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| 1 | Long-chain alkenones in Hotong Qagan Nur Lake sediments and its paleoclimatic implications显示文摘The long-chain alkenones present in the shallow sediment of Hotong Qagan Nur Lake in China are reported. According to the similarity of compositions and distributions of the alkenones determined commonly in the sediment section to those of marine sediment, it is reasonably referred that the alkenones might also originate from Prymnesiophyceae. ln addition, the parameter U37k'of alkenone is in positive correlation to δ18O values of authigenic calcium and magnesium minerals. This indicates that the parameter U37k'of long-chain alkenone is also available to indicate paleoclimate of high-salinity alkaline lake. | Guoying Sheng Keqin Cai Xuexian Yang Jialan Lu Guodong Jia Ping’an Peng Jiamo Fu | 1999 | Chinese Science Bulletin1999，44，3： | 15 |
| 2 | Distribution of tetraether lipids in surface sediments of the northern South China Sea:Implications for TEX_(86) proxies显示文摘Archaea 有能习惯于的类脂化合物开发的唯一的甘油 dialkyl 甘油 tetraether (GDGT ) paleotemperature 代理象 TEX86 那样。这研究是在华南海(SCS ) 为 paleotemperature 决心验证建议 GDGT 代理。样品在北 SCS 从核心顶沉积(05 厘米) 被收集。全部的类脂化合物被提取获得核心 GDGT,它被识别并且确定了使用液体层析团 spectrometry (最小公倍数) 。许多 isoprenoidal GDGT (iGDGTs ) 从 271.5 ng/g 干燥沉积到 1266.3 ng/g,弄干沉积分叉的 GDGT (bGDGTs ) ,据说源于陆上的来源,从 22.2 ng/g 干燥沉积到 56.7 ng/g 干燥沉积。导出 TEX86 的海表面温度从 20.9 牡敧挠湯瑳畲瑣潩獮椠 ? 散瑮慲? 湡 ? 潳瑵敨湲匠湩楡沈 ? 沈吗?? | Huangmin Ge Chuanlun L.Zhang Hongyue Dang Chun Zhu Guodong Jia | 2013 | Geoscience Frontiers2013，4，2： | 10 |
| 3 | Comparison of the carbon isotope composition of total organic carbon and long-chain n-alkanes from surface soils in eastern China and their significance显示文摘Surface soil samples collected over a high spatial resolution in eastern China were analyzed for carbon isotope composition(δ 13C) of total organic carbon(TOC) and higher plant-derived long-chain n-alkanes,with the latter reported as weighted mean values.The two sets of δ 13C values are significantly correlated and show similar trends in spatial variation.The spatial distribution of δ 13C shows less negative values in the mid-latitudes between 31°N and 40°N and more negative ones at higher and lower latitudes.This is consistent with previously reported carbon isotope data from surface soil phytoliths in the same region and suggests that the mid-latitude area provides relatively favorable growing conditions for C4 plants.Furthermore,δ 13C values of both TOC and long-chain n-alkanes from 12 surface soil samples collected from a small grassland in north China displayed similar carbon isotope values and the difference between paired δ 13C of a soil samples remains relatively constant.Our data demonstrate that in eastern China,soil δ 13C composition of both TOC and long-chain n-alkanes is effective indicators of C3/C4 ratios of the prevailing vegetation.This work suggests that -22‰ and -32‰ are good estimated end members for the weighted mean δ 13C values of long-chain n-alkanes(C27,C29 and C31 n-alkanes) from soils under dominant C4 or C3 vegetation,allowing us to reconstruct paleovegetation trends. | RAO ZhiGuo JIA GuoDong ZHU ZhaoYu WU Yi ZHANG JiaWu | 2008 | Chinese Science Bulletin2008，53，24： | 10 |
| 4 | Is the maximum carbon number of long-chain n-alkanes an indicator of grassland or forest? Evidence from surface soils and modern plants显示文摘The molecular distribution of long-chain n-alkanes in 62 soil samples collected from diverse locations across eastern China was analyzed.The long-chain n-alkanes were mostly dominated by n-C29 or n-C31,regardless of the overlying vegetation type at each site.The results were compared with those summarized from the literature,covering more than 100 soil samples within China and more than 300 genera of modern plants distributed worldwide.There were similar n-alkane distribution patterns for most genera, with no clear differences among grasses,shrubs,and trees.The evidence from analyses of surface soils and modern plants indicates that the relationship between the molecular distribution of long-chain n-alkanes of surface soils and source vegetation is highly complex,and is influenced by many factors.Further,it is suggested that source vegetation types should not be simply inferred from distribution patterns of long-chain n-alkanes in sediments. | RAO ZhiGuo WU Yi ZHU ZhaoYu JIA GuoDong HENDERSON Andrew | 2011 | Chinese Science Bulletin2011，56，16： | 9 |
| 5 | Relationship between climatic conditions and the relative abundance of modern C_3 and C_4 plants in three regions around the North Pacific显示文摘Using -24‰ and -14‰ as the endpoints of stable carbon isotopic composition of total organic carbon (δ 13CTOC) of surface soil under pure C3 and C4 vegetation, and surface soil δ 13CTOC data from eastern China, Australia and the Great Plains of North America, we estimate the relative abundance of C3/C4 plants (i.e., the ratio of C3 or C4 biomass to local primary production) in modern vegetation for each region. The relative abundance of modern C3/C4 vegetation from each region is compared to the corresponding climatic parameters (mean annual temperature and precipitation) to explore the relationship between relative C4 abundance and climate. The results indicate that temperature controls the growth of C4 plants. However, even where temperature is high enough for the growth of C4 plants, they will only dominate the landscape when precipitation declines as temperatures increase. Our results are consistent with those of other investigations of the geographic distribution of modern C4 plant species. Therefore, our results provide an important reference for interpretation of past C3/C4 relative abundance records in these three regions. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong CHEN FaHu BARTON Loukas ZHANG JiaWu QIANG MingRui | 2010 | Chinese Science Bulletin2010，55，18： | 7 |
| 6 | Effect of Altitude and Latitude on Surface Air Temperature across the Qinghai-Tibet Plateau显示文摘The correlation between mean surface air temperature and altitude is analyzed in this paper based on the annual and monthly mean surface air temperature data from 106 weather stations over the period 1961-2003 across the Qinghai-Tibet Plateau.The results show that temperature variations not only depend on altitude but also latitude,and there is a gradual decrease in temperature with the increasing altitude and latitude.The overall trend for the vertical temperature lapse rate for the whole plateau is approximately linear.Three methods,namely multivariate composite analysis,simple correlation and traditional stepwise regression,were applied to analyze these three correlations.The results assessed with the first method are well matched to those with the latter two methods.The apparent mean annual near-surface lapse rate is-4.8 °C /km and the latitudinal effect is-0.87 °C /?latitude.In summer,the altitude influences the temperature variations more significantly with a July lapse rate of-4.3°C /km and the effect of latitude is only-0.28°C /latitude.In winter,the reverse happens.The temperature decrease is mainly due to the increase in latitude.The mean January lapse rate is-5.0°C /km,while the effect of latitude is-1.51°C /?latitude.Comparative analysis for pairs of adjacent stations shows that at a small spatial scale the difference in altitude is the dominant factor affecting differences in mean annual near-surface air temperature,aided to some extent by differences of latitude.In contrast,the lapse rate in a small area is greater than the overall mean value for the Qinghai-Tibet Plateau (5 to 13°C /km).An increasing trend has been detected for the surface lapse rate with increases in altitude.The temperature difference has obvious seasonal variations,and the trends for the southern group of stations (south of 33? latitude) and for the more northerly group are opposite,mainly because of the differences in seasonal variation at low altitudes.For yearly changes,the temperature for high-altitude stations occurs earlier clearly.Temperature datasets at high altitude stations are well-correlated,and those in Nanjing were lagged for 1 year but less for contemporaneous correlations.The slope of linear trendline of temperature change for available years is clearly related to altitude,and the amplitude of temperature variation is enlarged by high altitude.The change effect in near-surface lapse rate at the varying altitude is approximately 1.0°C /km on the rate of warming over a hundred-year period. | WANG Keli SUN Jia CHENG Guodong JIANG Hao | 2011 | Journal of Mountain Science2011，8，6： | 7 |
| 7 | Nitrate δ^(15)N and δ^(18)O evidence for active biological transformation in the Changjiang Estuary and the adjacent East China Sea显示文摘The Changjiang Estuary has been considered as one of the most polluted estuaries in the world due to high nitrate (NO-3) input, especially in spring and summer. In this study, δ15N and δ18O of NO-3 , along with other chemical parameters in this area, were measured in spring to evaluate NO-3 biogeochemical processes. A simple two end-members mixing model was used to examine the relative contribution of the Changjiang River Diluted Water and marine water to NO-3 sources in the Changjiang Estuary and the adjacent East China Sea. The isotopic signals show that NO-3 behaved relatively and conservatively in Transect F and Transect P where assimilation was weak possibly due to vertical mixing, while active assimilation and weak nitrification occurred in Transect D. Spatial difference in assimilation was indicated by the~1:1 enrichment of δ15N and δ18O in the three transects, while spatial difference in nitrification was reflected by deviations of δ15 N and δ18O from assimilation line. Our results suggest that the input of the Changjiang River Diluted Water promoted NO-3 assimilation possibly by stratifying the water column which favored the phytoplankton growth. | CHEN Fajin CHEN Jianfang JIA Guodong JIN Haiyan XU Jie YANG Zhi ZHUANG Yanpei LIU Xizhen ZHANG Haisheng | 2013 | Acta Oceanologica Sinica2013，32，4： | 4 |
| 8 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 9 | Sea surface temperature variations in the southwestern South China Sea over the past 160 ka显示文摘在西南的华南海的海面温度(SST ) 从核心 MD01-2392 用 U_(37 )~ k paleothermometer 为过去的 160 ka 被重建了。冰川的时间(小姐 6 和 2 ) 和间冰期的时间之间的 Thetemperature 差别(错过 5。5 and1 ) 是 2。2 ~ 2.5 ℃。更年轻的 Dryas 事件在有孔虫目的δ ~(18 ) O 和 SST 记录的两 theplank 补品在最后冰川的消失期间被记录。在 MIS 5.5 以后, SST 显示了从 28 的进步冷却。6。5 ℃,在 LGM 达到顶点。在这个渐渐的冷却时期期间,温暖象小姐 5.3 那样的事件, 5。1 和 3 清楚地也被记录。由在学习核心和核心之间的 SST 的比较 17954,低或不南方的 SST 坡度的一个模式在冰纪期间在间冰期的时期和高南方的 SST 坡度期间被展出。这个模式显示强壮得多的东方亚洲冬季季风在比在间冰期的时期冰川。光谱分析给二突出的周期:与更多读了的前者,在南部的 SCS 建议那 SST 通过东方亚洲冬季季风的连接与高纬度的过程在音乐会改变了的 41 和 23 ka。 | XIE Hongqin JIA Guodong PENG Ping'an SHAO Lei | 2007 | Acta Oceanologica Sinica2007，26，2： | 3 |
| 10 | Modified vegetation-erosion dynamics model and its application in typical watersheds in the Loess Plateau显示文摘植被侵蚀模型在三个典型分水岭被使用多山并且在在到学习的西北的中国的黄土高原的溪谷区域在植被范围和土壤侵蚀率和各种各样的压力之间的动态关系。模型被介绍降雨和流量因素改进。然后,修改模型在 Luergou 和 Luoyugou 分水岭被使用。与修改模型一起的计算结果与原来的模型的结果相比。与修改模型一起的模仿的植被范围和土壤侵蚀率的精确极大地与原来的模型相比被改进。与增加植被范围和人的骚乱减少的土壤侵蚀率引起了高土壤侵蚀。 | CHEN Yuehong WANG Feixin LIU Guangquan YU Xinxiao JIA Guodong GAN Ping | 2011 | International Journal of Sediment Research2011，26，1： | 3 |
| 11 | Sedimentary records of black carbon in the sea area of the Nansha Islands since the last glaciation显示文摘Core 17962 taken from the sea area of the Nansha Islands recorded a sedimentary history of more than 30 000 years. The black carbon data from the core, which can inform us of the history of vegetation fires, show that during the last glaciation, especially during the last glacial maximum at about 18 kaBP, the fluctuation of the concentration and accumulation rate of the black carbon was relatively great, whereas it was small during the Holocene. The isotope composition of the black carbon indicates that the precursors of black carbon were mainly grasses from the last glaciation to the Holocene. The sub-alpine and alpine vegetation zones covered mainly with grass and bush on the lands around the southern South China Sea were probably the sources of black carbon. The altitudinal vegetation changes from the last glaciation to the Holocene gave rise to the changes of the sedimentary characteristics of black carbon. | Guodong Jia Ping’an Peng Guoying Sheng Jiamo Fu | 2000 | Chinese Science Bulletin2000，45，17： | 3 |
| 12 | Inhibition of the CDK9-cyclin T1 protein-protein interaction as a new approach against triple-negative breast cancer显示文摘Cyclin-dependent kinase 9(CDK9) activity is correlated with worse outcomes of triplenegative breast cancer(TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this protein-protein interaction(PPI) may offer promising avenues for selective CDK9 inhibition. Herein, we designed and generated a library of metal complexes bearing the 7-chloro-2-phenylquinoline CN ligand and tested their activity against the CDK9cyclin T1 PPI. Complex 1 bound to CDK9 via an enthalpically-driven binding mode, leading to disruption of the CDK9-cyclin T1 interaction in vitro and in cellulo. Importantly, complex 1 showed promising anti-metastatic activity against TNBC allografts in mice and was comparably active compared to cisplatin. To our knowledge, 1 is the first CDK9-cyclin T1 PPI inhibitor with anti-metastatic activity against TNBC. Complex 1 could serve as a new platform for the future design of more efficacious kinase inhibitors against cancer, including TNBC. | Sha-Sha Cheng Yuan-Qing Qu Jia Wu Guan-Jun Yang Hao Liu Wanhe Wang Qi Huang Feng Chen Guodong Li Chun-Yuen Wong Vincent Kam Wai Wong Dik-Lung Ma Chung-Hang Leung | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 13 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 14 | Partitioning tree water usage into storage and transpiration in a mixed forest显示文摘Background:Water migration and use are important processes in trees.However,it is possible to overestimate transpiration by equating the water absorbed through the plant roots to that diffused back to the atmosphere through stomatal transpiration.Therefore,it is necessary to quantify the water transpired and stored in plants.Method:The δ^(2)H/δ^(18)O technique and heat ratio method were used to explore the water usage of coniferous and broad-leaved tree species,including the proportions of water used for transpiration and water storage.Results:Platycladus orientalis and Quercus variabilis had strong plasticity in their water usage from different sources.Platycladus orientalis primarily used groundwater(30.5%)and the 60-100-cm soil layer(21.6%)throughout the experimental period and was sensitive to precipitation,absorbing water from the 0-20-cm layer(26.6%)during the rainy season.Quercus variabilis absorbed water from all sources(15.7%-36.5%)except from the 40-60-cm soil layer during the dry season.In addition,it did not change its water source but increased its groundwater uptake during the rainy season.The annual mean water fluxes of P.orientalis and Q.variabilis were 374.69 and 469.50 mm·year−1,with 93.49% and 93.91% of the water used for transpiration,respectively.However,nocturnal sap flow in P.orientalis and Q.variabilis was mainly used for water storage in the trunk rather than transpiration,which effectively alleviated drought stress and facilitated the transport of nutrients.Conclusions:The water stored in both species comprised 6%-7% of the total water fluxes and,therefore,should be considered in water balance models. | Ziqiang Liu Qianqian Liu Zijun Wei Xinxiao Yu Guodong Jia Jiang Jiang | 2021 | Forest Ecosystems2021，8，4： | 2 |
| 15 | Compound-specific hydrogen isotopes of long-chain n-alkanes extracted from topsoil under a grassland ecosystem in northern China显示文摘To investigate characteristics of H isotope variation in long-chain n-alkanes (δDn-alkanes) from higher plants in surface soils under a single ecosystem, 12 samples from a basalt regolith were randomly collected from Damaping in Wanquan County of Zhangjiakou in North China. Molecular distribution and C (δ13Cn-alkanes) and H isotopes of long-chain n-alkanes, as well as C isotopes of TOC (δ13CTOC), were analyzed. Both δ13CTOC and δ13Cn-alkanes values from four representative dominant long-chain n-alkanes (n-C27, n-C29, n-C31, n-C33) derived from terrestrial higher plants show minor variations among the 12 samples, indicating the major contributor is from local grasses with a uniform C3 photosynthetic pathway. In contrast, variations in δDn-alkanes values of the four long-chain n-alkanes are relatively large, with the more abundant homologs generally showing more negative δDn-alkanes values and less variation. However, variation of <30‰ among weighted averaged δDn-alkanes values of the four long-chain n-alkanes is not only less than that among δDn-alkanes values for different modern terrestrial C3 grasses from the specific locations, but also less than the literature values of δDn-alkanes of long-chain n-alkanes for single species over different seasons. Thus, because the sources of long-chain n-alkanes in surface soils and sediments are similarly from multiple individual plants, our results are significant in confirming that paleoclimatic, paleoenvironmental and paleohydrological information can be interpreted more accurately from δDn-alkanes values of long-chain n-alkanes from sediments, particularly terrestrial sediments with organic matter derived from in-situ plants. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong ZHANG Xiao WANG SuPing | 2011 | Science China Earth Sciences2011，54，12： | 2 |
| 16 | Detection and indication of 1,3,4-C27-29 triol in the sediment of northern South China Sea显示文摘After the detection of the 1,20,21-C_(29) long-chain triol in some sediments and freshwater pteridophytes, in this study, a new homologous long-chain triol, 1,3,4-C_(27-29), is detected for the first time in the Site4 B core sediment in the northern South China Sea. The hydroxyl location and length of the carbon chain of this newly discovered triol differ from those of 1,20,21-C_(29) triol. The test results of its molecular distribution and individual carbon isotope reveal that 1,3,4-C_(29) triol has a good correlation with n-C_(26-30) even carbon-numbered long-chain fatty alcohols, with R^2(n=68) values of 0.905, 0.929 and 0.903, respectively, and its carbon isotope composition, at –32.3‰±1.9‰, is similar to that of n-C_(26-30), at –29.13‰±0.87‰, –32.98‰±1.28‰, and –32.98‰±1.28‰. 1,3,4-C_(29) triol from the Site4 B core sediment and terrigenous long-chain fatty alcohol(n-C_(26-34)) show highly consistent distribution trends in the entire section; thus, the former could serve as a proxy indicator of the terrigenous input. Considering that the 1,20,21-C_(29) triol in previous research belongs to Azolla, which are fresh water pteridophytes, the 1,3,4-C_(27-29) triol identified in this study might have similar biogenetic derivation. Thus, determination of its biogenic area and growing environment could provide potential organic geochemical evidence supporting the terrigenous input and source in the northern South China Sea. | ZHU XiaoWei MAO ShengYi WU NengYou JIA GuoDong SUN YongGe GUAN HongXiang WU DaiDai | 2016 | Science China Earth Sciences2016，59，6： | 2 |
| 17 | Variation in water supply leads to different responses of tree growth to warming显示文摘Background:Global climate change,characterized by changes in precipitation,prolonged growing seasons,and warming-induced water deficits,is putting increased pressure on forest ecosystems globally.Understanding the impact of climate change on drought-prone forests is a key objective in assessing forest responses to climate change.Methods:In this study,we assessed tree growth trends and changes in physiological activity under climate change based on measurements of tree ring and stable isotopes.Additionally,structural equation models were used to identify the climate drivers influencing tree growth for the period 1957–2016.Results:We found that the mean basal area increment decreased first and then increased,while the water use efficiency showed a steady increase.The effects of climate warming on tree growth switched from negative to positive in the period 1957–2016.Adequate water supply,especially snowmelt water available in the early critical period,combined with an earlier arrival of the growing season,allowed to be the key to the reversal of the effects of warming on temperature forests.The analysis of structural equation models(SEM)also demonstrated that the growth response of Pinus tabuliformis to the observed temperature increase was closely related to the increase in water availability.Conclusions:Our study indicates that warming is not the direct cause of forest decline,but does indeed exacerbate droughts,which generally cause forest declines.Water availability at the beginning of the growing season might be critical in the adaptation to rising temperatures in Asia.Temperate forests may be better able to withstand rising temperatures if they have sufficient water,with boosted growth even possible during periods of rising temperatures,thus forming stronger carbon sinks. | Pengfei Zheng Dandan Wang Guodong Jia Xinxiao Yu Ziqiang Liu Yusong Wang Yonge Zhang | 2022 | Forest Ecosystems2022，9，1： | 2 |
| 18 | Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis显示文摘Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders that cause severe social,communication,and behavioral problems.Recent studies show that the variants of a histone methyltransferase gene KMT5B cause neurodevelopmental disorders(NDDs),including ASD,and the knockout of Kmt5b in mice is embryonic lethal.However,the detailed genotype-phenotype correlations and functional effects of KMT5B in neurodevelopment are unclear.By targeted sequencing of a large Chinese ASD cohort,analyzing published genome-wide sequencing data,and mining literature,we curated 39 KMT5B variants identified from NDD individuals.A genotype-phenotype correlation analysis for 10 individuals with KMT5B pathogenic variants reveals common symptoms,including ASD,intellectual disability,languages problem,and macrocephaly.In vitro knockdown of the expression of Kmt5b in cultured mouse primary cortical neurons leads to a decrease in neuronal dendritic complexity and an increase in dendritic spine density,which can be rescued by expression of human KMT5B but not that of pathogenic de novo missense mutants.In vivo knockdown of the Kmt5b expression in the mouse embryonic cerebral cortex by in utero electroporation results in decreased proliferation and accelerated migration of neural progenitor cells.Our findings reveal essential roles of histone methyltransferase KMT5B in neuronal development,prenatal neurogenesis,and neuronal migration. | Guodong Chen Lin Han Senwei Tan Xiangbin Jia Huidan Wu Yingting Quan Qiumeng Zhang Bin Yu Zhengmao Hu Kun Xia Hui Guo | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 19 | Construction of theVero cell culture system that can produce infectious HCV par-ticles显示文摘 | Guo Jia Yan Ran Xu Guodong | 2009 | Mol Biol Rep2009，36，： | 1 |
| 20 | Construction of the Vero cell culture system that can produce infectious HCV particles显示文摘 | Jia Guo Ran Yan Guodong Xu Weiyun Li Congyi Zheng | 2009 | Molecular Biology Reports2009，，1： | 1 |
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