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| 1 | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes显示文摘染色体编辑工具例如定期聚类短 palindromic 重复(CRISPR ) 联系了的 interspaced 系统(Cas ) 广泛地被用来包括动物接合子和人的房间在模型系统修改基因,并且为基本研究和临床的应用保持巨大的诺言。迄今为止,严肃的知识差距在人的早胚胎,并且在效率和在人的培植前胚胎使用象 CRISPR/Cas9 那样的技术的潜在的离开目标效果留在我们 DNA 修理机制的理解。在这份报告,我们使用了推进的接合子调查 CRISPR/Cas9-mediated 基因在人的房间编辑的 tripronuclear (3PN ) 。我们发现 CRISPR/Cas9 能有效地劈开内长的 -globin 基因(HBB ) 。然而,相应再结合的效率指导了 HBB 的修理(HDR ) 是低的,编辑胚胎是马赛克。离开目标劈开在由 T7E1 试金并且 whole-exome 定序揭示了的这些 3PN 接合子也是明显的。而且,内长的 delta-globin 基因(HBD ) 对 HBB 相应,与外长的施主 oligos 竞争了充当修理模板,导致倔强的变化。我们的数据也显示在这些胚胎的 HBB 地点的修理通过非转线路 HDR 小径优先地发生了。一起拿,我们的工作加亮紧迫的需要进一步改进 CRISPR/Cas9 平台的忠实和特性,为编辑的 CRSIPR/Cas9-mediated 的任何临床的应用程序的一个前提。 | Puping Liang Yanwen Xu Xiya Zhang Chenhui Ding Rui Huang Zhen Zhang Jie Lv Xiaowei Xie Yuxi Chen Yujing Li Ying Sun Yaofu Bai Zhou Songyang Wenbin Ma Canquan Zhou Junjiu Huang | 2015 | Protein & Cell2015，6，5： | 149 |
| 2 | Preface显示文摘This special issue of Acta Mathematica Scientia is dedicated to the celebration of the 70th birthday of Constantine M. Dafermos. Costas is the Alumni-Alumnae University Professor of Brown University, a Fellow of the American Academy of Arts and Sciences, | Chen, Gui-Qiang G. Hsiao, Ling Huang, Feimin Tzavaras, Athanasios Wang, Zhen | 2012 | Acta Mathematica Scientia2012，32，1： | 72 |
| 3 | Type synthesis of the rotational decoupled parallel mechanism based on screw theory显示文摘With the gradual deepening of study on the parallel mechanism,the difficulty brought by the existence of coupling to the theoretical analysis and practical application of parallel mechanisms is becoming increasingly apparent.The research on the decoupled parallel mechanism is currently one of the hot fields.Though most of the rotational parallel mechanisms,which has been widely used in spatial orientation fields,are not decoupled.It is comparative difficult for the synthesis of fully decoupled rotational parallel mechanisms,and the number of the existing parallel mechanisms which can realize rotational decoupling is limited.In addition,most of the existing rotational decoupled parallel mechanism are obtained depending on the experience of the researcher,and don't possess the general theoretical significance.Based on the screw theory,this paper presents the rotational conditions of the parallel mechanism through the analysis of the relationship between the degree of freedom of the parallel mechanism and its limbs.The synthesis rule of the limbs for decoupled rotational parallel mechanism is established according to the twist screw system of the limbs,which assures the decoupling of the rotations in each limb.The selection principle of the input pairs for the rotation driven limbs is proposed,then the type synthesis method for rotational decoupled parallel mechanisms is formed.With this type synthesis method,synthesis of the rotational decoupled parallel mechanisms is performed,which can provide a reference for the development of the novel type parallel mechanisms with independent intellectual property rights. | ZENG DaXing HUANG Zhen | 2011 | Science China(Technological Sciences)2011，54，4： | 49 |
| 4 | Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells显示文摘瞄准:调查 rosiglitazone 的效果, peroxisomeproliferator-ac-tivated 受体 gamma ( PPARy )收缩筋在在 hepatocellular carcinomacells 在染色体 10 基因( PTEN )和房间生长上删除的磷酸酶 andtensin 相当或相同事物的表示上,象这些 effects.Methods 的内在的机制一样: RT-PCR 和西方的 blottinganalyses 被执行在 Hep3B 房间 treatedwith rosiglitazone.3-( 4,5-Dimethylthiazol-2-yl )检测抄写和 PTEN 的表示 -2,5-diphenyl | Liang-qi CAO Xi-lin CHEN Qian WANG Xiao-hui HUANG Mao-chuan ZHEN Long-juan ZHANG Wen LI Jiong BI | 2007 | Acta Pharmacologica Sinica2007，28，6： | 32 |
| 5 | A general methodology for mobility analysis of mechanisms based on constraint screw theory显示文摘It is well known that the traditional Grübler-Kutzbach formula fails to calculate the mobility of some classical mechanisms or many modern parallel robots,and this situation seriously hampers mechani-cal innovation.To seek an efficient and universal method for mobility calculation has been a heated topic in the sphere of mechanism.The modified Grübler-Kutzbach criterion proposed by us achieved success in calculating the mobility of a lot of highly complicated mechanisms,especially the mobility of all recent parallel mechanisms listed by Gogu,and the Bennett mechanism known for its particular difficulty.With wide applications of the criterion,a systematic methodology has recently formed.This paper systematically presents the methodology based on the screw theory for the first time and ana-lyzes six representative puzzling mechanisms.In addition,the methodology is convenient for judgment of the instantaneous or full-cycle mobility,and has become an effective and general method of great scientific value and practical significance.In the first half,this paper introduces the basic screw theory,then it presents the effective methodology formed within this decade.The second half of this paper presents how to apply the methodology by analyzing the mobility of several puzzling mechanisms.Finally,this paper contrasts and analyzes some different methods and interprets the essential reason for validity of our methodology. | Zhen Huang JingFang Liu DaXing Zeng | 2009 | Science China(Technological Sciences)2009，52，5： | 30 |
| 6 | Displacement manifold method for type synthesis of lower-mobility parallel mechanisms显示文摘Type synthesis of lower-mobility parallel mechanisms is a hot and frontier topic in international academic and industrial field. Based on the Lie group theory, a displacement manifold synthesis method is proposed. For all the nine kinds of lower-mobility parallel mechanisms, the mechanism displacement manifold, limb displacement manifold and the geometrical conditions which guarantee that the intersection of the limb displacement manifold is the desired mechanism displacement manifold are enumerated. Various limb kinematic chains can be obtained using the product closure of displacement subgroup. Parallel mechanisms can be constructed with these limbs while obeying the geometrical conditions. Hence, all the nine kinds of lower-mobility parallel mechanisms can be synthesized using this method. Since displacement manifold deals with finite motion, the result mechanism of synthesis have full-cycle mobility. Novel architectures of lower-mobility parallel mechanisms can be obtained using this method. | LI Qinchuan HUANG Zhen Jacques Marie Hervé | 2004 | Science China(Technological Sciences)2004，47，6： | 28 |
| 7 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 8 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 9 | The South China Sea is not a mini-Atlantic: plate-edge rifting vs intra-plate rifting显示文摘The South China Sea,as‘a non-volcanic passive margin basin’in the Pacific,has often been considered as a small-scale analogue of the Atlantic.The recent ocean drilling in the northern South China Sea margin found,however,that the Iberian model of non-volcanic rifted margin from the Atlantic does not apply to the South China Sea.In this paper,we review a variety of rifted basins and propose to discriminate two types of rifting basins:plate-edge type such as the South China Sea and intra-plate type like the Atlantic.They not only differ from each other in structure,formation process,lifespan and geographic size,but also occur at different stages of the Wilson cycle.The intra-plate rifting occurred in the Mesozoic and gave rise to large oceans,whereas the plate-edge rifting took place mainly in the mid-Cenozoic,with three-quarters of the basins concentrated in the Western Pacific.As a member of the Western Pacific system of marginal seas,the South China Sea should be studied not in isolation on its origin and evolution,but in a systematic context to include also its neighboring counterparts. | Pinxian Wang Chi-Yue Huang Jian Lin Zhimin Jian Zhen Sun Minghui Zhao | 2019 | National Science Review2019，6，5： | 24 |
| 10 | Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection显示文摘AIM: To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori(H. pylori) in a multi-center randomized controlled trial.METHODS: A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in China. The patients were randomly assigned to four treatment groups as follows: patients in Groups 1 and 3 received rabeprazole(10 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively; patients in Groups 2 and 4 received rabeprazole(10 mg), bismuth(220 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively. The primary outcome measure was H. pylori eradication rate 4 wk after treatment by intention-to-treat and per protocol analysis, while the secondary outcome measures were symptom and sign changes at the end of treatment and 4 wk after the end of treatment, as well as the proportion of patients who developed adverse events.RESULTS: The demographic data of the four groups were not significantly different. Overall, 666 patients completed the scheme and were re-assessed with the 13C-urea breath test. The intention-to-treat analysis of the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 74.44%, 82.78%, 78.89% and 86.11%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. According tothe per protocol analysis, the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 81.21%, 89.22%, 85.54% and 92.26%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. The number of adverse events was 15(8.3%), 16(8.9%), 15(8.3%) and 17(9.4%) in Groups 1, 2, 3 and 4, respectively, including dizziness, vomiting, diarrhea, nausea, skin rash, itchy skin, and malaise. The symptoms were relieved without special treatment in all of the patients.CONCLUSION: Both 7- and 10-d quadruple furazolidone-based therapies achieve satisfactory H. pylori eradication rates. | Yong Xie Yin Zhu Hong Zhou Zhi-Fa Lu Zhen Yang Xu Shu Xiao-Bai Guo Hui-Zhen Fan Jian-Hua Tang Xue-Ping Zeng Jian-Bo Wen Xiao-Qing Li Xing-Xing He Jiu-Hong Ma Dong-Sheng Liu Cai-Bin Huang Ning-Jian Xu Nong-Rong Wang Nong-Hua Lu | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 11 | Analyses on the tectonic thermal evolution and influence factors in the deep-water Qiongdongnan Basin显示文摘To reveal the tectonic thermal evolution and influence factors on the present heat flow distribution, based on 154 heat flow data, the present heat flow distribution features of the main tectonic units are first analyzed in detail, then the tectonic thermal evolution histories of 20 profiles are reestablished crossing the main deep-water sags with a structural, thermal and sedimentary coupled numerical model. On the basis of the present geothermal features, the Qiongdongnan Basin could be divided into three regions: the northern shelf and upper slope region with a heat flow of 50–70 m W/m2, most of the central depression zone of 70–85 m W/m2, and a NE trending high heat flow zone of 85–105 m W/m2 lying in the eastern basin. Numerical modeling shows that during the syn-rift phase, the heat flow increases generally with time, and is higher in basement high area than in its adjacent sags. At the end of the syn-rift phase, the heat flow in the deepwater sags was in a range of 60–85 m W/m2, while in the basement high area, it was in a range of 75–100 m W/m2. During the post-rift phase, the heat flow decreased gradually, and tended to be more uniform in the basement highs and sags. However, an extensive magmatism, which equivalently happened at around 5 Ma, has greatly increased the heat flow values, and the relict heat still contributes about 10–25 m W/m2 to the present surface heat flow in the central depression zone and the southern uplift zone. Further analyses suggested that the present high heat flow in the deep-water Qiongdongnan Basin is a combined result of the thermal anomaly in the upper mantle, highly thinning of the lithosphere, and the recent extensive magmatism. Other secondary factors might have affected the heat flow distribution features in some local regions. These factors include basement and seafloor topography, sediment heat generation, thermal blanketing, local magmatic injecting and hydrothermal activities related to faulting and overpressure. | WANG Zhenfeng SHI Xiaobin YANG Jun HUANG Baojia SUN Zhen WANG Yahui JIANG Haiyan YU Chuanhai YANG Xiaoqiu | 2014 | Acta Oceanologica Sinica2014，33，12： | 22 |
| 12 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 13 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 14 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 15 | DESIGN OF 6-AXIS FORCE/TORQUE SENSOR BASED ON STEWART PLATFORM RELATED TO ISOTROPY显示文摘DESIGNOF6AXISFORCE/TORQUESENSORBASEDONSTEWARTPLATFORMRELATEDTOISOTROPYWangHongruiGaoFengHuangZhenMechanicalEngineeringInstit... | Wang, Hongrui Gao, Feng Huang, Zhen | 1998 | Chinese Journal of Mechanical Engineering1998，11，3： | 19 |
| 16 | Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020显示文摘Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version. | Caixia Dong Yuwei Ding Shanshan Weng Guichao Li Yanqing Huang Hanguang Hu Zhen Zhang Suzhan Zhang Ying Yuan | 2021 | Chinese Journal of Cancer Research2021，33，3： | 19 |
| 17 | Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance显示文摘AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study theircorrelation.METHODS HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell membrane.HCV RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 cases.HCV NS5 protein and RNAcoexistence was found in 2 cases.In 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in clusters.CONCLUSION The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the traditionalviewpoint.HCV infection might be involved inthe development of carcinoma of extrahepaticbile duct. | Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao Rui Yun Peng De Wen Wang | 2000 | World Journal of Gastroenterology2000，6，6： | 19 |
| 18 | Nedaplatin/Gemcitabine Versus Carboplatin/Gemcitabine in Treatment of Advanced Non-small Cell Lung Cancer: A Randomized Clinical Trial显示文摘Objective: To evaluate the efficacy and safety of nedaplatin/gemcitabine (NG) and carboplatin/gemcitabine (CG) in the management of untreated advanced non‐small cell lung cancer (NSCLC). Methods: Sixty‐two patients with previously untreated advanced NSCLC were recruited between June 2006 and November 2007. Subjects were randomly assigned to the NG arm (n=30) and the CG arm (n=32). Only patients (24 and 25 in the NG and CG arms, respectively) who completed ≥2 chemotherapy cycles were included in the data analysis. The primary outcome measure was the objective response rate (ORR). The secondary outcome measures included progression‐free survival (PFS), overall survival (OS) and adverse events. Results: There were no statistically significant differences in the efficacy measures (ORR, P=0.305; median PFS, P=0.198; median OS, P=0.961) or in the major adverse events (grade 3/4 neutropenia, P=0.666; grade 3/4 anemia, P=0.263; grade 3/4 thrombocytopenia, P=0.212) between the two treatment arms. However, there was a trend towards higher ORR (37.5% vs. 24.0%), longer PFS (6.0 vs. 5.0 months), and less adverse events in the NG arm. Conclusion: NG regimen seems to be superior over CG regimen for advance NSCLS, but further investigation is needed to validate this superiority. | Jin-ji Yang Qing Zhou Ri-qiang Liao Yi-sheng Huang Chong-rui Xu Zhen Wang Bin-chao Wang Hua-jun Chen Yi-long Wu | 2012 | Chinese Journal of Cancer Research2012，24，2： | 18 |
| 19 | Comparative Analysis of Characteristics of the Coupled and Decoupled Parallel Mechanisms显示文摘The existence of coupling makes the parallel mechanism possess some special advantages over the serial mechanism, while it is just the coupling that brings about the parallel mechanism some limitations, such as complex workspace, high nonlinear relationship between input and output, difficulties in static and dynamic analysis, and the development of control system, which restricts its application fields. The decoupled parallel mechanism is currently one of the research focuses of the mechanism fields, while the study on the different characteristics between the decoupled and coupled parallel mechanisms has not been reported. Therefore, this paper performs the systematic comparative analysis of the 3-RPUR and the 3-CPR parallel mechanisms. The features of the two mechanisms are described and their movement forms are analyzed with screw theory. The inverse and forward displacement solutions are solved and the Jacobian matrices are obtained. According to the Jacobian matrices and by using the theory of physical model of the solution space, the workspace, dexterity, velocity, payload capability, and stiffness of the mechanisms are analyzed with plotting the indices atlases. The research results prove that the effects of the coupling on the parallel mechanism are double-side, and then the adoption of the decoupled parallel mechanism should be determined by the requirements of the concrete application situation. The contents of this paper should be useful for the type synthesis and practical application of the parallel mechanism. | ZENG Daxing HOU Yulei LU Wenjuan HUANG Zhen | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 17 |
| 20 | Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress显示文摘Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H 2 O 2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H 2 O 2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. | Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao | 2014 | Neural Regeneration Research2014，9，3： | 17 |
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