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| 1 | Fault diagnosis of wind turbine bearing based on stochastic subspace identification and multi-kernel support vector machine显示文摘In order to accurately identify a bearing fault on a wind turbine, a novel fault diagnosis method based on stochastic subspace identification(SSI) and multi-kernel support vector machine(MSVM) is proposed. Firstly, the collected vibration signal of the wind turbine bearing is processed by the SSI method to extract fault feature vectors. Then, the MSVM is constructed based on Gauss kernel support vector machine(SVM) and polynomial kernel SVM. Finally, fault feature vectors which indicate the condition of the wind turbine bearing are inputted to the MSVM for fault pattern recognition. The results indicate that the SSI-MSVM method is effective in fault diagnosis for a wind turbine bearing and can successfully identify fault types of bearing and achieve higher diagnostic accuracy than that of K-means clustering, fuzzy means clustering and traditional SVM. | Hongshan ZHAO Yufeng GAO Huihai LIU Lang LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 12 |
| 2 | TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway显示文摘Thymic natural killer T(NKT)2 cells are a subset of invariant NKT cells with PLZF^(hi)GATA3^(hi)IL-4^(+).The differentiation of NKT2 cells is not fully understood.In the present study,we report an important role of TRAF3-interacting protein 3(TRAF3IP3)in the functional maturation and expansion of committed NKT2s in thymic medulla.Mice with T-cell-specific deletion of TRAF3IP3 had decreased thymic NKT2 cells,decreased IL-4-producing peripheral iNKTs,and defects in response toα-galactosylceramide.Positive selection and high PLZF expression in CD24^(+)CD44^(−) and CCR7^(+)CD44^(−) immature iNKTs were not affected.Only CD44^(hi)NK1.1^(−) iNKTs in Traf3ip3^(−/−) mice showed reduced expression of Egr2,PLZF,and IL-17RB,decreased proliferation,and reduced IL-4 production upon stimulation.This Egr2 and IL-4 expression was augmented by MEK1/ERK activation in iNKTs,and TRAF3IP3 at the trans-Golgi network recruited MEK1 and facilitated ERK phosphorylation and nuclear translocation.LT βR-regulated bone marrow-derived nonlymphoid cells in the medullary thymic microenvironment were required for MEK/ERK activation and NKT2 maturation.These data demonstrate an important functional maturation process in NKT2 differentiation that is regulated by MEK/ERK signaling at the trans-Golgi network. | Xinwei Zhang Ke Wang Weijia Zhao Li Cao Shusong Zhang Rong Jin Xiuyuan Sun Jie Hao Xiaojun Huang Mingzhao Zhu Hounan Wu Hongshan Zhao Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 3 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 4 | Polydentate-ligand-supported self-assembly of heterometallic T-shaped Co_4 Dy cluster showing slow magnetic relaxation显示文摘A novel mixed-valent heterometallic pentanuclear CoⅢ3 CoⅡ Dy Ⅲ cluster has been rationally assembled taking advantage of a bifunctional ligand with o-vanillin and tripodal tris(hydroxymethyl)aminomethane units. This unique heterometallic cluster represents a rare example of T-shaped molecules exhibiting slow magnetic relaxation. | KE HongShan GUO Yang ZHAO Lang TANG JinKui | 2012 | Science China Chemistry2012，55，6： | 1 |
| 5 | PTCH mutations in sporadic and Gorlin-syndrome-related odontogenic keratocysts 显示文摘 | Gu Xiaomei Zhao Hongshan Sun Lisha | 2006 | J Dent Res2006，85，9： | 1 |
| 6 | High-yield and low-cost separation of high-purity semiconducting single-walled carbon nanotubes with closed-loop recycling of raw materials and solvents显示文摘Semiconducting single-walled carbon nanotubes (s-SWCNTs) are the foundation of CNT-based electronics and optoelectronics. For practical applications, s-SWCNTs should be produced with high purity, high structural quality, low cost, and high yield. Currently conjugated polymer wrapping method shows great potential to fulfill these requirements due to its advantages of simple operation process, high purity separation, and easy scaling-up. However, only a small portion of both CNTs and polymers go into the final solution, and most of them are discarded after a single use, resulting in high cost and low yield. In this paper, we introduce a closed-loop recycling strategy, in which raw materials (CNTs and polymers) and solvents were all recycled and reused for multiple separation cycles. In each cycle, high-purity (> 99.9%) s-SWCNTs were obtained with no significant change of structural quality. After 7 times of recycling and separation, the material cost was reduced to ∼ 1% in comparison with commercially available products, and total yield was increased to 36% in comparison with 2%–5% for single cycle separation. Our proposed closed-loop recycling strategy paves the way for low-cost and high-yield mass production of high-quality s-SWCNTs. | Fang Liu Xingxing Chen Haoming Liu Jie Zhao Meiqi Xi Hongshan Xiao Tongkang Lu Yu Cao Yan Li Lianmao Peng Xuelei Liang | 2021 | Nano Research2021，14，11： | 1 |
| 7 | Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line显示文摘 | Haizhen Zhu Hongshan Zhao Christin D. Collins Sarah E. Eckenrode Qingguo Run Richard A. McIndoe James M. Crawford David R. Nelson Jin-Xiong She Chen Liu | 2003 | Hepatology2003，，5： | 1 |
| 8 | Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line显示文摘 | Haizhen Zhu Hongshan Zhao Christin D. Collins Sarah E. Eckenrode Qingguo Run Richard A. McIndoe James M. Crawford David R. Nelson Jin-Xiong She Chen Liu | 2003 | Hepatology2003，，5： | 1 |
| 9 | A rare Cu/Zn superoxide dismutase mutation causing familial ALS with variable age of onset and incomplete penetrance in China显示文摘 | Zhang Huagang Zhao Hongshan Lu Ming | 2005 | ALS2005，6，4： | 1 |
| 10 | Novel identification of a four-base-pair deletion mutation in PITX2 in a Rieger syndrome family显示文摘 | Wang Ying Zhao Hongshan Zhang Xiaoxia | 2003 | J Dent Res2003，82，： | 1 |
| 11 | PTCH mutations in nonsyndromic and Gorlin syndrome related odontogenic keratocysts显示文摘 | Gu Xiaomei Zhao Hongshan Sun Lisha | 2006 | J Dent Res2006，85，： | 1 |
| 12 | Estrogen receptor-gene polymorphisms in patients with periodontitis 显示文摘 | Zhang Li Meng Huanxin Zhao Hongshan | 2004 | J Periodont Res2004，39，5： | 1 |
| 13 | Association analysis between IL-1 family polymorphisms and aggressive periodontitis in Chinese 显示文摘 | Li Qiyan Zhao Hongshan Meng Huanxin | 2004 | J Periodontol2004，75，12： | 1 |
| 14 | Effect of soil sealing on the microbial biomass, N transformation and related enzyme activities at various depths of soils in urban area of Beijing, China显示文摘 | Dan Zhao Feng Li Rusong Wang Qingrui Yang Hongshan Ni | 2012 | Journal of Soils and Sediments2012，，： | 1 |
| 15 | Improving cis-regulatory elements modeling by consensus scaffolded mixture models显示文摘A position weight matrix(PWM) is widely accepted as a probabilistic representation for modeling protein-DNA binding specificity.Previous studies showed that for factors which bind to divergent binding sites,mixtures of multiple PWMs improve performance.We propose a consensus scaffolded mixutre PWM(CSM) model to improve cis-regulatory elements modeling by allowing overlapping components represented by a set of PWMs,each of which corresponds to a binding pattern and is scaffolded by a degenerate consensus.In addition,we propose a learning algorithm that involves an initial structure learning stage based on the frequent pattern mining and a refining stage based on the expectation maximization(EM) algorithm.We assess the merits of CSM using three independent criteria.In a case-study of transcription factor Leu3,the derived CSM models agree with conventional mixtures but show better fitness according to Fermi-Dirac distribution.Analysis of the human-mouse conservation of predicted binding sites of 83 JASPAR transcription factors(TFs) shows that the CSM is as good as or better than the simple mixture,the context-specific independent(CSI) mixture,and the single PWM model,for 83%,84%,and 75% of the cases,respectively.Five-fold cross validation on 46 TRANSFAC datasets shows that CSM model has better generality than other mixture models. | JIANG HongShan ZHAO Ying CHEN WenGuang ZHANG XueGong ZHENG WeiMin | 2013 | Science China(Information Sciences)2013，56，1： | 0 |
| 16 | Polydentate-ligand-supported self-assembly of heterometallic T-shaped Co_4Dy cluster showing slow magnetic relaxation显示文摘A novel mixed-valent heterometallic pentanuclear CoIII3CoIIDyIII cluster has been rationally assembled taking advantage of a bifunctional ligand with o-vanillin and tripodal tris(hydroxymethyl)aminomethane units. This unique heterometallic cluster represents a rare example of T-shaped molecules exhibiting slow magnetic relaxation. | KE HongShan GUO Yang ZHAO Lang TANG JinKui | 2012 | 中国科学:化学2012，42，6： | 0 |
| 17 | Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis显示文摘Genetic information is generally transferred from RNA to protein according to the classic“Central Dogma”.Here,we made a striking discovery that post-translational modification of a protein specifically regulates the editing of its own mRNA.We show that S-nitrosylation of cathepsin B(CTSB)exclusively alters the adenosine-to-inosine(A-to-I)editing of its own mRNA.Mechanistically,CTSB S-nitrosylation promotes the dephosphorylation and nuclear translocation of ADD1,leading to the recruitment of MATR3 and ADAR1 to CTSB mRNA.ADAR1-mediated A-to-I RNA editing enables the binding of HuR to CTSB mRNA,resulting in increased CTSB mRNA stability and subsequently higher steady-state levels of CTSB protein.Together,we uncovered a unique feedforward mechanism of protein expression regulation mediated by the ADD1/MATR3/ADAR1 regulatory axis.Our study demonstrates a novel reverse flow of information from the post-translational modification of a protein back to the post-transcriptional regulation of its own mRNA precursor.We coined this process as“Protein-directed EDiting of its Own mRNA by ADAR1(PEDORA)”and suggest that this constitutes an additional layer of protein expression control.“PEDORA”could represent a currently hidden mechanism in eukaryotic gene expression regulation. | Zhe Lin Shuang Zhao Xuesong Li Zian Miao Jiawei Cao Yurong Chen Zhiguang Shi Jia Zhang Dongjin Wang Shaoliang Chen Liansheng Wang Aihua Gu Feng Chen Tao Yang Kangyun Sun Yi Han Liping Xie Hongshan Chen Yong Ji | 2023 | Cell Research2023，33，7： | 0 |
| 18 | Desalted duck egg white nanogels as Pickering stabilizers for food-grade oil-in-water emulsion显示文摘Achieving the reuse of traditional egg by-products,salted duck egg whites(SEW),is an urgent problem to be solved.In this current work,we constructed a heat-induced gel-assisted desalination method for SEW.Subsequently,a top-down way was utilized to prepare desalted duck egg protein nanogels(DEPN)with uniformly distributed diameters and their application in the oil/water(O/W)interface system was explored.The results revealed that the increase of DEPN concentration could lower the droplet size,however,the size was negatively correlated with the oil phase fraction.Moreover,the effect of pH,ionic strength,and temperature on the emulsion stability demonstrated that the DEPN-stabilized emulsion displayed superior physical stability under different conditions.The addition of NaCl resulted in the significant decrease in droplet size of the emulsion,while further increasing the NaCl concentration,the droplet size did not decrease accordingly.Besides,heat-treatment and cold-treatment had little negative effect on the stability of the emulsion.Even if the droplet size of the emulsion increased at 80℃for 3 h,the morphology of the emulsion remained unchanged.Our study demonstrated DEPN had great potential as a stabilizer for food-grade Pickering emulsions. | Jingyun Zhao Xiaohan Guo Ze Chen Yalei Dai Hongshan Liang Qianchun Deng Shugang Li Bin Zhou | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
| 19 | 单细胞转录组分析揭示人类生殖系细胞与性腺微环境细胞之间的相互作用显示文摘文章简介人类胚胎生殖细胞(FGC,fetal germ cell)是精子和卵细胞的前体细胞,其正常发育对于物种稳定延续至关重要。然而,由于实验材料稀少以及缺少已知的特异性表面分选标志等原因,人们对于人类胚胎生殖细胞的发育进程知之甚少。 | Li Li Ji Dong Liying Yan Jun Yong Xixi Liu Yuqiong Hu Xiaoying Fan Xinglong Wu Hongshan Guo Xiaoye Wang Xiaohui Zhu Rong Li Jie Yan Yuan Wei Yangyu Zhao Wei Wang Yixin Ren Peng Yuan Zhiqiang Yan Boqiang Hu Fan Guo Lu Wen 汤富酬 乔杰 | 2018 | 科学新闻2018，0，4： | 0 |
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