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| 1 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 2 | New progress of microbial prospecting of oil and gas in China:Taking the Satellite Oilfield in Daqing as an example显示文摘The Microbial Prospecting of Oil and Gas(MPOG) is applied to the matured development area in the Satellite Oilfield in Daqing for the first time. And with the MPOG,the hydrocarbon accumulation regulation controlled by faults is interpreted,and the matured development area is extended out to western part. At the same time,four microbial anomalies are discovered. The MPOG results were verified by the hydrocarbon-bearing conditions of the 10 drilled wells within the following half a year,and the consistent rate is up to 80%,which add about 300×104 t of the explored petroleum-in-place. Through study and successful application of MPOG to the Satellite Oilfield,the basis of the application from the exploration to development field is substantially established,and standard system of microbial anomaly is more precisely built for the Satellite Oilfield,which provided an effective explanatory item for the studied and adjacent region,even for the whole Songliao Basin,and also a new technique for complicated reservoirs,especially for the later stage development of litho-reservoirs in China. Therefore,it must have profound influence upon the oil and gas exploration,especially upon the remaining oil,extension and reserves addition of the developed area in China. | YUAN ZhiHua1,ZHANG YuQing1,ZHAO Qing1,JIANG HuFu2,LIU YunYan2,LUO ZhongHua2,LI Xue1,WANG ShiTou1,LI Bo1,PAN GuoHui2,GAO XingYou2 & ZHANG GuoLiang2 1 Geochemistry Department of Yangtze University,Key Laboratory of Oil & Gas Resource and Exploration Technique of Ministry of Education of China,Jingzhou 434023,China 2 The 8th Oil Recovery Plant of Daqing Oilfield Co. Ltd.,PetroChina,Daqing 163515,China | 2009 | Science China Earth Sciences2009，52，S1： | 5 |
| 3 | DYNAMICS OF AN HIV-1 INFECTION MODEL WITH CELL-MEDIATED IMMUNE RESPONSE AND STOCHASTIC PERTURBATION显示文摘 | CHUNYAN JI DAQING JIANG | 2012 | International Journal of Biomathematics2012，5，5： | 4 |
| 4 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 5 | Quantitative studies of hydrocarbon loss of the Silurian bitumen sandstone in the Tarim Basin显示文摘The evolution of Tarim Basin experienced several tectonic movements,of which Caledonian movement caused a serious damage to reservoirs of Silurian. The earlier reservoirs size and the later hydrocarbon loss are two key factors to exploration prospect of Silurian. On the basis of net thickness of bituminous sandstone and recovery coefficient of crude oil converting to bitumen,the scale of the hydrocarbon loss of palaeo-accumulation in bitumen sandstone of Silurian was calculated (86.30×108t). The deter-mination of net thickness of bitumen sandstone was completed mainly by several methods,such as physical property demarcation,observing lithology,grains with oil inclusion (GOI) technology,and quantitative grains fluorescence (QGF) technology. The samples of black sandstone and white sand-stone were collected and compared by means of the methods mentioned above. The results showed that there was little hydrocarbon,or none,in the white sandstone. The recovery coefficient was ob-tained by the analyses of plentiful physical parameters of crude oil and bitumen sandstone,based on the hypothesis that nonhydrocarbon compounds and bitumen were invariable in the process of bitu-men forming. The calculated result,which is more scientific and actual,indicates the exploration pros-pect is more promising in Silurian of the Tarim Basin. | JIANG ZhenXue1,2,PANG XiongQi1,2,LIU LuoFu1,2,WANG XianDong3,ZHANG Jun4 & LI HongYi1,2 1 Basin and Reservoir Research Center,China University of Petroleum,Beijing 102249,China 2 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 3 Research Institute of Exploration and Development,Daqing Oilfield Company Ltd,Daqing 163712,China 4 Petroleum Exploration and Production Institute of SINOPEC,Beijing 100083,China | 2008 | Science China Earth Sciences2008，51，S2： | 3 |
| 6 | ANALYSIS OF A PREDATOR-PREY MODEL WITH DISEASE IN THE PREY显示文摘 | CHUNYANJI DAQING JIANG | 2013 | International Journal of Biomathematics2013，6，3： | 3 |
| 7 | A FINITE ELEMENT AND BOUNDARY ELEMENT METHOD OF NUMERICAL SIMULATION OF TWO DIMENSIONAL AND TWO PHASE FLOW显示文摘AFINITEELEMENTANDBOUNDARYELEMENTMETHODOFNUMERICALSIMULATIONOFTWODIMENSIONALANDTWOPHASEFLOWFanJiang;QuDe-bin;ZhangZi-xiang(Qin... | Fan Jiang Qu De-bin Zhang Zi-xiang (Qinhuangdao Branch of Daqing Petroleum Institute, Qinhuangdao 066000, P. R. China) | 1994 | Journal of Hydrodynamics1994，6，4： | 2 |
| 8 | Double-peak ageing behavior of Mg–2Dy–0.5Zn alloy显示文摘 | Guangli Bi Daqing Fang Lei Zhao Qingxin Zhang Jianshe Lian Qing Jiang Zhonghao Jiang | 2011 | Journal of Alloys and Compounds2011，，32： | 2 |
| 9 | Asymptotic behavior of global positive solution to a stochastic SIR model显示文摘 | Daqing Jiang Jiajia Yu Chunyan Ji Ningzhong Shi | 2011 | Mathematical and Computer Modelling2011，，1： | 2 |
| 10 | Dynamics of stochastic predator-prey models with distributed delay and stage structure for prey显示文摘In this paper,we analyze two stochastic predator-prey models with distributed delay and stage structure for prey.For the nonautonomous periodic case of the model,by using Khasminskii’s theory of periodic solution,we show that the system has at least one positive T-periodic solution.For the model which is disturbed by both white and telegraph noises,we obtain sufficient criteria for positive recurrence of the solutions to the model by constructing a suitable stochastic Lyapunov function with regime switching.The positive recurrence implies that both prey and predator populations will be persistent in the long term. | Qun Liu Daqing Jiang Tasawar Hayat | 2021 | International Journal of Biomathematics2021，14，4： | 2 |
| 11 | The ergodicity and extinction of stochastically perturbed SIR and SEIR epidemic models with saturated incidence显示文摘 | Qingshan Yang Daqing Jiang Ningzhong Shi Chunyan Ji | 2011 | Journal of Mathematical Analysis and Applications2011，，1： | 2 |
| 12 | Global stability and stochastic permanence of a non-autonomous logistic equation with random perturbation显示文摘 | Daqing Jiang Ningzhong Shi Xiaoyue Li | 2007 | Journal of Mathematical Analysis and Applications2007，，1： | 2 |
| 13 | Analysis of a Predator-prey Model with Modified Leslie-Gower and Holling-type II Schemes with Stochastic Perturbation显示文摘 | Chunyan Ji Daqing Jiang Ningzhong Shi | 2009 | J Math Anal Appl2009，359，： | 1 |
| 14 | Qualitative analysis of a stochastic ratio-dependent predator–prey system显示文摘 | Chunyan Ji Daqing Jiang Xiaoyue Li | 2010 | Journal of Computational and Applied Mathematics2010，，5： | 1 |
| 15 | The threshold of a stochastic SIS epidemic model with vaccination显示文摘 | ZHAO Yanan JIANG Daqing | 2014 | Applied Mathematics and Computation2014，243，： | 1 |
| 16 | A monotone method for constructing extremal solution to fourth-order periodic boundary value problems显示文摘 | Jiang Daqing Gao Wenjie Wang Aying | 2002 | Appl Math & Comput2002，132，4： | 1 |
| 17 | Analysis of a predator–prey model with modified Leslie–Gower and Holling-type II schemes with stochastic perturbation显示文摘 | Chunyan Ji Daqing Jiang Ningzhong Shi | 2009 | Journal of Mathematical Analysis and Applications2009，，2： | 1 |
| 18 | The extinction and persistence of the stochastic SIS epidemic model with vaccination显示文摘 | ZHAO Yanan JIANG Daqing O'Regan Donal | 2013 | Physica A Statistical Mechanics and its Applications2013，392，： | 1 |
| 19 | Stationary distribution of the stochastic SIS epidemic model with vaccination显示文摘 | LIN Yuguo JIANG Daqing WANG Shuai | 2014 | Physica A Statistical Mechanics and its Applications2014，394，： | 1 |
| 20 | Periodic boundary value problems and periodic solutions of second order FDE with upper and lower solutions显示文摘 | Wenjie Zuo Peixuan Weng Daqing Jiang | 2006 | Southeast Asian Bulletin of Mathematics2006，30，： | 1 |
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