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| 1 | Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination:Successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface显示文摘Coronavirus disease 2019(COVID-19)pandemic has spread in 220 countries/regions towreak havoc to human beings around theworld.At present,the second wave of COVID-19 has begun in many European countries.The complete control of COVID-19 is very urgent.Although China quickly brought the virus under control,there have been eight sporadic outbreaks in China since then.Both in Xinfadi of Beijing and Dalian outbreak of COVID-19,environmental swab samples related to imported cold chain food were tested nucleic acid positive for SARS-CoV-2.In this outbreak in Qingdao,we directly isolated SARS-CoV-2 from the cod outer package's surface swab samples.This is the first time worldwide,SARS-CoV-2 were isolated from the imported frozen cod outer package's surface,which showed that imported frozen food industry could import SARS-CoV-2 virus. | Peipei Liu Mengjie Yang Xiang Zhao Yuanyuan Guo Liang Wang Jing Zhang Wenwen Lei Weifang Han Fachun Jiang William J.Liu George F.Gao Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 41 |
| 2 | Effects of different mixing ratios on emissions from passenger cars fueled with methanol/gasoline blends显示文摘Regulated and unregulated emissions from four passenger cars fueled with methanol/gasoline blends at different mixing ratios (M15,M20,M30,M50,M85 and M100) were tested over the New European Driving Cycle (NEDC).Volatile organic compounds (VOCs) were sampled by Tenax TA and analyzed by thermal desorption-gas chromatograph/mass spectrometer (TD-GC/MS).Carbonyls were trapped on dinitrophenylhydrazine (DNPH) cartridges and analyzed by high performance liquid chromatography (HPLC).The results showed that total emissions of VOCs and BTEX (benzene,toluene,ethylbenzene,p,m,o-xylene) from all vehicles fueled with methanol/gasoline blends were lower than those from vehicles fueled with only gasoline.Compared to the baseline,the use of M85 decreased BTEX emissions by 97.4%,while the use of M15 decreased it by 19.7%.At low-to-middle mixing ratios (M15,M20,M30 and M50),formaldehyde emissions showed a slight increase while those of high mixing ratios (M85 and M100) were three times compared with the baseline gasoline only.When the vehicles were retrofitted with new three-way catalytic converters (TWC),emissions of carbon monoxide (CO),total hydrocarbon (THC),and nitrogen oxides (NOx) were decreased by 24%-50%,10%-35%,and 24%-58% respectively,compared with the cars using the original equipment manufacture (OEM) TWC.Using the new TWC,emissions of formaldehyde and BTEX were decreased,while those of other carbonyl increased.It is necessary that vehicles fueled with methanol/gasoline blends be retrofitted with a new TWC.In addition,the specific reactivity of emissions of vehicles fueled with M15 and retrofitted with the new TWC was reduced from 4.51 to 4.08 compared to the baseline vehicle.This indicates that the use of methanol/gasoline blend at a low mixing ratio may have lower effect on environment than gasoline. | Hong Zhao Yunshan Ge Jianwei Tan Hang Yin Jiadong Guo Wei Zhao Peipei Dai | 2011 | Journal of Environmental Sciences2011，23，11： | 12 |
| 3 | Two new free-living nematode species (Comesomatidae) from the mangrove wetlands in Fujian Province, China显示文摘Two new free-living marine nematode species from the mangrove wetlands of Fujian Province,China are identified and illustrated.Sabatieria conicoseta sp.nov.is characterized by its short conical somatic setae.There are 12–15 tubular pre-cloacal supplements and 12–15μm long straight gubernacular apophyses.Dorylaimopsis papilla sp.nov.is characterized by spicules which are 1.5–1.8 a.b.d.long with media cuticularized strip along entire spicules,and have a cephalated proximal end with small hooked.There are 16–18 small papillate precloacal supplements and 37–40μm long dorso-caudal gubernacular apophyses. | GUO Yuqing CHANG Yu YANG Peipei | 2018 | Acta Oceanologica Sinica2018，37，10： | 8 |
| 4 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 5 | Skin collagen fiber-based radar absorbing materials显示文摘By using skin collagen fiber (CF) as raw material,Schiff base structure containing CF (Sa-CF) was synthesized through CF-salicylaldehyde reaction.Then a novel radar absorbing material (Fe-Sa-CF) was prepared by chelating reaction between Sa-CF and Fe 3+.The coaxial transmission and reflection method was used to analyze the complex permittivity and complex magnetic permeability of these CF-based materials,and the radar cross section (RCS) method was used to investigate their radar absorbing properties in the frequency range of 1.0-18.0 GHz.Experimental results indicated that the conductivity of CF increased from initial 1.08×10-11 to 2.86×10-6 S/cm after being transferred into Fe-Sa-CF,and its dielectric loss tangent (tanδ) in the frequency range of 1.0-17.0 GHz also increased.These facts suggest that the Fe-Sa-CF is electric-loss type radar absorbing material.In the frequency range of 3.0-18.0 GHz,Sa-CF (1.0 mm in thickness) exhibited somewhat radar absorbing property with maximum radar reflection loss (RL) of-4.73 dB.As for Fe-Sa-CF,the absorbing bandwidth was broadened,and the absorbing intensity significantly increased in the frequency range of 1.0-18.0 GHz where a maximum radar RL of-9.23 dB was observed.In addition,the radar absorbing intensity of Fe-Sa-CF can be further improved by increasing membrane thickness.When the thickness reached to 2.0 mm,the RL values of Fe-Sa-CF were-15.0-18.0 dB in the frequency range of 7.0-18.0 GHz.Consequently,a kind of novel radar absorbing material can be prepared by chemical modification of collagen fiber,which is characterized by thin thickness,low density,broad absorption bandwidth and high absorption intensity. | LIU YiShan HUANG Xin GUO PeiPei LIAO XuePin SHI Bi | 2011 | Chinese Science Bulletin2011，56，2： | 5 |
| 6 | Urban Plant Diversity in Relation to Land Use Types in Built-up Areas of Beijing显示文摘Urban plants provide various ecosystem services and biodiversity for human well-being. It is necessary to examine the plant species and functional traits composition and the influencing factors. In this study, a field survey was conducted using the tessellation-randomized plot method to assess the plant species and functional traits variability in greenspaces across eight land use types(LUTs) in the built-up areas of Beijing, China. Results showed that the woody plants in the built-up areas of Beijing comprised 85 non-native species(57%), 21 pollen-allergenic species(14%), and 99 resistant species(67%). Residential areas, community parks and institutional areas had higher woody plant species richness than other LUTs. Native and extralimital native species were more widespread than exotic species. Proportions of species with resistances were low except for cold-and drought-resistance; consequently, a high intensity of management and maintenance is essential for survival of plants in this urban area. Caution should be exerted in selecting plant species with resistance to harsh conditions in different LUTs. Housing prices, distances from the urban center, years since the establishment of LUTs and greening rate were strongly correlated with the plant functional traits and species diversity. Urban forest managers should consider plant functional traits and LUT-specific strategies to maximize both forest and human health. | GUO Peipei SU Yuebo WAN Wuxing LIU Weiwei ZHANG Hongxing SUN Xu OUYANG Zhiyun WANG Xiaoke | 2018 | Chinese Geographical Science2018，28，1： | 4 |
| 7 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 8 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 9 | Analysis on Collapse Strength of Casing Wear显示文摘Carrying capacity of the casing will reduce after the casing is worn, which seriously affects the subsequent well drilling, well completion, oil extraction and well repair. A lot of researches on calculation of casing wear collapse strength have been done, but few of them focus on collapsing failure mechanism, and influencing factors and law of collapse strength. So, significant difference between estimated value and actual value of collapse strength comes into being. By theoretical analysis, numerical simulation and actual test, the collapsing failure mechanism of casing wear as well as the influencing factors and laws of collapse strength are investigated, and the investigation results show that collapse of crescent casing wear belongs to 'three hinged' instability. The severely-worn position on the casing is yielded into the plastic zone first then deformed greatly, which causes the plastic instability of the whole structure. The casing wear collapse strength presents changes of exponent, power function and linear trend with the residual casing wall thickness, wear radius and axial load, respectively. When the flexibility is less than 10°/30 m, the borehole bending has less impact on casing collapse strength. Thus, the computation model for the casing wear collapsing strength is established by introducing wear radius coefficient and casing equivalent yield strength, at the same time, the model is tested. The test results show that the relative error for the computation model is less than 5%. The research results provide a basis for design of the casing string strength and evaluation of down-hole safety. | LIANG Erguo LI Zifeng HAN Yong LI Guoqin GUO Peipei | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 3 |
| 10 | Molecular basis for ligand activation of the human KCNQ2 channel显示文摘The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy,pain and several other diseases related to neuronal hyper-excitability.A list of synthetic compounds have been developed to directly activate KCNQ2,yet our knowledge of their activation mechanism is limited,due to lack of high-resolution structures.Here,we report cryo-electron microscopy(cryo-EM)structures of the human KCNQ2 determined in apo state and in complex with two activators,ztz240 or retigabine,which activate KCNQ2 through different mechanisms.The activator-bound structures,along with electrophysiology analysis,reveal that ztz240 binds at the voltage-sensing domain and directly stabilizes it at the activated state,whereas retigabine binds at the pore domain and activates the channel by an allosteric modulation.By accurately defining ligand-binding sites,these KCNQ2 structures not only reveal different ligand recognition and activation mechanisms,but also provide a structural basis for drug optimization and design. | Xiaoxiao Li Qiansen Zhangc Peipei Guo Jie Fu Lianghe Mei Dashuai Lv Jiangqin Wang Dongwu Lai Sheng Ye Huaiyu Yang Jiangtao Guo | 2021 | Cell Research2021，31，1： | 3 |
| 11 | Interface science in polymer-based composite solid electrolytes in lithium metal batteries显示文摘Solid-state lithium metal batteries(SSLMBs)have attracted considerable attention as one of the most promising energy storage systems owing to their high safety and energy density.Solid electrolytes,particularly polymer-based composite solid electrolytes(CSEs),are considered promising electrolyte candidates for SSLMBs.However,theirwide application is inhibited by various electrochemical issues,such as low ionic conductivity,the growth of lithium dendrites,and poor cycling stability,which are related to interface issues within SSLMBs.In this review,the parameters related to various interfaces in the CSE of SSLMBs,including the interfaces between the polymer matrix and inorganic fillers,between the CSEs and the cathode,and between the CSEs and the lithium metal anode,are examined.Relevant issues and corresponding remediation strategies are proposed.Finally,future perspectives based on interfacial engineering and the characterization of polymer/inorganic filler interactions are proposed for building high-performance CSEs for use in SSLMBs. | Lingqiao Wu Yongtao Wang Xianwei Guo Peipei Ding Zhiyuan Lin Haijun Yu | 2022 | SusMat2022，2，3： | 2 |
| 12 | An Organic Solvent-Assisted Intercalation and Collection (OAIC) for Ti_(3)C_(2)T_(x) MXene with Controllable Sizes and Improved Yield显示文摘A good method of synthesizing Ti_(3)C_(2)T_(x)(MXene)is critical for ensuring its success in practical applications,e.g.,electromagnetic interference shielding,electrochemical energy storage,catalysis,sensors,and biomedicine.The main concerns focus on the moderation of the approach,yield,and product quality.Herein,a modified approach,organic solvent-assisted intercalation and collection,was developed to prepare Ti_(3)C_(2)T_(x) flakes.The new approach simultaneously solves all the concerns,featuring a low requirement for facility(centrifugation speed<4000 rpm in whole process),gram-level preparation with remarkable yield(46.3%),a good electrical conductivity(8672 S cm^(−1)),an outstanding capacitive performance(352 F g^(−1)),and easy control over the dimension of Ti_(3)C_(2)T_(x) flakes(0.47–4.60μm^(2)).This approach not only gives a superb example for the synthesis of other MXene materials in laboratory,but sheds new light for the future mass production of Ti_(3)C_(2)T_(x) MXene. | Danyao Qu Yingying Jian Lihao Guo Chen Su Ning Tang Xingmao Zhang Wenwen Hu Zheng Wang Zhenhuan Zhao Peng Zhong Peipei Li Tao Du Hossam Haick Weiwei Wu | 2021 | Nano-Micro Letters2021，13，11： | 2 |
| 13 | Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish显示文摘To decode biological processes,interfering with gene functions is a widely used strategy.There are a number of ways to interfere with gene functions.For instance,small interfering RNAs(siRNAs)are used to induce mRNA degradation;morpholinos are used to block protein translation(Nasevicius and Ekker,2000);CRISPR interference/inactive CRISPR-associated 9 nuclease(CRISPR-i/dCas9)is used to block mRNA transcription(Qi et al.,2013); | Peipei Zhu Zhipeng Ma Liwei Guo Wei Zhang Qinghe Zhang Ting Zhao Kunpeng Jiang Jinrong Peng Jun Chen | 2017 | Journal of Genetics and Genomics2017，44，11： | 2 |
| 14 | Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis显示文摘Background:Spermatogenesis is the process by which male gametes are formed from spermatogonial stem cells and it is essential for the reliable transmission of genetic information between generations.To date,the dynamic transcriptional changes of defined populations of male germ cells in pigs have not been reported.Results:To characterize the atlas of porcine spermatogenesis,we profiled the transcriptomes of~16,966 testicular cells from a 150-day-old pig testis through single-cell RNA-sequencing(scRNA-seq).The scRNA-seq analysis identified spermatogonia,spermatocytes,spermatids and three somatic cell types in porcine testes.The functional enrichment analysis demonstrated that these cell types played diverse roles in porcine spermatogenesis.The accuracy of the defined porcine germ cell types was further validated by comparing the data from scRNA-seq with those from bulk RNA-seq.Since we delineated four distinct spermatogonial subsets,we further identified CD99 and PODXL2 as novel cell surface markers for undifferentiated and differentiating spermatogonia,respectively.Conclusions:The present study has for the first time analyzed the transcriptome of male germ cells and somatic cells in porcine testes through scRNA-seq.Four subsets of spermatogonia were identified and two novel cell surface markers were discovered,which would be helpful for studies on spermatogonial differentiation in pigs.The datasets offer valuable information on porcine spermatogenesis,and pave the way for identification of key molecular markers involved in development of male germ cells. | Lingkai Zhang Fuyuan Li Peipei Lei Ming Guo Ruifang Liu Ling Wang Taiyong Yu Yinghua Lv Tao Zhang Wenxian Zeng Hongzhao Lu Yi Zheng | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 15 | Bentonite Reinforced Tough Composite Hydrogels as Potential Artificial Articular Cartilage显示文摘 | LU Xueting FENG Wei WANG Honglei HU Qianqian GUAN Shuang GUO Peipei | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 16 | MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation显示文摘 | Xiaorong Zhang Xinxin Zuo Bo Yang Zongran Li Yuanchao Xue Yu Zhou Jie Huang Xiaolu Zhao Jie Zhou Yun Yan Huiqiong Zhang Peipei Guo Hui Sun Lin Guo Yi Zhang Xiang-Dong Fu | 2014 | Cell2014，，： | 1 |
| 17 | Probing Molecular Frame Wigner Time Delay and Electron Wavepacket Phase Structure of CO Molecule显示文摘The time delay of photoelectron emission serves as a fundamental building block to understand the ultrafast electron emission dynamics in strong-field physics.Here,we study the photoelectron angular streaking of CO molecules by using two-color(400+800nm)corotating circularly polarized fields.By coincidently measuring photoelectrons with the dissociative ions,we present molecular frame photoelectron angular distributions with respect to the instantaneous driving electric field signatures.We develop a semiclassical nonadiabatic molecular quantum-trajectory Monte Carlo(MO-QTMC)model that fully captures the experimental observations and further ab initio simulations.We disentangle the orientation-resolved contribution of the anisotropic ionic potential and the molecular orbital structure on the measured photoelectron angular distributions.Furthermore,by analyzing the photoelectron interference patterns,we extract the sub-Coulomb-barrier phase distribution of the photoelectron wavepacket and reconstruct the orientation-and energy-resolved Wigner time delay in the molecular frame.Holographic angular streaking with bicircular fields can be used for probing polyatomic molecules in the future. | Zhenning Guo Peipei Ge Yiqi Fang Yankun Dou Xiaoyang Yu Jiguo Wang Qihuang Gong Yunquan Liu | 2022 | Ultrafast Science2022，，2： | 1 |
| 18 | A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury显示文摘 | Yan Wu Yan-Ping Wang Peipei Guo Xi-Hong Ye Jie Wang Shi-Ying Yuan Shang-Long Yao You Shang | 2012 | Journal of Molecular Neuroscience2012，，3： | 1 |
| 19 | Fengycin produced by Bacillus subtilis NCD-2 plays a major role in biocontrol of cotton seedling damping-off disease显示文摘 | Qinggang Guo Weixin Dong Shezeng Li Xiuyun Lu Peipei Wang Xiaoyun Zhang Ye Wang Ping Ma | 2013 | Microbiological Research2013，，： | 1 |
| 20 | Strong-field photoionization of intense laser fields by controlling optical singularities显示文摘The spatial features of a light field, such as in the form of the optical singularities, provide a new degree of freedom for the application of light fields in different areas of science and technology. However, although the exploration of structured light is growing rapidly, the investigation of strong-field photoionization using such light fields is noticeably lagging behind. Here, we present an experimental study that reveals the signatures of intense, structured light fields with controlled optical singularities in strong-field photoionization. The different types of optical singularities can be identified through photoionization observables,i.e., photoelectron momentum distributions(PMDs). By concurrently shifting the locations of the phase and polarization singularities, the focal electric field features can be designated, and subsequently, the photoionization appearances can be manipulated. In this process, the behaviors of the different intense optical singularities are clearly visualized by the PMDs. This work will advance both the strong-field science and singularity optics. | Yiqi Fang Zhenning Guo Peipei Ge Xueyan Ma Meng Han Xiaoyang Yu Yongkai Deng Qihuang Gong Yunquan Liu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，7： | 1 |
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