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| 1 | Morphology-selective synthesis of active and durable gold catalysts with high catalytic performance in the reduction of 4-nitrophenol显示文摘由 nanosized Au 粒子组成的一系列新奇催化剂与血小板(PL ) 在 micro-mesoporous ZSM-5/SBA-15 (ZSBA ) 材料限制了,杆(RD ) ,并且六角形棱柱(HP ) 形态学在 situ 被综合了。这些催化剂拥有 SBA-15 和 ZSM-5 结构并且在 ZSBA 以内由 Au nanoparticles (NP ) 的监禁展出他们的活跃地点的优秀稳定性。催化剂深入地被描绘了理解他们的结构性质关系。金 NP 尺寸和催化剂的毛孔结构,被发现对锻烧温度和合成条件敏感,被显示在 4-nitrophenol 的减小起重要作用。与短 mesochannels (210 nm ) 和一条大毛孔直径(6.7 nm ) ,而与长 mesochannels 和相对更小的毛孔尺寸, Au/ZSBA-HP 和 Au/ZSBA-RD 给穷人看催化活动, Au/ZSBA-PL 在 4-nitrophenol 的减小展出高催化的性能。在有不同金 NP 尺寸的催化剂的情况中,有 4.0 nm 的一条 Au NP 直径的 Au/ZSBA-PL-350 展出最高的反应率常数(0.14 min -1) 和周转频率(0.0341 s -1) 。另外, 4-nitrophenol 的减小上的反应参数的效果系统地被调查了。为在 Au/ZSBA 催化剂上的 4-nitrophenol 减小的可能的机制被建议。 | Daowei Gao Xin Zhang Xiaoping Dai Yuchen Qin Aijun Duan Yanbing Yu Hongying Zhuo Hairui Zhao Pengfang Zhang Yan Jiang Jianmei Li Zhen Zhao | 2016 | Nano Research2016，9，10： | 4 |
| 2 | Down-regulation of lipocalin 2 suppresses the growth of human lung adenocarcinoma through oxidative stress involving Nrf2/HO-1 signaling显示文摘Lipocalin 2 (LCN2 ) ,作为嗜中性的联系 gelatinase 的 lipocalin (NGAL ) 知道的多功能的能分泌的蛋白质,在许多癌症被表示。然而,很少在肺腺癌的发展对 NGAL 的生物功能被知道。在现在的学习,我们首先发现那 NGAL 表情在人的肺腺癌纸巾是起来调整的。另外, NGAL 表示的弄空减少了房间增长和导致的房间 apoptosis 的能力。而且与 N-acetylcysteine 的增加,反应的氧种类(ROS ) 的 scavenger, NGAL 弄空是足够的由通过原子因素的抑制产生 ROS 引起肺腺癌细胞的 apoptosis,这被发现 E2 相关的因素 2/heme oxygenase-1 抗氧化剂小径。最后,人的肺腺癌的生长上的 NGAL 下面规定的效果在 BALB/c 裸体老鼠被决定。这些调查结果证明 NGAL 可以是为有肺腺癌的病人的一个潜在的治疗目标。 | Baoquan Song Hairui Zhang Lei Jiang Ying Chi Jianjian Tian Wenjing Du Bentong Yu Zhongchao Han | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 3 | Boosting photocatalytic hydrogen evolution of g-C_(3)N_(4) catalyst via lowering the Fermi level of co-catalyst显示文摘The photocatalytic performances are highly dependent on the charge separation and surface reaction kinetics of photocatalysts.Aiming at figuring out the effects of co-catalyst with the lower Fermi level on photocatalytic activity,we tuned the Fermi level of Pt nanoparticles on g-C_(3)N_(4)(GCN)by introducing Co atom.Experimental results show that lowering the Fermi level of co-catalyst does not alter light absorption of GCN due to the invariable structure.Besides,Pt_(3)Co with a lower Fermi level contributes less positive influence on charge separation in GCN due to an opposite effect from the stronger electron-trap ability of Pt_(3)Co and increased band bending in GCN-Pt_(3)Co.The density functional theory(DFT)calculations indicate that GCN-Pt_(3)Co has faster surface reaction kinetics than GCN-Pt,owing to easier dissociation of H_(2)O molecules and faster desorption of H^(*)on Pt_(3)Co.Consequently,GCN-Pt_(3)Co exhibits an excellent H_(2) evolution rate with 2.91 mmol g^(-1)·h^(-1),which 2.67 times that of GCN-Pt. | Hairui Cai Bin Wang Laifei Xiong Jinglei Bi Hanjing Hao Xiaojing Yu Chao Li Jiamei Liu Shengchun Yang | 2022 | Nano Research2022，15，2： | 2 |
| 4 | Growth and thermal properties of YbVO4 single crystal显示文摘 | Yu Yonggui Cheng Yan Zhang Huaijin Wang Jiyang Cheng Xiufeng Xia Hairui | 2006 | Materials Letters2006，60，： | 1 |
| 5 | Activities of selected digestive enzymes during larval development of large yellow croaker ( Pseudosciaena crocea )显示文摘 | Hongming Ma Chantal Cahu José Zambonino Hairui Yu Qingyuan Duan Marie-Madeleine Le Gall Kangsen Mai | 2004 | Aquaculture2004，，1： | 1 |
| 6 | Characteristics of an Immobilized Yeast Cell System Using Very High Gravity for the Fermentation of Ethanol显示文摘 | Hairui Ji Jianliang Yu Xu Zhang Tianwei Tan | 2012 | Applied Biochemistry and Biotechnology2012，，1： | 1 |
| 7 | Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1显示文摘Osteoarthritis(OA)is a prevalent joint disease with no effective treatment strategies.Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis.Although multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on developing novel treatment strategies,the epigenetic control of OA remains unclear.Histone demethylase JMJD3 has been reported to mediate multiple physiological and pathological processes,including cell differentiation,proliferation,autophagy,and apoptosis.However,the regulation of JMJD3 in aberrant force-related OA and its mediatory effect on disease progression are still unknown.In this work,we confirmed the upregulation of JMJD3 in aberrant forceinduced cartilage injury in vitro and in vivo.Functionally,inhibition of JMJD3 by its inhibitor,GSK-J4,or downregulation of JMJD3 by adenovirus infection of sh-JMJD3 could alleviate the aberrant force-induced chondrocyte injury.Mechanistic investigation illustrated that aberrant force induces JMJD3 expression and then demethylates H3K27me3 at the NR4A1 promoter to promote its expression.Further experiments indicated that NR4A1 can regulate chondrocyte apoptosis,cartilage degeneration,extracellular matrix degradation,and inflammatory responses.In vivo,anterior cruciate ligament transection(ACLT)was performed to construct an OA model,and the therapeutic effect of GSK-J4 was validated.More importantly,we adopted a peptide-si RNA nanoplatform to deliver si-JMJD3 into articular cartilage,and the severity of joint degeneration was remarkably mitigated.Taken together,our findings demonstrated that JMJD3 is flow-responsive and epigenetically regulates OA progression.Our work provides evidences for JMJD3 inhibition as an innovative epigenetic therapy approach for joint diseases by utilizing p5RHH-si RNA nanocomplexes. | Yu Jin Zhen Liu Zhenxia Li Hairui Li Cheng Zhu Ruomei Li Ting Zhou Bing Fang | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 8 | Evidence of the formation mechanism of ZnO in aqueous solution显示文摘 | Wei Jia Suihu Dang Hairui Liu Zhuxia Zhang Chunyan Yu Xuguang Liu Bingshe Xu | 2012 | Materials Letters2012，，： | 1 |
| 9 | A straightforward spectral emissivity estimating method based on constructing random rough surfaces显示文摘Spectral emissivity is an essential and sensitive parameter to characterize the radiative capacity of the solid surface in scientific and engineering applications,which would be non-negligibly affected by surface morphology.However,there is a lack of assessment of the effect of roughness on emissivity and a straightforward method for estimating the emissivity of rough surfaces.This paper established an estimating method based on constructing random rough surfaces to predict rough surface(Geometric region)emissivity for metal solids.Based on this method,the emissivity of ideal gray and non-gray body surfaces was calculated and analyzed.The calculated and measured spectral emissivities of GH3044,K465,DD6,and TC4 alloys with different roughness were compared.The results show that the emissivity increases with the roughness degree,and the enhancement effect weakens with the increase of roughness or emissivity due to the existing limit(emissivityε=1.0).At the same time,the roughness would not change the overall spectral distribution characteristics but may attenuate the local features of the spectral emissivity.The estimated results are in good agreement with the experimental data for the above alloys'rough surfaces.This study provides a new reliable approach to obtaining the spectral emissivity of rough surfaces.This approach is especially beneficial for measuring objects in extreme environments where emissivity is difficult to obtain.Meanwhile,this study promotes an understanding of surface morphology's effect mechanism on emissivity. | Zezhan Zhang Mengchao Chen Lichuan Zhang Hongzu Li Hairui Huang Zilong Zhang Peifeng Yu Yi Niu Shan Gao Chao Wang Jing Jiang | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 10 | Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity显示文摘Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)therapy.Therefore,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB therapy.Here,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor cells.We demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell infiltration.Moreover,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in vivo.In order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor recurrence.We anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy. | Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma Tao Gong Ling Zhang Zhirong Zhang Xun Sun | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 11 | The effect of substrate grain size on burrowing ability and distribution characteristics of Perinereis aibuhitensis显示文摘Perinereis aibuhitensis(Grube, 1878) lives in marine sediments of estuary or shoal areas, where substrate has some crucial environmental factors affecting its burrowing and distribution. In order to provide basic data for the habitat selection and suitability evaluations of the artificial aquaculture of P. aibuhitensis, this paper conducted a quantified analysis of its burrowing ability and explored its behavioral preferences in different substrates,including mud(<75 μm), fine sand(125–250 μm), medium sand(250–500 μm), coarse sand(500–2 000 μm), gravel(2 000–4 000 μm) and ceramsite(4 000–8 000 μm). The research results revealed that substrate grain size significantly affected the burrowing time, burrowing rate, burrowing depth and distribution rate(P<0.01).Moreover, P. aibuhitensis demonstrated preferential selections relating to substrate grain sizes, had higher burrowing ability in ceramsite, mud and fine sand compared with other substrates. The strongest burrowing ability and the highest distribution rate were observed in ceramsite. The study indicated that P. aibuhitensis was sensitive to substrate grain size, which also had an impact on its burrowing process and population distribution.In the natural sea, substrates mainly composed of mud and fine sand are fit for aquaculture and stock enhancement. Based on behavioral preferences and ecological rehabilitation function of P. aibuhitensis, this paper proposes a symbiotic system of marine animals and halophytes, and constructs an ecosystem model of'Marine fish-Halophytes-Perinereis aibuhitensis' with P. aibuhitensis as the link. | Tao Sun Chun’e Liu Xingzuo Li Dongzhengyang An Hairui Yu Zheng Ma Feng Liu | 2019 | Acta Oceanologica Sinica2019，38，12： | 0 |
| 12 | Multiple Music Sentiment Classification Model Based on Convolutional Neural Network显示文摘The network community is a platform for people to communicate. In order to accurately analyze the emotions displayed in music community, this paper proposes a convolutional neural network classification model based on multi-dimensional emotions. Firstly, to solve the problem of feature extraction of emotion words under similar sentence patterns, it proposed a multi-emotion classification method and emotion vector splicing method that conform to music community emotion characteristics. Secondly, aiming at the coexistence of multiple categories of emotions in music comment text, it applied an emotional value measurement method based on music characteristics. Finally, the classification model was constructed with combining methods of emotion vector splicing and emotion value measurement. Through experimental analysis, this model is proved to have good performance in accuracy. | Jing Yang Fanfu Zeng Yong Wang Hairui Yu Le Zhang | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
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