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| 1 | Chemical vapor deposition growth of monolayer MoSe2 nanosheets显示文摘 | Jonathan C. Shaw Hailong Zhou Yu Chen Nathan O. Weiss Yuan Liu Yu Huang Xiangfeng Duan | 2014 | Nano Research2014，7，4： | 26 |
| 2 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 3 | The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin显示文摘In this study,self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals(QT-HNCs)with diameter around 280 nm(QT-HNCs-280)and550 nm(QT-HNCs-550)following oral and intravenous administration and the contribution of integral nanocrystals to oral bioavailability enhancement of QT was estimated by comparing the absolute exposure of integral QT-HNCs and total QT in the liver.Results showed that QT-HNCs could reside in vivo as intact nanocrystals for as long as 48 h following oral and intravenous administration.A higher accumulation of integral QT-HNCs in liver and lung was observed for both oral and intravenous administration of QT-HNCs.The particle size affects the absorption and biodistribution of integral QT-HNCs and total QT.As compared to QT-HNCs-550,QT-HNCs-280 with smaller particle size is more easily absorbed,but dissolves faster in vivo,leading to higher distribution of QT(146.90 vs.117.91 h·mg/mL)but lower accumulation of integral nanocrystals(6.82 e10 vs.15.27 e10 h·[p/s]/[μW/cm2])in liver following oral administration.Due to its slower dissolution and enhanced recognition by RES,QT-HNCs-550 with larger diameter shows higher liver distribution for both of QT(1015.80 h·mg/mL)and integral nanocrystals(259.63 e10 h·[p/s]/[μW/cm2])than those of QT-HNCs-280(673.82&77.66 e10 h·[p/s]/[μW/cm2])following intravenous administration.The absolute exposure of integral QT-HNCs in liver following oral administration of QT-HNCs are 8.78%for QT-HNCs-280 and 5.88%for QT-HNCs-550,while the absolute exposure of total QT for QT-HNCs-280 and QT-HNCs-550 are 21.80%and 11.61%,respectively.Owing to imprecise quantifcation method,a surprisingly high contribution of integral QT-HNCs to oral bioavailability enhancement of QT(40.27%for QT-HNCs-280 and 50.65%for QT-HNCs-550)was obtained.These results revealed signifcant difference in absorption and biodistrbution between integral nanocrystals and overall drugs following oral and intravenous administration of QT-HNCs,and provided a meaningful reference for the contribution of integral nanocrystals to overall bioavailability enhancement. | Baode Shen Chengying Shen Weifeng Zhu Hailong Yuan | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 10 |
| 4 | Biomarker Records of Phytoplankton Productivity and Community Structure Changes During the Last 14000 Years in the Mud Area Southwest off Cheju Island, East China Sea显示文摘The ecological environment in the East China Sea(ECS)and the Yellow Sea(YS)has changed significantly due to sea-level rising and the Kuroshio incursion since the last deglaciation.In this study,biomarker records of core F10B from the mud area southwest off Cheju Island(MSWCI)were generated to evaluate phytoplankton productivity and community structure changes in response to environmental evolution during the last 14 kyr.The contents of diatom,dinoflagellate and haptophyte biomarkers(brassicasterol,dinosterol and C37alkenones)display similar trends,with increasing phytoplankton productivity during the last 14kyr due to the increased influences of the Kuroshio,and especially due to the eddy-induced upwelling during the late Holocene.On the other hand,the contents of terrestrial biomarkers(C28+C30+C32n-alkanols)and terrestrial organic matter(TOM)proxies(TMBR′and BIT)all reveal decreasing TOM input into the area around the sampling site for the 14 kyr,mostly due to sea-level ris-ing.Phytoplankton biomarker ratios reveal a shift from a haptophyte-dominated community at 6.2 2.5 kyr BP to a diatom-dominated community at 2.5 1.45 kyr BP,likely caused by a stronger cold eddy circulation system at 2.5 1.45 kyr BP in the MSWCI. | YUAN Zineng XING Lei LI Li ZHANG Hailong XIANG Rong ZHAO Meixun | 2013 | Journal of Ocean University of China2013，12，4： | 10 |
| 5 | Solidification Simulation of Investment Castings of Single Crystal Hollow Turbine Blade显示文摘The three-dimensional solidification simulation of the investment castings of single crystal hollow turbine blade at the withdrawal rates of 2 mm/min, 4.5 mm/min and 7 mm/min has been performed with the finite element thermal analysis. The calculated results are in accordance with the experimental ones. The results show that with the increase of withdrawal rate the concave curvature of the liquidus isotherm is larger and larger, and the temperature gradients of the blades increase. No effects of withdrawal rate on the distribution of the temperature gradients of the starter and helical grain selector of the blades are observed at withdrawal rates of 2 mm/min, 4.5 mm/min and 7 mm/min. The relatively high temperature gradient between 500℃/cm and 1000℃/cm in the starter and helical grain selector is obtained at three withdrawal rates. | Jiarong LI, Shizhong LIU, Hailong YUAN and Zhengang ZHONGNational Key Laboratory of Advanced High Temperature Structural Materials, Beijing Institute of Aeronautical Materials, Beijing 100095, China | 2003 | Journal of Materials Science & Technology2003，19，6： | 9 |
| 6 | Short-range ordering and its effects on mechanical properties of high-entropy alloys显示文摘In this letter,we briefly summarize experimental and theoretical findings of fo rmation and characterization of short-range orderings(SROs)as well as their effects on the defo rmation behavior of high-entropy alloys(HEAs).We show that existence of SROs is a common yet key structural feature of HEAs,and tuning the degree of SROs is an effective way for optimizing mechanical properties of HEAs.In additional,the challenges concerning about formation mechanism and characterization of SROs in HEAs are discussed,and future research activities in this regard are also proposed. | Yuan Wu Fei Zhang Xiaoyuan Yuan Hailong Huang Xiaocan Wen Yihan Wang Mengyuan Zhang Honghui Wu Xiongjun Liu Hui Wang Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 8 |
| 7 | Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder with potentially deleterious consequences for fetuses.Although a clear correlation between the elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice,the underlying mechanisms remain elusive.Herein,we report that bile acids induce NF-κB pathway activation via G protein-coupled bile acid receptor 1(Gpbar1),with consequent upregulation of inflammatory genes in trophoblasts,leading to aberrant leukocyte infiltration and inflammation in placenta.Ursodeoxycholic acid(UDCA),a drug used clinically to treat ICP,competes with other bile acids for binding with Gpbar1 and thus inhibits bile acid-induced inflammatory response in trophoblasts and improves fetal survival in pregnant rats with obstructive cholestasis.Notably,inhibition of NF-κB by andrographolide is more effective than UDCA in benefiting placentas and fetuses.Thus,anti-inflammation therapy targeting Gpbar1/NF-κB pathway could be effective in suppressing bile acid-induced inflammation and alleviating ICP-associated fetal disorders. | YouHua Zhang YouDong Pan ChangDong Lin YaJuan Zheng Hao Sun HaiLong Zhang JunLei Wang MengYa Yuan Tao Duan QiaoLing Du JianFeng Chen | 2016 | Journal of Molecular Cell Biology2016，8，6： | 8 |
| 8 | Experimental Study and Numerical Simulation of Directionally Solidified Turbine Blade Casting显示文摘汽轮机片样品铸造物的方向性的团结过程在工作被调查。可变退却率用一致 rate.A 在一个退却过程并且与其它相比被使用为热放射转移和方向性的团结过程的微观结构模拟的数学模型基于 CA-FD 被开发方法。温度分发和微观结构被模仿并且与试验性的结果相比。迷路的谷物被预言并且与试验性的结果相比。站台的不平的温度分发是迷路的谷物的形成的主要原因。 | Jing YU Qingyan XU Baicheng LIU Jiarong LI Hailong YUAN Haipeng JIN | 2008 | Journal of Materials Science & Technology2008，24，3： | 4 |
| 9 | Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection显示文摘Foot-and-mouth disease virus(FMDV) rapidly causes cytopathic effects in susceptible cells. Incomplete viral clearance during the acute infection leads to persistent infection. The relationship between host gene expression and the persistent infection remains unclear. In this study, we analyzed the transcriptome profiles of BHK-21 cells acutely and persistently infected with FMDV to identify differences in gene expression. GO and KEGG enrichment analyses showed that the 8,378 differentially expressed genes were significantly enriched in categories including metabolism, biosynthesis, ribosome function, and endocytosis. In persistently infected BHK-21 cells, ribosome-and translation-related genes were significantly down-regulated. There were more differentially expressed immune-related genes during persistent infection than during acute infection. Two hundred and seventy-four genes were differentially expressed in both acutely and persistently infected BHK-21 cells. Among these genes, heat shock protein family B member 1(Hspb1) knockdown significantly inhibited FMDV replication. Our research provides a basis for further research to understand the mechanisms of persistent FMDV infection including the genes involved in FMDV replication. | Jiadai Li Lingling Han Yao Hao Yuncong Yuan Mingzhen Wang Xiu Xin Hailong Wang Fang Yu Congyi Zheng Chao Shen | 2020 | Virologica Sinica2020，35，1： | 4 |
| 10 | Indonesian Throughflow in an eddy-resolving ocean model显示文摘The performance of the eddy-resolving LICOM2.0 in simulating the Indonesian Throughflow has been evaluated against the INSTANT data in the present study.The mean vertical structures of the along strait velocities are simulated well in LICOM2.0,but the large velocities at the bottom of the Lifamatola Passage and the Timor Passage cannot be reproduced by LICOM2.0.The causes are considered to be both the errors in the topography and the tidal mixing at the bottom.Despite several biases in the mean velocities,the mean inflow and outflow volume transports in LICOM2.0 are almost identical to the INSTANT data.Compared with the lower resolution LICOM,the most significant improvement is the better simulation of the partitions of the inflow and outflow transports in individual straits.The outflow for low-resolution LICOM is mainly through the Ombai and Lombok Strait,whereas that for LICOM2.0 is mainly through the Timor Passage.The variability of the vertical structure of velocities and the volume transport are also investigated.LICOM2.0 overestimates the magnitude of the upper-layer currents and the amplitude of the variation.We also found that the largest correlation coefficient occurs in the shallowest strait,the Lombok,whereas the lowest occurs in the Timor Passage,especially in the upper layer.The latter may be caused by the unrealistic transport through the Torres Strait in LICOM2.0. | FENG Xue LIU HaiLong WANG FuChang YU YongQiang YUAN DongLiang | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
| 11 | An Equivalent Substitute Strategy for Constructing 3D Ordered Porous Carbon Foams and Their Electromagnetic Attenuation Mechanism显示文摘Three-dimensional(3D)ordered porous carbon is generally believed to be a promising electromagnetic wave(EMW)absorbing material.However,most research works targeted performance improvement of 3D ordered porous carbon,and the specific attenuation mechanism is still ambiguous.Therefore,in this work,a novel ultra-light egg-derived porous carbon foam(EDCF)structure has been successfully constructed by a simple carbonization combined with the silica microsphere template-etching process.Based on an equivalent substitute strategy,the influence of pore volume and specific surface area on the electromagnetic parameters and EMW absorption properties of the EDCF products was confirmed respectively by adjusting the addition content and diameter of silica microspheres.As a primary attenuation mode,the dielectric loss originates from the comprehensive effect of conduction loss and polarization loss in S-band and C band,and the value is dominated by polarization loss in X band and Ku band,which is obviously greater than that of conduction loss.Furthermore,in all samples,the largest effective absorption bandwidth of EDCF-3 is 7.12 GHz under the thickness of 2.13 mm with the filling content of approximately 5 wt%,covering the whole Ku band.Meanwhile,the EDCF-7 sample with optimized pore volume and specific surface area achieves minimum reflection loss(RL_(min))of−58.08 dB at 16.86 GHz while the thickness is 1.27 mm.The outstanding research results not only provide a novel insight into enhancement of EMW absorption properties but also clarify the dominant dissipation mechanism for the porous carbon-based absorber from the perspective of objective experiments. | Meng Zhang Hailong Ling Ting Wang Yingjing Jiang Guanying Song Wen Zhao Laibin Zhao Tingting Cheng Yuxin Xie Yuying Guo Wenxin Zhao Liying Yuan Alan Meng Zhenjiang Li | 2022 | Nano-Micro Letters2022，14，10： | 3 |
| 12 | Holocene Temperature Records from the East China Sea Mud Area Southwest of the Cheju Island Reconstructed by theU_(37)~K~' and TEX_(86) Paleothermometers显示文摘As an important marginal sea under the influences of both the Changjiang River and the Kuroshio,the East China Sea (ECS) environment is sensitive to both continental and oceanic forcing.Paleoenvironmental records are essential for understanding the long-term environmental evolution of the ECS and adjacent areas.However,paleo-temperature records from the ECS shelf are currently very limited.In this study,the'K37U and TEX86paleothermometers were used to reconstruct surface and subsurface temperature changes of the mud area southwest of the Cheju Island (Site F10B) in the ECS during the Holocene.The results indicate that temperature changes of F10B during the early Holocene (11.6 6.2 kyr) are associated with global climate change.During the period of 6.2 2.5 kyr,the similar variability trends of smoothing average of T (the difference between surface and subsurface temperature) of Site F10B and the strength of the Kuroshio suggest that the Kuroshio influence on the site started around 6.2 kyr when the Kuroshio entered the Yellow Sea and continued to 2.5 kyr.During the late Holocene (2.5 1.45 kyr) ,apparent decreases of'K37U sea surface temperature (SST) and T imply that the direct influence of the Kuroshio was reduced while cold eddy induced by the Kuroshio gradually controlled hydrological conditions of this region around 2.5 kyr. | XING Lei JIANG Yiqing YUAN Zineng ZHANG Hailong LI Li ZHOU Liping ZHAO Meixun | 2013 | Journal of Ocean University of China2013，12，4： | 3 |
| 13 | Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute for Hominis Placenta on CCl4-induced liver fibrosis显示文摘Objective:Fufang Biejia Ruangan Tablet(FBRT) is widely used for the treatment of liver fibrosis.However,Hominis Placenta(HP),as an important adjuvant of FBRT,has been restricted for medicinal using due to the limited availability,ethical controversy and safety issues.The present study aimed to investigate the therapeutic effects of novel FBRT(N-FBRT) with sheep placenta(SP) as substitute for HP on liver fibrosis and explore its possible mechanisms.Different dosages of SP in N-FBRT were also evaluated.Methods:Rats were subcutaneously injected with CCl_(4)to induce liver fibrosis and then treated with NFBRT and FBRT.The anti-hepatic fibrosis effect was determined based on biomarkers analysis of liver function and hepatic fibrosis,and the liver pathology was visualized by H&E staining and Masson staining.The oxidative stress and inflammatory cytokines were also detected.Immunohistochemical staining of a-SMA,real time PCR and Western blotting were performed to evaluate hepatic stellate cells(HSCs)activation and TGF-β1/Smad signaling pathway.Results:N-FBRT and FBRT could ameliorate CCl_(4)-induced liver fibrosis and improve liver function,as evidenced by lowering serum biomarkers levels of liver function and hepatic fibrosis,and decreasing hepatic Hyp content and collagen deposition,and improving the hepatic morphology and architecture changes.Moreover,the anti-liver fibrosis effect was better when the dosage of SP used in N-FBRT was 1/2 of HP in FBRT.Administration of N-FBRT markedly alleviated oxidative stress and inflammatory cytokines,and inhibited a-SMA expression.Furthermore,the mRNA expression of Col Ⅰ,Col Ⅲ,a-SMA and TGF-β1,and proteins expression of a-SMA,TGF-β1,Smad2/3 and p-Smad2/3 were significantly down-regulated by N-FBRT treatment.Conclusion:SP can be used as substitute for HP to prepare N-FBRT for the treatment of liver fibrosis and the anti-liver fibrosis effect of N-FBRT is achieved by eliminating oxidative stress and inflammation,and inhibiting HSCs activation and ECM production by blocking TGF-β1/Smad signaling pathway. | Baode Shen Li Deng Yuan Liu Ruisheng Li Chengying Shen Xiao Liu Yinchao Li Hailong Yuan | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 14 | Effect Evaluation of Collective Forestry Tenure Reform and Forest Farmers' Willingness to Participate in the Reform: A Case Study of Shaowu, Fujian Province显示文摘Since 2003, China has carried out the pilot of collective forest tenure reform (CFTR). Inrecent years, there have been lots of researches about evaluation of the CFTR, which are, however,mostly qualitative research with little focus on the quantitative research. This paper used the AnalyticHierarchy Process (AHP) and expert assignment method to define the comprehensive evaluation indexes and monitoring indexes of the CFTR. In this study, the authors did a quantitative evaluation of the CFTR in Shaowu, Fujian Province, which was scored as 0.844, indicating more significant effect. The authors investigated 100 farmer households there, and the data showed that the average household income has grown by 49.2% in the 6 years after the CFTR implementation, while the forestry incomehas grown by 108.3%, indicating that farmers’ income increased significantly after the CFTR. Factor analysis shows that CFTR has been the key factor to increase farmers’ income. | CHEN Xingliang WU Hailong YUAN Songsong | 2011 | Chinese Forestry Science and Technology2011，10，Z1： | 1 |
| 15 | Terrestrial and marine biomarker estimates of organic matter sources and distributions in surface sediments from the East China Sea shelf显示文摘 | Lei Xing Hailong Zhang Zineng Yuan Yao Sun Meixun Zhao | 2011 | Continental Shelf Research2011，，10： | 1 |
| 16 | A Generative Adversarial Networks for Log Anomaly Detection显示文摘Detecting anomaly logs is a great significance step for guarding system faults.Due to the uncertainty of abnormal log types,lack of real anomaly logs and accurately labeled log datasets.Existing technologies cannot be enough for detecting complex and various log point anomalies by using human-defined rules.We propose a log anomaly detection method based on Generative Adversarial Networks(GAN).This method uses the Encoder-Decoder framework based on Long Short-Term Memory(LSTM)network as the generator,takes the log keywords as the input of the encoder,and the decoder outputs the generated log template.The discriminator uses the Convolutional Neural Networks(CNN)to identify the difference between the generated log template and the real log template.The model parameters are optimized automatically by iteration.In the stage of anomaly detection,the probability of anomaly is calculated by the Euclidean distance.Experiments on real data show that this method can detect log point anomalies with an average precision of 95%.Besides,it outperforms other existing log-based anomaly detection methods. | Xiaoyu Duan Shi Ying Wanli Yuan Hailong Cheng Xiang Yin | 2021 | Computer Systems Science & Engineering2021，37，4： | 1 |
| 17 | Insight into the in vivo fate of intravenous herpetrione amorphous nanosuspensions by aggregation-caused quenching probes显示文摘Intravenous nanosuspensions are attracted growing attention as a viable strategy for development of intravenous formulations of poorly water-soluble drugs.However,only few information about the biological fate of intravenous nanosuspensions is currently known,especially amorphous nanosuspensions are not reported yet.In this study,the in vivo fate of herpetrione(HPE)amorphous nanosuspensions following intravenous administration was explored by using an aggregation-caused quenching(ACQ)probe and HPLC methods.The ACQ probe is physically embedded into HPE nanoparticles via anti-solvent method to form HPE hybrid nanosuspensions(HPE-HNSs)for bioimaging.HPE-HNSs emit strong and stable fluorescence,but fluorescence quenches immediately upon the dissolution of HPE-HNSs,confirming the selfdiscrimination of HPE-HNSs.Following intravenous administration of HPE-HNSs,integral HPE-HNSs and HPE show similar degradation and biodistribution,with rapid clearance from blood circulation and obvious accumulation in liver and lung.Due to the slower dissolution and enhanced recognition by reticuloendothelial system,450 nm HPE-HNSs accumulate more in liver,lung and spleen than that of 200 nm HPE-HNSs.These results demonstrate that integral HPE-HNSs determine the in vivo performance of HPEHNSs.This study provides insight into the in vivo fate of intravenous amorphous nanosuspensions. | Lingyu Hang Chengying Shen Baode Shen Hailong Yuan | 2022 | Chinese Chemical Letters2022，33，11： | 1 |
| 18 | Simultaneous removal of SO2 , NO and mercury using TiO2-aluminum silicate fiber by phohotocatalysis显示文摘 | YUAN Yuan ZHANG Junying LI Hailong | 2012 | Chem Eng J2012，192，： | 1 |
| 19 | Graphene: An Emerging Electronic Material显示文摘 | Nathan O. Weiss Hailong Zhou Lei Liao Yuan Liu Shan Jiang Yu Huang Xiangfeng Duan | 2012 | Adv. Mater2012，，43： | 1 |
| 20 | Modeling of grain selection during directional solidification of single crystal superalloy turbine blade castings显示文摘 | Dong Pan Qingyan Xu Baicheng Liu Jiarong Li Hailong Yuan Haipeng Jin | 2010 | JOM2010，，5： | 1 |
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