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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 3 | Epigenetic regulation in plant abiotic stress responses显示文摘In eukaryotic cells,gene expression is greatly influenced by the dynamic chromatin environment.Epigenetic mechanisms,including covalent modifications to DNA and histone tails and the accessibility of chromatin,create various chromatin states for stress-responsive gene expression that is important for adaptation to harsh environmental conditions.Recent studies have revealed that many epigenetic factors participate in abiotic stress responses,and various chromatin modifications are changed when plants are exposed to stressful environments.In this review,we summarize recent progress on the cross-talk between abiotic stress response pathways and epigenetic regulatory pathways in plants.Our review focuses on epigenetic regulation of plant responses to extreme temperatures,drought,salinity,the stress hormone abscisic acid,nutrient limitations and ultraviolet stress,and on epigenetic mechanisms of stress memory. | Ya-Nan Chang Chen Zhu Jing Jiang Huiming Zhang Jian-Kang Zhu Cheng-Guo Duan | 2020 | Journal of Integrative Plant Biology2020，62，5： | 14 |
| 4 | Progress in the stratigraphy and geochronology of the Shuidonggou site,Ningxia,North China显示文摘In the past years we carried out further stratigraphy division in field and it is found that rich stone artifacts can be found in fluvial-shallow lake-alluvial sediments on the terrace Ⅱ of Biangou River, in Shuidonggou site, Ningxia and they are SDG1, 2 and 7. More luminescence and AMS 14C dating in laboratory show that Paleolithic culture develops during the Upper Paleolithic period with ages of 35―20 ka. The Paleolithic culture of SDG 1 is a little earlier than that of SDG 2 similar to SDG 7. The sandy sediments on terrace Ⅱ of Biangou River deposits in the past 72―18 ka, corresponding to Last Glacial. SDG2 has a stable sedimentary environment, resulting in the continuous stratigraphy, thickest deposits and rich environment and culture information, which can be regarded as the important and classic paleoanthropological section of Late Pleistocene in this region. | LIU DeCheng WANG XuLong GAO Xing XIA ZhengKai PEI ShuWen CHEN FuYou WANG HuiMing | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 5 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 6 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 7 | An ACCUMULATION AND REPLICATION OF CHLOROPLASTS 5 gene mutation confers light green peel in cucumber显示文摘The peel color of fruit is an important commercial trait in cucumber,but the underlying molecular basis is largely unknown.A mutant showing light green exocarp was discovered from ethyl methane sulfonate(EMS) mutagenized cucumber line 406 with dark green exocarp.Genetic analysis showed the mutant phenotype is conferred by a single recessive gene,here designated as lgp(light green peel).By re-sequencing of bulked segregants,we identified the candidate gene Csa7Go51430 encoding ACCUMULATION AND REPLICATION OF CHLOROPLASTS 5(ARC5) that plays a vital role in chloroplast division in Arabidopsis.A single nucleotide polymorphism(SNP) causing amino acid alteration in the conserved GTPase domain of Csa7G051430 showed co-segregation with the altered phenotype.Furthermore,the transient RNA interference of this gene resulted in reduced number and enlarged size of chloroplasts,which were also observed in the Igp mutant.This evidence supports that the non-synonymous SNP in Csa7G051430 is the causative mutation for the light green peel.This study provides a new allele for cucumber breeding for light green fruits and additional resource for the study of chloroplast development. | Qian Zhou Shenhao Wang Bowen Hu Huiming Chen Zhonghua Zhang Sanwen Huang | 2015 | Journal of Integrative Plant Biology2015，57，11： | 6 |
| 8 | A Truncated F-Box Protein Confers the Dwarfism in Cucumber显示文摘Dwarfism is an important plant architecture trait in crop breeding(Peng et al.,1999;Sasaki el al.,2002).In cucurbits.the compact plant type was proposed to develop new varieties for the once-over mechanical harvest for concentrated fruit set and higher densities(Li et al.,2011;Mondal et al.,2011).Several recessive genes in cucurbits have been reported to confer the phenotype of short internodes or bushy plant habits,such as compact,cp-2,and dw in cucumber(Cucumis | Tao Lin Shenhao Wang Yang Zhong Dongli Gao Qingzhi Cui Huiming Chen Zhonghua Zhang Huolin Shen Yiqun Weng Sanwen Huang | 2016 | Journal of Genetics and Genomics2016，43，4： | 5 |
| 9 | Synchrotron radiation X-ray powder diffraction techniques applied in hydrogen storage materials--A review显示文摘Synchrotron radiation is an advanced collimated light source with high intensity. It has particular advantages in structural characterization of materials on the atomic or molecular scale. Synchrotron radiation X-ray powder diffraction(SR-XRPD) has been successfully exploited to various areas of hydrogen storage materials. In the paper, we will give a brief introduction on hydrogen storage materials, X-ray powder diffraction(XRPD), and synchrotron radiation light source. The applications of ex situ and in situ time-resolved SR-XRPD in hydrogen storage materials, are reviewed in detail. Future trends and proposals in the applications of the advanced XRPD techniques in hydrogen storage materials are also discussed. | Honghui Cheng Chen Lu Jingjing Liu Yongke Yan Xingbo Han Huiming Jin Yu Wang Yi Liu Changle Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 10 | A Fuzzy PID Algorithm for a Novel Miniature Spherical Robots with Three-dimensional Underwater Motion Control显示文摘We proposed and developed a small bionic amphibious spherical robot system for tasks such as coastal environment monitoring and offshore autonomous search and rescue.Our third-generation bionic small amphibious spherical robots have many disadvantages,such as the lack of maneuverability and a small operating range.It is difficult to accomplish underwater autonomous motion control with these robots.Therefore,we proposed a fourth-generation amphibious spherical robot.However,the amphibious spherical robot developed in this project has a small and compact design,with limited sensors and external sensing options.This means that the robot has weak external information collection capabilities.We need to make the real time operation of the robot's underwater motion control system more reliable.In this paper,we mainly used a fuzzy Proportional-Integral-Derivative(PID)control algorithm to design an underwater motion control system for a novel robot.Moreover,we compared PID with fuzzy PID control methods by carrying out experiments on heading and turning bow motions to verify that the fuzzy PID is more robust and exhibits good dynamic performance.We also carried out experiments on the three-dimensional(3D)motion control to validate the design of the underwater motion control system. | Liwei Shi Yao Hu Shuxiang Su Shuxiang Guo Huiming Xing Xihuan Hou Yu Liu Zhan Chen Zan Li Debin Xia | 2020 | Journal of Bionic Engineering2020，17，5： | 4 |
| 11 | Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment显示文摘Umbilical cord mesenchymal stem cells(UCMSCs)transplantation has been proposed as a promising treatment modality for myocardial infarction(MI),but the low retention rate remains a considerable challenge.Injectable natural polymer hydrogels with conductivity ability are highly desirable as cell delivery vehicles to repair infarct myocardium and restore the cardiac function.In this work,we developed a hydrogel system based on gelatin methacrylate(GelMA)and oxidized dextran(ODEX)as cell delivery vehicles for MI.And dopamine could be used as a reductant of graphene oxide(GO)to form reductive GO(rGO).By adjusting the amount of rGO,the conductivity of hydrogels with 0.5 mg/mL rGO concentration(≈10^(-4)S/cm)was similar to that of natural heart tissue.In vitro cell experiments showed that the prepared hydrogels had excellent biocompatibility and cell delivery ability of UCMSCs.More importantly,GelMA-O5/rGO hydrogel could promote UCMSCs growth and proliferation,improve the myocardial differentiation ability of UCMSCs,and up-regulate the expression of cTnI and Cx43.Further in vivo experiments demonstrated that GelMA-O5/rGO/UCMSCs Hydrogel could significantly improve the ejection fraction(EF)of rats and significantly reduce myocardial infarct area compared to PBS group,promote the survival of UCMSCs,enhance the expression level of cTnI and Cx43,and decrease the expression level of caspase-3.The findings of this study suggested that the injectable conductive GelMA-O5/rGO hydrogel encapsulating UCMSCs could improve damaged myocardial tissue and reconstruct myocardial function,which will be a promising therapeutic strategy for cardiac repair. | Shuoji Zhu Changjiang Yu Nanbo Liu Mingyi Zhao Zerui Chen Jian Liu Ge Li Huanlei Huang Huiming Guo Tucheng Sun Jimei Chen Jian Zhuang Ping Zhu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 12 | Development and molecular analysis of a novel acetohydroxyacid synthase rapeseed mutant with high resistance to sulfonylurea herbicides显示文摘With the increasing promotion of simplified rapeseed cultivation in recent years,the development of cultivars with high resistance to herbicides is urgently needed.We previously developed M342,which shows sulfonylurea herbicide resistance,by targeting acetohydroxyacid synthase(AHAS),a key enzyme in branched-chain amino acid synthesis.In the present study,we used a progeny line derived from M342 for an additional round of ethyl methane sulfonate mutagenesis,yielding the novel mutant DS3,which harbored two mutations in AHAS genes and showed high sulfonylurea resistance.One mutation was the substitution Trp574 Leu,as in M342,according to Arabidopsis protein sequencing.The other site was a newly recognized substitution,Pro197 Leu.A KASP marker targeting Pro197 Leu was developed and reliably predicted the response to sulfonylurea herbicides in the F2 population.The combination of Trp574 Leu and Pro197 Leu in DS3 produced a synergistic effect that greatly increased herbicide resistance.Analysis of the protein structures of AHAS1 and AHAS3 in wild-type and single-gene mutant plants revealed three-dimensional protein conformational changes that could account for differences in herbicide resistance characteristics including toxicity tolerance,AHAS enzyme activity,and AHAS gene expression. | Yue Guo Changle Liu Weihua Long Jianqin Gao Jiefu Zhang Song Chen Huiming Pu Maolong Hu | 2022 | The Crop Journal2022，10，1： | 3 |
| 13 | PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis显示文摘In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1.Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains.CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology.Importantly,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival.Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD. | Weili Yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong Huiming Yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li | 2022 | Protein & Cell2022，13，1： | 3 |
| 14 | A THEORETICAL SOLUTION OF CYLINDRICALLY ISOTROPIC CYLINDRICAL TUBE FOR AXISYMMETRIC PLANE STRAIN DYNAMIC THERMOELASTIC PROBLEM显示文摘A dynamic thermoelastic solution of a cylindrically isotropic cylindrical tube or solid cylinderwith axisymmetric plane deformations is developed.Since there exist thermal boundary conditions and trac-tions on the two surfaces of a cylindrical tube,the problem under consideration is with inhomogeneous bound-ary conditions.Therefore we introduce a special function to transform the inhomogeneous boundary conditionsto homogeneous ones for an unknown function.Then by using the method of separation of variables,the un-known function can be expressed as the multiplication series of Bessel functions and unknown time functions.Thirdly,by virtue of the orthogonal properties of Bessel functions,the equations about these unknown timefunctions are derived and the solutions are obtained.Finally,the displacement is obtained by adding the twoparts mentioned above.By means of the present method,integral transform can be avoided.It is suitable forarbitrary thermal loads and mechanical loads.Numerical results are also presented for thermal shocked,cy-lindrically isotropic cylindrical tube and solid cylinder. | Ding Haojiang Wang Huiming Chen Weiqiu | 2001 | Acta Mechanica Solida Sinica2001，14，4： | 3 |
| 15 | Techno-economic analysis of MJ class high temperature Superconducting Magnetic Energy Storage(SMES) systems applied to renewable power grids显示文摘High temperature Superconducting Magnetic Energy Storage(SMES) systems can exchange energy with substantial renewable power grids in a small period of time with very high efficiency. Because of this distinctive feature, they store the abundant wind power when the power network is congested and release the energy back to the system when there is no congestion. However, considering the cost and lifespan of SMES systems, there is an urgent demand to conduct a cost-benefit analysis to justify its role in smart grid development. This study explores the application and performs economic analysis of a 5 MJ SMES in a practical renewable power system in China based on the PSCAD/EMTDC software. An optimal location of SMES in Zhangbei wind farm is presented using real power transmission parameters. The stabilities of the renewable power grid with and without SMES are discussed. In addition, a financial feasibility study is conducted by comparing the cost and the savings from wind power curtailment of deploying SMES and battery. The economic analysis tries to find the balance between SMES investment cost and wind farm operation cost by using real data over a calendar year. The technical analysis can help guide the optimal allocation of SMES for compensating power system instability with substantial wind power. Further, the economic analysis provides a useful indication of its practical application feasibility to fight the balance between cost and benefit. | Jiahui Zhu Panpan Chen Chenghong Gu Hongjie Zhang Jianwei Li Huiming Zhang Ming Qiu Jianlin Li Weijia Yuan Ignacio Hernando Gil | 2018 | Global Energy Interconnection2018，1，2： | 3 |
| 16 | A New Gene Conferring the Glabrous Trait in Cucumber Identified Using MutMap显示文摘Tubercles and spines on fruit peel are important commercial traits in cucumber(Cucumis sativus L.). From an ethyl methane sulfonate cucumber mutant library,we discovered a new glabrous mutant that bears no tubercle or spine on fruit peel and fewer and smaller trichomes on the stem and leaves. The new locus is here designated as glabrous2(gl2). Genome sequencing of the mutant and linkage analysis revealed that a non-synonymous mutation in the Csa1G056960 gene rendered the gl2 phenotype. The mutated gene encodes a C-type lectin receptor-like tyrosine protein kinase. This study provides a novel allele for elucidating the genetic basis of wart and trichome development and a new tool for breeding glabrous cucumber varieties. | XU Mengnan WANG Shenhao ZHANG Shu CUI Qingzhi GAO Dongli CHEN Huiming HUANG Sanwen | 2015 | Horticultural Plant Journal2015，1，1： | 2 |
| 17 | Spider diversity in Fanjing Mountain Nature Reserve, Guizhou, China, Ⅱ: Clubionidae(Araneae)显示文摘Totally fourteen species of Clubionidae are reported from the Fanjing Mountain Nature Reserve in this paper, including six species as new to science, namely, Clubiona corrugata B?senberg & Strand, 1906(♂♀), C. dichotoma Wang, Chen & Zhang ZS, sp. nov.(♂♀), C. fanjingshan Wang, Chen & Zhang ZS, sp. nov.(♂), C. globosa Wang, Chen & Zhang ZS, sp. nov.(♂♀), C. grucollaris Yu, Zhang & Chen, 2017, C. huiming Wang, Zhang F & Zhang ZS, sp. nov.(♂), C. japonicola B?senberg & Strand, 1906(♂♀), C. jucunda(Karsch, 1878)(♂♀), C. manshanensis Zhu & An, 1988(♂♀), C. pterogona Yang, Song & Zhu, 2003(♀), C. subapplanata Wang, Chen & Zhang ZS, sp. nov.(♂♀), C. subcylindrata Wang, Chen & Zhang ZS, sp. nov.(♂♀), C. subrostrata Zhang & Hu, 1991(♂♀) and Pristidia ramosa Yu, Sun & Zhang, 2012(♀). All species are described or redescribed, and photoed, except Clubiona grucollaris Yu, Zhang & Chen, 2017. Drawings of all new species are also provided. | Luyu Wang Huiming Chen Panlong Wu Feng Zhang Zhisheng Zhang | 2018 | Zoological Systematics2018，43，3： | 2 |
| 18 | Molecular Isolation of the M Gene Suggests That a Conserved-Residue Conversion Induces the Formation of Bisexual Flowers in Cucumber Plants显示文摘 | Li Zheng Huang Sanwen Liu Shiqiang Pan Junsong Zhang Zhonghua Tao Qianyi Shi Qiuxiang Jia Zhiqi Zhang Weiwei Chen Huiming Si Longting Zhu Lihuang Cai Run | 2009 | Genetics2009，，4： | 2 |
| 19 | Mg AmorphousZr_(0.9)Ti_(0.1)(Ni_(0.57)Mn_(0.28)V_(0.1)Co_(0.05))_(2.1)Composite for Hydrogen Storage显示文摘The reactive mechanical alloying (RMA) method was used to produce Mg-40 wt pct amorphous Zr0.9Ti0.1(Ni0.57-Mn0.25V0.1Co0.05)2.1 composite in this study, and the absorption/desorption property of the composite was improved remarkably. The composite possessed excellent kinetic properties even at moderate temperature (393 K) without activation. Owing to the formation of the embrittle MgH2, the reactive mechanical milling process reduced the particle size of Mg and made the composite phase being highly efficiently distributed, which determined the excellent hydriding properties of the composite. | Haiyan LENG, Demin CHEN, Manqi LU, Haifeng ZHANG, Huiming CHENG and Ke YANGInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2003 | Journal of Materials Science & Technology2003，19，2： | 2 |
| 20 | Evaluation of policies and practices to prevent mother to child transmission of hepatitis B virus in China: Results from China GAVI project final evaluation显示文摘 | Fuqiang Cui Huiming Luo Fuzhen Wang Hui Zheng Xiaohong Gong Yuansheng Chen Zhenhua Wu Ning Miao Mark Kane Karen Hennessey Stephen C. Hadler Yvan J. Hutin Xiaofeng Liang Weizhong Yang | 2013 | Vaccine2013，，： | 2 |
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