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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Experimental free-space quantum secure direct communication and its security analysis显示文摘We report an experimental implementation of free-space quantum secure direct communication based on single photons.The quantum communication scheme uses phase encoding,and the asymmetric Mach–Zehnder interferometer is optimized so as to automatically compensate phase drift of the photons during their transitions over the free-space medium.At a 16 MHz pulse repetition frequency,an information transmission rate of 500 bps over a 10 m free space with a mean quantum bit error rate of 0.49%±0.27%is achieved.The security is analyzed under the scenario that Eve performs the collective attack for single-photon state and the photon number splitting attack for multi-photon state in the depolarizing channel.Our results show that quantum secure direct communication is feasible in free space. | DONG PAN ZAISHENG LIN JIAWEI WU HAORAN ZHANG ZHEN SUN DONG RUAN LIUGUO YIN AND GUI LU LONG | 2020 | Photonics Research2020，8，9： | 5 |
| 3 | Three Tiaobu Feishen therapies protect human alveolar epithelial cells against cigarette smoking and tumor necrosis factor-mlear factor-kappa B pathwayα-induced inflamation by nuc显示文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions. | Chen Yulong Wu Yaosong Li Jiansheng Feng Suxiang Hao Lili Liu Xuefang Zheng Wanchun Dong Haoran Qin Yanqin Yin Sugai Zhao Peng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 4 | Insights into the influence of temperature on the adsorption behavior of sodium oleate and its response to flotation of quartz显示文摘Temperature affects the flotation of quartz in the calcium/sodium oleate(Na OL)system,while there is a lack of understanding of its potential mechanism.Therefore,in this work,the flotation response of quartz to temperature was investigated via micro-flotation experiments,interface property analyses,and theoretical calculations.Flotation results demonstrated that increasing temperature contributed to higher flotation recovery of quartz,which enhanced the removal of quartz from hematite.Surface tension results revealed that higher temperatures lowered the critical micelle concentration(CMC)and surface tension of the Na OL solution,and thus enhanced its surface activity.Solution chemistry calculations and X-ray photoelectron spectroscopy(XPS)measurements confirmed that the increased content of Ca(OH)+achieved by increasing temperatures enhanced the adsorption amounts of calcium species(acting as activation sites)on the quartz surface.Dynamic light scattering(DLS)measurements verified that the association degree of RCOOàto form(RCOO)22àwas strengthened.Furthermore,adsorption density measurements and molecular dynamics(MD)simulations confirmed that increasing the temperature facilitated Na OL adsorption toward the surface of the quartz,which was attributed to the stronger interaction between Na OL and the calcium-activated quartz surface at higher temperatures.As a result,quartz flotation was improved by increasing temperatures.Accordingly,a possible adsorption model was proposed. | Shaohang Cao Wanzhong Yin Bin Yang Zhanglei Zhu Haoran Sun Qiuyue Sheng Keqiang Chen | 2022 | International Journal of Mining Science and Technology2022，32，2： | 4 |
| 5 | Forecasting Scenario Generation for Multiple Wind Farms Considering Time-series Characteristics and Spatial-temporal Correlation显示文摘Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series characteristics and spatial-temporal correlation of wind power generation. In this paper, the marginal distribution model and the dependence structure are combined to describe these complex characteristics. On this basis, a scenario generation method for multiple wind farms is proposed. For the marginal distribution model, the autoregressive integrated moving average-generalized autoregressive conditional heteroskedasticity-t (ARIMA-GARCH-t) model is proposed to capture the time-series characteristics of wind power generation. For the dependence structure, a time-varying regular vine mixed Copula (TRVMC) model is established to capture the spatial-temporal correlation of multiple wind farms. Based on the data from 8 wind farms in Northwest China, sufficient scenarios are generated. The effectiveness of the scenarios is evaluated in 3 aspects. The results show that the generated scenarios have similar fluctuation characteristics, autocorrelation, and crosscorrelation with the actual wind power sequences. | Qingyu Tu Shihong Miao Fuxing Yao Yaowang Li Haoran Yin Ji Han Di Zhang Weichen Yang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 3 |
| 6 | Realization of quantum secure direct communication over 100 km fiber with time-bin and phase quantum states显示文摘Rapid progress has been made in quantum secure direct communication in recent years.For practical application,it is important to improve the performances,such as the secure information rate and the communication distance.In this paper,we report an elaborate physical system design and protocol with much enhanced performance.This design increased the secrecy capacity greatly by achieving an ultra-low quantum bit error rate of<0.1%,one order of magnitude smaller than that of existing systems.Compared to previous systems,the proposed scheme uses photonic time-bin and phase states,operating at 50 MHz of repetition rate,which can be easily upgraded to over 1 GHz using current on-the-shelf technology.The results of our experimentation demonstrate that the proposed system can tolerate more channel loss,from 5.1 dB,which is about 28.3 km in fiber in the previous scheme,to 18.4 dB,which corresponds to fiber length of 102.2 km.Thus,the experiment shows that intercity quantum secure direct communication through fiber is feasible with present-day technology. | Haoran Zhang Zhen Sun Ruoyang Qi Liuguo Yin Gui-Lu Long Jianhua Lu | 2022 | Light(Science & Applications)2022，11，5： | 2 |
| 7 | Quantitative Analysis of Relationship Between Pore Structure and Compressive Strength of Foamed Concrete显示文摘The effect of dry density,water-cement ratio,the addition of fly ash,and sand content on the porosity and pore distribution of foamed concrete is investigated.Digital microscopy and Image J software are employed to examine the landscape of pores with different sizes.Based on the Balshin empirical formula,a mathematical model is established to quantitatively predict the relationship between the pore structures and the compressive strength of foamed concrete.The results well demonstrate that there is a significant correlation between the modified formula and empirical parameters. | Geng Fei Yin Wanyun Xie Jianguang Liu Shoucheng Li Haoran Gui Jingneng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 2 |
| 8 | A Great late Ediacaran ice age显示文摘The emergence of the Ediacara biota soon after the Gaskiers glaciation ca.580 million years ago(Ma)implies a possible glacial fuse for the evolution of animals.However,the timing of Ediacaran glaciation remains controversial because of poor age constraints on the∼30 Ediacaran glacial deposits known worldwide.In addition,paleomagnetic constraints and a lack of convincing Snowball-like cap carbonates indicate that Ediacaran glaciations likely did not occur at low latitudes.Thus,reconciling the global occurrences without global glaciation remains a paradox.Here,we report that the large amplitude,globally synchronous ca.571–562 Ma Shuram carbon isotope excursion occurs below the Ediacaran Hankalchough glacial deposit in Tarim,confirming a post-Shuram glaciation.Leveraging paleomagnetic evidence for a∼90°reorientation of all continents due to true polar wander,and a non-Snowball condition that rules out low-latitude glaciations,we use paleogeographic reconstructions to further constrain glacial ages.Our results depict a‘Great Ediacaran Glaciation’occurring diachronously but continuously from ca.580–560 Ma as different continents migrated through polar–temperate latitudes.The succession of radiation,turnover and extinction of the Ediacara biota strongly reflects glacial–deglacial dynamics. | Ruimin Wang Bing Shen Xianguo Lang Bin Wen Ross N.Mitchell Haoran Ma Zongjun Yin Yongbo Peng Yonggang Liu Chuanming Zhou | 2023 | National Science Review2023，10，8： | 2 |
| 9 | Role of surface roughness in the magnesite flotation and its mechanism显示文摘Surface roughness has a significant influence on mineral flotation.The assisting effect of surface roughness on minerals flotation is extensively investigated from its physical properties(e.g.,the existing form of asperity and its size),however,the associated effect on mineral flotation based on the differences in surface chemical property caused by surface roughness has been rarely touched.With such a question in mind,in this study,we investigated the flotation recoveries of two batches of magnesite particles with varying degree of surface roughness produced by two different mills,and associated the flotation performances to their surface chemical properties(amount of adsorption sites for the collector)via a series of detections,including Scanning Electron Microscope-Energy Dispersive Spectrometry(SEM-EDS)observations,X-ray photoelectron spectroscopy(XPS)analysis,adsorption capacity tests,and contact angle measurements.Finally,we concluded that rougher magnesite particles could provide more active sites(Mg^(2+))for a larger capacity of sodium oleate(NaOL),thereby improving the hydrophobicity and floatability. | Zhanglei Zhu Yafeng Fu Wanzhong Yin Haoran Sun Keqiang Chen Yuan Tang Bin Yang | 2022 | Particuology2022，20，3： | 2 |
| 10 | Coexpression of bile salt hydrolase gene and catalase gene remarkably improves oxidative stress and bile salt resistance in Lactobacillus casei 显示文摘 | Guohong Wang Sheng Yin Haoran An | 2010 | J Ind Mierobiol Biotechnol2010，9，： | 1 |
| 11 | Probing the dynamic structural changes of DNA using ultrafast laser pulse in graphene-based optofluidic device显示文摘The ultrafast monitoring of deoxyribonucleic acid(DNA)dynamic structural changes is an emerging and rapidly growing research topic in biotechnology.The existing optical spectroscopy used to identify different dynamical DNA structures lacks quick response while requiring large consumption of samples and bulky instrumental facilities.It is highly demanded to develop an ultrafast technique that monitors DNA structural changes with the external stimulus or cancer-related disease scenarios.Here,we demonstrate a novel photonic integrated graphene-optofluidic device to monitor DNA structural changes with the ultrafast response time.Our approach is featured with an effective and straightforward design of decoding the electronic structure change of graphene induced by its interactions with DNAs in different conformations using ultrafast nanosecond pulse laser and achieving refractive index sensitivity of~3×10^(−5) RIU.This innovative technique for the first time allows us to perform ultrafast monitoring of the conformational changes of special DNA molecules structures,including G-quadruplex formation by K+ions and i-motif formation by the low pH stimulus.The graphene-optofluidic device as presented here provides a new class of label-free,ultrafast,ultrasensitive,compact,and cost-effective optical biosensors for medical and healthcare applications. | Bannur NShivananju Lu Zhou Yuefeng Yin Wenzhi Yu Babar Shabbir Haoran Mu Xiaozhi Bao Yiqiu Zhang Sun Tian Qingdong Ou Shaojuan Li Mohammad MHossain Yupeng Zhang Huaiyu Shao Guichuan Xing Nikhil V.Medhekar Chang-Ming Li Jian Liu Qiaoliang Bao | 2021 | InfoMat2021，3，3： | 1 |
| 12 | The First Attempt for Accounts of Environmental Chemistry and Technology Research显示文摘In the field of environmental chemical science and technology,researchers have been publishing high-quality research articles on a specific discovery as well as comprehensive reviews on a broader area.After multiple years of research and publication of individual reports,they are looking for a new venue for scientific communication,which will not only summarize a series of their past achievements but also further extend the discussion without including a comprehensive review of 200+articles. | Jinyong Liu Yin Wang Haoran Wei | 2020 | Frontiers of Environmental Science & Engineering2020，14，5： | 0 |
| 13 | Idiopathic pulmonary fibrosis associated with circulating autoantibodies:a Chinese cohort of a long-term follow-up study显示文摘The term of interstitial pneumonia with autoimmune features(IPAF),based on a combination of clinical,serological,and morphological domains(specific chest imaging features,histopathological features,or multi-compartment involvement,including non-specific interstitial pneumonia[NSIP],organizing pneumonia,NSIP with organizing pneumonia overlap and lymphoid interstitial pneumonia). | Hui Wang Haoran Chen Yin Liu Xin Yan Yujuan Gao Hourong Cai Jinghong Dai | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 14 | Influence of bottom and sand curtain on hydrodynamic performance of otter boards显示文摘Numerical simulation is an important method for calculating the hydrodynamic performance of otter boards used in sea floor trawling.Although such simulations have been explored in prior studies,the effects of the proximity of the otter boards to the seafloor and the plume of upward-drawn sediment during bottom trawling have largely been ignored.In this study,we assessed these factors.The results show that within the angles of attack used during normal operations,the effect of the seafloor bottom boundary of the flow field on the hydrodynamic performance of an otter board is obvious.We found that when the ratio of the distance between the bottom of an otter board and the surface boundary of the flow field to the chord length of the board exceeds 0.4,the influence of the bottom boundary of the flow field on the hydrodynamic performance of the board is negligible.For values of less than 0.4,the seafloor bottom boundary has an increasingly obvious impact on the hydrodynamic performance as this ratio decreases.We also found that the turbid plume of ocean floor sediment raised during bottom trawling has an obvious effect on the lift and resistance coefficients of an otter board at high angles of attack.At low angles,this effect on the lift-to-drag ratio is reversed and less obvious.The simulation results show that the optimal lift-to-drag ratio decreases with an increase in the sediment concentration;however,beyond a certain threshold,an increasing concentration of sediments was not found to have an obvious impact on the lift-to-drag ratio. | Haoran Li Weiguo Qian Wenhua Chu Qing Yun Chunqin Yin | 2023 | Aquaculture and Fisheries2023，8，6： | 0 |
| 15 | Investigation of the relationship between DNA-dependent protein kinase and lymphatic metastasis in colorectal cancer显示文摘Objective: To investigate DNA-dependent protein kinase (DNA-PK) expression,and its relationship with lymphat-ic metastasis in colorectal cancer. Methods: Tumor tissues from 60 patients,divided into two groups according to lymphatic metastasis,were immunohistochemically stained to detect the DNA-PK expression including Ku70,Ku80 and PKcs proteins. Results: Positivity of both Ku70 and Ku80 in colorectal cancer was negatively correlated with lymphatic metastasis with an r value of -0.57 and -0.38,respectively. Similar correlation was found between Ku expression,especially Ku70,and long-term survival. PKcs,however,displayed no significant correlation. Statistical analysis failed to detect any correlation between DNA-PK expression,and clinical characteristics,such as age,sex,tumor location,tumor thickness and distant metastasis (P>0.05). Conclusion: DNA-PK expression,especially Ku70 expression,is negatively correlated with lymphatic metastasis,and the survival of patients with colorectal cancer. Ku70 expression may be a potential indicator for the preoperative evaluation,and prognosis in colorectal cancer. | Yueyu Chen Zhaohui Liu Kun Zhu Yuelong Wu Haoran Yin | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 0 |
| 16 | Role of tannin pretreatment in flotation separation of magnesite and dolomite显示文摘Flotation separation of magnesite and its calcium-containing carbonate minerals is a difficult problem.Recently,new regulat-ors have been proposed for magnesite flotation decalcification,although traditional regulators such as tannin,water glass,sodium carbon-ate,and sodium hexametaphosphate are more widely used in industry.However,they are rarely used as the main regulators in research because they perform poorly in magnesite and dolomite single-mineral flotation tests.Inspired by the limonite presedimentation method and the addition of a regulator to magnesite slurry mixing,we used a tannin pretreatment method for separating magnesite and dolomite.Microflotation experiments confirmed that the tannin pretreatment method selectively and largely reduces the flotation recovery rate of dolomite without affecting the flotation recovery rate of magnesite.Moreover,the contact angles of the tannin-pretreated magnesite and dolomite increased and decreased,respectively,in the presence of NaOl.Zeta potential and Fourier transform infrared analyses showed that the tannin pretreatment method efficiently hinders NaOl adsorption on the dolomite surface but does not affect NaOl adsorption on the magnesite surface.X-ray photoelectron spectroscopy and density functional theory calculations confirmed that tannin interacts more strongly with dolomite than with magnesite. | Xiufeng Gong Jin Yao Jun Guo Bin Yang Haoran Sun Wanzhong Yin Yulian Wang Yafeng Fu | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，3： | 0 |
| 17 | Ring-VCO-based phase-locked loops for clock generation–design considerations and state-of-the-art显示文摘This article overviews the design considerations and state-of-the-art of the ring voltage-controlled oscillator(VCO)-based phase-locked loops(PLLs)for clock generation in different applications.Partic-ularly,the objective of the current work is to evaluate the required PLL performance among the fundamental metrics of power,jitter and area.An in-depth treatment of the mainstream PLL architectures and the associated design techniques enables them to be compared analyt-ically and benchmarked with respect to their figure-of-merit(FoM).The paper also summarizes the key concerns on the selection of dif-ferent circuit techniques to optimize the clock performance under dif-ferent scenarios. | Shiheng Yang Jun Yin Yueduo Liu Zihao Zhu Rongxin Bao Jiahui Lin Haoran Li Qiang Li Pui-In Mak Rui P.Martins | 2023 | Chip2023，2，2： | 0 |
| 18 | Single-axis ultrasound levitation system with annular clamping forces显示文摘Based on the principle of acoustic levitation,a single-axis ultrasonic levitation system(SAULS) with convex sides was designed.A normal SAULS only provides a levitation force(LF) against the gravity of the sample.While,such systems also provide an annular clamping force(ACF) surrounding the levitated samples,and improve levitation stability of samples in the standing wave field.Using the finite-difference time-domain method,we investigated the force distributions in different resonance cavities and the factors that influence the magnitude of the levitation force in optimizing the SAULS and the ACF.The theoretical analyses and experimental results indicate that the stability of levitation in this special SAULS is improved with the ACF from its designed convex-side feature.It can be developed into a simple device in levitating and moving samples steadily in related experiments and applications. | YIN Guanjun LI Pan FAN Haoran GUO Jianzhong | 2019 | Chinese Journal of Acoustics2019，38，2： | 0 |
| 19 | Variation in Bombyx mori immune response against fungal pathogen Beauveria bassiana with variability in cell wallβ-1,3-glucan显示文摘Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of fungi.However,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain unclear.Three Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx mori.The molecular mechanisms underlying the immune response in B.mori were investigated using RNA sequencing,which revealed differences in the immune response to different B.bassiana strains at 12 h post-infection.Immunofluorescence assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence strains.BmβGRP4 silencing in B.mori with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of B.bassiana was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by BmβGRP4.Furthermore,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between B.bassiana strains.These results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of B.mori. | Yulong Wang Zhen Liu Xuebing Yin Shihong Liu Kai Wang Rongjie Wan Haoran Chen Xinyang Li Bo Huang | 2024 | Insect Science2024，31，1： | 0 |
| 20 | Three Tiaobu Feishen formulae reduces cigarette smoke-induced inflammation in human airway epithelial cells显示文摘OBJECTIVE: To investigate the therapeutic efficacy of Tiaobu Feishen formulae(TBFS) on cigarette smoke-induced inflammation in vitro using lipopolysaccharide(LPS)-induced and cigarette smoke extract(CSE)-induced NCI-H292 cells.METHODS: We evaluated the inhibitory effects of Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF) on the expressions of inflammatory cytokines including tumor necrosis factor(TNF)-α and interleukin(IL)-8, matrix metalloproteinase(MMP)-9, tissue inhibitor of matrix metalloprotease(TIMP)-1, and superoxide dismutase(SOD) in H292 cells stimulated with LPS or CSE. Their related transcription factors and signaling pathways were also analyzed.RESULTS: BJF, BYF, and YZF significantly inhibited the LPS-or CSE-induced expressions of TNF-α, IL-8,MMP-9, TIMP-1, and SOD in H292 cells, and suppressed the activation of transcription factors including nuclear transcription factor(NF)-κB, activator protein(AP)-1, and signal transducers and activators of transcription(STAT) 3 and their corresponding pathways, including NF-κB, mitogen-activated protein kinase(MAPK), STAT3, and peroxisome proliferator-activated receptor(PPAR).CONCLUSION: BJF, BYF, and YZF effectively suppressed inflammatory responses, protease-antiprotease imbalance, and oxidative stress induced by LPS and CSE, an effect that was closely associated with the inhibition of the NF-κB, MAPK, STAT3, and PPAR pathways. | Dong Haoran Liu Xuefang Zheng Wanchun Feng Suxiang Li Jiansheng Qin Yanqin Wu Yaosong Chen Yulong Yin Sugai Zhao Peng | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 0 |
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