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| 1 | Indocyanine Green Nanoparticles for Theranostic Applications显示文摘Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics. | Zonghai Sheng Dehong Hu Miaomiao Xue Meng He Ping Gong Lintao Cai | 2013 | Nano-Micro Letters2013，5，3： | 11 |
| 2 | Long-term eficacy of plasma-derived hepatitis B vaccine among Chinese children:a 12-year folow-up study显示文摘INTRODUCTIONToevaluatelongtermeficacyofaplasmaderivedhepatitisBvaccineandprovideevidencefordecisionmakingonthevaccineboost... | LIAO Su Su 1, LI Rong Cheng 2, LI Hui 1, YANG Jin Ye 2, ZENG Xian Jia 1, GONG Jian 2, WANG Shu Sheng 2, LI Yan Ping 2 and ZHANG Kong Lai 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
| 3 | Mitochondrial Modulation of Apoptosis Induced by Low-dose Radiation in Mouse Testicular Cells显示文摘Objective To investigate whether apoptosis induced by low-dose radiation(LDR) is regulated by mitochondrial pathways in testicular cells.Methods Male mice were exposed to whole-body LDR,and changes in mitochondrial function and in expression of apoptotic factors were analyzed in the testicular cells as follows.Total nitric-oxide synthase(T-NOS) and Na+/K+ATPase activities were biochemically assayed.Reactive oxygen species(ROS) and mitochondrial membrane potential(Δψm) were determined by flow cytometry using fluorescent probes.Levels of mRNAs encoding cytochrome c(Cyt c) and apoptosis-inducing factor(AIF) were quantified by real-time reverse-transcription PCR(RT-PCR).Expression of Cyt c,AIF,caspase-9,and caspase-3 at the proteinlevel was assessed by western blotting and immunohistochemistry.Results LDR induced an increase in T-NOS activity and ROS levels,and a decrease in Na+/K+ATPase activity and mitochondrial Δψm,in the testicular cells.The intensity of these effects increased with time after irradiation and with dose.The cells showed remarkable swelling and vacuolization of mitochondria,and displayed a time- and dose-dependent increase in the expression of Cyt c,AIF,procaspase-9,and procaspase-3.Activation of the two procaspases was confirmed by detection of the cleaved caspases.The changes in expression of the four apoptotic factors were mostly limited to spermatogonia and spermatocytes.Conclusion LDR can induce testicular cell apoptosis through mitochondrial signaling pathways. | FANG Fang GONG Ping Sheng ZHAO Hong Guang BI Yu Jing ZHAO Gang GONG Shou Liang WANG Zhi Cheng | 2013 | Biomedical and Environmental Sciences2013，26，10： | 9 |
| 4 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy显示文摘As one of near-infrared(NIR) fluorescent(FL) nanoprobes, gold nanoclusters(Au NCs) are delicated to passive-targeting tumors for NIR FL imaging, but which easily cleared by the kidneys for the small size(<1.5 nm). Herein, the well-defined gold clusters nanoassembly(Au CNA) was synthesized by the selfassembly of Au NCs based on protein cross-linking approach. The as-prepared Au CNA demonstrated highly effective cellular uptake and precise tumor targeting compared to that of Au NCs. Moreover, with the irradiation of 660 nm laser, Au CNA generated largely reactive oxygen species(ROS) for photodynamic therapy(PDT). In vitro and [39_TD$IF]in vivo PDT revealed that Au CNA exhibited largely cell death and significantly tumor removal at a low power density of 0.2 W/cm^2. It could be speculated that the laser-excited Au CNA produced photon energy, which further obtained electron from oxygen to generate radical species.Therefore, Au CNA as a photosensitizer could realize NIR FL imaging and NIR laser induced PDT. | Hao-Dong Cui De-Hong Hu Jing-Nan Zhang Guan-Hui Gao Cui-Fang Zheng Ping Gong Xing-Hua Xi Zong-Hai Sheng Lin-Tao Cai | 2017 | Chinese Chemical Letters2017，28，7： | 3 |
| 7 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 8 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 9 | Comparative Study on Overexpression of HER2/neu and HER3 in Gastric Cancer显示文摘 | Xiu Li Zhang Yun Sheng Yang Dong Ping Xu Jian Hui Qu Ming Zhou Guo Yan Gong Jin Huang | 2009 | World Journal of Surgery2009，，10： | 1 |
| 10 | High‐intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene‐loaded ultrasound‐targeted microbubbles improved the survival of rabbits with VX2 liver tumor显示文摘 | Shi‐Ji Zhou Sheng‐Wei Li Ji‐Jian Wang Zuo‐Jin Liu Guo‐Bing Yin Jian‐Ping Gong Chang‐An Liu | 2012 | 2012 (9-10)2012，，9： | 1 |
| 11 | Comparative Study on Overexpression of HER2/neu and HER3 in Gastric Cancer显示文摘 | Xiu Li Zhang Yun Sheng Yang Dong Ping Xu Jian Hui Qu Ming Zhou Guo Yan Gong Jin Huang | 2009 | World Journal of Surgery2009，，10： | 1 |
| 12 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 13 | Persistent organic pollutants in the Tibetan surface soil: Spatial distribution, air–soil exchange and implications for global cycling显示文摘 | Xiao-ping Wang Jiu-jiang Sheng Ping Gong Yong-gang Xue Tan-dong Yao Kevin C. Jones | 2012 | Environmental Pollution2012，，： | 1 |
| 14 | Microfluidic Fabrication of Porous Polymer Microspheres: Dual Reactions in Single Droplets显示文摘 | Gong Xiuqing Wen Weijia Ping Sheng | 2009 | Langmuir2009，25，12： | 1 |
| 15 | Selected non- Saccharomyces wine yeasts in controlled multistarter fermentations with Saccharomyces cerevisiae on alcoholic fermentation behaviour and wine aroma of cherry wines显示文摘 | Shu Yang Sun Han Sheng Gong Xiao Man Jiang Yu Ping Zhao | 2014 | Food Microbiology2014，，： | 1 |
| 16 | Persistent organic pollutants in the Tibetan surface soil: Spatial distribution, air–soil exchange and implications for global cycling显示文摘 | Xiao-ping Wang Jiu-jiang Sheng Ping Gong Yong-gang Xue Tan-dong Yao Kevin C. Jones | 2012 | Environmental Pollution2012，，： | 1 |
| 17 | Synthesis and Bronchodilatory Activities of New Pyrazolo[4,3-d]pyrimidin-7-ones显示文摘Twelve novel pyrazolo [4,3-d] pyrimidin-7-ones were synthesized and their structures were confirmed by IR, 1H NMR and MS. Their in vitro bronchodilatory activities were tested in guinea-pigs. The pharmacological results show that compound 11c has more potent activity than aminophylline. | Dun WANG, Yan Fang ZHAO, De Sheng YU, Ping GONG* Shenyang Pharmaceutical University, Shenyang 110016 | 2003 | Chinese Chemical Letters2003，14，12： | 0 |
| 18 | Planar-symmetry-breaking induced antisymmetric magnetoresistance in van der Waals ferromagnet Fe_(3)GeTe_(2)显示文摘Recently discovered magnetic van der Waals(vdW)materials provide an ideal platform to explore low-dimensional magnetism and spin transport.Its vdW interaction nature opens up unprecedented opportunities to build vertically stacked heterostructures with novel properties and functionalities.By engineering the planar structure as an alternative degree of freedom,herein we demonstrate an antisymmetric magnetoresistance(MR)in a vdW Fe_(3)GeTe_(2)flake with a step terrace that breaks the planar symmetry.This antisymmetric MR originates from a sign change of the anomalous Hall effect and the continuity of the current transport near the boundary of magnetic domains at the step edge.A repeatable domain wall due to the unsynchronized magnetization switching is responsible for this sign change.Such interpretation is supported by the observation of field-dependent domain switching,and the step thickness,temperature,and magnetic field orientation dependent MR.This work opens up new opportunities to encode magnetic information by controlling the planar domain structures in vdW magnets. | Ping Liu Caixing Liu Zhi Wang Meng Huang Guojing Hu Junxiang Xiang Chao Feng Chen Chen Zongwei Ma Xudong Cui Hualing Zeng Zhigao Sheng Yalin Lu Gen Yin Gong Chen Kai Liu Bin Xiang | 2022 | Nano Research2022，15，3： | 0 |
| 19 | Paired quasi-periodic pulsations of hard X-ray emission in a solar flare显示文摘We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 UT.Several subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak struc-tures.These subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive phase.The periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence level.The paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our observation.The precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands. | Hai-Sheng Zhao Dong Li Shao-Lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong Liu Wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-Jing Liu Ya-Qing Liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 20 | Invasive stratified mucin-producing carcinoma (ISMC) of the uterinecervix: An analysis of 6 cases with distinctive clinicopathologicalfeatures显示文摘Invasive stratified mucin-producing carcinoma(ISMC)is a recently described histologic variant of high-risk human papillomavirus(HPV)-associated endocervical adenocarcinoma,as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion(SMILE).ISMC can display variable architectural patterns and usually coexists with other more conventional types of HPV-associated carcinomas,which makes diagnosis and differential diagnosis of ISMC is difficult for pathologists.Moreover,the prognosis of ISMC is still controversial.We analyzed 6 ISMCs with detailed pathological and clinical information.Intraepithelial lesion,including 1 high-grade squamous intraepithelial lesion and 1 SMILE,was found.Various architectures were observed(including nest,glandular,solid,trabecular,and single cell).Nuclear peripheral palisading,apoptotic bodies and mitoses,and variable cytoplasmic mucin vacuoles were seen in all of our cases.The predominance of neutrophils infiltration was seen in only 1 tumor.All the tumors infiltrated the cervical stroma in Silva pattern C manner.p63 and/or p40 was characteristically expressed in the peripheral cells in only 2 cases.High-risk HPV infection was observed in 3/3 detected cases.All the patients were alive during the follow-up time.Recognition of this infrequent tumor may help pathologists and oncologists for an accurate diagnosis and a better understanding of the clinicopathological behavior. | TING LAN SHENG QIN XIAOJIN GONG PING ZHENG JIAXIN YAN YANG LIU | 2021 | BIOCELL2021，45，5： | 0 |
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