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| 1 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 2 | Nutrient Composition and Distance from Point Placement to the Plant Affect Rice Growth显示文摘Point placement of urea is an efficient technology to improve urea use efficiency in transplanted rice(Oryza sativa L.), but it is largely unknown how nutrient composition in the point placement and the distance from placement site to the plant influence rice root distribution and growth, nutrient uptake, and rice grain yield. A controlled greenhouse experiment was conducted using both N-and P-deficient soil with point placement of N only or N and P together(N + P) at a distance close to or far from the plant,in comparison to an N-spilt application and a no-N control. Both nutrient composition and distance significantly affected rice root growth. Compared with the N point placement, the N + P point placement led to smaller root length and mass densities, higher specific root length(SRL) around the placement site, smaller root system, higher straw mass and grain yield, and higher N and P uptake. The difference between the N + P and N point placements was greater when close to the plant than when far from the plant. It is suggested that higher SRL around the placement site is essential for improving nutrient uptake and rice grain yield, and simultaneous point placement of N and P has a synergistic effect on rice growth. | HU Fengqin WANG Huoyan MOU Pu ZHOU Jianmin | 2018 | Pedosphere2018，28，1： | 4 |
| 3 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 4 | Preparation of bioconjugates of CdTe nanocrystals for cancer marker detection显示文摘 | HU Fengqin RAN Yuliang ZHOU Zhuan | 2006 | Nanotechnol2006，17，： | 1 |
| 5 | Self-supported porous copper oxide nanosheet arrays for efficient and selective electrochemical conversion of nitrate ions to nitrogen gas显示文摘Electrochemical techniques have shown advantages for the removal of low-concentration nitrate.Here,copper oxide nanosheets were grown on self-supporting nickel foam(NF)to prepare electrodes(CuO/NF),which realized the rapid and highly selective conversion of nitrate pollutants in sewage into nontoxic and harmless N_(2).The CuO/NF afforded 100%NO_(3)^(-)removal within 100 min and 99.53%selectivity for N_(2)at-50 mA without producing a lot of by-products(NO_(2)-,NH_(4)^(+),and N_(2)H_(4)).Furthermore,81.8%of NO_(3)^(-)was removed under the given conditions after six experimental repetitions.These results suggest that the cat-alyst has excellent electrochemical stability.The performance of CuO/NF for the electrocatalytic removal of NO_(3)^(-)in simulated wastewater(which contained Cl^(-) and SO_(4)^(2-))was almost unaffected.Because of the high efficiency,high stability,and low cost of CuO/NF,this catalyst is practical for the removal of nitrate for wastewater purification. | Xue Li Xue Zhao Jiapei Lv Xiuxiu Jia Shuxing Zhou Yimin Huang Fengqin Chang Hucai Zhang Guangzhi Hu | 2023 | Journal of Materials Science & Technology2023，，6： | 1 |
| 6 | Adsorption of Oxygen on K_(x)C_(60) Studied by Photoelectron Spectroscopy显示文摘Photoemission spectra of vacuum deposited K-incorporated C_(60)-K_(x)C_(60)(x≈6),before and after exposure to oxygen,show that the interaction between oxygen and potassium forms an overlayer of 40 A K-O complex with stoichiometry near to that of potassium peroxide K_(2)O_(2) on the surface.In contrary to the oxidation of potassium film,no potassium oxide K_(2)O has been observed. | YAO Jun LIU Fengqin DENG Junzhuo XUN Kun WANG Zuquan LU Sihua WU Sicheng JIANG Mingluo GU Zhengnan ZHOU Xihuang | 1992 | Chinese Physics Letters1992，9，6： | 0 |
| 7 | Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways显示文摘Chaenomeles speciosa(Sweet)Nakai cultivated widely in temperate regions possesses anti-inflammatory properties,however,the underlying molecular mechanisms remain not fully understood.In this study,a purified phenolic extract of C.speciosa rich in chlorogenic acid,procyanidin B1 and catechin(determined by HPLC-Q-TOF-MS/MS)exhibited dose-dependent anti-inflammatory effects on lipopolysaccharide(LPS)-treated RAW264.7 macrophages.The extract at 30μg/mL was most potent and enabled most cells in normal morphology under LPS stimulation without causing cytotoxicity.The extract suppressed the levels of nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β),and the mRNA and protein expressions of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling pathways.Therefore,the phenolic extract from C.speciosa is a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics. | Fuxia Hu Chao Liu Fengqin Wang Changxin Zhou Maotong Zhu Dongxiao Sun-Waterhouse Zhaosheng Wang | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 8 | Electrochemical co-reduction of Y(Ⅲ)and Al(Ⅲ)in a fluoride molten salt system and electrolytic preparation of Y-Al intermediate alloys显示文摘In this study,a molten salt co-reduction method was proposed for preparing Y-Al intermediate alloys and the electrochemical co-reduction behaviors of Y(Ⅲ)and Al(Ⅲ)and the reaction mechanism of intermetallic compound formation were investigated by transient electrochemical techniques.The results show that the reduction of Y(Ⅲ)at the Mo electrode is a reversible electrochemical process with a single-step transfer of three electrons,which is controlled by the mass transfer rate.The diffusion coefficient of Y(Ⅲ)in the fluoride salt at a temperature of 1323 K is 5.0238×10^(-3)cm^(2)/s.Moreover,the thermodynamic properties associated with the formation of Y-Al intermetallic compounds were estimated using a steady-state electrochemical method.Y-Al intermediate alloy containing 92 wt%yttrium was prepared by constant current electrolysis at 1323 K in the LiF-YF_(3)-AIF_(3)-Y_(2)O_(3)(6 wt%)-Al_(2)O_(3)(1 wt%)system at a cathodic current density of 8 A/cm^(2)for 2 h.The Y-Al intermediate alloy is mainly composed ofα-Y2Al and Y phases.The development and application of this innovative technology have solved major technical problems,such as a long production process,high energy consumption,and serious segregation of alloy elements at this stage. | Guoqing Yu Lin Zhou Fengqin Liu Siming Pang Dehong Chen Hongliang Zhao Zhengping Zuo | 2022 | Journal of Rare Earths2022，40，12： | 0 |
| 9 | Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies显示文摘Mutations of epigenetic regulators are pervasive in human tumors.ASXL1 is frequently mutated in myeloid malignancies.We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A(H2AK119ub1),a Polycomb repressive mark.However,a complete mechanistic understanding of ASXL1 in transcriptional regulation and tumor suppression remains to be defined.Here,we find that depletion of Asxl1 confers murine 32D cells to IL3-independent growth at least partly due to sustained activation of PI3K/AKT signaling.Consistently,Asxl1 is critical for the transcriptional activation of Pten,a key negative regulator of AKT activity.Then we confirm that Asxl1 is specifically enriched and required for H2AK119 deubiquitylation at the Pten promoter.Interestingly,ASXL1 and PTEN expression levels are positively correlated in human blood cells and ASXL1 mutations are associated with lower expression levels of PTEN in human myeloid malignancies.Furthermore,malignant cells with ASXL1 downregulation or mutations exhibit higher sensitivity to the AKT inhibitor MK2206.Collectively,this study has linked the PTEN/AKT signaling axis to deregulated epigenetic changes in myeloid malignancies.It also provides a rationale for mechanism-based therapy for patients with ASXL1 mutations. | Lei Cao Xianyou Xia Yu Kong Fengqin Jia Bo Yuan Rui Li Qian Li YuxinWang Mingrui Cui Zhongye Dai Huimin Zheng Jesper Christensen Yuan Zhou Xudong Wu | 2020 | Journal of Molecular Cell Biology2020，12，9： | 0 |
| 10 | Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis显示文摘Background:Ulcerative colitis(UC)is a progressive chronic inflammatory disorder.Neutrophils play a critical role in regulating in-testinal mucosal homeostasis in UC.Spleen tyrosine kinase(Syk)is involved in several inflammatory diseases.Here,we evaluated the effects and underlying mechanisms of Syk on neutrophil immune-responses in UC.Methods:Syk expression in the colonic tissues of patients with UC was determined using quantitative reverse transcription-polymerase chain reaction(qRT-PCR),western blotting,and immunohistochemistry.Colonic biopsies from patients with UC were obtained for single-cell RNA-sequencing.Neutrophils isolated from peripheral blood were pre-treated with R788(a Syk inhibitor)and gene differences were determined using RNA sequencing.Neutrophil functions were analyzed using qRT-PCR,flow cytometry,and Transwell assay.R788 was administered daily to mice with dextran sulfate sodium(DSS)-induced colitis to verify the effects of Syk on intestinal inflammation.Results:Syk expression was increased in inflamed mucosa and neutrophils of patients with UC and positively correlated with dis-ease activity.Pharmacological inhibition of Syk in neutrophils decreased the production of pro-inflammatory cytokines,chemokines,neutrophil extracellular traps,reactive oxygen species,and myeloperoxidase.Apoptosis and migration of neutrophils were sup-pressed by Syk blockade.Syk blockade ameliorated mucosal inflammation in DSS-induced murine colitis by inhibiting neutrophil-associated immune responses.Mechanistically,Syk regulated neutrophil immune-responses via the mammalian target of rapamycin kinase/rubicon-like autophagy enhancer-dependent autophagy pathway.Conclusions:Our findings indicate that Syk facilitates specific neutrophil functional responses to mucosal inflammation in UC,and its inhibition ameliorates mucosal inflammation in DSS-induced murine colitis,suggesting its potential as a novel therapeutic target for UC treatment. | Fengqin Zhu Dehuai Jing Huihui Zhou Zongjing Hu Yan Wang Guiyuan Jin Yonghong Yang Guangxi Zhou | 2023 | Precision Clinical Medicine2023，6，4： | 0 |
| 11 | Feedback and contribution of vegetation, air temperature and precipitation to land surface temperature in the Yangtze River Basin considering statistical analysis显示文摘Land surface temperature(LST),especially day-night LST difference(LSTd-LSTn),is a key variable for the stability of terrestrial ecosystems,affected by vegetation and climate change.Quantifying the contribution and feedback of vegetation and climate to LST changes is critical to developing mitigation strategies.Based on LST,Normalized vegetation index(NDVI),land use(LU),air temperature(AT)and precipitation(Pre)from 2003 to 2021,partial correlation was used to analyze the response of LST to vegetation and climate.The feedback and contribution of both to LST were further quantifed by using spatial linear relationships and partial derivatives analysis.The results showed that both interannual LST(LSTy)and LSTd-LSTn responded negatively to vegetation,and vegetation had a negative feedback effect in areas with significantly altered.Vegetation was also a major contributor to the decline of LSTd-LSTn.With the advantage of positive partial correlation area of 94.99%,AT became the main driving factor and contributor to LSTy change trend.Pre contributed negatively to both LSTy and LSTd-LSTn,with contributions of-0.004℃/y and-0.022℃/y,respectively.AT played a decisive role in LST warming of YRB,which was partially mitigated by vegetation and Pre.The present research contributed'to,the,detection,of LST changes and improved understanding of the driving mechanism. | Jinlian Liu Xinyao Zhou Hanya Tang Fengqin Yan Shiwei Liu Xuguang Tang Zhi Ding Ke Jiang Pujia Yu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 12 | Photoemission Evidence for Dilute K-doped Phase Kx C_(60) with x<0.2显示文摘A shift about 0.3eV to higher binding energy is reported in the valence band and Cls core level of Kx C_(60)(x<0.2).Analysis shows that the result could not be interpreted by a mixture of C_(60) and K3 C_(60).A dulite K-doped phase and fermi level pinning near the lowest unoccupied molecular orbital derived band caused by K-doping are proposed. | WANG Zuquan LIU Fengqin DENG Junzhuo YAO Jun XUN Kun LÜSihua WU Sichengi JIANG Mingluo GU Zhengnan ZHOU Xihuang | 1992 | Chinese Physics Letters1992，9，9： | 0 |
| 13 | Computed tomography-based delta-radiomics enabling early prediction ofshort-term responses to concurrent chemoradiotherapy for patients withnon-small cell lung cancer显示文摘Objective:To explore the potential of computed tomography(CT)-based delta-radiomics in predicting early shortterm responses to concurrent chemoradiotherapy for patients with non-small cell lung cancer(NSCLC),in order to determine the optimal time point for the prediction.Methods:A total of 20 patients with pathologically confirmed NSCLC were prospectively enrolled in this study,who did not receive surgical treatment between February 2021 and February 2022.For each case,a total of 1,210 radiomic features(RFs)were extracted from both planning CT(pCT)images along with each of the subsequent three weeks of CT images.EffectiveΔRFs were selected using intra-class correlation coefficient(ICC)analysis,Pearson's correlation,ANOVA test(or Mann-Whitney U-test),and univariate logistic regression.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve was used to evaluate the potential to predict short-term responses of different time points.Results:Among the 1,210ΔRFs for 1-3 weeks,121 common features were retained after processing using ICC analysis and Pearson's correlation.These retained features included 54 and 58 of all time points that differed significantly between the response and non-response groups for the first and third months,respectively(P<0.05).After univariate logistic regression,11 and 44 features remained for the first and third months,respectively.Finally,eightΔRFs(P<0.05,AUC=0.77-0.91)that can discriminate short-term responses in both at 1 and 3 months with statistical accuracy were identified.Conclusion:CT-based delta-radiomics has the potential to provide reasonable biomarkers of short-term responses to concurrent chemoradiotherapy for NSCLC patients,and it can help improve clinical decisions for early treatment adaptation. | Fengqin Zhou Jianping Bi Shen Wu Yi Ding Jun Chen Mengting Yuan Yaoyao He Guang Han Zilong Yuan | 2023 | Radiation Medicine and Protection2023，4，4： | 0 |
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