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| 1 | Failure mechanism and stability control of a large section of very soft roadway surrounding rock shear slip显示文摘The measured data and simulation test phenomenon of surrounding rock deformation and failure at the project site indicate that shear failure which firstly occurs in surrounding rock, block slip and second shear failure are the root cause of deformation and damage of supporting structure of the surrounding rock at a large scale. We derived limit load of surrounding rock shear slip failure and reasonable support resistance of given load by means of shear slip line field theory, discussed the main factors which influence the limit load of surrounding rock. Shear slip line field and limit load of circular tunnel surrounding rock were obtained by means of physical simulation test, which agreed well with the theoretical analysis results. Based on the theoretical analysis and physical simulation test, the cause deformation and failure at large scale of Xinshanghai No. 1 coal mine big section ingate was analyzed, and the shear failure resistance and block slip in surrounding rock were proposed as the core technical supporting ideas. Proper range of supporting resistance which came from calculation was suggested. The support scheme which is mainly composed of large grouting anchor, sprayed anchor net support technique and full-face grille concrete finally ended the dilemma of repeated failure and mending of ingate and created critical conditions for smooth production in the coal mine. | Meng Bo Jing Hongwen Chen Kunfu Su Haijian | 2013 | International Journal of Mining Science and Technology2013，23，1： | 22 |
| 2 | Fracture evolution characteristics of sandstone containing double fissures and a single circular hole under uniaxial compression显示文摘The uniaxial compression experiments on the sandstone samples containing double fissures and a single circular hole were carried out by using electro-hydraulic servo universal testing machine to investigate the effect of rock bridge angle β and fissure angle α on mechanical properties and evolution characteristics of cracks.The results show that the peak strength,peak strain and elastic modulus of defected specimens decrease comparing with those for intact sample,and show a decreased trend firstly and then increase with β changing from 0° to 90°.The peak strength and elastic modulus achieve the minimum value as the rock bridge angle is 60°,while the peak strain reaches the minimum value with the rock bridge angle of 45°.The crack initiation of tested rock samples occurs firstly in stress concentration areas at tips of prefabricated fissures under uniaxial compression,and then propagates constantly and coalescences with the prefabricated hole.Some secondary cracks initiate and propagate as well until buckling failure happens.The rock bridge angle has a great influence on crack initiation,coalescence,final failure mode,crack initiation stress and transfixion stress.The peak strength varies significantly,while the elastic modulus and peak strain change slightly,and the failure modes are also different due to the influence of fissure angle. | Chen Minliang Jing Hongwen Ma Xiujun Su Haijian Du Mingrui Zhu Tantan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 11 |
| 3 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 4 | Stress evolution and support mechanism of a bolt anchored in a rock mass with a weak interlayer显示文摘By applying experimental method, the bolt stress and supporting mechanism is studied during the deformation process of a rock mass containing a weak interlayer. The force measuring bolt is installed manually and instrumented five pairs of symmetrical strain gauges. The experimental results show that the fully grouted bolt suffers tensile, compressive, bending and shear stress at the same time. The bolt stress evolution is closely related to the deformation stages of the rock mass which are very gradually varying stage, gradually varying stage at the pre-peak and suddenly varying stage at the post peak stage.The axial compressive stress in the bolt is mainly induced by the moment. Thus, in most cases the axial compressive stress is distributed on one side of the bolt. For axial stresses, induced by the axial force and the bending moment at the post-peak stage, three types of changing are observed, viz. increasingincreasing type, decreasing-increasing type and increasing-decreasing type. The stress characteristics of the bolt section in the weak interlayer are significantly different from those in the hard rock. The failure models of the anchored bolt are tensile failure and shear failure, respectively. The bolt not only provides constraints on the free surface of the rock mass, but also resists the axial and lateral loading by the bending moment. This study provides valuable guidelines for bolting support design and its safety assessment. | Ding Shuxue Jing Hongwen Chen Kunfu Xu Guo'an Meng Bo | 2017 | International Journal of Mining Science and Technology2017，27，3： | 9 |
| 5 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 6 | Effects of key design parameters of tine furrow opener on soil seedbed properties显示文摘The structural parameters of tine furrow openers have significant effects on soil property of seed furrow in no-till planting,thereby affecting crop growth and yields.In order to analyze the effects of key parameters of tine furrow openers on soil properties(soil bulk density,soil water-stable aggregates(WSA),and soil disturbance)of the surface soil layer of 0-10 cm and surface straw disturbance,the tine furrow openers with different structural parameters,including cutting edge thickness,cutting edge curve,penetration clearance angle and rake angle,were designed and tested under no-till conditions.Orthogonal test and single factor test were performed to analyze the effects of different parameters.Results showed that the rake angle,cutting edge thickness and cutting edge curve had significant effects on cross-sectional area of furrow(Af)and disturbance of surface straw;the rake angle had a significant effect on soil bulk density.Soil types and operating depth had significant effects on soil disturbance caused by tine furrow openers.The concave type tine furrow opener produced the lowest soil disturbance and soil bulk density of seed furrow,the highest surface straw disturbance and the greatest content of WSA(>0.5 mm).With increasing rake angles of tine furrow opener,the width of seedbed(Wsb)and the Af decreased first and then increased,respectively,while the width of soil throw(Wst)and the height of ridge(Hr)increased.The Wsb and Af created by tine furrow opener with 60°rake angle were significantly lower than that with others,respectively.The tine furrow opener with rake angle ranged from 45°to 60°created the lowest soil bulk density.As the penetration clearance angle increased,the content of WSA(>0.5 mm)decreased,but the effect of penetration clearance angle on the content of WSA(<0.5 mm)was not significant.The cutting edge thickness(<2 mm)had no significant effects on soil properties of seedbed.This study could provide a reference for optimal design of the tine furrow opener to create more suitable seedbed environment,and promote the application of the light no-till planters. | Zhang Xiangcai Li Hongwen Du Ruicheng Ma Shaochun He Jin Wang Qingjie Chen Wanzhi Zheng Zhiqi Zhang Zhiqiang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 7 |
| 7 | Numerical simulations of failure behavior around a circular opening in a non-persistently jointed rock mass under biaxial compression显示文摘Pre-existing discontinuities change the mechanical properties of rock masses,and further influence failure behavior around an underground opening.In present study,the failure behavior in both Inner and Outer zones around a circular opening in a non-persistently jointed rock mass under biaxial compression was investigated through numerical simulations.First,the micro parameters of the PFC^(3D) model were carefully calibrated using the macro mechanical properties determined in physical experiments implemented on jointed rock models.Then,a parametrical study was undertaken of the effect of stress condition,joint dip angle and joint persistency.Under low initial stress,the confining stress improves the mechanical behavior of the surrounding rock masses;while under high initial stress,the surrounding rock mass failed immediately following excavation.At small dip angles the cracks around the circular opening developed generally outwards in a step-path failure pattern;whereas,at high dip angles the surrounding rock mass failed in an instantaneous intact rock failure pattern.Moreover,the stability of the rock mass around the circular opening deteriorated significantly with increasing joint persistency. | Yang Xuxu Jing Hongwen Chen Kunfu | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 8 | Construction of brewing-wine Aspergillus oryzaepyrG- mutant bypyrG gene deletion and its application in homology transformation显示文摘 | Yu Du Guizhen Xie Chunfa Yang Baishan Fang Hongwen Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 6 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Cd3(C3N3S3)2 coordination polymer/graphene nanoarchitectures for enhanced photocatalytic H2O2 production under visible light显示文摘For a long time, there has been global concern over the environment and energy problems. Recently, the problems, which have brought about serious effect on the global living condition, have been in the ‘‘spotlight' and given impetus to the universal's efforts to head for the same direction: stem the worst warming and strive for the renewable energy source. Hydrogen peroxide(H_2O_2) is undoubtedly a good choice,which holds the promise as a clean, efficient, safe and transferrable energy carrier. Octahedral coordination polymer, Cd_3(C_3N_3S_3)_2, was found to be a robust photocatalyst for H_2O_2 generation under visible light irradiation. To further improve the H_2O_2 generation efficiency, adhering the octahedron to reduced graphene(rGO) was applied as the strategy herein. The study shows that by adhering Cd_3(C_3N_3S_3)_2to rGO, the formation of H_2O_2 is 2.5-fold enhanced and its deformation is concurrently suppressed. This work not only demonstrates the effectiveness of adhering Cd_3(C_3N_3S_3)_2polymer to rGO for the improvement of the polymer's photocatalytic performance, but also proposes a general way for the fabrication of graphene/coordination compound hybrids for maximizing their synergy. | Jie Xu Zhenye Chen Hongwen Zhang Guibin Lin Huaxiang Lin Xuxu Wang Jinlin Long | 2017 | Science Bulletin2017，62，9： | 4 |
| 11 | Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer显示文摘 | Qingshan Chang Yadong Zhang Kevin J. Beezhold Deepak Bhatia Hongwen Zhao Jianguo Chen Vince Castranova Xianglin Shi Fei Chen | 2008 | Journal of Hepatology2008，，2： | 3 |
| 12 | Integrated DNA-based/biochemical screening for early diagnosis of multiple endocrine neoplasia type 2A (MEN2A)显示文摘Multiple endocrine neoplasia type 2A (MEN2A), a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated following confirmation of the proband's diagnosis by pathological findings and DNA/biochemical screening. DNA samples from 4 other family members were collected and exon 5, 8, 10, 11, 13, 16 and 18 of the RET proto-oncogene were sequenced and then analyzed. A missense mutation of TGG (Trp) to TGC (Cys) at codon 634 (the classic MEN2A mutation) in exon 11 of the RET gene was detected in 3 family members, including the proband. Sequencing data were compared with the human gene mutation database. Elevated serum calcitonin level was detected initially; medullary thyroid carcinoma was revealed in the 3 cases and adrenal pheochromocy-toma was also found in the proband. Elective operations were successfully performed on the adrenal and thyroid glands because of pheochromocytoma and medullary thyroid carcinoma. Our case study confirms that integrated DNA-based/biochemical screening is crucial for early diagnosis of MEN2A and is helpful in the screening of their relatives. In addition, DNA-based screening may occasionally uncover a previously unknown RET sequence. | Qin Cui Wen Wang Zhenzhen Fu Xin Shao Zhihong Zhang Mei Zhang Xianxia Ju Kunlin Wang Jiawei Chen Hongwen Zhou | 2013 | The Journal of Biomedical Research2013，27，2： | 3 |
| 13 | Chemical oxidation of arsenic in the environment and its application in remediation: A mini review显示文摘Arsenic(As)contamination in soil and water poses a serious threat to the ecosystem health and human beings,and is of widespread concern.The main As species found in soil and water are arsenite As(Ⅲ)and arsenate As(V).Because As(Ⅲ)is more toxic and often more mobile than As(Ⅴ),many remediation strategies aim to oxidize As(Ⅲ)to As(Ⅴ).In the environment,the reduction of As(Ⅴ)under anaerobic conditions is mainly mediated by microorganisms,but the oxidation of As(Ⅲ)under aerobic conditions can be mediated primarily by chemical processes.This article first reviews the existing knowledge on chemical oxidation of As(Ⅲ)in the environment,with an emphasis on the roles of iron(Fe)and manganese(Mn)oxides.The application of Fe and Mn oxides for the remediation of As-contaminated soil and water is then summarized.The oxidation of As(Ⅲ)by oxygen is very slow in the absence of catalysts.Many Mn oxides,on the other hand,can efficiently oxidize As(Ⅲ).Although the oxidation of As(Ⅲ)by Fe(Ⅲ)is also slow,this process can be accelerated by light or Fe(Ⅱ).Iron and Mn oxides are widely used for the remediation of As-contaminated soil and water,with Fe oxides generally acting as absorbents while Mn oxides as oxidants.To better understand and regulate As transformation and transport in the environment,further study is needed on the mechanisms and influencing factors of As(Ⅲ)oxidation by Fe and Mn oxides,and the development of innovative methods and materials based on Fe and Mn oxides are desired. | Chaolei YUAN Qi LI Zhaoyang SUN Wenjun ZHANG Jiangrong CHEN Zheng CHEN Shuo NA Hongwen SUN | 2023 | Pedosphere2023，33，1： | 2 |
| 14 | Effects of 11 years of conservation tillage on soil organic matter fractions in wheat monoculture in Loess Plateau of China显示文摘 | Haiqing Chen Ruixing Hou Yuanshi Gong Hongwen Li Mingsheng Fan Yakov Kuzyakov | 2009 | Soil & Tillage Research2009，，1： | 2 |
| 15 | Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18显示文摘 | Guoshun Shen Ningyi Jin Mingxiao Ma Kuoshi Jin Min Zheng Tianzhong Zhuang Huijun Lu Guangze Zhu Hongtao Jin Minglan Jin Xiaowei Huo Xiaoguang Qin Ronglan Yin Chang Li Hongwen Li Yang Li Zhenzhen Han Yifeng Chen Miaomiao Jin | 2007 | Vaccine2007，，21： | 2 |
| 16 | Direct measurement of the linear energy transfer of ions in silicon for space application显示文摘The single event effect(SEE) is an important consideration in electronic devices used in space environments because it can lead to spacecraft anomalies and failures. The linear energy transfer(LET) of ions is commonly investigated in studies of SEE. The use of a thin detector is an economical way of directly measuring the LET in space. An LET telescope consists of a thin detector as the front detector(D1), along with a back detector that indicates whether D1 was penetrated. The particle radiation effect monitor(PREM) introduced in this paper is designed to categorize the LET into four bins of 0.2–0.4, 0.4–1.0, 1.0–2.0 and 2.0–20 Me V·cm^2/mg, and one integral bin of LET>20 Me V·cm^2/mg. After calibration with heavy ions and Geant4 analysis, the LET boundaries of the first four bins are determined to be 0.236, 0.479, 1.196, 2.254, and 17.551 Me V·cm^2/mg, whereas that of the integral bin is determined to be LET>14.790 Me V·cm^2/mg. The acceptances are calculated by Geant4 analysis as 0.452, 0.451, 0.476, 0.446, and 1.334, respectively. The LET accuracy is shown to depend on the thickness of D1; as D1 is made thinner, the accuracy of the measured values increases. | CHEN HongFei YU XiangQian SHAO SiPei SHI WeiHong CUI ZhanGuo XIANG HongWen HAO ZhiHua ZOU JiQing ZHONG WeiYing ZOU Hong | 2016 | Science China(Technological Sciences)2016，59，1： | 2 |
| 17 | Laser Milling of Cavity in Ceramic Substrate by Fracture-machining Element Technique显示文摘 | Tsai C H Chen Hongwen | 2003 | Journal of Materials Processing Technology2003，136，123： | 1 |
| 18 | β-Correction spectrophotometrie investigation of copper chelate solution with acid chrome blue K and determination of trace copper显示文摘 | GAO Hongwen CHEN Yunsheng ZHANG Pengfei | 1999 | Asian Journal of Chemistry1999，11，2： | 1 |
| 19 | Optimization of process parameters for key enzymes accumulation of 1,3 - propanediol production from Klebsiella pneumoniae 显示文摘 | Chen Hongwen Fang Baishan Hu Zongding | 2005 | Bio-chemical Engineering Journal2005，25，： | 1 |
| 20 | Variations of the relativistic electron flux after a magnetospheric compression event显示文摘On January 21, 2015, a sharp increase of the solar wind dynamic pressure impacted the magnetosphere. The magnetopause moved inward to the region L< 8 without causing a geomagnetic storm. The flux of the relativistic electrons in the outer radiation belt decreased by half during this event based on the observations of the particle radiation monitor(PRM) of the fourth of the China-Brazil Earth Resource Satellites(CBERS-4). The flux remained low for approximately 11 d; it did not recover after a small magnetic storm on January 26 but after a small magnetic storm on February 2. The loss and recovery of the relativistic electrons during this event are investigated using the PRM data, medium-and high-energy electron observations of NOAA-15 and the Van Allen Probes, medium-energy electron observations of GOES-13, and wave observations of the Van Allen Probes. This study shows that the loss of energetic electrons in this event is related to magnetospheric compression. The chorus waves accelerate the medium-energy electrons, which causes the recovery of relativistic electrons. The Van Allen Probes detected strong chorus waves in the region L =3–6 from January 21 to February 2. However, the flux of medium-energy electrons was low in the region. This implies that the long-lasting lack of recovery of the relativistic electrons after this event is due to the lack of the medium-energy'seed' electrons. The medium-energy electrons in the outer radiation belt may be a clue to predict the recovery of relativistic electrons. | CHEN Zhe CHEN HongFei LI YiFan XIANG HongWen YU XiangQian SHI WeiHong HAO ZhiHua ZOU Hong ZOU JiQing ZHONG WeiYing | 2017 | Science China(Technological Sciences)2017，60，4： | 1 |
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