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| 1 | Multicenter case-control study of the risk factors for ulcerative colitis in China显示文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. | Yu-Fang Wang Qin Ou-yang Bing Xia Li-Na Liu Fang Gu Kai-Fang Zhou Qiao Mei Rui-Hua Shi Zhi-Hua Ran Xiao-Di Wang Pin-Jin Hu Kai-Chun Wu Xin-Guang Liu Ying-Lei Miao Ying Han Xiao-Ping Wu Guo-Bing He Jie Zhong Guan-Jian Liu | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | A study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines显示文摘INTRODUCTION Cell apoptosis,which involves the biologic regulation of the numbers and vital activity of cells,is an important metaboloc process in both normal cells and tumor cells. | Qin Long Gu Ning Li Li Zheng Gang Zhu Hao Ran Yin Yan Zhen Lin | 2000 | World Journal of Gastroenterology2000，6，3： | 12 |
| 4 | Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances显示文摘Lactic acid bacteria(LAB)are a representative probiotic.As the dominant flora in the human intestinal tract,LAB can regulate the balance of human intestinal flora and improve host health.The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population,with excellent probiotics and high antibacterial activity.After 16S ribosomal RNA(rRNA)homology and phylogenetic tree analysis,potential probiotics were tested for their antibacterial activity,resistance to artificial gastrointestinal fluid and drugs,surface hydrophobicity,and safety.Three strains of LAB with acid resistance,bile salt resistance,epithelial cell adhesion,and no multidrug resistance were selected:Lactobacillus salivarius,Leuconostoc lactis,and Lactobacillus paracasei.Analysis of the antibacterial active substances in the three strains and their fermentation broths revealed that the main antibacterial substances of L.lactis were organic acids,whereas those of L.salivarius and L.paracasei were organic acids and bacteriocins with broad-spectrum antibacterial activity.These three strains of probiotic LAB with high antibacterial activity were identified as bacterial resources that could potentially be used to develop probiotic preparations for the prevention and treatment of intestinal diseases caused by intestinal pathogens. | Zhijing LIU Cong XU Ran TIAN Wan WANG Jiage MA Liya GU Fei LIU Zhanmei JIANG Juncai HOU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，7： | 10 |
| 5 | Functional Characterization of the Promoter and Second Intron of CUM1 During Flower Development in Cucumber(Cucumis sativus L.)显示文摘The characterization of flower specific promoter is critical during flower development by cucumber transformation technology.AGAMOUS(AG)is an organ identity gene that is required for carpel and stamen development in Arabidopsis.The promoter and second intron of AG contain multiple regulatory elements that confer proper spatial and temporal expression.Cucumber is an important vegetable with unisexual flowers.Cucumber MADS-box 1(CUM1)is the AG homolog in cucumber,belonging to the eu AG lineage along with AG.In situ hybridization showed that CUM1 was specifically expressed in the stamens and carpels of cucumber.GUS staining indicated that the second intron of CUM1 confers stamen-specific expression,while the promoter of CUM1 drives both stamen-and carpel-specific expression during the early stages of flower development,but is restricted to carpel-and connectivum-specific expression during the late stages of flower development.Furthermore,a yeast one-hybrid assay demonstrated that two auxin response factors(Cs ARF13 and Cs ARF17)had bound directly to the second intron of CUM1.Our data suggest that different regulatory circuits operate in AG homologs in plant species with distinct sex types. | GU Ran LIU Xiaofeng ZHAO Wensheng YAN Shuangshuang SUN Linhan WU Binning ZHANG Xiaolan | 2018 | Horticultural Plant Journal2018，4，3： | 9 |
| 6 | Drone-based entanglement distribution towards mobile quantum networks显示文摘Satellites have shown free-space quantum-communication ability;however,they are orbit-limited from full-time all-location coverage.Meanwhile,practical quantum networks require satellite constellations,which are complicated and expensive,whereas the airborne mobile quantum communication may be a practical alternative to offering full-time all-location multi-weather coverage in a cost-effective way.Here,we demonstrate the first mobile entanglement distribution based on drones,realizing multi-weather operation including daytime and rainy nights,with a Clauser-Horne-Shimony-Holt S-parameter measured to be 2.41±0.14 and 2.49±0.06,respectively.Such a system shows unparalleled mobility,flexibility and reconfigurability compared to the existing satellite and fiber-based quantum communication,and reveals its potential to establish a multinode quantum network,with a scalable design using symmetrical lens diameter and single-mode-fiber coupling.All key technologies have been developed to pack quantum nodes into lightweight mobile platforms for local-area coverage,and arouse further technical improvements to establish wide-area quantum networks with high-altitude mobile communication. | Hua-Ying Liu Xiao-Hui Tian Changsheng Gu Pengfei Fan Xin Ni Ran Yang Ji-Ning Zhang Mingzhe Hu Jian Guo Xun Cao Xiaopeng Hu Gang Zhao Yan-Qing Lu Yan-Xiao Gong Zhenda Xie Shi-Ning Zhu | 2020 | National Science Review2020，7，5： | 6 |
| 7 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 8 | Recent Progress in Surface Integrity Research and Development显示文摘1.Introduction Surface integrity has great significance for the quality and performance of machined components,and has therefore been increasingly recognized by industry.In particular,within certain industries that require high reliability,such as the aerospace industry,surface integrity is one of the most relevant indexes used to evaluate the quality of machined parts.Thus,obtaining updated knowledge on surface integrity is of great interest to both the academic community and industry[1]. | Fengzhou Fang Chunyang Gu Ran Hao Kaiyuan You Siyu Huang | 2018 | Engineering2018，4，6： | 5 |
| 9 | Effect of mechanical threshing on damage and vigor of maize seed threshed at different moisture contents显示文摘Mechanical threshing used when preparing maize seeds for planting subjects seed to damage and reduces seed quality.The purpose of this study was to assess the effect of mechanical threshing on the quality of maize seed threshed at different moisture contents(MCs).Seeds of dent maize JK968 and flint maize DD2 were threshed at 12,15,18,21,and 24% MC.The damage degree was determined by iodine staining,and seed vigor was assessed by standard germination(SG),cold test germination(CTG),accelerated aging germination(AAG),seedling emergence rate,and seedling root and shoot length.The results showed that the damage percentage increased,and the seed vigor parameters decreased with increasing seed MC during threshing in both cultivars.For obtaining high seed quality,indicated by at least 90,85,and 80% of SG,AAG,and CTG,respectively,JK 968 and DD2 should be threshed at MC lower than 15 and 18%,respectively.Furthermore,the damage mainly occurred in the apical part of seeds,irrespective of the threshing MC in both cultivars.When the embryo was damaged,seedling emergence rates were significantly reduced with great influence on shoot length.Damage to the endosperm resulted in little effect on seedling performance.Flint maize DD2 was more tolerant to mechanical threshing than dent maize JK968.These results provided technical reference for the production and processing of high vigor maize seeds. | GU Ri-liang HUANG Ran JIA Guang-yao YUAN Zhi-peng REN Li-sha LI Li WANG Jian-hua | 2019 | Journal of Integrative Agriculture2019，18，7： | 5 |
| 10 | Primary analysis and screening of microRNAs in gastric cancer side population cells显示文摘AIM: To explore the micro RNA(mi RNA) profiles and to determine the key mi RNAs within the side population(SP) cells of the gastric cancer cell line MKN-45. METHODS: We used fluorescence-activated cell sorting and Hoechst 33342 labeling to obtain SP cells from the human gastric carcinoma cell line MKN-45. The mi RNA expression profiles of the SP and major population(MP) cells were examined using a mi RNA gene chip, and key mi RNAs were obtained according to aberrant expression and the mi RNAs' possible targets as predicted by bioinformatics. RESULTS: Using a significance criterion of a 1.5-fold or greater difference in expression level, we observed an increase in the expression of 34 mi RNAs and a decrease in the expression of 34 mi RNAs when comparing SP to MP cells. Using quantitative real-time reverse transcription-polymerase chain reaction to test for differentially expressed mi RNAs combined with bioinformatics results, we found that the downregulated mi RNAs, such as hsa-mi R-3175 and hsa-mi R-203, and the upregulated mi RNAs, including hsa-mi R-130 a, hsa-mi R-324-5p, hsa-mi R-34 a, and hsa-mi R-25-star, may be important in maintaining and regulating the characteristics of SP cells. CONCLUSION: There are key mi RNAs expressed within the SP cells of the gastric cancer cell line MKN-45, andinclude hsa-mi R-3175, hsa-mi R-203, hsa-mi R-130 a, hsami R-324-5p, hsa-mi R-34 a, and hsa-mi R-25-star. | Hai-Hong Zhang Guo-Li Gu Xiang-Yang Zhang Feng-Zhi Li Li Ding Qin Fan Ran Wu Wei Shi Xin-Yan Wang Lin Chen Xue-Ming Wei Xiao-Ying Yuan | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 11 | Targeting integrin pathways:mechanisms and advances in therapy显示文摘Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix(ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide range of states in health and diseases.Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms,including protein-protein interactions,conformational changes,and trafficking.Due to their exposure on the cell surface and sensitivity to the molecular blockade,integrins have been investigated as pharmacological targets for nearly 40 years,but given the complexity of integrins and sometimes opposite characteristics,targeting integrin therapeutics has been a challenge.To date,only seven drugs targeting integrins have been successfully marketed,including abciximab,eptifibatide,tirofiban,natalizumab,vedolizumab,lifitegrast,and carotegrast.Currently,there are approximately 90 kinds of integrin-based therapeutic drugs or imaging agents in clinical studies,including small molecules,antibodies,synthetic mimic peptides,antibody-drug conjugates(ADCs),chimeric antigen receptor(CAR)T-cell therapy,imaging agents,etc.A serious lesson from past integrin drug discovery and research efforts is that successes rely on both a deep understanding of integrin-regulatory mechanisms and unmet clinical needs.Herein,we provide a systematic and complete review of all integrin family members and integrin-mediated downstream signal transduction to highlight ongoing efforts to develop new therapies/diagnoses from bench to clinic.In addition,we further discuss the trend of drug development,how to improve the success rate of clinical trials targeting integrin therapies,and the key points for clinical research,basic research,and translational research. | Xiaocong Pang Xu He Zhiwei Qiu Hanxu Zhang Ran Xie Zhiyan Liu Yanlun Gu Nan Zhao Qian Xiang Yimin Cui | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 12 | Synthesis of 3-Phenyl-6-formyl-3, 4-dihydro-2H-1, 3-benzoxazine显示文摘A novel benzoxazine monomer containing aldehyde group, 3-phenyl-6-formyl-3, 4-dihydro-2H-1, 3-benzoxazine (Ald-B), was synthesized via the Mannich condensation of formaldehyde, p-hydroxybenzaldehyde and aniline. Its structure was characterized by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR). The side reaction in the synthesis is discussed. | Qi Chao RAN Qiao TIAN Yi GU | 2006 | Chinese Chemical Letters2006，17，10： | 3 |
| 13 | Do microRNA 96, 145 and 221 expressions really aid in Lhe prognosis of prostate carcinoma?显示文摘MicroRNAs (米尔) 是被报导了正在答应诊断工具的小 noncoding RNA。我们使用了量的即时反向的抄写 PCR (RT-qPCR ) 分析在前列腺肿瘤的表示 miRNAs 取样决定它的预示的价值的差别。从 2007 ~ 2009,肿瘤纸巾从 73 个激进的前列腺切除术标本被获得。差别表示了 miR-96, -145 和 -221 被 TaqMan RT-qPCR 用所有 73 纸巾验证。预示的价值用 Kaplan-Meier 和考克斯回归分析以生物化学的复发被估计。为我们的耐心的队,吝啬的年龄是 64.7 年(50-76 年) ,吝啬的前列腺特定的抗原(PSA ) 是 7.5 ng ml −1 。在后续时期期间(平均数, 19.4 个月) , 73 中的 14 个(19.2 %) 病人们发展了生物化学的复发。miR-96, -145 和 -221 的表示与对方一起强烈相关,但是在 miRNA 表示和 clinicopathologic 参数之间没有关联。用木头等级测试的 Kaplan-Meier 幸存曲线与病理学的舞台显示出减少的生物化学的没有复发的间隔(P< 0.001 ) 。另外,有超过 8 的格利森分数的病人, 6 与格利森一起与那些相比得分,在 Kaplan-Meier 分析(P=0.001 ) 显示出减少的生物化学的没有复发的间隔。然而, miR-96, -145 和 -221 的表示没用考克斯在 Kaplan-Meier 幸存曲线或由 multivariate 分析与生物化学的复发间隔相关比例的危险回归模型也。在结论,我们没观察在 miR-96, -145 和 -221 和 clinicopathologic 参数的表达式之间的重要关联。为了在临床的实践作为一个诊断工具利用 miRNA,更多的研究被需要理解 miRNA 机制,识别 miRNA 目标,并且进一步描绘 miRNA,工作。 | Sung Gu Kang Young Ran Ha Seo Jin Kim Seok Ho Kang Hong Seok Park Jeong Gu Lee Jun Cheon | 2012 | Asian Journal of Andrology2012，14，5： | 2 |
| 14 | A Partial First-Order Affine-Scaling Method显示文摘We present a partial first-order affine-scaling method for solving smooth optimization with linear inequality constraints. At each iteration, the algorithm considers a subset of the constraints to reduce the complexity. We prove the global convergence of the algorithm for general smooth objective functions, and show it converges at sublinear rate when the objective function is quadratic. Numerical experiments indicate that our algorithm is efficient. | Ran GU Ya Xiang YUAN | 2019 | Acta Mathematica Sinica,English Series2019，35，1： | 2 |
| 15 | Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study显示文摘 | Juan-Ni Gong Zhen-Guo Zhai Yuan-Hua Yang Yan Liu Song Gu Tu-Guang Kuang Wan-Mu Xie Ran Miao Chen Wang | 2015 | Chinese Medical Journal2015，，23： | 2 |
| 16 | Amyloid-β depresses excitatory cholinergic synaptic transmission in Drosophila显示文摘Objective Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to cognitive dysfunctions like Alzheimer's disease (AD). Although amyloid-β (Aβ) aggregation is a pathological hallmark of AD, the mechanisms by which Aβ peptides modulate cholinergic synaptic transmission and memory loss remain obscure. This study was aimed to investigate the potential synaptic modulation by Aβ of the cholinergic synapses between olfactory receptor neurons and projection neurons (PNs) in the olfactory lobe of the fruit fly. Methods Cholinergic spontaneous and miniature excitatory postsynaptic current (mEPSC) were recorded with whole-cell patch clamp from PNs in Drosophila AD models expressing Aβ40, Aβ42, or Aβ42Arc peptides in neural tissue. Results In fly pupae (2 days before eclosion), overexpression of Aβ42 or Aβ42Arc, but not Aβ40, led to a significant decrease of mEPSC frequency, while overexpression of Aβ40, Aβ42, or Aβ42Arc had no significant effect on mEPSC amplitude. In contrast, Pavlovian olfactory associative learning and lifespan assays showed that both short-term memory and lifespan were decreased in the Drosophila models expressing Aβ40, Aβ42, or Aβ42Arc. Conclusion Both electrophysiological and behavioral results showed an effect of Aβ peptide on cholinergic synaptic transmission and suggest a possible mechanism by which Aβ peptides cause cholinergic neuron degeneration and the consequent memory loss. | Liqun Fang Jingjing Duan Dongzhi Ran Zihao Fan Ying Yan Naya Huang Huaiyu Gu Yulan Zhu | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 17 | Predictors of non-response to cardiac resynchronization therapy implantation in patients with class Ⅰ indications: the markedly dilated left ventricular end-diastolic dimension and the presence of fragmented QRS显示文摘Background Cardiac resynchronization therapy(CRT)is a highly effective treatment in patients with a class I recommendation.However,a small proportion of the strictly selected patients still fail to respond.This study was designed to identify predictors of non-response in patients with class I indications for CRT and determine the non-response probability of the patients.Methods A total of 296 consecutive patients with a class I recommendation received CRT from January 2009 to January 2017 were retrospectively analyzed.Multivariate logistic regression analysis was performed to identify predictors for non-response(defined as cardiac death,heart transplantation,or HF hospitalization during 1-year follow-up).Results Among 296 patients,30(10.1%)met non-response.Multivariate analysis demonstrated that non-response to CRT was associated with a fragmented QRS(odd ratio(OR)=2.86,95%CI:1.14–7.12;P=0.025)and left ventricular end-diastolic dimension(LVEDD)≥77 mm(OR=3.02,95%CI:1.17–7.82;P=0.022).Patients with both of the predictors had a non-response probability of 46.2%(95%CI:19.1%–73.3%).Conclusion In patients with left bundle branch block and wider QRS duration,the proportion of non-response to CRT is not low in real world.The presence of the dilated LVEDD or fragmented QRS is a strong predictor of non-response to CRT.The probability of non-response in the patients with the two predictors was 46.2%. | Yi-Ran HU Wei HUA Sheng-Wen YANG Min GU Hong-Xia NIU Li-Gang DING Jing WANG Ran JING Xiao-Han FAN Shu ZHANG | 2019 | Journal of Geriatric Cardiology2019，16，7： | 2 |
| 18 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 19 | Scar-centered dilation in the treatment of large keloids显示文摘BACKGROUND Hypertrophic scars and keloid treatment is a major problem in plastic surgery.While small keloids can be treated with resection followed by radiotherapy,large keloids require treatment with a tissue expander.Conventional methods increase the need for auxiliary incisions,causing new scar hyperplasia.AIM To introduce a new method for the treatment of keloids with an expander.METHODS Between 2018 and 2021,we performed surgeries to treat large keloids in nine patients with a two-stage approach.In the first stage,an intrascar incision was made in the keloid,and a customized expander was implanted under the keloid and the surrounding normal skin.A period of 3-6 mo was allowed for skin expansion.In the second stage,after the initial incision healed,a follow-up surgery was performed to remove the expander,resect the keloid,and repair the expanded skin flap.To accomplish this,an incision was made along the scar boundary to avoid making a new surgical incision and creating new scars.Superficial radiotherapy was then performed postoperatively.RESULTS Two patients had anterior chest keloids.After treatment,the anterior chest incision was broken repeatedly and then sutured again after debridement.It healed smoothly without scar hyperplasia.Keloids were successfully removed in 7 patients without recurrence.CONCLUSION This method was performed through a keloid incision and with a custom expander embedded.After full expansion,the keloid was directly resected using a linear suture,which avoids new surgical incisions and scars and can successfully remove large-area keloids.The treatment is effective,providing new insights and strategies for the treatment of similar large-area keloid and hypertrophic scar cases in the future. | Min Wu Jie-Yu Gu Ran Duan Bo-Xuan Wei Feng Xie | 2022 | World Journal of Clinical Cases2022，10，18： | 2 |
| 20 | Origin of High Efficiency and Long-Term Stability in Ionic Liquid Perovskite Photovoltaic显示文摘Environment-friendly protic amine carboxylic acid ionic liquids(ILs)as solvents is a significant breakthrough with respect to traditional highly coordinating and toxic solvents in achieving efficient and stable perovskite solar cells(PSCs)with a simple one-step air processing and without an antisolvent treatment approach.However,it remains mysterious for the improved efficiency and stability of PSCs without any passivation strategy.Here,we unambiguously demonstrate that the three functions of solvents,additive,and passivation are present for protic amine carboxylic acid ILs.We found that the ILs have the capability to dissolve a series of perovskite precursors,induce oriented crystallization,and chemically passivate the grain boundaries.This is attributed to the unique molecular structure of ILs with carbonyl and amine groups,allowing for strong interaction with perovskite precursors by forming C=O…Pb chelate bonds and N-H…I hydrogen bonds in both solution and film.This finding is generic in nature with extension to a wide range of IL-based perovskite optoelectronics. | Lingfeng Chao Tingting Niu Hao Gu Yingguo Yang Qi Wei Yingdong Xia Wei Hui Shouwei Zuo Zhaohua Zhu Chengjie Pei Xiaodong Li Jing Zhang Junfeng Fang Guichuan Xing Hai Li Xiao Huang Xingyu Gao Chenxin Ran Lin Song Li Fu Yonghua Chen Wei Huang | 2020 | Research2020，，1： | 2 |
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