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| 1 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 2 | High-temperature oxidation behavior of modified 4Al alumina-forming austenitic steel: Effect of cold rolling显示文摘The oxidation behavior and mechanism of as-received and 30 % cold-rolled alumina-forming austenitic(AFA) steel were investigated in dry air at 700℃.The results show that the mass gain per unit area curves of as-received and 30 % cold-rolled steels subject to near-parabolic law before 100 h oxidation time.Two samples both show higher high-temperature oxidation resistance due to the formation of dense Al_(2)O_(3) oxide scale.Gradual spallation of outer scale results in the formation of continuous and dense alumina scale.Dislocations can act as short-circuit diffusion channel for the diffusion of Al from alloy matrix to surface,and also provide nucleation sites for B2-NiAl phase,which ensure the continuous formation of Al_(2)O_(3) scale. | Qiuzhi Gao Ziyun Liu Huijun Li Hailian Zhang Chenchen Jiang Aimin Hao Fu Qu Xiaoping Lin | 2021 | Journal of Materials Science & Technology2021，，9： | 5 |
| 3 | Grain nucleation and growth behavior of a Sn-Pb alloy affected by direct current: An in situ investigation显示文摘In situ synchrotron X-ray radiography was used to study the effect of direct current(DC) on the grain nucleation and growth of Sn-50 wt.%Pb alloy. The results showed that applying DC adequately during solidification could effectively enhance the grain nucleation and inhibit its growth. Imaging of comparative experiments with varying DC intensity indicated that the final grain size, determined by the competition between grain nucleation and growth, was sensitively dependent on the DC intensity. It was found that the average grain size was decreased from 1632 to 567 μm with DC density of 1.5 A/mm^2 compared to the case without DC. Beyond this value, raising the current density may cause a significant decrease in the nucleation rate, and thus lead to a coarsening of the grain structure. | Fenfen Yang Zongning Chen Fei Cao Rong Fan Huijun Kang Wanxia Huang Qingxi Yuan Tiqiao Xiao Yanan Fu Tongmin Wang | 2017 | Journal of Materials Science & Technology2017，33，10： | 5 |
| 4 | Microstructural characteristics and mechanical behavior of B4Cp/6061Al composites synthesized at different hot-pressing temperatures显示文摘B4Cp/6061Al composites have become important structural and functional materials and can be fabricated by powder metallurgy and subsequent hot rolling. In this work, the effects of the hot-pressing temperature on microstructures and mechanical behaviors of the B4Cp/6061Al composites were investigated. The results showed that compared with the T4 heat treated B4Cp/6061Al composite hot pressed at 560℃, the yield strength and failure strain of the composites hot pressed at 580℃ were increased to 235 MPa and 18.4%, respectively. This was associated with the interface bonding strength between the B4C particles and the matrix. However, the reaction products, identified to be MgAl2O4 phases, were detected in the composites hot pressed at 600℃. The formation of the MgAl2O4 phases resulted in the Mg depletion, thus reducing the yield strength to 203.5 MPa after the T4 heat treatment due to the effect of the solid solution strengthening being weakened. In addition, the variation of hardness and electrical conductivity was mainly related to the Mg content in the matrix. Based on the as-rolled microstructures observed by SEM, SR-μCT and fracture surfaces, the deformation schematic diagram was depicted to reflect the tensile deformation process of the composites. | Minqiang Gao Zongning Chen Huijun Kang Enyu Guo Rengeng Li Ying Fu Honglan Xie Tongmin Wang | 2019 | Journal of Materials Science & Technology2019，35，8： | 4 |
| 5 | Three dimensional microstructures and wear resistance of Al-Bi immiscible alloys with different grain refiners显示文摘The three dimensional(3D) microstructures of Al-Bi alloys with different grain refiners(Al-5Ti-B, Al-3B and Al-3Ti) have been studied using synchrotron X-ray microtomography. The relationships between the microstructures and the corresponding wear behavior are verified through the friction and wear tests. The worn surfaces of the samples with grain refiners tested under 15 and 60 N loads are analyzed using Scanning Electron Microscopy(SEM). The results indicate that the addition of grain refiners is beneficial to the size and distribution of the Bi-rich particles in Al-Bi alloys. Compared with Al-5Ti-B and Al-3B grain refiners, the Bi-rich particles are more uniformly distributed and spherical with finer size with the addition of Al-3Ti grain refiner. The refinement renders the Al-20wt%Bi alloy refined by Al-3Ti the superior wear resistance with respect to those refined by Al-5Ti-B and Al-3B grain refiners, corresponding to the microstructures with fine and uniformly distributed Bi-rich particles in the Al matrix. | WANG TongMin CAO Fei CHEN ZongNing KANG HuiJun ZHU Jing FU YaNan XIAO TiQiao LI TingJu | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 6 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 7 | New insights in pre-replication complex formation with single-molecule visualization显示文摘Precise genomic DNA replication is critical for faithful transferring of genetic information to the next generation.Genomic DNA replication consists of three different stages:initiation,elongation and termination.In eukaryotic cells,DNA replication initiates from multiple | Huijun Xue Xin Xu Yu V. Fu | 2015 | Science Bulletin2015，60，12： | 2 |
| 8 | H5N6禽流感病毒的基因起源、进化和流行显示文摘2014~2016年间对我国16个省份活禽市场的监测,共鉴定了3174份流感阳性样品,分离并测序了1135份禽流感病毒,分属于31种亚型。 | yuhai bi quanjiao chen qianli wang jianjun chen tao jin gary wong chuansong quan jun liu jun wu renfu yin lihua zhao mingxin li zhuang ding rongrong zou wen xu hong li huijun wang kegong tian guanghua fu yu huang alexander shestopalov shoujun li bing xu hongjie yu tingrong luo lin lu xun xu yang luo 刘映霞 史卫峰 刘翟 高福 | 2017 | 科学新闻2017，0，4： | 2 |
| 9 | Operando Converting BiOCl into Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) for Efficient Electrocatalytic Reduction of Carbon Dioxide to Formate显示文摘Bismuth-based materials(e.g., metallic, oxides and subcarbonate) are emerged as promising electrocatalysts for converting CO_(2) to formate. However, Bio-based electrocatalysts possess high overpotentials, while bismuth oxides and subcarbonate encounter stability issues. This work is designated to exemplify that the operando synthesis can be an effective means to enhance the stability of electrocatalysts under operando CO_(2)RR conditions. A synthetic approach is developed to electrochemically convert Bi^(O)Cl into Cl-containing subcarbonate(Bi_(2)O_(2)(CO_(3))_(x)Cl_(y)) under operando CO_(2)RR conditions. The systematic operando spectroscopic studies depict that BiOCl is converted to Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) via a cathodic potential-promoted anion-exchange process. The operando synthesizedBi_(2)O_(2)(CO_(3))_(x)Cl_(y) can tolerate-1.0 V versus RHE, while for the wet-chemistry synthesized pure Bi_(2)O_(2)CO_(3),the formation of metallic Bio occurs at-0.6 V versus RHE. At-0.8 V versus RHE, Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) can readily attain a FEHCOO-of 97.9%,much higher than that of the pure Bi_(2)O_(2)CO_(3)(81.3%). DFT calculations indicate that differing from the pure Bi_(2)O_(2)CO_(3)-catalyzed CO_(2)RR, where formate is formed via a *OCHO intermediate step that requires a high energy input energy of 2.69 eV to proceed, the formation of H COO-over Bi_(2)O_(2)(CO_(3))_(x)Cl_(y) has proceeded via a *COOH intermediate step that only requires low energy input of 2.56 eV. | Huai Qin Fu Junxian Liu Nicholas M.Bedford Yun Wang Joshua Wright Peng Fei Liu Chun Fang Wen Liang Wang Huajie Yin Dongchen Qi Porun Liu Hua Gui Yang Huijun Zhao | 2022 | Nano-Micro Letters2022，14，7： | 1 |
| 10 | Structural and photocatalytic degradation characteristics of hydrothermally treated mesoporous TiO 2显示文摘 | Taicheng An Jikai Liu Guiying Li Shanqing Zhang Huijun Zhao Xiangying Zeng Guoying Sheng Jiamo Fu | 2008 | Applied Catalysis A General2008，，2： | 1 |
| 11 | Production of low acid value edible oil with reduced TFAs by electrochemical hydrogenation in a diaphragm reactor显示文摘 | FU Hong YANG Lin YUAN Huijun | 2008 | J Am Oil Chem Soc2008，85，11： | 1 |
| 12 | Preparation and characterization of hydrophobic TiO 2 pillared clay: The effect of acid hydrolysis catalyst and doped Pt amount on photocatalytic activity显示文摘 | Xuejun Ding Taicheng An Guiying Li Shanqing Zhang Jiaxin Chen Jianmei Yuan Huijun Zhao Hui Chen Guoying Sheng Jiamo Fu | 2008 | Journal of Colloid And Interface Science2008，，： | 1 |
| 13 | Study on diffusion behavior and microstructural evolution of Al/Cu bimetal interface by synchrotron X-ray radiography显示文摘 | Tongmin Wang Fei Cao Peng Zhou Huijun Kang Zongning Chen Yanan Fu Tiqiao Xiao Wanxia Huang Qingxi Yuan | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 14 | Development and application of knowledge-based subject group integration platforms:A case study of Shanghai Institute of Ceramics,CAS显示文摘Purpose:According to the different requirements of research group users,we established the knowledge-based subject group integration platforms of Shanghai Institute of Ceramics,the Chinese Academy of Sciences(abbreviated as SIC CAS hereinafter),which were designed and constructed to better meet the needs of CAS research groups for their development,collaboration and communication.Design/methodology/approach:We first identified the requirements of users via preliminary investigation,and then chose CASI1 P,iLibrary and XKE technology,respectively as the building tools compatible with the major demands of users.These steps helped us complete the layout design of SIC CAS integration platforms,as well as its knowledge organization and integration.Findings:According to the need of users,we applied three types of platform construction technologies to five SIC integration platforms,and formulated standard norms for the further construction process,which could provide useful reference for a sustainable development for the extensive construction in CAS institutes.Research limitations:In order to make the SIC integration platforms more intelligent and have more functions,we need to enlarge the scale of the Platforms and upgrade the building tools for the platform construction.Practical implications:The nature of SIC sub-project integration platforms is to construct a content-sensitive environment which can embed knowledge services and knowledge applications seamlessly into scientific activities,so the Platform is expected to be a useful tool to help researchers better understand the recent development of the research field and form collaborations with their peers.Originality/value:SIC integration platforms are the only pilot construction that used 3different platform technologies in the first batch of knowledge-based subject group integration platforms of the Chinese Academy of Sciences.The construction is user-centered throughout the whole process,namely,from the technology selection,content construction to the sustainable development of the platforms,which are all based on user requirements.During this process,we have not only established sustainable mechanisms for both the personalized feedback and security management of the institutional knowledge of SIC CAS,but also formed a service team for the sustainable development of SIC integration platforms. | Yu LIU Jian FU Huijun ZHENG Hao CHEN Zhiping YANG | 2014 | Chinese Journal of Library and Information Science2014，，2： | 1 |
| 15 | JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis显示文摘Jasmonate(JA)regulates various aspects of plant growth and development and stress responses,with prominent roles in male reproductive development and defenses against herbivores and necrotrophic pathogens.JASMONATE-ZIM DOMAIN(JAZ)proteins are key regulators in the JA signaling pathway and function to repress the expression of JA-responsive genes.Here,we show that JAZ proteins directly interact with several chromatin-associated Polycomb proteins to mediate repressive chromatin modifications at JA-responsive genes and,thus,their transcriptional repression in Arabidopsis.Genetic analyses revealed that the developmental defects,including anther and pollen abnormalities,resulting from loss or block of JA signaling were partially rescued by loss of Polycomb protein-mediated chromatin silencing(Polycomb repression).We further found that JAZ-mediated transcriptional repression during anther and pollen development requires Polycomb proteins at four key Regulatory loci.Analysis of genome-wide occupancy of a Polycomb factor and transcriptome reprogramming in response to JA revealed that Polycomb repression is involved in the repression of various JA-responsive genes.Taken together,our study reveals an important chromatin-based mechanism for JAZ-mediated transcriptional repression and JA signaling in plants. | Zicong Li Xiao Luo Yang Ou Huijun Jiao Li Peng Xing Fu Alberto P.Macho Renyi Liu Yuehui He | 2021 | Molecular Plant2021，14，5： | 1 |
| 16 | Preparation and characterization of hydrophobic TiO 2 pillared clay: The effect of acid hydrolysis catalyst and doped Pt amount on photocatalytic activity显示文摘 | Xuejun Ding Taicheng An Guiying Li Shanqing Zhang Jiaxin Chen Jianmei Yuan Huijun Zhao Hui Chen Guoying Sheng Jiamo Fu | 2008 | Journal of Colloid And Interface Science2008，，2： | 1 |
| 17 | Fatal spontaneous rupture of common iliac artery associated with fibromuscular dysplasia显示文摘A previously healthy 25-year-old man with no known risk factors was presented at the emergency room with a 3 h history of abdominal and loin pain.Physical examination and lab data showed no specific findings except tenderness,slight white cell count elevation and decreased haemoglobin level.The patient’s condition deteriorated over the following hours and he died despite resuscitation attempts.Autopsy revealed a 2.5-cm longitudinal tear in the intima of the right common iliac artery,which formed a thrombosed false lumen extending to the abdominal aorta proximally and to the left common iliac artery.Histopathologic examination revealed the characteristic changes of fibromuscular dysplasia(FMD).FMD involving the common iliac arteries is extremely rare;only six cases have been reported previously,and only two of those included forensic findings.The presented case is the first case of FMD with intimal tearing in the right common iliac artery,with propagation to the left common iliac artery and abdominal aorta.When a previously healthy young adult without hypertension or other risk factors presents with acute abdominal and loin pain,systemic vascular disease should be on the list of differential diagnoses.Careful and complete evaluation of multiple arteries can be critical. | Xiang Xu Mengchen Tsai Ning Xiao Xiaohui Tan Fu Zhang Yangeng Yu Qi Wang Weibing Xie Huijun Wang Dongri Li | 2019 | Forensic Sciences Research2019，4，4： | 1 |
| 18 | Operando reconstruction-induced CO_(2)reduction activity and selectivity for cobalt-based photocatalysis显示文摘The oxygen atom coordination inducing the structure reconstruction of the catalytic site is identified and recognized ambiguously,which is related to accurately declare the mechanism in a dynamic catalytic process.Herein,we demonstrated that the reconstructed catalytic sites would lead to a remarkable performance for photocatalytic CO_(2)reduction.At the initial 4-cycles testing,the in-situ formation of CoOx active sites on the Co(CoP)surface performed an increasing transient activity and selectivity toward CO evolution.The formation of reconstructive Co-O bond and the appearance of intermediate specie CO were simultaneously observed by the pre-operando Raman,revealing the dynamic relationship between catalytic site structure and the photocatalytic properties.Moreover,density functional theory calculations showed that the electronic structure of the reconstructive surface sites could modulate the ability of CO_(2)adsorption and CO desorption.The reduced barrier energy for the rate-determining step finally improved the activity and selectivity of CO_(2)reduction. | Kun Zhao Weiying Pang Shuaiyu Jiang Canyu Hu Porun Liu Dandan Cui Xuefei An Baojuan Tian Chao Gao Pan Zhang Meng Tian Dong Fu Huijun Zhao | 2023 | Nano Research2023，16，4： | 1 |
| 19 | Aldolase A promotes proliferation and G1/S transition via the EGFR/MAPK pathway in non-small cell lung cancer显示文摘Background:Our previous study demonstrated that aldolase A(ALDOA)is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial-mesenchymal transition and tumorigenesis.The pre-sent study aimed to explore the function of ALDOA in the modulation of non-small cell lung cancer(NSCLC)prolifera-tion and cell cycle progression and the potential mechanism.Methods:ALDOA was knocked down by short hairpin RNA in H520 and H1299 cells.ALDOA was overexpressed with vectors carrying the full-length ALDOA sequence in H1299 and H157 cells.The proliferation capacities were assessed with immunohistochemical staining,Cell Counting Kit-8 and colony formation assays.The cell cycle distribution was examined by flow cytometry,and molecular alterations were determined by western blotting.Cell synchronization was induced with nocodazole.The stability of cyclin D1 mRNA was tested.The pyruvate kinase M2 and ALDOA protein distributions were examined.Aerobic glycolysis was evaluated with Cell Titer-Glo assay,glucose colorimetric assay and lactate colorimetric assay.Results:ALDOA knockdown inhibited the proliferation and G1/S transition in H520 cells.Conversely,ALDOA over-expression promoted the proliferation and G1/S transition in H157 cells.The cell cycle synchronization assay showed that ALDOA expression increased in the G1 phase and G1/S transition.Furthermore,ALDOA knockdown reduced cyclin D1 expression by regulating epidermal growth factor receptor/mitogen-activated protein kinase(EGFR/MAPK)pathway.Similar results were found in H1299 and H157 cells.The inhibition of mitogen-activated protein kinase kinase 1/2 prompted the nuclear distribution of ALDOA.Additionally,ALDOA knockdown reduced nuclear distribution of PKM2,the extracellular lactate and intracellular adenosine triphosphate concentrations and elevated the extracellular glucose concentration.Conclusions:ALDOA contributed to activation of the EGFR/MAPK pathway,thus promoting cyclin D1 expression and enhancing proliferation and G1/S transition in NSCLC.Additionally,ALDOA facilitated NSCLC aerobic glycolysis. | Hailu Fu Huijun Gao Xiaoyu Qi Lei Zhao Donghua Wu Yuxin Bai Huimin Li Xuan Liu Jun Hu Shujuan Shao | 2018 | Cancer Communications2018，38，1： | 0 |
| 20 | Energy flexibility characteristics of centralized hot water system in university dormitories显示文摘The large-scale application of renewable energy is an important strategy to achieve the goal of carbon neutrality in the building sector.Energy flexibility is essential for ensuring balance between energy demand and supply when targeting the maximum penetration rate of renewable energy during the operation of regional integrated energy systems.Revealing the energy flexibility characteristics of centralized hot water systems,which are an important source of such flexibility,is of great significance to the optimal operation of regional integrated energy systems.Hence,in this study,based on the annual real-time monitoring data,the energy flexibility of the centralized hot water system in university dormitories is evaluated from the perspective of available storage capacity(C_(ADR)),recovery time(t_(recovery)),and storage efficiency(η_(ADR)),by the data-driven simulation method.The factors influencing the energy flexibility of the centralized hot water system are also analyzed.Available storage capacity has a strong positive correlation with daily water consumption and a strong negative correlation with daily mean outdoor temperature.These associations indicate that increased water use on the energy flexibility of the centralized hot water system is conducive to optimal dispatching.In contrast,higher outdoor temperature is unfavorable.The hourly mean value of the available storage capacity in spring and winter is found to be around 80 kWh in the daytime,and about twice that in summer and autumn.Recovery time is evenly distributed throughout the year,while t_(recovery)/C_(ADR)in spring and winter is about half that in summer.The storage efficiency was significantly higher in spring,summer,and winter than in autumn.The hourly mean storage efficiency was found to be about 40%in the daytime.The benefits of activating energy flexibility in spring and winter are the best,because these two seasons have higher available storage capacity and storage efficiency,while the benefit of activating energy flexibility is the highest at 6:00 a.m.,and very low from midnight to 3:00 a.m. | Zhiqin Rao Shuqin Chen Isaac Lun Lizhi Shen Ang Yu Huijun Fu | 2023 | Building Simulation2023，16，4： | 0 |
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