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| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 3 | Dynamics for multistage pool formation of Lunnan low uplift in Tarim Basin显示文摘Lunnan area in the Tarim Basin has become animportant onshore oil production base in China. Formationof the oil and gas pools in the low uplift of Lunnan has ex-perienced a comparatively complex process of dynamics.Based on the hydrocarbon generation period of source rocks,the formation period of cap rocks and traps, the analysis oforganic inclusion and the analysis of bitumen in the reservoir,this paper draws the conclusion that the low uplift area ofLunnan has experienced three pool formation periods: thePermian period, the Cretaceous-Early Tertiary period andthe Late Tertiary-Quaternary period and two oil and gasreservoir adjustment periods: the Late Permian period andthe Late Tertiary-Quaternary period. The comprehensivestudy indicates that the large-scale Ordovician buried hill,formed in Early Hercynian, became the reservoir during thePermian period, because the Cambrian-Lower Ordovicianoil was discharged laterally into the reservoir along the topof the Ordovician weathering crust from south to north. Thereservoir experienced a complicated process-reconstruc-tion in the end of Permian, adjustment in Cretaceous-EarlyTertiary and re-discharging process in Late Tertiary-Qua-ternary, leading to the early original heavy oil reservoir ofmarine facies and the late original light oil reservoir and gaspool. Carboniferous, Triassic and Jurassic oil and gas reser-voirs result from upward adjustment and re-distribution ofOrdovician oil and gas reservoirs. Of those results, the for-mation of Triassic-Jurassic oil and gas pools came under theinfluence of the northward-tilting structure. The oil and gassourcing from the different hydrocarbon source rock inter-vals vertically migrated into the base unconformity of Trias-sic system. Then the oil and gas migrated laterally fromnorth to south and accumulated into the reservoir. | HE Dengfa JIA Chengzao LIU Shaobo PAN Wenqing WANG Shejiao | 2002 | Chinese Science Bulletin2002，47，S1： | 11 |
| 4 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 5 | Progress and challenges towards additive manufacturing of SiC ceramic显示文摘Silicon carbide(SiC)ceramic and related materials are widely used in various military and engineering fields.The emergence of additive manufacturing(AM)technologies provides a new approach for the fabrication of SiC ceramic products.This article systematically reviews the additive manufacturing technologies of SiC ceramic developed in recent years,including Indirect Additive Manufacturing(Indirect AM)and Direct Additive Manufacturing(Direct AM)technologies.This review also summarizes the key scientific and technological challenges for the additive manufacturing of SiC ceramic,and also forecasts its possible future opportunities.This paper aims to provide a helpful guidance for the additive manufacturing of SiC ceramic and other structural ceramics. | Rujie HE Niping ZHOU Keqiang ZHANG Xueqin ZHANG Lu ZHANG Wenqing WANG Daining FANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 9 |
| 6 | 16S rRNA is a better choice than COI for DNA barcoding hydrozoans in the coastal waters of China显示文摘Identification of hydrozoan species is challenging, even for taxonomic experts, due to the scarcity of distinct morphological characters and phenotypic plasticity. DNA barcoding provides an efficient method for species identification, however, the choice between mitochondrial cytochrome c oxidase subunit I(COI) and large subunit ribosomal RNA gene(16S) as a standard barcode for hydrozoans is subject to debate. Herein, we directly compared the barcode potential of COI and 16S in hydrozoans using 339 sequences from 47 pelagic hydrozoan species. Analysis of Kimura 2-parameter genetic distances(K2P) documented the mean intraspecific/interspecific variation for COI and 16S to be 0.004/0.204 and 0.003/0.223, respectively. An obvious 'barcoding gap' was detected for all species in both markers and all individuals of a species clustered together in both the COI and 16S trees. These results suggested that the species within the studied taxa can be efficiently and accurately identified by COI and 16S. Furthermore, our results confirmed that 16S was a better phylogenetic marker for hydrozoans at the genus level, and in some cases at the family level. Considering the resolution and effectiveness for barcoding and phylogenetic analyses of Hydrozoa, we strongly recommend 16S as the standard barcode for hydrozoans. | ZHENG Lianming HE Jinru LIN Yuanshao CAO Wenqing ZHANG Wenjing | 2014 | Acta Oceanologica Sinica2014，33，4： | 7 |
| 7 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 8 | Involvement of Jasmonate- signaling pathway in the herbivore-induced rice plant defense显示文摘The expression patterns of eight defense- related genes in the herbivore-infested and jasmonate- treated (jasmonic acid, JA and its derivative MeJA) rice leaves were analyzed using RT-PCR. The results showed that Spodoptera litura Fabricius (Lepidoptera: Noctuidae) herbi-vory induced the expression of lipoxygenase (LOX) and al-lene oxide synthase (AOS) genes that are involved in the jasmonate-signaling pathway. Moreover, S. litura damage resulted in the expression of farnesyl pyrophosphate syn-thase (FPS), Bowman-birk proteinase inhibitor (BBPI), phenylalanine ammonia-lyase (PAL) and other rice defense- related genes that were also induced by aqueous JA treat-ment or gaseous MeJA treatment. These indicated that in rice leaves, the JA-related signaling pathway was involved in the S. litura-induced chemical defense. Mechanical damage and brown planthopper (BPH), Nilaparvata lugens (St錶) (Homoptera: Delphacidae) damage induced the expression of LOX gene, but both treatments did not induce the expression of AOS gene. However, BPH damage induced the expression of acidic pathogen-related protein 1 (PR-1a), Chitinase (PR-3), and PAL genes, which is involved in the salicylate- signaling pathway. It was suggested that salicylate-related signaling pathway or other pathways, rather than jas-monate-signaling pathway was involved in the BPH-induced rice plant defense. | XU Tao ZHOU Qiang CHEN Wei ZHANG Guren HE Guofeng GU Dexiang ZHANG Wenqing | 2003 | Chinese Science Bulletin2003，48，18： | 6 |
| 9 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 10 | Recent progress about 2D metal dichalcogenides: Synthesis and application in photodetectors显示文摘In recent years, two-dimensional (2D) layered metal dichalcogenides (MDCs) have received enormous attention on account of their excellent optoelectronic properties. Especially, various MDCs can be constructed into vertical/lateral heterostructures with many novel optical and electrical properties, exhibiting great potential for the application in photodetectors. Therefore, the batch production of 2D MDCs and their heterostructures is crucial for the practical application. Recently, the vapour phase methods have been proved to be dependable for growing large-scale MDCs and related heterostructures with high quality. In this paper, we summarize the latest progress about the synthesis of 2D MDCs and their heterostructures by vapour phase methods. Particular focus is paid to the control of influence factors during the vapour phase growth process. Furthermore, the application of MDCs and their heterostructures in photodetectors with outstanding performance is also outlined. Finally, the challenges and prospects for the future application are presented. | Yongfeng Pei Rui Chen Hang Xu Dong He Changzhong Jiang Wenqing Li Xiangheng Xiao | 2021 | Nano Research2021，14，6： | 2 |
| 11 | Oxygen vacancies enable the visible light photoactivity of chromium-implanted TiO2 nanowires显示文摘Although computational studies have demonstrated that metal ion doping can effectively narrow the bandgap of TiO_(2),the visible-light photoactivity of metal-doped TiO_(2) photoanodes is still far from satisfactory.Herein,we report an effective strategy to activate the visible-light photoactivity of chromiumimplanted TiO_(2) via the incorporation of oxygen vacancies.The chromium-doped TiO_(2) activated by oxygen vacancies(Cr-TiO_(2)-vac)exhibited an incident photon-to-electron conversion efficiency(IPCE)of~6.8%at450 nm,which is one of the best values reported for metal-doped TiO_(2).Moreover,Cr-TiO_(2)-vac showed no obvious photocurrent decay after 100 h under visible-light illumination. | Xianyin Song Wenqing Li Xiaojing Liu Yishang Wu Dong He Zunjian Ke Li Cheng Changzhong Jiang Gongming Wang Xiangheng Xiao Yat Li | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 12 | Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects:fabrication,structural characterization and property evaluation显示文摘This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encapsulating OA+UA with ALPs(ALP:OA+UA,50:1;OA:UA,1:1)changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups.ALP-OA/UA nanoparticles had a particle size and zeta potential(in water)of 199.1 nm/-7.15 mV,with a narrow unimodal size distribution,and excellent pH,salt solution,temperature and storage stability.Compared with ALPs,ALPOA/UA nanoparticles showed enhanced anti-inflammatory activity(especially at a dose of 100μg/mL)in a CuSO-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines(TNF-α,IL-1βand IL-8).Therefore,ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules. | Shanshan Zhu Zhichang Qiu Xuguang Qiao Geoffrey I.N.Waterhouse Wenqing Zhu Wenting Zhao Qiuxia He Zhenjia Zheng | 2023 | Food Science and Human Wellness2023，12，2： | 2 |
| 13 | Reduction of azides to amines or amides with zinc and ammonium chloride as reducing agent显示文摘 | Lin Wenqing Zhang Xiaomei He Ze | 2002 | Synth Commun2002，32，21： | 1 |
| 14 | Modeling of Nucleation and Growth of M_(23)C_6 Carbide in Multi-component Fe-based Alloy显示文摘Three-dimensional atom probe (3DAP) technique has been used to study the nucleation and growth of M23C6 carbide in a supersaturated multi-component Fe-based alloy aged at 800°C. 3D images indicate that the radius of M23C6 carbide after ageing for 10 min is about 9 nm. Concentration profiles of alloy elements in the carbide are also obtained. Combined with PANDAT and Thermo-Calc software, attempts to model the early stages of precipitation are present. The calculated particle size and composition of M23C6 carbide is in good agreement with 3DAP data. | Naqiong Zhu Yanlin He Wenqing Liu Lin Li Shuigen Huang Jef Vleugels Omer Van der Biest | 2011 | Journal of Materials Science & Technology2011，27，8： | 1 |
| 15 | In-situ structural evolution of Bi_(2)O_(3) nanoparticle catalysts for CO_(2) electroreduction显示文摘Under the complex external reaction conditions,uncovering the true structural evolution of the catalyst is of profound significance for the establishment of relevant structure–activity relationships and the rational design of electrocatalysts.Here,the surface reconstruction of the catalyst was characterized by ex-situ methods and in-situ Raman spectroscopy in CO_(2)electroreduction.The final results showed that the Bi_(2)O_(3) nanoparticles were transformed into Bi/Bi_(2)O_(3) two-dimensional thin-layer nanosheets(NSs).It is considered to be the active phase in the electrocatalytic process.The Bi/Bi_(2)O_(3) NSs showed good catalytic performance with a Faraday efficiency(FE)of 94.8%for formate and a current density of 26 mA cm^(−2) at−1.01 V.While the catalyst maintained a 90%FE in a wide potential range(−0.91 V to−1.21 V)and long-term stability(24 h).Theoretical calculations support the theory that the excellent performance originates from the enhanced bonding state of surface Bi-Bi,which stabilized the adsorption of the key intermediate OCHO^(∗) and thus promoted the production of formate. | Hongbo Wang Chongyang Tang Bo Sun Jiangchao Liu Yan Xia Wenqing Li Changzhong Jiang Dong He Xiangheng Xiao | 2022 | International Journal of Extreme Manufacturing2022，4，3： | 1 |
| 16 | Deactivation of a Ce! TiO2 catalyst by SO2 in the selective catalytic reduction of NO by NHz 显示文摘 | Xu Wenqing He Hong Yu Yunbo | 2009 | J Phys Chem C2009，113，11： | 1 |
| 17 | Plastic-film mulch in Chinese agriculture: Importance and problems显示文摘 | Yan Changrong He Wenqing Neil C Turner | 2014 | World Agriculture2014，4，2： | 1 |
| 18 | Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway显示文摘Objective:Protein convertase subtilisin/Kexin type 9(PCSK9)has been found to be closely associated with the occurrence and development of numerous tumors.However,the precise role of PCSK9 and its relationship to the development of hepatocellular carcinoma(HCC)remain largely unknown.This study aimed to clarify these issues.Methods:The expression levels of PCSK9 in HCC tissues and HCC cell lines were determined by the quantitative reverse transcription polymerase chain reaction,Western blot,and immunohistochemical analyses,and the effects of PCSK9 expression on HCC cell biological traits were investigated by overexpressing and downregulating PCSK9 expression in vivo and in vitro.Additionally,the mechanism by which PCSK9 mediated dissociation of glutathione S-transferase Pi 1(GSTP1)dimers and phosphorylation of the Jun N-terminal kinase(JNK)pathway components were investigated.Results:PCSK9 expression levels were significantly lower in HCC tissues than in adjacent non-tumor samples.In vivo and in vitro experiments suggested that PCSK9 inhibited HCC cell proliferation and metastasis.Further analysis showed that PCSK9 interacted with GSTP1 and promoted GSTP1 dimer dissociation and JNK signaling pathway inactivation in HCC cells.Moreover,the relationships between PCSK9 protein expressions and clinical outcomes were investigated.The PCSK9-lo group displayed a significantly shorter overall survival(OS;median OS:64.2 months vs.83.2 months;log-rank statistic:4.237;P=0.04)and recurrencefree survival(RFS;median RFS:26.5 months vs.46.6 months;log-rank statistic:10.498;P=0.001)time than the PCSK9-hi group.Conclusions:PCSK9 inhibited HCC cell proliferation,cell cycle progression,and apoptosis by interacting with GSTP1 and suppressing JNK signaling,suggesting that PCSK9 might act as a tumor suppressor and be a therapeutic target in HCC patients. | Mingyan He Jing Hu Tingting Fang Wenqing Tang Bei Lv Biwei Yang Jinglin Xia | 2022 | Cancer Biology & Medicine2022，19，1： | 1 |
| 19 | Endogenous amino acid loss at the terminal ileum of rats fed water-extractable or alkali-extractable soluble non-starch polysaccharides obtained from wheat bran when fed with and without xylanase显示文摘 | He Yonghui Lu Wenqing Piao Xiangshu | 2006 | Journal of Animal and Veterinary Advances2006，5，： | 1 |
| 20 | Ultrahigh Thermoelectric Performance by Electron and Phonon Critical Scattering in Cu2Se1‐xIx显示文摘 | Huili Liu Xun Yuan Ping Lu Xun Shi Fangfang Xu Ying He Yunshan Tang Shengqiang Bai Wenqing Zhang Lidong Chen Yue Lin Lei Shi He Lin Xingyu Gao Xingmin Zhang Hang Chi Ctirad Uher | 2013 | Mater2013，，45： | 1 |
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