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| 1 | Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions显示文摘Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classifica-tion is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes in-cluding PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distri-bution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and hap-lotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM. | Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang Chunjie Xiao | 2010 | Journal of Genetics and Genomics2010，37，6： | 36 |
| 2 | Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity显示文摘B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes. | Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu | 2018 | Cellular & Molecular Immunology2018，15，7： | 10 |
| 3 | Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism显示文摘To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete. | YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China | 2008 | Science China(Life Sciences)2008，51，5： | 7 |
| 4 | Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China显示文摘在有在少数的必要高血压的 1 WNK1 基因中国的 Hani 和 Yi 组织的 exon 的多型性的协会在盒子控制学习被调查。包含 WNK1 基因 exon 的 1257 bp 的顺序 1 在 1307 个个人(649 个必要高血压题目和 658 控制) 被决定在 Hani 和 Yi 少数组识别 SNP。十一以前已知的 SNP (rs3168640, rs11885, rs11554421 和 rs34880640 ) 中的四个被识别。SNP 分析显示 SNP rs11885 和 rs11554421 显著地在 Hani 和 Yi 人口与高血压被联系,并且 rs34880640 显著地在 Hani 然而并非在 Yi 人口与高血压被联系,为 covariates 调整了。Haplotype 分析显示 haplotype H1 显著地减少了在两张人口的高血压的风险。这些结果建议 WNK1 多型性在 Hani 和 Yi 人口涉及必要高血压的倾向,它的效果显示出清楚的人口特性。这发现在决定基因因素把疾病治疗与疾病并且这样联系了支持了人口特性的重要性。 | Yina Cun Jin Li Wenru Tang Xiaozhi Sheng Haijing Yu Bingrong Zheng Chunjie Xiao | 2011 | Journal of Genetics and Genomics2011，38，4： | 7 |
| 5 | Rational design of novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructures for all-solid-state asymmetric supercapacitors显示文摘Constructing graphene-based heterostructures with large interfacial area is an efficient approach to enhance the electrochemical performance of supercapacitors but remains great challenges in their synthesis.Herein,a novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructure(a-Fe_(2)O_(3)NDs/RGO)aerogel was facilely synthesized via excessive metal-ion-induced self-assembly and subsequent calcination route using Prussian blue/graphene oxide(PB/GO)composite aerogel as precursors.The deliberately designed a-Fe_(2)O_(3)NDs/RGO heterostructure offers a highly interconnected porous conductive network,large heterostructure interfacial area,and plenty of accessible active sites,greatly facilitating the electron transfer,electrolyte diffusion,and pseudocapacitive reactions.The obtained a-Fe_(2)O_(3)NDs/RGO aerogel could be used as flexible free-standing electrodes after mechanical compression,which exhibited a significantly enhanced specific capacitance of 347.4 F·g^(-1)at 1 A·g^(-1),extraordinary rate capability of 184 F·g^(-1)at 10 A·g^(-1),and decent cycling stability.With the as-prepared a-Fe_(2)O_(3)NDs/RGO as negative electrodes and the Co_(3)O_(4)NDs/RGO as positive electrodes,an all-solid-state asymmetric supercapacitor(a-Fe_(2)O_(3)NDs/RGO//Co_(3)O_(4)NDs/RGO asymmetric supercapacitor(ASC))was assembled,which delivered a high specific capacitance of 69.1 F·g^(-1)at 1 A·g^(-1)and an impressive energy density of 21.6 W·h·k·g^(-1)at 750 W·k·g^(-1),as well as good cycling stability with a capacity retention of 94.3%after 5,000 cycles.This work provides a promising avenue to design high-performance graphene-based composite electrodes and profound inspiration for developing advanced flexible energy-storage devices. | Chenxiao Wu Zhifang Zhang Zhonghui Chen Zuimin Jiang Huiyu Li Haijing Cao Yongsheng Liu Yanyan Zhu Zebo Fang Xiangrong Yu | 2021 | Nano Research2021，14，4： | 6 |
| 6 | An effective poly(p-phenylenevinylene) polymer adhesion route toward three-dimensional nitrogen-doped carbon nanotube/reduced graphene oxide composite for direct electrocatalytic oxygen reduction显示文摘做 Heteroatom 的 nanocarbons 在氧减小反应(ORR ) 为使用有优秀潜力。然而,建设三维(3D ) 有好 electrocatalytic 表演遗体的做 N 的碳材料挑战。此处,一(p-phenylenevinylene )(PPV ) poly,先锋粘附线路为 3D 的建设被开发做 N 的减少的 graphene oxide-PPV 锻烧碳的 nanotubes (N-RGO-PPV (c)-CNTs) 。在合成, PPV 先锋为 RGO 和 CNT 的强壮的粘附起胶水的作用。在高温度, PPV 能从玻璃质的状态经历转变到一粘滞状态。因此,与多多孔的结构合成、如脊的 N-RGO-PPV (c)-CNT 合拢了 graphene 薄片能在高温度在 nitridation 期间被形成,它为为 ORR 的更活跃的地点的生产是有利的。作为 ORR 催化剂, N-RGO-PPV (c)-CNT composites 在碱的电解质展出了优异催化活动。获得的发作潜力(E 0.92 V 和 5.7 mAe 的催化当前的密度的发作 ) 并且最大化空间利用。有五的 DI-TENG 在 12 厘米物浥湥?景愠氠睯漠敶灲瑯湥楴污漠?的体积重复了单位??噭琠?捡楨癥??‰?敬畣慬?敤潳灲楴湯?硅数楲敭瑮污祬洠慥?敲?楤晦牥湥楴污眠牯?畦据楴湯愠??畦据楴湯漠?整灭牥瑡牵?桳睯?敤潳灲楴湯瀠慥獫愠??愠摮????桴楥?汥'虪罐嫖蹫u潲数瑲敩?桳睯朠敲瑡瀠瑯湥楴污映牯爠慥?楴敭?湩猠瑩?潭楮潴楲杮漠?潭敬畣慬?摡潳灲楴湯愠摮搠獥牯瑰潩??瑬潨杵?桴?潭敬畣慬?摡潳灲楴湯椭摮'讚涌畺{?湩琠敨攠敬瑣潲楮?潷歲映湵瑣潩?獩瘠牥?敳獮瑩癩?椠?潤獥渠瑯栠癡?湡?...?睯癥牥?桴?整灭牥瑡牵?敤数摮湥祣漠?桴? | Yu Fu Chungui Tian Fangyuan Liu Lei Wang Haijing Yan Bai Yang | 2016 | Nano Research2016，9，11： | 3 |
| 7 | A dual-active Co-CoO heterojunction coupled with Ti_(3)C_(2)-MXene for highly-performance overall water splitting显示文摘Development of cost-effective and highly-efficient bifunctional hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts is crucial for overall water splitting in practical utilization.Herein,we proposed a novel non-noble metal bifunctional,HER/OER electrocatalyst by synergistically coupling a dual-active Co-based heterojunction(Co-CoO)with high conductive and stable two-dimensional Ti_(3)C_(2)-MXene(defined as Co-CoO/Ti^(3)CrMXene).A series of characterizations and theoretical calculations'verify that the synergistic effect of metallic Co with HER activity and Coo with OER performance leads to superb bifunctional catalytic performance,and Ti_(3)C_(2)-MXene can enhance electrical conductivity and prevent the aggregation of the Co-based catalysts,thereby improving both the activity arid stability.Co-Co0/Ti_(3)C_(2)-MXene presents low onset potential(11onse1)of 8 mV and,Tafel slope of 47 mV·dec^(-1) for HER(close to that of Pt/C)and 17onset of 196 mV and Tafel slope of 47 mV·dec^(-1) for OER(superior to:that of Ru02).Assembled as an electrolyzer,Co-CoO/Ti_(3)C_(2)-MXene shows a low voltage of 1.55 V at 10 mA·cm^(-2),high Faradaic efficiency and remarkable stability.It can be driven by a solar cell of-1.55 V for consecutive production of hydrogen and oxygen gases. | Dezheng Guo Xin Li Yanqing Jiao Haijing Yan Aiping Wu Ganceng Yang Yu Wang Chungui Tian Honggang Fu | 2022 | Nano Research2022，15，1： | 2 |
| 8 | Evolutionary characteristics of exons expressed at different abundance levels in mammals显示文摘With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms. | YU HaiJing FANG Lin LI Xin ZHANG XiaoYan YE Jia LI Jie HU WeiHong ZHENG BingRong XIAO ChunJie | 2009 | Chinese Science Bulletin2009，54，19： | 1 |
| 9 | The relationship between CYP17 -34T/C polymorphism and acne in chinese subjects revealed by sequencing显示文摘 | LI HE ZHI YANG HAIJING YU | 2006 | Dermatology2006，212，： | 1 |
| 10 | Digital gene expression profiling analysis of DNA repair pathways in colon cancer stem population of HT29 cells显示文摘癌症干细胞(CSC ) 贡献新瘤损害的恶化和发展。当很可得到的临床的途径例如化学药品和放射治疗,将杀死癌症房间的多数时,他们都不杀死他们。一些抵抗房间象 CSC 一样,能由于他们的优秀自我维持的能力幸存,甚至在挑战性的环境。在现在的学习,我们响应单个海滨的损坏和双海滨从 HT29 房间线调查了冒号 CSC 的 DNA 修理基因的 mRNA 水平裂缝,以及在基础切除的关键基因的明显的 upregulation 修理,失配修理,非相应加入结束,并且在这些房间的相应再结合小径。数字基因表示分析在可以在 DNA 修理起重要作用的 CD44 + HT29 房间识别了 upregulated 基因。我们的结果表明冒号 CSC 忍受有效 DNA 修理能力,它可能在重复化学药品和放射治疗以后解释冒号 CSC 的幸存。 | Wenxue Wang Guoxiu Zhang Jing Yang Huan Gu Lei Ding Haijing Yu Min Yu Qinghua Cui Xinglai Ji Meizhang Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 11 | Comparative study on bio- remedia- tion of eutrophic river water, using two biofilm processes 显示文摘 | Haijing Yu Wenping Cao | 2014 | RSC Advances2014，，48： | 1 |
| 12 | Comparative study on bio-remedia-tion of eutrophic river water,using two biofilm processes 显示文摘 | Haijing Yu Wenping Cao | 2014 | RSC Advances2014，48，： | 1 |
| 13 | The Relationship between CYP17 -34T/C Polymorphism and Ache in Chinese Subjects Revealed by Sequencing显示文摘 | Li He Zhi Yang Haijing Yu Baoweng Cheng Wenru Tang Yongli Dong Chunjie Xiao | 2006 | Dermatology2006，212，： | 1 |
| 14 | Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer显示文摘Currently,precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver cancer.Herein,we synthesized Mn-doped Ti MOFs(Mn-Ti MOFs)nanosheets by in-situ doping method and applied them for microwave therapy.Infrared thermal imaging results indicate Mn-Ti MOFs can rapidly increase the temperature of normal saline,attributing to the porous structure improving microwave-induced ion collision frequency.Moreover,Mn-Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn doping.At the same time,Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging(r2/r1=2.315).Further,results on HepG2 tumor-bearing mice prove that microwave-triggered Mn-Ti MOFs nearly eradicate the tumors after 14 days of treatment.Our study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer. | Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu | 2023 | Bioactive Materials2023，，9： | 1 |
| 15 | Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina显示文摘Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina(UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex-and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients:the adjusted odds ratios(ORs) per standard deviation increase in Shannon and Simpson indices were 1.30(95% confidence interval, 1.01-1.70) and 1.36(1.05-1.81), respectively. Two common species(depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis;P ≤ 0.002) and three rare species(depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45;P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of Lphenylalanine degradation(P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients(OR = 2.76 [1.17-8.16]). Moreover, Streptococcus parasanguinis was negatively correlated with fecal citrulline(Spearman's r_(s)=-0.470, P = 0.009), a metabolite depleted in UA patients(OR = 0.26 [0.08-0.63]). These findings are informative to help understand the metabolic connection between gut microbiota and UA. | Xuezhen Liu Miaoyan Shen Han Yan Pinpin Long Haijing Jiang Yizhi Zhang Lue Zhou Kuai Yu Gaokun Qiu Handong Yang Xiulou Li Xinwen Min Meian He Xiaomin Zhang Hyungwon Choi Chaolong Wang Tangchun Wu | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
| 16 | Light quality affects incidence of powdery mildew expression of defance-related genes and associated metabolism in cucumber plants显示文摘 | WANG Hong JIANG Yuping YU Haijing | 2010 | Eu J Plant Pathol2010，127，1： | 1 |
| 17 | Phylogeny and Evolution of the Drosophila nasuta Subgroup Based on Mitochondrial ND4 and ND4L Gene Sequences显示文摘 | Haijing Yu Wen Wang Shu Fang Ya-Ping Zhang Fei-Jann Lin Zhen-Cheng Geng | 1999 | Molecular Phylogenetics and Evolution1999，，3： | 1 |
| 18 | Comparative study on bio-remedia- tion of eutrophic river water, using two biofilm processes显示文摘 | Haijing Yu Wenping Cao | 2014 | RSC advances2014，48，： | 1 |
| 19 | Relationship between theCAG repeat polymorphism in the androgen receptor gene and acnein the Han ethnic group显示文摘 | Zhi Yang Haijing Yu Baowen Cheng | 2009 | Dermatology2009，218，4： | 1 |
| 20 | Relationship between the CAG Repeat Polymorphism in the Androgen Receptor Gene and Acne in the Han Ethnic Group显示文摘 | Zhi Yang Haijing Yu Baowen Cheng etc | 2009 | Dermatology2009，218，1： | 1 |
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