy of self-made Gengnian decoction on expressions of phosphatidylinositol 3-kinase(PI3 K),protein kinase B(Akt)and mammalian target of rapamycin(m TOR)in ovarian tissues of perimenopausal rats.They were identified with symptom pattern of kidney-Yang deficiency in terms of Traditional Chinese Medicine.METHODS:Female Sprague-Dawley rats aged10-12 months were selected.Estrous cycle was observed by vaginal smears of keratinocytes to screen the perimenopausal model rats.The chosen rats were randomly divided into five groups,including perimenopausal model of kidney-Yang deficiency group(24 rats),self-made Gengnian decoction of high-dose group(24 rats),self-made Gengnian decoction of middle-dose group(24 rats),self-made Gengnian decoction of low dose group(24 rats)and tibolone control group(24 rats).In addition,rats aged 4-6 months were selected as young control group.The perimenopausal model rats of kidney-Yang deficiency were prepared by alternative intramuscular injection of hydrocortisone 5 mg·kg^-1·d^-1The successfully prepared models in self-made Gengnian decoction of high-dose,middle-dose and low-dose groups and tibolone control group were given self-made Gengnian decoction 26.4,13.2 and 6.6 mg·kg^-1·d^-1,and tibolone tablets solvent 0.22 mg·kg^-1·d^-1,respectively,through intragastric administration.Models group and young control group were given the same dose of normal saline,1 time a day for 15 consecutive days.24 h after the last administration,blood and ovarian tissues were collected after anesthesia with 20%ethyl carbamate.The follicles of different levels in ovarian tissue were observed and counted by histopathological hematoxylin-eosin staining.Enzyme linked immunosorbent assay was applied to test insulin-like growth factor-1(IGF-1)level in the serum of experimental rats.The expression levels of PI3 K,phosphorylated-Akt(p-Akt)and phosphorylated-m TOR(p-m TOR)m RNA in ovarian tissue were detected by quantitative real-time polymerase chain reaction.RESULTS:The total follicle counts of perimenopausal model rats with kidney-Yang deficiency were significantly reduced,and the number of follicles(mainly increased in preantral follicles and antral follicles)in perimenopausal model rats with kidney-Yang deficiency was significantly increased after intervention of high and middle doses of Gengnian decoction and tibolone(P<0.05).Compared with normal rats in young control group,the levels of IGF-1 in serum of perimenopausal rats with kidney-Yang deficiency were significantly decreased(P<0.01),and those intervened by high dose of Gengnian decoction and tibolone were significantly up-regulated.The relative expression levels of PI3 K,p-Akt,p-m TOR m RNA in ovarian tissues of perimenopausal rats with kidney-Yang deficiency were significantly lower than those of young rats(P<0.01),and those intervened by high dose of Gengnian decoction and tibolone were significantly up-regulated(P<0.05).CONCLUSION:Self-made Gengnian decoction can increase the levels of IGF-1,PI3 K,Akt and m TOR m RNA expression in serum. | Zhang Fan Cao Junyan Zhang Xin Wang Jing Yi Xu | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 1 |
| 4 | Regulation of BCG-Polysaccharide Nucleic Acid and Dexamethasone on Th1/Th2 Cytokines from Peripheral Blood Mononuclear Cells in Oral Lichen Planus显示文摘 | Gang Zhou Mingwen Fan Junyan Liu | 2004 | The Chinese Journal of Dental Research2004，7，1： | 1 |
| 5 | Synthesis and characterization of inexpensive 3-N^8-benzy- loxycarbonyl-L-lysyl-morpholine-2, 5-dione 显示文摘 | Yao Junyan Yang Qingfang Fan Xiaodong | 2007 | Front Chem China2007，2，2： | 1 |
| 6 | Multiplug filtration clean‐up with multiwalled carbon nanotubes in the analysis of pesticide residues using LC – ESI ‐ MS / MS显示文摘 | Pengyue Zhao Sufang Fan Chuanshan Yu Junyan Zhang Canping Pan | 2013 | J Sep Science2013，，20： | 1 |
| 7 | Convenient and efficient access to tri-and tetra-substituted 4-fluoropyridines via a[3+2]/[2+1]cyclization reaction显示文摘A[3+2]/[2+1]cycloaddition reaction of gem–difluorocyclopropenes is presented,offering a mild and efficient approach to accessing tri-and tetra-substituted 4-fluoropyridines in moderate to good yields with excellent regioselectivity.Multiple synthetic applications,including process-scale reactions,modification of bioactive molecules,derivatization reactions and synthesis of the analogue of the PKM2 modulator,are subsequently described. | Xuejiao Tang Kun Liu Zeming Qu Junyan Zhan Rukui Zhu Fan Teng Lili Meng Yanmin Huang Chusheng Huang Yimiao He Qiang Zhu | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 8 | Derivative estimates of averaging opera tors and extension显示文摘We study the derivative operator of the generalized spherical mean S^γt. By considering a more general multiplier m^Ωγ,b=Vn-2/2+γ(|ξ|)|ξ|^bΩ(ξ') and finding the smallest γ such that m^Ωγ,b is an Hp multiplier, we obtain the optimal range of exponents (γ,β,p)to ensure the H^p(R^n) boundedness of a^βS^γ1f(x). As an application, we obtain the derivative estimates for the solution for the Cauchy problem of the wave equation on H^p(R^n) spaces. | Junyan ZHAO Dashan FAN | 2019 | Frontiers of Mathematics in China2019，14，2： | 0 |
| 9 | Patent Applications of Pharmaceutical Industry in Liaoning: Current Situation and Suggestions显示文摘Objective To analyze the current situation of pharmaceutical patents in Liaoning Province with the background of increasing emphasis on intellectual property rights in the pharmaceutical industry and the application of pharmaceutical-related patents having taken shape in Liaoning Province.Methods The invention patent information applied by Liaoning pharmaceutical manufacturers before December 31,2018 was obtained from Qixinbao APP,and then the retrieval data was also obtained through detailed search on patent information inquiry websites in China and other countries.The types of drug patents were separately extracted by Excel.Data analysis was carried out according to drug category,applicant type,legal status and transfer situation.Results and Conclusion A thorough discussion on the current situation of patent applications in pharmaceutical industry of Liaoning Province reveals that the number of patent applications is large but they are lack of creativity.Meanwhile,few patent applications are made by individual.Besides,there are fewer international patent applications for pharmaceutical patents in Liaoning Province.The problems in patent applications include the followings,such as insufficient patent applications and unbalanced proportion of patent applications.In order to promote the stable development of pharmaceutical market in Liaoning Province,some suggestions are raised. | Zhao Zhe Sheng Mengdi Fan Junyan Liu Yanwen Dong Li | 2019 | Asian Journal of Social Pharmacy2019，14，4： | 0 |
| 10 | A monolithic K-band phase-locked loop for microwave radar application显示文摘A monolithic K-band phase-locked loop(PLL) for microwave radar application is proposed and implemented in this paper. By eliminating the tail transistor and using optimized high-Q LC-tank, the proposed voltage-controlled oscillator(VCO) achieves a tuning range of 18.4 to 23.3 GHz and reduced phase noise. Two cascaded current-mode logic(CML) divide-by-two frequency prescalers are implemented to bridge the frequency gap, in which inductor peaking technique is used in the first stage to further boost allowable input frequency.Six-stage TSPC divider chain is used to provide programmable division ratio from 64 to 127, and a second-order passive loop filter with 825 kHz bandwidth is also integrated on-chip to minimize required external components.The proposed PLL needs only approximately 18.2 μs settling time, and achieves a wide tuning range from 18.4 to 23.3 GHz, with a typical output power of –0.84 dBm and phase noise of 91:92 d Bc/Hz @ 1 MHz. The chip is implemented in TSMC 65 nm CMOS process, and occupies an area of 0.56 mm^2 without pads under a 1.2 V single voltage supply. | Guangyao Zhou Shunli Ma Ning Li Fan Ye Junyan Ren | 2017 | Journal of Semiconductors2017，38，2： | 0 |
| 11 | Outcomes of surgery for epiblepharon accompanied with lower eyelid retraction secondary to buphthalmos in children显示文摘Importance:In cases of epiblepharon with lower eyelid retraction secondary to glaucoma,correcting epiblepharon alone is ineffective.Combined surgery should be performed to obtain satisfactory outcomes.Objective:To investigate outcomes after surgery to correct epiblepharon with lower eyelid retraction secondary to buphthalmos in children.Methods:A retrospective analysis of six eyes in four patients was performed included lower lid retractor recession combined with marginal rotation with tarsal fixation.The margin reflex distance-2,lagophthalmus,resolution of clinical symptoms,and complications were assessed during 6 to 12 months of follow-up.Results:In all cases,epiblepharon and lagophthalmus were corrected,symptoms of photophobia and epiphora were relieved,and the corneal epithelium was repaired.The margin reflex distance-2 decreased and remained normal during the follow-up period,but slightly regressed within 6 months postoperatively.Interpretation:Epiblepharon caused by buphthalmos in children is often associated with lower eyelid retraction.Lower lid retractor recession combined with marginal rotation with tarsal fixation fundamentally solves the problems of high eyelid tension,lower eyelid retraction,and epiblepharon and reduces the recurrence rate. | Wenhong Cao Yuan Wang Li Li Yunwei Fan Wen Liu Cheng Li Tianwei Liang Junyan Zhang Qian Wu | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 12 | Mongolia Contributed More than 42%of the Dust Concentrations in Northern China in March and April 2023显示文摘Dust storms are one of the most frequent meteorological disasters in China,endangering agricultural production,transportation,air quality,and the safety of people’s lives and property.Against the backdrop of climate change,Mongolia’s contribution to China’s dust cannot be ignored in recent years.In this study,we used the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),along with dynamic dust sources and the HYSPLIT model,to analyze the contributions of different dust sources to dust concentrations in northern China in March and April 2023.The results show that the frequency of dust storms in 2023 was the highest observed in the past decade.Mongolia and the Taklimakan Desert were identified as two main dust sources contributing to northern China.Specifically,Mongolia contributed more than 42%of dust,while the Taklimakan Desert accounted for 26%.A cold high-pressure center,a cold front,and a Mongolian cyclone resulted in the transport of dust aerosols from Mongolia and the Taklimakan Desert to northern China,where they affected most parts of the region.Moreover,two machine learning methods[the XGBoost algorithm and the Synthetic Minority Oversampling Technique(SMOTE)]were used to forecast the dust storms in March 2023,based on ground observations and WRF-Chem simulations over East Asia.XGBoost-SMOTE performed well in predicting hourly PM10 concentrations in China in March 2023,with a mean absolute error of 33.8μg m−3 and RMSE of 54.2μg m−3. | Siyu CHEN Dan ZHAO Jianping HUANG Jiaqi HE Yu CHEN Junyan CHEN Hongru BI Gaotong LOU Shikang DU Yue ZHANG Fan YANG | 2023 | Advances in Atmospheric Sciences2023，40，9： | 0 |
| 13 | Xixiang Biota——Another Rare Scientific Window of the Cambrian Explosion显示文摘Objective The Xixiang biota is a specially preserved micro oryctocoenose discovered in the Lower Cambrian Kuanchuanpu member of Dengying Formation at Zhangjiagou section of Xixiang County in southern Shaanxi Province.The Kuanchuanpu member is a set of neritic carbonate sedimentary formation containing phosphorus and silicon.Its lithology is mainly | LIU Yunhuan WANG Qi SHAO Tiequan DONG Junyan TANG Hanhua ZHANG Yanan JIANG Kaituo HU Bo WANG Zhaojing PANG Guotao MA Yingying FAN Ziyang | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 0 |
| 14 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
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