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| 1 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 2 | A Case of COVID-19 Detected in a Cargo Worker at Pudong Airport-Shanghai Municipality, China, November 8, 2020显示文摘On November 8,2020,a 51-year-old male went to the fever clinic of Shanghai Pudong New Area People’s Hospital for diagnosis and treatment of symptoms and was tested for coronavirus disease 2019(COVID-19).In the early hours of November 9,the municipal and district-level CDCs determined his nucleic acid test results were positive,and after consultation with experts,comprehensive clinical examination,and inspection of imaging results,the COVID-19 diagnosis was confirmed. | Fanghao Fang Yang Song Lipeng Hao Kai Nie Xiaodong Sun | 2020 | China CDC weekly2020，2，47： | 8 |
| 3 | Recent Advances in Self-Supported Layered Double Hydroxides for Oxygen Evolution Reaction显示文摘Electrochemical water splitting driven by clean and sustainable energy sources to produce hydrogen is an efficient and environmentally friendly energy conversion technology.Water splitting involves hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),in which OER is the limiting factor and has attracted extensive research interest in the past few years.Conventional noble-metal-based OER electrocatalysts like IrO_(2) and RuO_(2) suffer from the limitations of high cost and scarce availability.Developing innovative alternative nonnoble metal electrocatalysts with high catalytic activity and long-term durability to boost the OER process remains a significant challenge.Among all of the candidates for OER catalysis,selfsupported layered double hydroxides(LDHs)have emerged as one of the most promising types of electrocatalysts due to their unique layered structures and high electrocatalytic activity.In this review,we summarize the recent progress on self-supported LDHs and highlight their electrochemical catalytic performance.Specifically,synthesis methods,structural and compositional parameters,and influential factors for optimizing OER performance are discussed in detail.Finally,the remaining challenges facing the development of self-supported LDHs are discussed and perspectives on their potential for use in industrial hydrogen production through water splitting are provided to suggest future research directions. | Libo Wu Luo Yu Xin Xiao Fanghao Zhang Shaowei Song Shuo Chen Zhifeng Ren | 2020 | Research2020，，1： | 7 |
| 4 | Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,China,2016–2020显示文摘Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shanghai,China,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December 2020.In the past five years,CVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five years.In addition to entire VP1 sequencing,complete genome sequencing and recombination analysis of CVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic analysis.The CVA10sequences in this study mainly belonged to genogroup C and presented 91%-100%nucleotide identity with other Chinese isolates based on VP1 region.For the first time,our study reported the appearance of CVA10 genogroup D in Chinese mainland,which had led to large-scale outbreaks in Europe previously.The recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with CVA16 genogroup D.To conclusion,CVA10 genogroup C was the predominant genogroup in Shanghai during 2016-2020.CVA10 recombinant genogroup D was firstly reported in circulating in Chinese mainland.Continuous surveillance is needed to better understand the evolution relationships and transmission pathways of CVA10 to help to guide disease control and prevention. | Jiayu Wang Jiajing Liu Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling Liu Chongshan Li Wanju Zhang Xi Zhang Zheng Teng | 2022 | Virologica Sinica2022，37，2： | 5 |
| 5 | Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway显示文摘Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone metabolism.Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also blurring.Here,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically investigated.The nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes structure.The early bone formation around implant is significantly accelerated by the nanoporous surface in vivo.Meanwhile,the macrophage recruitment and osteoclast formation are increased and decreased respectively.Mechanistically,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of osteoclastogenesis.In addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine profiles.In conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis. | Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen Fanhui Meng Wen Song Yumei Zhang | 2022 | Bioactive Materials2022，7，2： | 4 |
| 6 | Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity显示文摘Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. | Zhe Li Yide He Lasse Hyldgaard Klausen Ning Yan Jing Liu Fanghao Chen Wen Song Mingdong Dong Yumei Zhang | 2021 | Bioactive Materials2021，6，5： | 4 |
| 7 | Temporal allocation of metabolic tolerance to transgenic Bt cotton in beet armyworm,Spodoptera exigua(Hübner)显示文摘Digestive and detoxification enzyme activity and nutrient composition were examined in the body of fourth instar beet armyworms,Spodoptera exigua(Hübner),fed on transgenic Bacillus thuringiensis(Bt) and non-Bt cotton for different time periods.Nutrient composition and specific enzyme activities differed significantly between the S.exigua fed Bt vs.non-Bt cotton.At 1,6 and 24 h,free fatty acid and glucose levels were significantly lower in S.exigua fed on Bt cotton than those fed on non-Bt cotton.S.exigua fed on Bt cotton had significantly higher trypsin and total superoxide dismutase(T-SOD) activities and significantly lower lipase,carboxylesterase and acetylcholinesterase activities than non-Bt fed worms for all feeding time periods.Differences were also observed among feeding times within each cotton variety group.Significantly lower free fatty acid and total amino acid were observed in S.exigua fed on Bt cotton for 24 h than in those fed for 1 h.Significantly lower activities of lipase and trypsin were detected in S.exigua fed on Bt cotton for 24 h than those for 1 and 4 h.However,carboxylesterase and acetylcholinesterase activities in S.exigua fed on Bt cotton for 24 h were significantly higher than those for 1,4 and 6 h.The interaction between cotton variety and feeding time significantly affected the activities of lipase,trypsin,acetylcholinesterase and T-SOD enzymes in S.exigua.Measuring the temporal allocation of protection and detoxification enzyme activities in the body of S.exigua in response to B.thuringiensis can provide a meaningful evaluation on the metabolic tolerance of herbivorous insects under the continuous selection pressure of a toxic protein. | GUO JianYing WU Gang WAN FangHao | 2011 | Science China(Life Sciences)2011，54，2： | 4 |
| 8 | A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease显示文摘Chronic kidney disease(CKD)poses a great burden to global public health as current therapies are generally ineffective.Early detection and effective therapy are crucial for the future prevention and progression of CKD.Nanoparticles(NPs)vary by particle size,charge,shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties,targetability,or the bioavailability of drugs.Thus,the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD.This review describes the current experimental research,clinical applications of NPs,the current challenges,and upcoming opportunities in the diagnosis and treatment of CKD. | Yanhong Ma Fanghao Cai Yangyang Li Jianghua Chen Fei Han Weiqiang Lin | 2020 | Bioactive Materials2020，5，3： | 3 |
| 9 | Constructing Biophore of Uroselective α1-Adrenoceptor antagonist显示文摘Aim The biophore of uroselective α1-adrenoceptor antagonist was studied by using Apex-3D software on an O2 Silicon Graphics Computer Station. Methods Five known antagonism (Indoramin, GG-818, RS100975, R-YM12167,and KMD-3213), which possess both good selectivity and high affinities to prostate and α1-AR subtype, were chosen for htilding the biophore. Using an autoraatic filtering software for obtaining reasonable biophorcs, the filter parameters were selected: P (probability) >0.8, active (number of active compounds)≥4, and size (descriptor center)≥3. Results Three biophorcs conformed to the requirements, each of whom contained a basic center, an aromatic ring center and H-site according to the structure-activity relationships of known α1-adrenoceptor antagonist. Conclusion The biophore model developed by computer simulation with Apex-3D software can be used to design and synthesize a new α1-adrenoeeptor antagonist with high activity and low side effect. | FANGHao LUJing-fen XIALin | 2003 | Journal of Chinese Pharmaceutical Sciences2003，12，4： | 3 |
| 10 | Multi-Stage Fluid Charging and Critical Period of Hydrocarbon Accumulation of the Sinian Dengying Formation in Central Sichuan Basin显示文摘Objective The natural gas exploration of the Sinian reservoirs in the central Sichuan Basin has made a significant breakthrough in recent years,and has thus attracted much attention among geologists.The Sichuan Basin is known to have complicated geological settings,which has experienced multiple stages of tectonic evolution,fluid charging and | XU Fanghao XU Guosheng LIANG Jiaju YUAN Haifeng LIU Yong XU Fanggen | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 2 |
| 11 | Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol显示文摘 | Fanghao Lu Jun Xing Xinying Zhang Shiyun Dong Yajun Zhao Lina Wang Hulun Li Fan Yang Changqing Xu Weihua Zhang | 2013 | Molecular and Cellular Biochemistry (-)2013，，1： | 2 |
| 12 | Bemisia tabaci biotype Q dominates other biotypes across China 显示文摘 | Teng Xi Wan Fanghao Chu Dong | 2010 | Florida Entomolo- gist2010，93，3： | 1 |
| 13 | Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol显示文摘 | Fanghao Lu Jun Xing Xinying Zhang Shiyun Dong Yajun Zhao Lina Wang Hulun Li Fan Yang Changqing Xu Weihua Zhang | 2013 | Molecular and Cellular Biochemistry . 2013 (1-2)2013，，： | 1 |
| 14 | Activities of digestive and detoxification enzymes in multiple generations of beet armyworm, Spodoptera exigua(Hübner), in response to transgenic Bt cotton显示文摘 | Guo Jianying Wu Gang Wan Fanghao | 2010 | Journal of Pest Science2010，83，4： | 1 |
| 15 | Differentiation trajectories and biofunctions of symbiotic and un-symbiotic fate cells in root nodules of Medicago truncatula显示文摘The root nodule is a complex symbiotic nitrogen fixation factory,in which cells are highly heterogeneous.However,the differentiation trajectories and interconnection of nodule cells remain largely unknown.In this study,we set up a modified protocol for nodule protoplast preparation and performed a single-cell RNA sequencing profiling of the indeterminate Medicago truncatula nodule.We designated 13 cell clusters with specific expression patterns in 14-day post inoculation nodules and constructed a spatial and functional cellular map based on experimental data and bioinformatic analyses.Pseudotime analysis further revealed that two groups of apical meristematic cells develop into symbiotic and un-symbiotic fate cells along their particular trajectories.Biofunction analysis of each cell cluster revealed their particularity and interrelation,especially that the un-infected cells in nitrogen fixation zone are also involved in nitrogen assimilation by undertaking the asparagine synthesis.Collectively,our data offer an important resource for investigating the mechanism of nodule organogenesis and symbiotic nitrogen fixation. | Qinyi Ye Fugui Zhu Fanghao Sun Tai-Cheng Wang Jiale Wu Peng Liu Chen Shen Jiangli Dong Tao Wang | 2022 | Molecular Plant2022，15，12： | 1 |
| 16 | Nitrogen mass flow in China's animal production system and environmental implications显示文摘 | Wang Fanghao Dou Zhengxia Ma Lin | 2010 | Journal of Environmental Quality2010，39，5： | 1 |
| 17 | The distribution and economic losses of alien species invasion to China显示文摘 | Haigen Xu Hui Ding Mingyan Li Sheng Qiang Jianying Guo Zhengmin Han Zongguo Huang Hongying Sun Shunping He Hairong Wu Fanghao Wan | 2006 | Biological Invasions2006，，7： | 1 |
| 18 | A Beam Stabilization Algorithm Based on Nonlinear Observer for Low Cost Satcom-on-the-Move显示文摘 | TIAN Fanghao WANG Rong GAO Feifei YAO Minli | 2014 | China Communications2014，11，A01： | 0 |
| 19 | Ultrasensitive tunable terahertz lithium niobate metasurface sensing based on bound states in the continuum显示文摘Lithium niobate’s substantial nonlinear optical and electro-optic coefficients have recently thrust it into the limelight.This study presents a thorough review of bound states in the continuum(BICs)in lithium niobate metasurfaces,also suggesting their potential for sensing applications.We propose an all-dielectric tunable metasurface that offers high Q factor resonances in the terahertz range,triggered by symmetry-protected BICs.With exceptional sensitivity to changes in the refractive index of the surrounding medium,the metasurface can reach a sensitivity as high as 947 GHz/RIU.This paves the way for ultrasensitive tunable terahertz sensors,offering an exciting path for further research. | XINYAO YU FANGHAO LI TINGTING LANG JIANYUAN QIN XIAO MA | 2023 | Photonics Research2023，11，12： | 0 |
| 20 | Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancerprogression显示文摘Recent studies suggested that LIM and SH3 protein 1(LASP-1)is a promising therapeutic target for renal cell cancer(RCC).This study aimed to explore the role of LASP-1 in RCC.For this purpose,LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis.Cell proliferation,migration,invasion,and gene expression were detected by CCK-8 assay,Transwell assay,and Western blot analysis.The results showed that LASP-1 was highly expressed in RCC,and its expression level,t was positively correlated with lymph node metastasis and tumor,nodes,and metastases(TNM)stage.The knockdown of LASP-1 expression significantly inhibited the proliferation of RCC cells,increased the apoptosis rate,and inhibited RCC cell invasion and migration by inhibiting epithelial–mesenchymal transition.We conclude that LASP-1 promotes RCC progression and metastasis and is a promising therapeutic target for RCC. | FANGHAO SUN WENCHAO ZHAO LIANSHENG ZHANG HONGGUI MA JIAN ZHOU YOUGAN CHEN JIANQUAN HOU | 2020 | BIOCELL2020，44，4： | 0 |
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