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| 1 | Distribution and assessment of heavy metals in the surface sediment of Yellow River, China显示文摘Large amounts of heavy metals discharged by industrial cities that are located along the middle reach of Yellow River, China have detrimental impacts on both the ecological environment and human health. In this study, fourteen surface sediment samples were taken in the middle reach of the Yellow River. Contents of Zn, Pb, Ni, Cu, Cr, Cd, As were measured, and the pollution status was assessed using three widely used pollution assessment methods, including the single factor index method, Nemerow pollution index method and potential ecological risk index. The concentrations of the studied heavy metals followed the order: Zn > Cr > Cu > Ni > Pb > As > Cd. Nearly 50% of sites had Cu and Cr accumulation. The concentration of Cu at the Yiluo River exceeded the secondary standard value of the Environmental quality standard for soils. Comparison of heavy metal concentrations between this study and other selected rivers indicated that Cu and Cr may be the major pollutants in our case. The single factor index indicated that many samples were at high levels of pollution for Cu and Cd; the Nemerow pollution index indicated that the Yihe River, Luohe River, Yiluo River and Huayuankou were polluted. According to the results of potential ecological risk assessment, Cd in the tributaries of Luo River, Yihe River,and Yiluo River showed high risk toward the ecosystem and human health, Cd in Huanyuankou and Cu in Yiluo River showed a middle level of risk and other samples were at a low level of risk. | Nan Yan Wenbin Liu Huiting Xie Lirong Gao Ying Han Mengjing Wang Haifeng Li | 2016 | Journal of Environmental Sciences2016，28，1： | 33 |
| 2 | A prospective comparative study on neovascular glaucoma and non- neovascular refractory glaucoma following Ahmed glaucoma valve implantation显示文摘 | Li Zheng Zhou Minwen Wang Wei Huang Wenbin Chen Shida Li Xingyi Gao Xinbo Zhang Xiulan | 2014 | Chinese Medical Journal2014，，8： | 18 |
| 3 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Efficient generation of transgenic chickens using the spermatogonial stem cells in vivo and ex vivo transfection显示文摘The highly efficient novel methods to produce transgenic chickens were established by directly in-jecting the recombinant plasmid containing green fluorescent protein (GFP) gene into the cock's testis termed as testis-medianted gene transfer (TMGT), and transplanting transfected spermatogonial stem cells (TTSSCs). For the TMGT approach,four dosages of pEGFP-N1 DNA/cationic polymer complex were injected intratesticularly. The results showed: (1) 48 h after the injection,the percentages of testis cells expressing GFP were 4.0%, 8.7%, 10.2% and 13.6% in the 50, 100, 150 and 200 μg/mL group, re-spectively. The difference from the four dosage groups was significant (P<0.05). On day 25 after the injection, a dosage-dependent and time-dependent increase in the number of transgenic sperm was observed. The percentages of gene expression reached the summit and became stable from day 70 to 160, being 12.7%, 12.8%, 15.9% and 19.1%, respectively. The difference from the four dosage groups was also significant (P<0.05). (2) 70 d after the injection, strong green fluorescent could be observed in the seminiferous tubules by whole-mount in-situ hybridization. (3) 70 d after the injection, the semen was collected and used to artificially inseminate wild-type females. The blastoderms of F1 and F2 transgenic chicken expressed GFP were 56.2% (254/452) and 53.2% (275/517), respectively. The detec-tion of polymerase chain reaction (PCR) of F1 and F2 transgenic chicken blood genomic DNA showed that 56.5% (3/23) of F1 and 52.9% (9/17) of F2 were positive. Southern blot showed GFP DNA was in-serted in their genomic DNAs. (4) Frozen whole mount tissue sections of F1 and F2 transgenic chicken liver, heart, kidney and muscle showed that the rates of green fluorescent positive were between 50.0% and 66.7%. (5) With the TTSSCs method, SSCs ex vivo transfected with GFP were transplanted into recipient roosters whose endogenic SSCs had been resoluted. The donor SSCs settled and GFP ex-pression became readily detectable in the frozen whole mount tissue sections of recepient testes. Moreover, sperms carrying GFP could be produced normally. The results of artificially inseminating wild-type females with these sperms showed 12.5% (8/64) of offspring embryo expressed GFP and 11.1% (2/18) hatched chicks were tested transgenic. Our data therefore suggest TMGT and TTSSCs are the feasible methods for the generation of transgenic chickens. | LI BiChun SUN GuoBo SUN HuaiChang XU Qi GAO Bo ZHOU GuanYue ZHAO WenMing WU XinSheng BAO WenBin YU Fei WANG KeHua CHEN GuoHong | 2008 | Science China(Life Sciences)2008，51，8： | 13 |
| 5 | Brain dynamic mechanisms on the visual attention scale with Chinese characters cues显示文摘The temporal dynamics in brain evoked by the scale of visual attention with the cues of Chinese characters were studied by recording event-related potentials (ERPs). With the fixed orientation of visual attention, 14 healthy young participants performed a search task in which the search array was preceded by Chinese characters cues, '大, 中, 小' (large, medium, small). 128 channels scalp ERPs were recorded to study the role of visual attention scale played in the visual spatial attention. The results showed that there was no significant difference in the ERP components evoked by the three Chinese characters cues except the in-feroposterior N2 latency. The targets evoked P2, N2 amplitudes and latency have significant differences with the different cues of large, middle and small, while P1 and N1 components had no significant difference. The results suggested that the processing of scale of visual attention was mainly concerned with P2, N2 components, while the P1, N1 components were mainly related with | GAO Wenbin WEI Jinghan PENG Xiaohu WEI Xing LUO Yuejia | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 6 | Review-material degradation assessed by digital image processing:Fundamentals,progresses,and challenges显示文摘Material degradation is accompanied by the changes in surface structure,morphology,and composition.These changes can be recorded by a variety of image acquisition devices that export digital images in grayscale or true color to a detector.Information regarding corrosion type and extent can be extracted with image processing methods.This paper provides a comprehensive review of material degradation assessed by digital image processing.Digital image processing systems used to assess material degradation are briefly reviewed,and the algorithms developed to process metallic materials degradation images are described.Physical and electrochemical methods that can be used to support digital image processing results are summarized,and future work that will augment the present methods of evaluating material degradation are discussed. | Da-Hai Xia Shizhe Song Lei Tao Zhenbo Qin Zhong Wu Zhiming Gao Jihui Wang Wenbin Hu Yashar Behnamian Jing-Li Luo | 2020 | Journal of Materials Science & Technology2020，52，18： | 8 |
| 7 | Actual evapotranspiration of subalpine meadows in the Qilian Mountains, Northwest China显示文摘As a main component in water balance,evapotranspiration(ET)is of great importance for water saving,especially in arid and semi-arid areas.In this study,the FAO(Food and Agriculture Organization)Penman-Monteith model was used to estimate the magnitude and temporal dynamics of reference evapotranspiration(ET0)in 2014 in subalpine meadows of the Qilian Mountains,Northwest China.Meanwhile,actual ET(ETc)was also investigated by the eddy covariance(EC)system.Results indicated that ETc estimated by the EC System was 583 mm,lower than ET0(923 mm)estimated by the FAO Penman-Monteith model in 2014.Moreover,ET0 began to increase in March and reached the peak value in August and then declined in September,however,ETc began to increase from April and reached the peak value in July,and then declined in August.Total ETc and ET0 values during the growing season(from May to September)were 441 and 666 mm,respectively,which accounted for 75.73%of annual cumulative ETc and 72.34%of annual cumulative ET0,respectively.A crop coefficient(kc)was also estimated for calculating the ETc,and average value of kc during the growing season was 0.81(ranging from 0.45 to 1.16).Air temperature(Ta),wind speed(u),net radiation(Rn)and soil temperature(Ts)at the depth of 5 cm and aboveground biomass were critical factors for affecting kc,furthermore,a daily empirical kc equation including these main driving factors was developed.Our result demonstrated that the ETc value estimated by the data of kc and ET0 was validated and consistent with the growing season data in 2015 and 2016. | GAO Yunfei ZHAO Chuanyan Muhammad W ASHIQ WANG Qingtao RONG Zhanlei LIU Junjie MAO Yahua GUO Zhaoxia WANG Wenbin | 2019 | Journal of Arid Land2019，11，3： | 8 |
| 8 | An improved motion compensation method for high resolution UAV SAR imaging显示文摘The polynomial and sinusoidal motion errors always exist in the unmanned aero vehicle(UAV)SAR due to the small size and low velocity of the platform,causing serious spectrum compressing/stretching and significant spectral replicas of the azimuth signal.The motion errors induce serious blurring of the SAR image and'ghost targets',and can hardly be precisely estimated by the conventional motion compensation(MOCO)method.In this paper,an improved MOCO method is proposed to estimate and eliminate the motion errors in the high resolution UAV SAR without high precision inertial navigation system(INS)data.The time domain range walk correction(RWC)operation in the coarse phase error estimation process of the proposed MOCO method is the key operation that ensures the estimation accuracy of the whole MOCO method.Finally,the validity of the improved MOCO method is verified by computer simulations and real UAV SAR data processing. | FAN BangKui DING ZeGang GAO WenBin LONG Teng | 2014 | Science China(Information Sciences)2014，57，12： | 6 |
| 9 | Simulation and Field Testing of Multiple Vehicles Collision Avoidance Algorithms显示文摘A global planning algorithm for intelligent vehicles is designed based on the A* algorithm, which provides intelligent vehicles with a global path towards their destinations. A distributed real-time multiple vehicle collision avoidance(MVCA)algorithm is proposed by extending the reciprocal n-body collision avoidance method. MVCA enables the intelligent vehicles to choose their destinations and control inputs independently,without needing to negotiate with each other or with the coordinator. Compared to the centralized trajectory-planning algorithm, MVCA reduces computation costs and greatly improves the robustness of the system. Because the destination of each intelligent vehicle can be regarded as private, which can be protected by MVCA, at the same time MVCA can provide a real-time trajectory planning for intelligent vehicles. Therefore,MVCA can better improve the safety of intelligent vehicles. The simulation was conducted in MATLAB, including crossroads scene simulation and circular exchange position simulation. The results show that MVCA behaves safely and reliably. The effects of latency and packet loss on MVCA are also statistically investigated through theoretically formulating broadcasting process based on one-dimensional Markov chain. The results uncover that the tolerant delay should not exceed the half of deciding cycle of trajectory planning, and shortening the sending interval could alleviate the negative effects caused by the packet loss to an extent. The cases of short delay(< 100100 ms) and low packet loss(< 5%) can bring little influence to those trajectory planning algorithms that only depend on V2 V to sense the context, but the unpredictable collision may occur if the delay and packet loss are further worsened. The MVCA was also tested by a real intelligent vehicle, the test results prove the operability of MVCA. | Chaoyue Zu Chao Yang Jian Wang Wenbin Gao Dongpu Cao Fei-Yue Wang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 6 |
| 10 | Environmentally Tough and Stretchable MXene Organohydrogel with Exceptionally Enhanced Electromagnetic Interference Shielding Performances显示文摘Conductive hydrogels have potential applications in shielding electromagnetic(EM)radiation interference in deformable and wearable electronic devices,but usually suffer from poor environmental stability and stretching-induced shielding performance degradation.Although organohydrogels can improve the environmental stability of materials,their development is at the expense of reducing electrical conductivity and thus weakening EM interference shielding ability.Here,a MXene organohydrogel is prepared which is composed of MXene network for electron conduction,binary solvent channels for ion conduction,and abundant solvent-polymer-MXene interfaces for EM wave scattering.This organohydrogel possesses excellent anti-drying ability,low-temperature tolerance,stretchability,shape adaptability,adhesion and rapid self-healing ability.Two effective strategies have been proposed to solve the problems of current organohydrogel shielding materials.By reasonably controlling the MXene content and the glycerol-water ratio in the gel,MXene organohydrogel can exhibit exceptionally enhanced EM interference shielding performances compared to MXene hydrogel due to the increased physical cross-linking density of the gel.Moreover,MXene organohydrogel shows attractive stretching-enhanced interference effectiveness,caused by the connection and parallel arrangement of MXene nanosheets.This well-designed MXene organohydrogel has potential applications in shielding EM interference in deformable and wearable electronic devices. | Yuanhang Yu Peng Yi Wenbin Xu Xin Sun Gao Deng Xiaofang Liu Jianglan Shui Ronghai Yu | 2022 | Nano-Micro Letters2022，14，5： | 6 |
| 11 | Decomposition of hexachlorobenzene over Al_2O_3 supported metal oxidecatalysts显示文摘Decomposition of hexachlorobenzene(HCB)was investigated over several metal oxides(i.e.,MgO,CaO,BaO,La2O3,CeO2,MnO2, Fe2O3,and Co3O4)supported on Al2O3,which was achieved in closed system at a temperature of 300°C.Catalysts were prepared by incipient wetness impregnation with different metal oxides loading and impregnating solvents.The decomposition effciency of different catalysts for this reaction depends on the nature of the metal oxide used,and Al2O3 supported La2O3 was found to be the most active one.Pentachlorobenzene(PeCB),and all tetrachlorobenzene(TeCB),trichlorobenzene(TrCB),and dichlorobenzene(DCB)isomers were detected after the decomposition reaction,indicating that the decomposition was mainly a dechlorination process.The detection of all lower chlorinated benzenes suggested the complexity of decomposition and the presence of more than one dechlorination pathway. | Lifei ZHANG Minghui ZHENG Bing ZHANG Wenbin LIU Lirong GAO Te BA Zhiyuan REN Guijin SU | 2008 | Journal of Environmental Sciences2008，20，12： | 4 |
| 12 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 13 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 14 | Comprehensive Proteomic Profiling of Patients'Tears Identifies Potential Biomarkers for the Traumatic Vegetative State显示文摘The vegetative state is a complex condition with unclear mechanisms and limited diagnostic, prognostic,and therapeutic methods. In this study, we aimed to explore the proteomic profile of tears from patients in a traumatic vegetative state and identify potential diagnostic markers using tears—a body fluid that can be collected noninvasively. Using i TRAQ quantitative proteomic technology, in the discovery phase, tear samples collected from 16 patients in a traumatic vegetative state and 16 normal individuals were analyzed. Among 1080 identified tear proteins, 57 were upregulated and 15 were downregulated in the patients compared to the controls. Bioinformatics analysis revealed that the differentially-expressed proteins were mainly involved in the wound response and immune response signaling pathways. Furthermore, we verified the levels of 7 differentially-expressed proteins in tears from50 traumatic vegetative state patients and 50 normal controls(including the samples used in the discovery phase) using ELISA. The results showed that this 7-protein panel had a high discrimination ability for traumatic vegetative state(area under the curve = 0.999). In summary, the altered tear proteomic profile identified in this study provides a basis for potential tear protein markers for diagnosis and prognosis of the traumatic vegetative state and also provides novel insights into the mechanisms of traumatic vegetative state. | Qilin Tang Chao Zhang Xiang Wu Wenbin Duan Weiji Weng Junfeng Feng Qing Mao Shubin Chen Jiyao Jiang Guoyi Gao | 2018 | Neuroscience Bulletin2018，34，4： | 3 |
| 15 | Leaf gas exchange and photosynthesis curves of Elymus nutans and Potentilla anserina under fencing and grazing conditions in the Qilian Mountains, Northwest China显示文摘Potentilla anserina L.and Elymus nutans Griseb.are dominant species in the subalpine meadows of China.Grazing is one of the most important factors that influence community structure and productivity of subalpine meadows.Understanding how grazing changes photosynthetic capability is essential for preservation and restoration of grasslands.However,information about the effects of grazing on photosynthetic capability remains inadequate.Experiments were conducted in fencing and grazing areas in the Qilian Mountains,Northwest China.The leaf gas exchange and photosynthetic curves of P.anserina and E.nutans were measured at different growth stages.Results showed that grazing decreased the values of leaf gas exchange parameters,such as net photosynthetic rate,stomatal conductance,transpiration rate,and intercellular CO2 concentration of P.anserina and E.nutans.In addition,grazing decreased the values of net photosynthetic rate-photosynthetically active radiation(PN-PAR)curve parameters,such as light-saturated net photosynthetic rate,apparent quantum efficiency,light compensation point,light saturation point,and dark respiration rate.Our results demonstrated that grazing was the primary limiting factor for photosynthesis of dominant grassland species in the study area. | LIU Junjie WANG Xiaoping GAO Yunfei RONG Zhanlei ZHANG Guangde WANG Wenbin GE Lijuan MAO Yahua GUO Zhaoxia ZHAO Chuanyan | 2019 | Journal of Arid Land2019，11，3： | 3 |
| 16 | Effect of Interlayers on Microstructure and Properties of 2205/Q235B Duplex Stainless Steel Clad Plate显示文摘In this research,2205/Q235 B clad plates were prepared by a vacuum hot rolling composite process.The effects of adding Fe,Ni,and Nb interlayers on the bonding interface structures and the shear strengths of the clad steel plates were studied.The results showed that 2205 duplex stainless steel and the three interlayers produced a large amount of plastic deformation and low-angle boundaries,and the main structures were the recrystallized and deformed grains.There were many recrystallized grains in the microstructure of the Q235 B low-carbon steel due to the low deformation in the rolling process.The Fe interlayer had better wettability with the two kinds of steel,but the lower strength led to the reduction of shear strength by about14 MPa compared with the original clad steel plate.The C element in the Q235 B low-carbon steel easily diffused into the Fe interlayer,and the clad steel plate attained a poor corrosion resistance because a large decarburization area was formed.The Nb interlayer reacted with the Mo element in the 2205 duplex stainless steel to form an Nb-Mo binary alloy,which generated long-banded ferrite.The decarburization area was also produced because the Nb reacted with the C element in the Q235 B to form hard and brittle NbCx.As a result,the shear strength was significantly reduced by about 282 MPa,and the corrosion resistance of the bonding surface was deteriorated.The Ni interlayer did not react with the alloy elements in both sides,and therefore effectively prevented element diffusion and improved the corrosion resistance of the bonding surface.Due to the low strength of the Ni interlayer and the increased number of bonding surfaces of the clad steel plates,the shear strength was reduced to some extent(about 40 MPa),but it still met the engineering application standards. | Fengqiang Xiao Dongpo Wang Wenbin Hu Lei Cui Zhiming Gao Lanju Zhou | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 2 |
| 17 | Improved spectrum reconstruction technique based on chirp rate modulation in stepped-frequency SAR显示文摘To improve the efficiencies of the traditional spectrum reconstruction techniques, an improved spectrum reconstruction technique(ISRT) based on chirp rate modulation(CRM) is proposed. With the help of a CRM operation, a reconstructed wideband signal with a narrow pulse width can be obtained. Compared with the traditional time domain spectrum reconstruction technique(TSRT), ISRT is less time-consuming since much less samples are needed. Compared with the traditional frequency domain spectrum reconstruction technique(FSRT), the reconstructed signal is a chirp signal, which has no limitation on the subsequent imaging algorithm.What is more, processing steps of ISRT are optimized, and the computational burden is less than that of TSRT and FSRT. Both simulation results and real data processing have verified the validity of ISRT. | GAO WenBin DING ZeGang ZHU DongLin ZENG Tao LONG Teng | 2015 | Science China(Information Sciences)2015，58，10： | 2 |
| 18 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 19 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity显示文摘Triple-negative breast cancer(TNBC)is the most challenging subtype of breast cancer.Various endeavor has been made to explore the molecular biology basis of TNBC.Herein,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in TNBC.KTN1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor prognosis.In functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and invasiveness.RNA-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further experiments.CXCL8 depletion inhibited the tumorigenesis and progression of TNBC.Additionally,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in vivo.Furthermore,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of cells.Moreover,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 protein.Taken together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and progression.KTN1 may be a potential molecular target for the development of TNBC treatment. | Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang Hsien-Da Huang Xiang Gao Chang Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 20 | Electroless Ni–P–SiC composite coatings with superfine particles显示文摘 | Gao Jiaqiang Liu Lei Wu Yating Shen Bin Hu Wenbin | 2005 | Surface & Coatings Technology2005，，20： | 2 |
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