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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 3 | 8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin显示文摘AIM:To evaluate whether 8-bromo-7-methoxychrysin(BrMC),a synthetic analogue of chrysin,inhibits the properties of cancer stem cells derived from the human liver cancer MHCC97 cell line and to determine the potential mechanisms.METHODS:CD133+cells were sorted from the MHCC97 cell line by magnetic activated cell sorting,and amplified in stem cell-conditioned medium to obtain the enriched CD133+sphere forming cells(SFCs).The stem cell properties of CD133+SFCs were validated by the tumorsphere formation assay in vitro and the xenograft nude mouse model in vivo,and termed liver cancer stem cells(LCSCs).The effects of BrMC on LCSCs in vitro were evaluated by MTT assay,tumorsphere formation assay and transwell chamber assay.The effects of BrMC on LCSCs in vivo were determined using a primary and secondary xenograft model in Balb/c-nu mice.Expressions of the stem cell markers,epithelialmesenchymal transition(EMT)markers andβ-catenin protein were analyzed by western blotting or immunohistochemical analysis.RESULTS:CD133+SFCs exhibited stem-like cell properties of tumorsphere formation and tumorigenesis capacity in contrast to the parental MHCC97 cells.We found that BrMC preferentially inhibited proliferation and self-renewal of LCSCs(P<0.05).Furthermore,BrMC significantly suppressed EMT and invasion of LCSCs.Moreover,BrMC could efficaciously eliminate LCSCs in vivo.Interestingly,we showed that BrMC decreased the expression ofβ-catenin in LCSCs.Silencing ofβ-catenin by small interfering RNA could synergize the inhibition of self-renewal of LCSCs induced by BrMC,while Wnt3a treatment antagonized the inhibitory effects of BrMC.CONCLUSION:BrMC can inhibit the functions and characteristics of LCSCs derived from the liver cancer MHCC97 cell line through downregulation ofβ-catenin expression. | Mei-Fang Quan Li-Hong Xiao Zhi-Hong Liu Hui Guo Kai-Qun Ren Fei Liu Jian-Guo Cao Xi-Yun Deng | 2013 | World Journal of Gastroenterology2013，19，43： | 22 |
| 4 | Size distribution of chemical elements and their source apportionment in ambient coarse, fine, and ultrafine particles in Shanghai urban summer atmosphere显示文摘Ambient coarse particles (diameter 1.8-10 μm), fine particles (diameter 0.1-1.8 μm), and ultrafine particles (diameter < 0.1 μm) in the atmosphere of the city of Shanghai were sampled during the summer of 2008 (from Aug 27 to Sep 08). Microscopic characterization of the particles was investigated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDX). Mass concentrations of Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb in the size-resolved particles were quantified by using synchrotron radiation X-ray fluorescence (SRXRF). Source apportionment of the chemical elements was analyzed by means of an enrichment factor method. Our results showed that the average mass concentrations of coarse particles, fine particles and ultrafine particles in the summer air were 9.38 ± 2.18, 8.82 ± 3.52, and 2.02 ± 0.41 μg/m3, respectively. The mass percentage of the fine particles accounted for 51.47% in the total mass of PM10, indicating that fine particles are the major component in the Shanghai ambient particles. SEM/EDX results showed that the coarse particles were dominated by minerals, fine particles by soot aggregates and fly ashes, and ultrafine particles by soot particles and unidentified particles. SRXRF results demonstrated that crustal elements were mainly distributed in the coarse particles, while heavy metals were in higher proportions in the fine particles. Source apportionment revealed that Si, K, Ca, Fe, Mn, Rb, and Sr were from crustal sources, and S, Cl, Cu, Zn, As, Se, Br, and Pb from anthropogenic sources. Levels of P, V, Cr, and Ni in particles might be contributed from multi-sources, and need further investigation. | Senlin Lu Rui Zhang Zhenkun Yao Fei Yi Jingjing Ren Minghong Wu Man Feng Qingyue Wang | 2012 | Journal of Environmental Sciences2012，24，5： | 22 |
| 5 | CD133:A cancer stem cells marker, is used in colorectal cancers显示文摘Colorectal cancer is one of the most common malignant tumors worldwide. A model of cancer development involving cancer stem cells has been put forward because it provides a possible explanation of tumor hierarchy. Cancer stem cells are characterized by their proliferation, tumorigenesis, differentiation, and selfrenewal capacities, and chemoradiotherapy resistance. Due to the role of cancer stem cells in tumor initiation and treatment failure, studies of cancer stem cell markers, such as CD133, have been of great interest. CD133, a five-transmembrane glycoprotein, is widely used as a marker to identify and isolate colorectal cancer stem cells. This marker has been investigated to better understand the characteristics and functions of cancer stem cells. Moreover, it can also be used to predict tumor progression, patient survival, chemoradiotherapy resistance and other clinical parameters. In this review, we discuss the use of CD133 in the identification of colorectal cancer stem cell, which is currently controversial. Although the function of CD133 is as yet unclear, we have discussed several possible functions and associated mechanisms that may partially explain the role of CD133 in colorectal cancers. In addition, we focus on the prognostic value of CD133 in colorectal cancers. Finally, we predict that CD133 may be used as a possible target for colorectal cancer treatment. | Fei Ren Wei-Qi Sheng Xiang Du | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 6 | Laparoscopic cystogastrostomy for the treatment of pancreatic pseudocysts: A case report显示文摘Pancreatic pseudocysts(PPs) are collections o pancreatic secretions that are lined by fibrous tissue and may contain necrotic debris or blood. The interventions including percutaneous, endoscopic o surgical approaches are based on the size, location symptoms and complications of a pseudocyst With the availability of advanced imaging system and cameras, better hemostatic equipments and excellent laparoscopic techniques, most pseudocyst can be found and managed by laparoscopy. We describe a case of a 30-year-old male patient with a pancreatic pseudocyst amenable to laparoscopi cystogastrostomy. An incision was made through the anterior gastric wall to expose the posterior gastri wall in close contact with the pseudocyst using an ultrasonically activated scalpel. Then, another incision was made for cystogastrostomy to obtain complete and unobstructed drainage. The patient recovered well after operation and was symptom-free during a 6-mo follow-up, suggesting that laparoscopi cystogastrostomy is a safe and effective alternative to open cystogastrostomy for minimally invasive management of PPs. | Qin-song Sheng Da-Zhi Chen Ren Lang Zhong-Kui Jin Dong-Dong Han Li-Xin Li Yong-Jiu Yang Ping Li Fei Pan Dong Zhang Zhao-Wei Qu Qiang He | 2008 | World Journal of Gastroenterology2008，14，30： | 15 |
| 7 | Metallic nanostructures for light trapping in energy-harvesting devices显示文摘Solar energy is abundant and environmentally friendly.Light trapping in solar-energy-harvesting devices or structures is of critical importance.This article reviews light trapping with metallic nanostructures for thin film solar cells and selective solar absorbers.The metallic nanostructures can either be used in reducing material thickness and device cost or in improving light absorbance and thereby improving conversion efficiency.The metallic nanostructures can contribute to light trapping by scattering and increasing the path length of light,by generating strong electromagnetic field in the active layer,or by multiple reflections/absorptions.We have also discussed the adverse effect of metallic nanostructures and how to solve these problems and take full advantage of the light-trapping effect. | Chuan Fei Guo Tianyi Sun Feng Cao Qian Liu Zhifeng Ren | 2014 | Light(Science & Applications)2014，3，1： | 14 |
| 8 | Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma:a single-center,single-arm,phase 2 study显示文摘Advanced intrahepatic cholangiocarcinoma(ICC)has a dismal prognosis.Here,we report the efficacy and safety of combining toripalimab,lenvatinib,and gemcitabine plus oxaliplatin(GEMOX)as first-line therapy for advanced ICC.Thirty patients with pathologically confirmed advanced ICC received intravenous gemcitabine(1 g/m2)on Days 1 and 8 and oxaliplatin(85 mg/m2)Q3W for six cycles along with intravenous toripalimab(240 mg)Q3W and oral lenvatinib(8 mg)once daily for one year.The expression of programmed death-ligand 1(PD-L1)and genetic status was investigated in paraffin-embedded tissues using immunohistochemistry and whole-exome sequencing(WES)analysis.The primary endpoint was the objective response rate(ORR).Secondary outcomes included safety,overall survival(OS),progression-free survival(PFS),disease control rate(DCR)and duration of response(DoR).As of July 1,2022,the median follow-up time was 23.5 months,and the ORR was 80%.Twenty-three patients achieved partial response,and one achieved complete response.Patients(21/30)with DNA damage response(DDR)-related gene mutations showed a higher ORR,while patients(14/30)with tumor area positivity≥1(PD-L1 staining)showed a trend of high ORR,but without significant difference.The median OS,PFS,and DoR were 22.5,10.2,and 11.0 months,respectively.The DCR was 93.3%.Further,56.7%of patients experienced manageable grade≥3 adverse events(AEs),commonly neutropenia(40.0%)and leukocytopenia(23.3%).In conclusion,toripalimab plus lenvatinib and GEMOX are promising first-line regimens for the treatment of advanced ICC.A phase-III,multicenter,double-blinded,randomized study to validate our findings was approved by the National Medical Products Administration(NMPA,No.2021LP01825). | Guo-Ming Shi Xiao-Yong Huang Dong Wu Hui-Chuan Sun Fei Liang Yuan Ji Yi Chen Guo-Huan Yang Jia-Cheng Lu Xian-Long Meng Xin-Ying Wang Lei Sun Ning-Ling Ge Xiao-Wu Huang Shuang-Jian Qiu Xin-Rong Yang Qiang Gao Yi-Feng He Yang Xu Jian Sun Zheng-Gang Ren Jia Fan Jian Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 12 |
| 9 | Chinese physicians' perceptions of fecal microbiota transplantation显示文摘AIM: To explore Chinese physicians' perceptions towards fecal microbiota transplantation(FMT) and to provide information and an assessment of FMT development in China.METHODS: A self-administered questionnaire was developed according to the FMT practice guidelines and was distributed to physicians in hospitals via Internet Research Electronic Data Capture(REDcap) software and electronic mails to assess their attitudes toward and knowledge of FMT. The questionnaire included a brief introduction of FMT that was followed by 20 questions. The participants were required to respond voluntarily, under the condition of anonymity and without compensation. Except for the fill-in-the-blank questions, all of the other questions were required in the REDcap data collection systems, and the emailed questionnaires were completed based on eligibility.RESULTS: Up to December 9, 2014, 844 eligible questionnaires were received out of the 980 distributed questionnaires, with a response rate of 86.1%. Among the participants, 87.3% were from tertiary hospitals, and there were 647(76.7%) gastroenterologists and 197(23.3%) physicians in other departments(nongastroenterologists). Gastroenterologists' awareness of FMT prior to the survey was much higher than non-gastroenterologists'(54.3 vs 16.5%, P < 0.001); however, acceptance of FMT was not statistically different(92.4 vs 87.1%, P = 0.1603). Major concerns of FMT included the following: acceptability to patients(79.2%), absence of guidelines(56.9%), and administration and ethics(46.5%). On the basis of understanding, the FMT indications preferred byphysicians were recurrent Clostridium difficile infection(86.7%), inflammatory bowel disease combined with Clostridium difficile infection(78.6%), refractory ulcerative colitis(70.9%), ulcerative colitis(65.4%), Crohn's disease(59.4%), chronic constipation(43.7%), irritable bowel syndrome(39.1%), obesity(28.1%) and type 2 diabetes(23.9%). For donor selection, the majority of physicians preferred individuals with a similar gut flora environment to the recipients. 76.6% of physicians chose lower gastrointestinal tract as the administration approach. 69.2% of physicians considered FMT a safe treatment. CONCLUSION: Chinese physicians have awareness and a high acceptance of FMT, especially gastroenterologists, which provides the grounds and conditions for the development of this novel treatment in China. Physicians' greatest concerns were patient acceptability and absence of guidelines. | Rong-Rong Ren Gang Sun Yun-Sheng Yang Li-Hua Peng Shu-Fang Wang Xiao-Hong Shi Jing-Quan Zhao Yong-Ling Ban Fei Pan Xue-Hong Wang Wei Lu Jian-Lin Ren Ying Song Jiang-Bin Wang Qi-Ming Lu Wen-Yuan Bai Xiao-Ping Wu Zi-Kai Wang Xiao-Mei Zhang Ye Chen | 2016 | World Journal of Gastroenterology2016，22，19： | 12 |
| 10 | Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis显示文摘Boron (B) toxicity to plants is responsible for low crop productivity in many regions of the world. Here we report a novel and effective means to alleviate the B toxicity to plants under high B circumstance. Functional characterization of AtTIP5;1, an aquaporin gene, re-vealed that overexpression of AtTIP5;1 (OxAtTIP5;1) in Arabidopsis significantly increased its tolerance to high B toxicity. Compared to wild-type plants, OxAtTIP5;1 plants exhibited longer hypocotyls, accelerated development, increased silique production under high B treatments. GUS staining and quantitative RT-PCR (qRT-PCR) results demonstrated that the expression of AtTIP5;1 was induced by high B concentration treatment. Subcellular localization analysis revealed that the AtTIP5;1-GFP fusion protein was localized on the tonoplast membrane, which was consistent with the prediction based on bioinformatics. Taken together, our results suggest that AtTIP5;1 is in-volved in B transport pathway possibly via vacuolar compartmentation for B, and that overexpression of AtTIP5;1 in plants may provide an effective way to overcome the problem resulting from high B concentration toxicity. | Yongqi Pang, Lijuan Li, Fei Ren, Pingli Lu, Pengcheng Wei, Jinghui Cai, Lingguo Xin, Juan Zhang, Jia Chen, Xuechen Wang State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China | 2010 | Journal of Genetics and Genomics2010，37，6： | 11 |
| 11 | Effect of steam-flaking on chemical compositions,starch gelatinization,in vitro fermentability,and energetic values of maize,wheat and rice显示文摘Intact and steam-flaked grains of maize,wheat and rice(with whole hulls) were analyzed for chemical composition,starch gelatinization degree(SGD) and in vitro fermentation characteristics to investigate the influence of cereal type and steam-flaking(SF) processing on their nutritive values.The treatments were arranged in a 3×2 factorial design.Obvious differences(P<0.001) in chemical composition and energetic values were observed among the different cereal types.SGD and gas production(GP) rate was significantly increased(P<0.001) by SF processing.SF processing also increased(P<0.01) the proportion of propionic acid and decreased the acetic:propionic acid ratio in vitro.Steam-flaking also increased organic matter digestibility and the energetic value of the cereal grains,especially rice.Based on these results,rice probably is more amendable to SF processing than maize and wheat.In conclusion,it is feasible to partially substitute maize grain with wheat or rice in ruminant diets,and steam-flaking can significantly improve the nutritional value of wheat and rice grains. | QIAO Fu-qiang WANG Fei REN Li-ping ZHOU Zhen-ming MENG Qing-xiang BAO Yu-hong | 2015 | Journal of Integrative Agriculture2015，14，5： | 11 |
| 12 | Meditation promotes insightful problem-solving by keeping people in amindful and alert conscious state显示文摘Although previous studies have shown that sleep can inspire insight,it is still unclear whether meditation can promote insight.Meditation differs from other types of passive rest such as relaxation and sleep because it requires full consciousness andmindfulness of targets such as one's breathing.Forty-eight university students without meditation experience were recruited to learn a simple meditation technique.They were given a list of 10 insight problems to solve (the pre-test session).In this study,we focused on the unsolved problems and examined if they could be successfully solved after a 20min rest interval with or without meditation.Results showed that relative to the control group that listened to Chinese or English words and made a language judgment,the groups who learned meditation successfully solved significantly more failed problems from the pre-test session,providing direct evidence for the role of meditation in promoting insight.Further analysis showed that maintaining amindful and alert state during meditation (raising a hand to report every 10 deep breaths compared to every 100 deep breaths) resulted in more insight regarding the failed items from the pre-test session.This implies that it was watchfulness in meditation,rather than relaxation,that actually contributed to insight.Consistently,in the meditation session or control task,the percentage of alpha waves—a brain index of mental relaxation—was negatively correlated with insight.These results suggest a meditation-based insight-promoting mechanism different from that involved in passive rest such as relaxation and sleep. | REN Jun HUANG ZhiHui LUO Jing WEI GaoXia YING XiaoPing DING ZhiGuang WU YiBin LUO Fei | 2011 | Science China(Life Sciences)2011，54，10： | 11 |
| 13 | Evaluation of Latest TMPA and CMORPH Precipitation Products with Independent Rain Gauge Observation Networks over High-latitude and Low-latitude Basins in China显示文摘The Tropical Rainfall Measuring Mission(TRMM) Multi-satellite Precipitation Analysis(TMPA) and National Oceanic and Atmospheric Administration(NOAA) Climate Prediction Center(CPC) morphing technique(CMORPH) are two important multi-satellite precipitation products in TRMM-era and perform important functions in GPM-era. Both TMPA and CMORPH systems simultaneously upgraded their retrieval algorithms and released their latest version of precipitation data in 2013. In this study, the latest TMPA and CMORPH products(i.e., Version-7 real-time TMPA(T-rt) and gauge-adjusted TMPA(T-adj), and Version-1.0 real-time CMORPH(C-rt) and Version-1.0 gauge-adjusted CMORPH(C-adj)) are evaluated and intercompared by using independent rain gauge observations for a 12-year(2000–2011) period over two typical basins in China with different geographical and climate conditions. Results indicate that all TMPA and CMORPH products tend to overestimate precipitation for the high-latitude semiarid Laoha River Basin and underestimate it for the low-latitude humid Mishui Basin. Overall, the satellite precipitation products exhibit superior performance over Mishui Basin than that over Laoha River Basin. The C-adj presents the best performance over the high-latitude Laoha River Basin, whereas T-adj showed the best performance over the low-latitude Mishui Basin. The two gauge-adjusted products demonstrate potential in water resource management. However, the accuracy of two real-time satellite precipitation products demonstrates large variability in the two validation basins. The C-rt reaches a similar accuracy level with the gauge-adjusted satellite precipitation products in the high-latitude Laoha River Basin, and T-rt performs well in the low-latitude Mishui Basin. The study also reveals that all satellite precipitation products obviously overestimate light rain amounts and events over Laoha River Basin, whereas they underestimate the amount and events over Mishui Basin. The findings of the precision characteristics associated with the latest TMPA and CMORPH precipitation products at different basins will offer satellite precipitation users an enhanced understanding of the applicability of the latest TMPA and CMORPH for water resource management, hydrologic process simulation, and hydrometeorological disaster prediction in other similar regions in China. The findings will also be useful for IMERG algorithm development and update in GPM-era. | JIANG Shanhu REN Liliang YONG Bin HONG Yang YANG Xiaoli YUAN Fei | 2016 | Chinese Geographical Science2016，26，4： | 10 |
| 14 | Land Use Changes in Northeast China Driven by Human Activities and Climatic Variation显示文摘Human-induced land use/cover change (LUCC) forms an important component of global environmental change. Therefore, it is important to study land use/cover and its change at local, regional and global scales. In this paper we conducted the study of land use change in Northeast China, one of the most important agricultural zones of the nation. From 1986 to 2000, according to the study results obtained from Landsat images, widespread changes in land use/cover took place in the study area. Grassland, marsh, water body and woodland decreased by 9864, 3973, 1367 and 10,052km2, respectively. By comparison, paddy field, dry farmland, and built-up land expanded by 7339, 17193 and 700km2, respectively. Those changes bore an interactive relationship with the environment, especially climate change. On the one hand, climate warming created a potential environment for grassland and marsh to be changed to farmland as more crops could thrive in the warmer climate, and for dry farmland to paddy field. On the other hand, the changed surface cover modified the local climate. Those changes, in turn, have adversely influenced the local environment by accelerating land degradation. In terms of socio-economic driving forces, population augment, regional economic development, and national and provincial policies were confirmed as main driving factors for land use change. | WANG Zongming LIU Zhiming SONG Kaishan ZHANG Bai ZHANG Sumei LIU Dianwei REN Chunying YANG Fei | 2009 | Chinese Geographical Science2009，19，3： | 10 |
| 15 | Lyzl4, a novel mouse sperm-related protein, is involved in fertilization显示文摘鸡类型(c 类型) 溶解酵素的角色,原型溶解酵素,在免疫在许多有机体被描绘了。在这研究,我们克隆新奇 c 类型像溶解酵素的基因, Lyzl4,它位于老鼠染色体 9F4 并且与通常认为的信号肽和一个朊酶劈开地点编码了 145 氨基酸。在酵母表示的成熟 recombinant Lyzl4 蛋白质没显示出 bacteriolytic 活动。顺序排列分析证明在 c 类型溶解酵素的 20 不变的残余中的 3 个在 Lyzl4 被改变。改变的氨基酸(D52G ) 之一位于催化领域。Lyzl4 mRNA 有选择地在成年鼠标在睾丸和 epididymis 被表示,与改变越过不同发展阶段的表达式水平。Lyzl4 蛋白质的高水平在 acrosomal 区域和尾巴的主要的片的精子上被发现。在有它的特定的抗体的精子的 Lyzl4 蛋白质的免疫中立化显著地以一种剂量依赖者方式在 vitro 授精百分比减少了,建议 Lyzl4 可能为授精是重要的。 | Ruilin Sun Ruling Shen Jun Li Guojiang Xu Jun Chi Limei Li Jianke Ren Zhugang Wang Jian Fei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 9 |
| 16 | Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease显示文摘To date,we still lack disease-modifying therapies for Alzheimer's disease(AD).Here,we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD.Five patients with mild to moderate AD received oral benfotiamine(300 mg daily) over 18 months.All patients were examined by positron emission tomography with Pittsburgh compound B(PiB-PET) and exhibited positive imaging with pamyloid deposition,and three received PiB-PET imaging at follow-up.The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination(MMSE) with an average increase of 3.2 points at month18 of benfotiamine administration.The three patients who received follow-up PiB-PET had a 36.7%increase in the average standardized uptake value ratio in the brain compared with that in the first scan.Importantly,the MMSE scores of these three had an average increase of 3 points during the same period.Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation.Our study provides new insight to the development of diseasemodifying therapy. | Xiaoli Pan Zhichun Chen Guoqiang Fei Shumei Pan Weiqi Bao Shuhua Ren Yihui Guan Chunjiu Zhong | 2016 | Neuroscience Bulletin2016，32，6： | 9 |
| 17 | Primary and secondary control in DC microgrids: a review显示文摘With the rapid development of power electronics technology, microgrid(MG) concept has been widely accepted in the field of electrical engineering. Due to the advantages of direct current(DC)distribution systems such as reduced losses and easy integration with energy storage resources, DC MGs have drawn increasing attentions nowadays. With the increase of distributed generation, a DC MG consisting of multiple sources is a hot research topic. The challenge in such a multi-source DC MG is to provide voltage support and good power sharing performance. As the control strategy plays an important role in ensuring MG’s power quality and efficiency, a comprehensive review of the state-of-art control approaches in DC MGs is necessary. This paper provides an overview of the primary and secondary control methods under the hierarchical control architecture for DC MGs. Specifically,inner loop and droop control approaches in primary control are reviewed. Centralized, distributed and decentralized approach based secondary control is discussed in details.Key findings and future trends are also presented at last. | Fei GAO Ren KANG Jun CAO Tao YANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 8 |
| 18 | Progress in ENSO prediction and predictability study显示文摘ENSO is the strongest interannual signal in the global climate system with worldwide climatic, ecological and societal impacts. Over the past decades, the research about ENSO prediction and predictability has attracted broad attention. With the development of coupled models, the improvement in initialization schemes and the progress in theoretical studies, ENSO has become the most predictable climate mode at the time scales from months to seasons. This paper reviews in detail the progress in ENSO predictions and predictability studies achieved in recent years. An emphasis is placed on two fundamental issues: the improvement in practical prediction skills and progress in the theoretical study of the intrinsic predictability limit. The former includes progress in the couple models, data assimilations, ensemble predictions and so on, and the latter focuses on efforts in the study of the optimal error growth and in the estimate of the intrinsic predictability limit. | Youmin Tang Rong-Hua Zhang Ting Liu Wansuo Duan Dejian Yang Fei Zheng Hongli Ren Tao Lian Chuan Gao Dake Chen Mu Mu | 2018 | National Science Review2018，5，6： | 8 |
| 19 | Autoimmune pancreatitis:report of two cases and literature review显示文摘BACKGROUND:Autoimmune pancreatitis(AIP)is a unique chronic inflammation of the pancreas in which autoimmune mechanisms are involved in the pathogenesis.It is characterized by clinical,histopathological,radiographic,serologic and therapeutic features.Since it was first described in 1995,increasing numbers of AIP patients have been diagnosed.METHODS:In this study,the data from 2 patients with AIP who had elevation of serum immunoglobulin G,positive autoantibody,swelling of the pancreas and narrowing of the main pancreatic duct on imaging were analyzed retrospectively.RESULTS:With the initial diagnosis of AIP,both patients underwent regular prednisone therapy,which was initiated at a dose of 40 mg per day with a tapering schedule of 5 mg every 2 weeks.The patients responded very well to treatment with prednisone.CONCLUSIONS:AIP is a relatively new disease entity.Although it is diagnosed by distinct characteristics of the clinical,radiologic,histopathologic,and serologic findings,many questions require further clarification,including its relationship to other autoimmune diseases and misdiagnosis as pancreaticobiliary malignancies. | Sheng, Qin-Song Chen, Da-Zhi Lang, Ren He, Qiang Han, Dong-Dong Pan, Fei Li, Ping Qu, Zhao-Wei | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 20 | Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease显示文摘 | GAO Fei WANG Zan-xin MEN Jian-long REN Jing WEI Min-xin | 2011 | Chinese Medical Journal2011，，11： | 8 |
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