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| 1 | 2008中西方BNP专家共识显示文摘1.前言
2008年6月,来自中国、美国、欧洲的急诊科、心血管科、实验室及内科临床专家相聚在中国上海。 | Alan Maise Christian Mueller W. Frank Peacock Gerasimos Filippatos Hu Dayi 胡大一(主译) 刘梅颜(主译) 吴寸草(翻译) 王博雅(翻译) 黄睿(翻译) | 2009 | 中国医药导刊2009，11，10： | 76 |
| 2 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 3 | Assessing the productivity function of soils. A review显示文摘 | Lothar Mueller Uwe Schindler Wilfried Mirschel T. Shepherd Bruce Ball Katharina Helming Jutta Rogasik Frank Eulenstein Hubert Wiggering | 2010 | Agronomy for Sustainable Development2010，，3： | 1 |
| 4 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
| 5 | D2-40: a reliable marker in the diagnosis of pleural mesothelioma 显示文摘 | Mueller AM Franke FE Muller KM | 2006 | Pathobiology2006，73，2： | 1 |
| 6 | Fibronectin-Induced Proliferation in Thyroid Cells Is Mediated by αvβ3 Integrin through Ras/Raf-1/MEK/ERK and Calcium/CaMKII Signals显示文摘 | Maddalena Illario Anna Lina Cavallo Sara Monaco Ennio Di Vito Frank Mueller Luigi A. Marzano Giancarlo Troncone Gianfranco Fenzi Guido Rossi Mario Vitale | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，： | 1 |
| 7 | Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer显示文摘 | Maria–Theresa Mueller Patrick C. Hermann Juliane Witthauer Belen Rubio–Viqueira Simon F. Leicht Stephan Huber Joachim W. Ellwart Mona Mustafa Peter Bartenstein Jan G. D’Haese Michael H. Schoenberg Frank Berger Karl–Walter Jauch Manuel Hidalgo Christopher | 2009 | Gastroenterology2009，，： | 1 |
| 8 | Feedback EDF Scheduling of Real-Time Tasks Exploiting Dynamic Voltage Scaling显示文摘 | Yifan Zhu Frank Mueller | 2005 | Real - Time Systems (-)2005，，1： | 1 |
| 9 | Human Resources as Strategic Assets : An Evolutionary Resource-Based Theory 显示文摘 | Frank Mueller | 1996 | Journal of Management Studies1996，33，6： | 1 |
| 10 | New product diffusion models in marketing: A review and directions for research显示文摘 | Mahajan Vijay Eitan Mueller Frank M Bass | 1990 | Journal of Marketing1990，54，： | 1 |
| 11 | Contribution of lymphatic drainage system in corneal allograft rejection in mice显示文摘 | Friedrich Hoffmann Er-Ping Zhang Anja Mueller Felix Schulte Hans-Dieter Foss Juergen Franke Sarah E. Coupland | 2001 | Graefe’s Archive for Clinical and Experimental Ophthalmology2001，，11： | 1 |
| 12 | Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer显示文摘 | Maria–Theresa Mueller Patrick C. Hermann Juliane Witthauer Belen Rubio–Viqueira Simon F. Leicht Stephan Huber Joachim W. Ellwart Mona Mustafa Peter Bartenstein Jan G. D’Haese Michael H. Schoenberg Frank Berger Karl–Walter Jauch Manuel Hidalgo Christopher | 2009 | Gastroenterology2009，，3： | 1 |
| 13 | D2-40:A reliable marker in the diagnosis of pleural mesothelioma显示文摘 | Mueller A M Franke F E Muller K M | 2006 | Pathobiology2006，73，： | 1 |
| 14 | Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity显示文摘 | Philipp Jakob Carola Doerries Sylvie Briand Pavani Mocharla Nicolle Kr?nkel Christian Besler Maja Mueller Costantina Manes Christian Templin Christof Baltes Markus Rudin Heiner Adams Mathias Wolfrum Georg Noll Frank Ruschitzka Thomas F. Lüscher Ulf Landme | 2012 | Circulation2012，，25： | 1 |
| 15 | Mid-Region Pro-Hormone Markers for Diagnosis and Prognosis in Acute Dyspnea显示文摘 | Alan Maisel Christian Mueller Richard Nowak W. Frank Peacock Judd W. Landsberg Piotr Ponikowski Martin Mockel Christopher Hogan Alan H.B. Wu Mark Richards Paul Clopton Gerasimos S. Filippatos Salvatore Di Somma Inder Anand Leong Ng Lori B. Daniels Sean-Xa | 2010 | Journal of the American College of Cardiology2010，，19： | 1 |
| 16 | Proactive process-level live migration and back migration in HPC environments 显示文摘 | Chao Wang Frank Mueller Christian Engelmann | 2011 | Journal of Parallel and Distributed Computing2011，72，2： | 1 |
| 17 | Neuromuscular trunk activation patterns in back pain patients during one-handed lifting显示文摘AIM To analyze neuromuscular activity patterns of the trunk in healthy controls(H) and back pain patients(BPP) during one-handed lifting of light to heavy loads. METHODS After assessment of back pain(graded chronic pain scale according to von Korff) all subjects(n = 43) performed a warm-up(treadmill walking). Next, subjects were instructed to lift 3 × a 20 kg weight placed in front of them(with both hand) onto a table(height: 0.75 m). Subsequently, all subjects lifted with one hand(left-side, 3 repetitions) a weight of 1 kg(light), 10 kg(middle) and 20 kg(heavy) in random order from the ground up onto the table left of them. Trunk muscle activity was assessed with a 12-lead EMG(6 ventral/6 dorsal muscles; 4000 Hz). EMG-RMS(%) was averaged over the 3 repetitions and analyzed for the whole one-handed lifting cycle, then normalized to RMS of the two-handed lifting. Additionally, the mean(normalized) EMG-RMS of four trunk areas [right/left ventral area(VR/VL); right/left dorsal area(DR/DL)] was calculated. Data were analyzed descriptively(mean ± SD) followed by student's t-test comparing H and BPP(α = 0.05). With respect to the unequal distribution of subjects in H and BPP, a matched-group analysis was conducted. Seven healthy controls were gender- and age-matched(group H_(matched)) to the 7 BPP. In addition, task failure was calculated and compared between H/H_(matched) vs BPP using χ~2. RESULTS Seven subjects(3m/4f; 32 ± 7 years; 171 ± 7 cm; 65 ± 11 kg) were assigned to BPP(pain grade ≥ 2) and 36(13m/23f; 28 ± 8 years; 174 ± 10 cm; 71 ± 12 kg) to H(pain grade ≤ 1). H and BPP did not differ significantly in anthropometrics(P > 0.05). All subjects were able to lift the light and middle loads, but 57% of BPP and 22% of H were not able to lift the heavy load(all women). χ~2 analysis revealed statistically significant differences in task failure between H vs BPP(P = 0.03). EMG-RMS ranged from 33% ± 10%/30% ± 9%(DL, 1 kg) to 356% ± 148%/283% ± 80%(VR, 20 kg) in H/BPP with no statistical difference between groups regardless of load(P > 0.05). However, the EMG-RMS of the VR was greatest in all lifting tasks for both groups and increased with heavier loads. CONCLUSION Heavier loading leads to an increase(2- to 3-fold) in trunk muscle activity with comparable patterns. Heavy loading(20 kg) leads to task failure, especially in women with back pain. | Juliane Mueller Tilman Engel Stephan Kopinski Frank Mayer Steffen Mueller | 2017 | World Journal of Orthopedics2017，8，2： | 0 |
| 18 | Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods显示文摘Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant dentistry.The knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation material.Therefore,this work aimed to assess if the electrochemistry(EC)measurements of the corrosion process correlate with the surface features at various time points during the surface degradation,in order to describe the degradation process of Mg and Mg alloys more reliably,under the assumption that differences in EC behavior can be detected and related to specific patterns on the surface.In this test setup,a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys(Mg2Ag,Mg4Ag,and Mg6Ag).Specimens were investigated using different circulating cell culture solutions as electrolytes,these were minimum essential medium(MEM),Hank’s Balanced Salt Solution(HBSS),and MEM+(MEM with added sodium hydrogen carbonate)at 37℃.Open circuit potential measurements(OCP)over 30 min followed by cyclic polarization were performed.The electrochemistry data,including OCP,exchange current density and corrosion potential,were compared with visible changes at the surface during these treatments over time.The results show that the addition of silver(Ag)leads to a“standardization”of the degradation regardless of the selected test medium.It is currently difficult to correlate the visible microscopic changes with the data taken from the measurements.Therefore,further investigations are necessary. | Yuqiuhan Zhang Tycho Zimmermann Wolf-Dieter Mueller Frank Witte Florian Beuer Andreas Schwitalla | 2022 | Bioactive Materials2022，7，1： | 0 |
| 19 | Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells显示文摘很小的 superparamagnetic 氧化铁 nanoparticles (VSOP ) 很快在动脉粥样硬化患者损害积累,由磁性的回声成像(MRI ) 的从而创新的匾可视化。这研究被执行识别 VSOP 的举起机制进动脉粥样硬化患者匾。低密度的脂蛋白受体缺乏(有先进动脉粥样硬化的 LDLR /) 老鼠在 VSOP 的静脉内的管理以后在各种各样的时间点用 MRI 和传播电子显微镜学(TEM ) 被分析。验尸, MRI 检测了在注射以后动脉粥样硬化患者匾把 10 min 标记的 VSOP,并且信号在开始的 3 h 上增加了。TEM 表明标记的集中的匾被 VSOP 的加速的 transcytosis 通过覆盖动脉粥样硬化患者损害的 endothelial 房间调停。有 endocytosis 禁止者和小介入 RNA (siRNA ) 的实验揭示了包含调停 clathrin 、调停 caveolin 的过程的 dynamin 依赖的机制。在房间文化实验, endothelial VSOP 举起在 proatherogenic 流动和 TNF 刺激下面被提高,两个都是在匾区域的现在的条件。我们的学习证明 VSOP 启用对加速的 endothelial transcytosis 的非侵略的 MRI 评价,在动脉粥样硬化患者的重要 pathomechanism 匾形成。 | Wolfram C. Poller Evelyn Ramberger Philipp Boehm-Sturm Susanne Mueller Konstantin Moller Norbert Lowa Frank Wiekhorst Susanne Wagner Matthias Taupitz Eyk Schellenberger Gert Baumann Karl Stangl Verena Stangl Antje Ludwig | 2016 | Nano Research2016，9，11： | 0 |
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