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| 1 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 2 | Petrogenesis and dating of the Kangding complex,Sichuan Province显示文摘An analysis of major and trace element geochemistry and SHRIMP U-Pb zircon dating of mafic, intermediate, and felsic rocks from the Mianning metamorphic complex of Si- chuan Province was conducted. One of our conclusions is that a majority of the zircons crystal- lized between 721 and 773 Ma in a magmatic regime. The complexes contain early to late Pa- leo-proterozoic relict zircons from ancient continental crust. The oldest age, 2468 Ma, may rep- resent the basement of the Yangtze block. Overgrowth zircon rims and palingenetic zircons have been observed and dated, and are believed to have formed after crystallization, during Paleozoic and Mesozoic metamorphic-anatexis. We also conclude that depletion of Nb, Ta, HREE, in a spider-diagram normalized to primitive mantle and calc-alkaline association, implies that they formed in island-arc or under-plating settings. | CHEN Yuelong 1 , LUO Zhaohua 1 , ZHAO Junxiang, LI Zhihong, ZHANG Hongfei & SONG Biao 3 1. Faculty of Earth Sciences and Natural Resources, China University of Geosciences, Beijing 100083, China 2. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 3. Beijing SHRIMP Center, Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，5： | 40 |
| 3 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 4 | Additional risk in extreme precipitation in China from 1.5℃to 2.0℃global warming levels显示文摘To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the pre-industrial level. As climate change risks may be region-dependent, changes in magnitude and probability of extreme precipitation over China are investigated under those two global warming levels based on simulations from the Coupled Model Inter-Comparison Projects Phase 5. The focus is on the added changes due to the additional half a degree warming from 1.5 ℃ to 2 ℃ . Results show that regional average changes in the magnitude do not depend on the return periods with a relative increase around 7% and 11% at the 1.5 ℃ and 2 ℃ global warming levels, respectively. The additional half a degree global warming adds an additional increase in the magnitude by nearly 4%. The regional average changes in term of occurrence probabilities show dependence on the return periods, with rarer events(longer return periods) having larger increase of risk. For the 100-year historical event, the probability is projected to increase by a factor of 1.6 and 2.4 at the 1.5 ℃ and 2 ℃ global warming levels, respectively.The projected changes in extreme precipitation are independent of the RCP scenarios. | Wei Li Zhihong Jiang Xuebin Zhang Laurent Li Ying Sun | 2018 | Science Bulletin2018，63，4： | 24 |
| 5 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 6 | The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. | Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang | 2017 | Science Bulletin2017，62，11： | 21 |
| 7 | Design of Bionic Saw Blade for Corn Stalk Cutting显示文摘 | Honglei Jia | 2013 | Journal of Bionic Engineering2013，10，4： | 20 |
| 8 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 9 | Identification of Hercynian shoshonitic intrusive rocks in central Hainan Island and its geotectonic implications显示文摘An identification has been made of some shoshonitic intrusive rocks in central Hainan Island recently. These rocks are K-rich (K2O=2.9%―5.1%, K2O/Na2O=0.95―2.12), distinctly enriched in LILE and LREE, strongly depleted in Nb, Ta, and moder- ately depleted in Sr and Ti, with (87Sr/86Sr)i = 0.70859―0.71425 and ε Nd(t) = (?2.77―?7.49). They were derived from an EMⅡ-type mantle source. The enrichment process is related to metasomatism of depleted mantle caused by a great amount of fluid-melt released from oceanic crust and terri- genous sediments at great depth (eclogite facies) during the subduction of the South China plate under the Indochina-South China Sea plate in the Carbon- iferous–Early Permian. A SHRIMP U-Pb zircon dating yields a crystallization age of 272±7 Ma for the sho- shonitic intrusions, which is coeval with the strongly peraluminous granites found in central Hainan Island. These two kinds of rocks generally possess syn-intrusion ductile deformation structures. Thus they are considered to have been generated during the early stage (syn-thrust phase) of a post-collisional event. The primary magma of shoshonitic rocks was produced at a depth > 80 km by decompression- dehydration melting of previously enriched litho- spheric mantle wedge, phlogopite-bearing garnet peridotite, which was in turn caused by the break-off of a descendent slab and upwelling of a hot as- thenosphere. The rising of melts was accompaniedby crustal contamination and crystallization fractiona- tion (AFC). Combining with other related data, it is proposed that the southwards subduction and amal- gamation of the South China plate with the Indo- China-South China Sea plate took place at ca. 287- 278 Ma, which was a part of the convergence proc- ess of the Pangea supercontinent. The suture zone was probably located along the line of Song Ma-Beibu Gulf-north margin of the Yunkai Moun- tains-Wuyi Mountains. | XIE Caifu ZHU Jinchu DING Shijiang ZHANG Yeming FU Tai'an LI Zhihong | 2006 | Chinese Science Bulletin2006，51，20： | 17 |
| 10 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 11 | Ubi1 intron-mediated enhancement of the expression of Bt cry1Ah gene in transgenic maize (Zea mays L.)显示文摘The cry1Ah gene was one of novel insecticidal genes cloned from Bacillus thuringiensis isolate BT8. Two plant expression vectors containing cry1Ah gene were constructed. The first intron of maize ubiqutin1 gene was inserted between the maize Ubiquitin promoter and cry1Ah gene in one of the plant expressing vectors (pUUOAH). The two vectors were introduced into maize immature embryonic calli by microprojectile bombardment, and the reproductively plants were acquired. PCR and Southern blot analysis showed that foreign genes had been integrated into maize genome and inherited to the next generation stably. The ELISA assay to T1 and T2 generation plants showed that the expression of Cry1Ah protein in the construct containing the ubi1 intron (pUUOAH) was 20% higher than that of the intronless construct (pUOAH). Bioassay results showed that the transgenic maize harboring cry1Ah gene had high resistance to the Asian corn borers and the insecticidal activity of the transgenic maize containing the ubi1 intron was higher than that of the intronless construct. These results indicated that the maize ubi1 intron can enhance the expression of the Bt cry1Ah gene in transgenic maize | WANG YueBing LANG Zhihong ZHANG Jie HE KangLai SONG FuPing HUANG DaFang | 2008 | Chinese Science Bulletin2008，53，20： | 15 |
| 12 | Effect of dietary interventions on the intestinal microbiota of Mongolian hosts显示文摘The gut microbiota of Mongolian hosts has distinctive characteristics due to their meat- and dairyoriented daily diets and unique genotype.The aim of the present study was to investigate the effect of switching from the typical high protein and fat Mongolian diets to carbohydrate-rich meals composed principally of wheat,rice and naked oats on the host gut microbiota within 3 weeks.Our study took the advantage of the long sequence reads produced by the Pac Bio single molecule real-time sequencing technology to enable the profiling of subjects' gut microbiota communities along the diet intervention to the species precision.We found that the bacterial richness and diversity decreased apparently along the diet intervention.During the diet intervention,the gut microbiota composition displayed no significant difference at phylum level(with major phyla of Firmicutes,Bacteroidetes,Tenericutes and Proteobacteria).The relative abundances of some genera such as Bacteroidetes,Faecalibacterium,Roseburia,Alistipes,Streptococcus,and Oscillospira were significantly altered after the diet switching started.Notably,significant changes were also observed in the proportions of the species Bacteroides dorei,Bacteroides fragilis,Bacteroides thetaiotaomicron,Ruminococcus albus,Ruminococcus faecis,Roseburia faecis and Eubacterium ventriosum.These results have demonstrated that diet and host gut microbiota is closely linked. | Jing Li Haiyan Xu Zhihong Sun Qiangchuan Hou Lai-Yu Kwok Wuri Laga Yanjie Wang Huimin Ma Zhongjie Yu Bilige Menghe Heping Zhang | 2016 | Science Bulletin2016，61，20： | 14 |
| 13 | Geochemical Characteristics and Geological Significance of Early Permian Baya'ertuhushuo Gabbro in South Great Xing'an Range显示文摘领域地质的调查和 geochemical 分析在南方伟人 Xing'an 在 Baya'ertuhushuo 斑粝岩上被执行范围。当以前想了,领域调查表明斑粝岩是 magmatic 侵入而非一间 ophiolite 套房的一个部件。标明日期的诱导地联合的血浆团光谱学(LA-ICP-MS ) U-Pb 显示的锆石激光脱离斑粝岩在 274275 妈,被形成就作为 Dashizhai 形成(P1d ) 的普遍暴烈的岩石,在学习区域的 monzogranites 和 miarolitic 碱长石花岗石。斑粝岩有在 47.23 wt% 之间的 SiO2 内容,分别地, 50.17 wt% ,高 MgO 和 FeOT 6.9511.29 满足 wt% 和 7.3212.24 wt% ,它在 SiO2-K2O 图属于 low-K tholeiitic 系列。使球粒状陨石正常化的稀土元素元素(REE ) 模式和斑粝岩的原始使披风正常化的蜘蛛图除了大离子亲石元素元素(LILE ) 的丰富类似于正常海中央理兹暗岩(N-MORB ) 的那些,例如 Rb, Ba 和 K。在踪迹元素构造的歧视的图,样品主要也在 situ Lu-Hf 同位素的分析在 N-MORB 领域,和锆石里被阴谋显示斑粝岩从弄空的披风发源。通过 geochemical 特征的合成研究和 Baya'ertuhushuo 斑粝岩的 petrogenesis ,在区域的 Dashizhai 形成和 granitoids 的暴烈的岩石,在 Xilinhot-Xiwuqi 区域的早二叠的 magmatism 在岩流圈 upwelling 的构造背景形成了,这被建议,它被 subducted 的打破离开引起Paleo亚洲的海洋平板。 | LIU Jianfeng CHI Xiaoguo ZHAO Zhi ZHANG Xingzhou MA Zhihong WANG Tiefu HU Zhaochu | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 12 |
| 14 | A memetic algorithm for path planning of curvature-constrained UAVs performing surveillance of multiple ground targets显示文摘The problem of generating optimal paths for curvature-constrained unmanned aerial vehicles(UAVs) performing surveillance of multiple ground targets is addressed in this paper.UAVs are modeled as Dubins vehicles so that the constraints of UAVs' minimal turning radius can be taken into account. In view of the effective surveillance range of the sensors equipped on UAVs, the problem is formulated as a Dubins traveling salesman problem with neighborhood(DTSPN). Considering its prohibitively high computational complexity, the Dubins paths in the sense of terminal heading relaxation are introduced to simplify the calculation of the Dubins distance, and a boundary-based encoding scheme is proposed to determine the visiting point of every target neighborhood. Then, an evolutionary algorithm is used to derive the optimal Dubins tour. To further enhance the quality of the solutions, a local search strategy based on approximate gradient is employed to improve the visiting points of target neighborhoods. Finally, by a minor modification to the individual encoding, the algorithm is easily extended to deal with other two more sophisticated DTSPN variants(multi-UAV scenario and multiple groups of targets scenario).The performance of the algorithm is demonstrated through comparative experiments with other two state-of-the-art DTSPN algorithms identified in literature. Numerical simulations exhibit that the algorithm proposed in this paper can find high-quality solutions to the DTSPN with lower computational cost and produce significantly improved performance over the other algorithms. | Zhang Xing Chen Jie Xin Bin Peng Zhihong | 2014 | Chinese Journal of Aeronautics2014，27，3： | 12 |
| 15 | Effect of Tiaoshen Kaiqiao acupuncture in the treatment of ischemic post-stroke depression:a randomized controlled trial显示文摘OBJECTIVE:To observe the effect of Tiaoshen Kaiqiao acupuncture in the treatment of ischemic post-stroke depression.METHODS:This research was a single-blind, positive-controlled trial done in a single entity.Totally58 patients with ischemic post-stroke depression were randomly divided into two groups.The acupuncture group was given Tiaoshen Kaiqiao acupuncture therapy and placebo starch tablets treatment,while the control group was treated with fluoxetine tablets and body acupuncture treatment.Evaluated the clinical efficacy of the two groups with Hamilton Depression Scale(HAMD),Anti Depression Drug Side Effects Rating Scale(SERS), Clinical Global Impression Scale(CGI) respectively before treatment, the fourth weekend of treatment, the eighth weekend of treatment,the twelfth weekend of treatment.The adverse reactions in two groups were observed and documented.RESULTS:The HAMD scale scores of the two groups in different treatment period were significantly decreased compared with that before treatment(P < 0.05); the score reduction of HAMD scale between the two groups had no significant differences(P > 0.05).There was significant difference between the SERS scores of two groups(P < 0.05); the control group had more adverse reactions, and the score would be increased with the extension of treatment time.Effect index(EI) of CGI in the acupuncture group is better than that of control group(P < 0.05).CONCLUSION:The effects of Tiaoshen Kaiqiao acupuncture and fluoxetine in the treatment of ischemic post-stroke depression were similar, but the former had no obvious adverse reaction and side effects. | Li Menghan Zhang Bo Meng Zhihong Sha Tao Han Yuhui Zhao Hong Zhang Chunhong | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 10 |
| 16 | Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines显示文摘单性生殖的胚胎的茎(足) 细胞为学习位于印的 genomic 下面的分子的机制提供一个珍贵试管内模型系统。然而,足房间的 thepluripotency 和父亲一般地表示的印的基因的表示侧面一直不是充分探索了。在这研究,三根老鼠足房间线被建立,在扩大文化的这些房间的区别潜力被评估。无差别的房间有正常核型和同型结合的染色体,并且表示了 ES-cell-specific 分子的标记。房间在超过 50 个段落以后仍然保持无差别并且展出了 pluripotentdifferentiation 能力。确定的 ES 房间的所有三根线生产了 teratomas;ES 房间的二根线生产了怪物和细菌线传播。而且,在这些房间的父亲一般地表示的印的基因 Snrpn, U2af1-rs1, Peg3,影响, Zfp127, Dlk1 和 Mest 的激活被检测。父亲一般地表示的印的基因被发现在单性生殖的联盟者的胚囊阶段被表示的一些激活胚胎试管内,他们的表示水平与扩大的足细胞培养增加了。而且,我们在足房间的这些父亲一般地表示的印的基因的激活在 ther 的甲基化与一个变化被联系的数据表演鼓舞了差别 methylated 区域。这些调查结果为足房间的 thepluripotency 提供直接证据并且在足房间表明在脱氧核糖核酸甲基化模式和父亲一般地表示的印的基因的激活之间的协会。因此,确定的 ES 房间线为在哺乳动物的开发学习 epigenetic 规定提供一个珍贵模型。 | Hua Jiang Bowen Sun Weicheng Wang Zhihong Zhang Furong Gao Guilai Shi Bing Cui XiangyinKong Zhao He Xiaoyan Ding Ying Kuang Jian Fei Yi Juan Sun Yun Feng Ying Jin | 2007 | Cell Research2007，17，9： | 10 |
| 17 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 18 | Brassinosteroid Enhances Jasmonate-Induced Anthocyanin Accumulation in Arabidopsis Seedlings显示文摘Jasmonate (JA) regulates plant development, mediates defense responses, and induces anthocyanin biosynthesis as well. Previously, we isolated the psc1 mutant that partially suppressed coi1 insensitivity to JA, and found that brassinosteroid (BR) was involved in JA signaling and negatively regulated JA inhibition of root growth in Arabidopsis. In this study it was shown that JA-induced anthocyanin accumulation was reduced in BR mutants or in wild type treated with brassinazole, an inhibitor of BR biosynthesis, whereas it was induced by an application of exogenous BR. It was also shown that the'late'anthocyanin biosynthesis genes including DFR, LDOX , and UF3GT, were induced slightly by JA in the BR mutants relative to wild type. Furthermore, the expression level of JA-induced Myb/bHLH transcription factors such as PAP1, PAP2, and GL3, which are components of the WD-repeat/Myb/bHLH transcriptional complexes that mediate the 'late' anthocyanin biosynthesis genes, was lower in the BR mutants than that in wild type. These results suggested that BR affects JA-induced anthocyanin accumulation by regulating the 'late' anthocyanin biosynthesis genes and this regulation might be mediated by the WD-repeat/Myb/bHLH transcriptional complexes. | Zhihong Peng Chengyun Han Libing Yuan Kun Zhang Hongman Huang Chunmei Ren | 2011 | Journal of Integrative Plant Biology2011，53，8： | 9 |
| 19 | Comparison of clinical effectiveness of acupuncture and a Western drug on allergic rhinitis:study protocol for a randomized controlled trial显示文摘OBJECTIVE: To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis(PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation H1-receptor antagonist, cetirizine hydrochloride.METHODS: This multicenter, randomized, controlled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screening period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharmacotherapy(1∶1) for 4 weeks with a 4-week follow-up. The primary outcome will be changes in7-day average total nasal symptom score. Secondary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-nasal symptom score.RESULTS:The presence and seriousness of psychological and emotional impairments should be considered in therapeutic programs for allergic rhinitis.No clinical trial for treating allergic rhinitis via acupuncture regulation of psychological and emotionalactivitieshasbeenreported.CONCLUSION:The findings of the trial will allow us to determine the effects of the mind(Shen)-regulation treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydrochloride. | Yanping Wang Sheng Chen Peng Wang Cheng Tan Chang Zhang Zhihong Shi Jiping Zhao | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 9 |
| 20 | Future Changes in Extreme High Temperature over China at 1.5℃-5℃ Global Warming Based on CMIP6 Simulations显示文摘Extreme high temperature(EHT)events are among the most impact-related consequences related to climate change,especially for China,a nation with a large population that is vulnerable to the climate warming.Based on the latest Coupled Model Intercomparison Project Phase 6(CMIP6),this study assesses future EHT changes across China at five specific global warming thresholds(1.5℃-5℃).The results indicate that global mean temperature will increase by 1.5℃/2℃ before 2030/2050 relative to pre-industrial levels(1861-1900)under three future scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5),and warming will occur faster under SSP5-8.5 compared to SSP1-2.6 and SSP2-4.5.Under SSP5-8.5,global warming will eventually exceed 5℃ by 2100,while under SSP1-2.6,it will stabilize around 2℃ after 2050.In China,most of the areas where warming exceeds global average levels will be located in Tibet and northern China(Northwest China,North China and Northeast China),covering 50%-70%of the country.Furthermore,about 0.19-0.44 billion people(accounting for 16%-41%of the national population)will experience warming above the global average.Compared to present-day(1995-2014),the warmest day(TXx)will increase most notably in northern China,while the number of warm days(TX90p)and warm spell duration indicator(WSDI)will increase most profoundly in southern China.For example,relative to the present-day,TXx will increase by 1℃-5℃ in northern China,and TX90p(WSDI)will increase by 25-150(10-80)days in southern China at 1.5℃-5℃ global warming.Compared to 2℃-5℃,limiting global warming to 1.5℃ will help avoid about 36%-87%of the EHT increases in China. | Guwei ZHANG Gang ZENG Xiaoye YANG Zhihong JIANG | 2021 | Advances in Atmospheric Sciences2021，38，2： | 8 |
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