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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Impending HRT wave precursors to the Wenchuan M_s8.0 earthquake and methods of earthquake impending prediction by using HRT wave显示文摘We deployed four geo-electric monitoring stations in Sichuan and Yunnan provinces from 2004, using the new generation of equipment (PS-100) and technologies to capture the HRT wave earthquake precursor. Before the Wenchuan Ms8.0 earthquake, we recorded the HRT wave precursor at the only operating station in Hongge (HG, Δ=465 km) and found that significant impending signal had been recorded at the station in the early morning ( 0―5 am) of 12th of May, 2008. The precursor for this earthquake is consistent with precursors recorded for other strong earthquakes. The measured physical properties (geo-resistivity and telluric-current) show tidal wave period oscillations from several days to several months before the earthquakes and the amplitude of such HT oscillation increases significantly towards the occurrence of an earthquake. These HT and RT waves from the epicenter have a causal relationship with the earthquakes that happened several days later. The arrival time of two RT waves is proportional to the distance from the station to the epicenter. The estimated natural decay of the amplitude is correlated with the natural period (T0) of the earthquake fault, which is proportional to the fault length. From this relationship, we can predict the earthquake magnitude. For magnitude 6―9 earthquakes, the natural period is about 1―6 hours. Such oscillation comes from the epicenter area and they can propagate several thousand kilometers in the Earth's crust. Before a strong earthquake in the shallow crust, the conductive pore fluid will experience major changes before the fault rapture. Such fluid change will emit an oscillation in the pore fluid pressure. This is the mechanism for the HRT wave generation. Since the China Earthquake Administration funded the HRT wave short-term earth-quake prediction project in 2003, the first record of HRT precursor wave has been recorded from the 2004-12-26 Sumatra Mw9.0 earthquake with the largest epicentre distance Δ=2900 km. Thereafter, we have captured HRT waves from more than twenty strong earthquakes, which are well-matched and show repeatability, consistency and regularity. All our observation with the HRT waves demonstrate that HRT wave precursors to earthquakes indeed exist. Strong earthquakes can be predicted and short-term and impending earthquake prediction is achievable in the very near future. From all the observations, including the ones at HG station from Wenchuan Ms8.0 earthquake, we conclude that using HRT wave to predict earthquakes is feasible. | QIAN FuYe ZHAO BiRu QIAN Wei ZHAO Jian HE ShiGen ZHANG HongKui LI ShiYu LI ShaoKun YAN GuLiang WANG ChengMin SUN ZhenKai ZHANG DongNing LU Jun ZHANG Ping YANG GuoJun SUN JiaLin GUO ChunSheng TANG YuXiong XU JianMing XIA KunTao JU Hang YIN BangHong LI Ming YANG DongSheng QI WeiLuo HE TaiMing GUAN HuaPing ZHAO YuLin | 2009 | Science China Earth Sciences2009，52，10： | 8 |
| 3 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 4 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 5 | Linear dynamic system method for tactile object classification显示文摘Lots of tactile sequences can be obtained by using a dexterous hand for grasping different objects.The ability of robotic environmental perception and dexterous manipulation will be significantly improved after these tactile sequences are correctly classified.Therefore,tactile sequences are separated into series of subgroups,and a method based on linear dynamical system(LDS)is used to extract features.Since these LDSs lie in nonEuclidean space,the Martin distance,which is a measurement different from Euclidean distance,is applied to calculate the distance between two LDSs,and the K-Medoid algorithm is used for clustering.The codebook is obtained after clustering and is used to represent time sequences to get a Bag-of-System(Bo S).Then the Bo S and labels are sent to Extreme Learning Machine(ELM)to train a classifier.Finally,three databases,KTH-7,KTH-10 and TSH-8 are used to evaluate our algorithm. | MA Rui LIU HuaPing SUN FuChun YANG QingFen GAO Meng | 2014 | Science China(Information Sciences)2014，57，12： | 3 |
| 6 | Unexpected intercalation-dominated potassium storage in WS2 as a I potassium-ion battery anode显示文摘Unexpected intercalation-dominated process is observed duri ng K^+insertion in WS2 in a voltage range of 0.01-3.0 V.This is different fromthe previously reported two-dimensional(2D)transition metal dichalcogenides that undergo a conversion reaction in a low voltage rangewhen used as anodes in potassium-ion batteries.Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate thedifferention storage mechanisms.The Na^+storage proceeds through intercalation and conversion reactions while the K^+storage is governedby an intercalation reaction.Owing to the reversible K^+intercalation in the van der Waals gaps,the WS2 anode exhibits a low decay rate of 0.07%per cycle,delivering a capacity of 103 mAh·g^-1 after 100 cycles at 100 mA·g^-1.It maintains 57%capacity at 800 mA·g^-1 and shows stablecyclability up to 400 cycles at 500 mA·g^-1.Kinetics study proves the facilitation of K^+transport is derived from the intercalation-dominatedmecha nism.Furthermore,the mechanismis verified by the density functional theory(DFT)calculations,showing that the progressive expansion of the interlayer space can account for the observed results. | Vuhan Wu Yang Xu Yueliang Li Pengbo Lyu Jin Wen Chenglin Zhang Min Zhou Yaoguo Fang Huaping Zhao Ute Kaiser Yong Lei | 2019 | Nano Research2019，12，12： | 3 |
| 7 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 8 | Lattice Effect on Magnetic and Electrical Properties of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)Films显示文摘Lattice effect on magnetic and electrical transport properties of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)films prepared by RF magnetron sputtering technique were investigated.With the decrease of the average ions radius ,the structure of Ln_(2/3)Pb_(1/3)MnO_3(Ln=La,Pr,Nd)targets transit from the rhombohedral phase to the orthorhombic phase,and the Curie temperature reduces rapidly with the decrease of .The electrical properties show that films are the metallic state which can be fitted to the formula:ρ(T)=ρ0+ρ1T^2+ρ2T^(4.5) at low temperatures.The temperature range of the ferromagnetic metallic state becomes narrow with the decrease of.The phenomenon can be explained by the lattice effect. | Li'an HAN Huaping YANG Yongjun HE | 2008 | Journal of Materials Science & Technology2008，24，5： | 2 |
| 9 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 10 | Bronsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate: a green catalyst and recyelable medium for estefifieation 显示文摘 | ZHU Huaping YANG Fan TANG Jie | 2003 | Green Chemistry2003，5，1： | 1 |
| 11 | Brnsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate:a green catalyst and recyclable medium for esterification显示文摘 | Yang Fan Tang Jie | 2003 | Green Chemistry2003，5，： | 1 |
| 12 | Bridgman growth of CdWO 4 single crystals显示文摘 | Huaping Xiao Hongbing Chen Fang Xu Chengyong Jiang Peizhi Yang | 2007 | Journal of Crystal Growth2007，，： | 1 |
| 13 | Efficient Photocatalytic Degradation of the Persistent PET Fiber‑Based Microplastics over Pt Nanoparticles Decorated N‑Doped TiO_(2) Nanoflowers显示文摘Fiber-based microplastics(FMPs)are highly persistent and ubiquitously exist in the wastewater of textile industry and urban sewage.It remains challenging to completely remove such newly emerged organic pollutants by the predominant physical techniques.In this work,we investigated a photocatalytic degradation catalyzed by TiO_(2) catalyst to demonstrate the feasibility of implementing efficient chemical protocol to fast degrading polyethylene terephthalate(PET)-FMPs(a major FMP type existing in environment).The result shows that a hydrothermal pretreatment(180℃/12 h)is necessary to induce the initial rough appearance and molecular weight reduction.With the comprehensive action of the nano-flower shaped N doped-TiO_(2) catalyst(Pt@N-TiO_(2)-1.5%)on the relatively low molecular weight intermediates,an approximate 29%weight loss was induced on the pretreated PET-FMPs,which is about 8 times superior to the untreated sample.This work not only achieves a superior degradation effect of PET-FMPs,but also provides a new inspiration for the proposal of reduction strategies in the field of environmental remediation in the future. | Dawang Zhou Hongxia Luo Fangzhou Zhang Jing Wu Jianping Yang Huaping Wang | 2022 | Advanced Fiber Materials2022，4，5： | 1 |
| 14 | Experimental Realization of an Extreme-Parameter Omnidirectional Cloak显示文摘An ideal transformation-based omnidirectional cloak always relies on metamaterials with extreme parameters,which were previously thought to be too difcult to realize.For such a reason,in previous experimental proposals of invisibility cloaks,the extreme parameters requirements are usually abandoned,leading to inherent scattering.Here,we report on the frst experimental demonstration of an omnidirectional cloak that satisfes the extreme parameters requirement,which can hide objects in a homogenous background.Instead of using resonant metamaterials that usually involve unavoidable absorptive loss,the extreme parameters are achieved using a nonresonant metamaterial comprising arrays of subwavelength metallic channels manufactured with 3D metal printing technology.A high level transmission of electromagnetic wave propagating through the present omnidirectional cloak,as well as signifcant reduction of scattering feld,is demonstrated both numerically and experimentally.Our work may also inspire experimental realizations of the other full-parameter omnidirectional optical devices such as concentrator,rotators,and optical illusion apparatuses. | Bin Zheng Yihao Yang Zheping Shao Qinghui Yan Nian-Hai Shen Lian Shen Huaping Wang Erping Li Costas MSoukoulis Hongsheng Chen | 2019 | Research2019，，1： | 1 |
| 15 | Bronsted acidic ionic liquid I - methylimidazolium tetrafluoroborate: a green catalyst and recyclable medium for esterification 显示文摘 | ZHU HUAPING YANG FAN TANG JIE | 2003 | Green Chemistry2003，5，： | 1 |
| 16 | Detection of foodborne pathogens using bioconjugated nanomaterials显示文摘 | YANG Hua LI Huaping JIANG Xiuping | 2008 | Microfluid Nanofluid2008，5，： | 1 |
| 17 | γ‐Ray‐Responsive Supramolecular Hydrogel Based on a Diselenide‐Containing Polymer and a Peptide显示文摘 | Wei Cao Xiaoli Zhang Xiaoming Miao Zhimou Yang Huaping Xu | 2013 | Angew Chem Int Ed2013，，24： | 1 |
| 18 | Involvement of mitogen-activated protein kinase pathways in N-methyl-D-aspartate-induced excitotoxicity显示文摘Previous studies have shown that mitogen-activated protein kinase(MAPK) signaling pathways are involved in N-methyl-D-aspartate(NMDA)-mediated excitotoxicity.However,a systematic observation or analysis of the role of these various MAPK pathways in excitotoxicity processes does not exist.The present study further evaluated the role and contribution of three MAPK pathways extracellular signal-regulated kinase,c-Jun N-terminal kinase,and p38 MAPK in an NMDA-mediated excitotoxicity model using MAPK-specific inhibitor.Results demonstrated that c-Jun N-terminal kinase inhibitor SP600125 and/or p38 MAPK inhibitor SB203580 inhibited NMDA-induced reduction in cell viability,as well as reduced NMDA-induced lactate dehydrogenase leakage and reactive oxygen species production.However,PD98059,an inhibitor of extracellular signal-regulated kinase,did not influence this model.Results demonstrated an involvement of c-Jun N-terminal kinase and p38 MAPK,but not extracellular signal-regulated kinase,in NMDA-mediated excitotoxicity in cortical neurons. | Xiaorong Yang Ping Sun Huaping Qin Rui Wang Ye Wang Ruihong Shi Xin Zhao Ce Zhang | 2011 | Neural Regeneration Research2011，6，4： | 1 |
| 19 | An efficient and high-throughput protocol for Agrobacterium -mediated transformation based on phosphomannose isomerase positive selection in Japonica rice ( Oryza sativa L.)显示文摘 | Yongbo Duan Chenguang Zhai Hao Li Juan Li Wenqian Mei Huaping Gui Dahu Ni Fengshun Song Li Li Wanggen Zhang Jianbo Yang | 2012 | Plant Cell Reports2012，，9： | 1 |
| 20 | Small target detection in infrared video sequence using robust dictionary learning显示文摘 | Yang Chunwei Liu Huaping Liao Shouyi | 2015 | Infrared Physics & Technology2015，68，： | 1 |
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