|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel Method for Spatial Angle Measurement Based on Rotating Planar Laser Beams显示文摘Spatial angle measurement,especially the measurement of horizontal and vertical angle,is a basic method used for industrial large-scale coordinate measurement.As main equipments in use,both theodolites and laser trackers can provide very high accuracy for spatial angle measurement.However,their industrial applications are limited by low level of automation and poor parallelism.For the purpose of improving measurement efficiency,a lot of studies have been conducted and several alternative methods have been proposed.Unfortunately,all these means are either low precision or too expensive.In this paper,a novel method of spatial angle measurement based on two rotating planar laser beams is proposed and demonstrated.Photoelectric receivers placed on measured points are used to receive the rotating planner laser signals transmitted by laser transmitters.The scanning time intervals of laser planes were measured,and then measured point's horizontal/vertical angles can be calculated.Laser plane's angle parameters are utilized to establish the abstract geometric model of transmitter.Calculating formulas of receiver's horizontal/vertical angles have been derived.Measurement equations' solvability conditions and judgment method of imaginary solutions are also presented after analyzing.Proposed method for spatial angle measurement is experimentally verified through a platform consisting of one laser transmitter and one optical receiver.The transmitters used in new method are only responsible for providing rotating light plane signals carrying angle information.Receivers automatically measure scanning time of laser planes and upload data to the workstation to calculate horizontal angle and vertical angle.Simultaneous measurement of multiple receivers can be realized since there is no human intervention in measurement process.Spatial angle measurement result indicates that the repeatable accuracy of new method is better than 10'.Proposed method can improve measurement's automation degree and speed while ensuring measurement accuracy. | YANG Linghui YANG Xueyou ZHU Jigui DUAN Muqiong LAO Dabao | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 18 |
| 2 | Electron-withdrawing functional ligand promotes CO2 reduction catalysis in single atom catalyst显示文摘Electrochemical carbon dioxide reduction reaction (CO2RR) powered by renewable electricity offers an attractive approach to reduce carbon emission and at the same time produce valuable chemicals/fuels.To design efficient CO2 reduction electrocatalyst,it is important to understand the structure-activity relationship.Herein,we design a series of single Co atoms electrocatalysts with well-defined active sites electronic structures,which exhibit outstanding CO2RR activity with controllable selectivity to CO.Experimental and density functional theory (DFT) calculation studies show that introducing nitro (amino) ligand next to single Co atom catalytic center with electron-withdrawing (electron-donating) capability favors (hinders) CO2 reduction catalysis.This work provides an in-depth understanding of how functional ligand affects the splitting of transition metal 3d electron orbital,thereby changing the electron transfer from transition metal active site to CO2,which is closely related to the Gibbs free energy of the rate-determining step (CO2+e^-+*→*CO2^-). | Xinyi Ren Song Liu Huicong Li Jie Ding Linghui Liu Zhichong Kuang Ling Li Hongbin Yang Fuquan Bai Yanqiang Huang Tao Zhang Bin Liu | 2020 | Science China Chemistry2020，63，12： | 3 |
| 3 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 4 | Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling显示文摘The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen. | Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 5 | Extracting sparse error of robust PCA for face recognition in the presence of varying illumination and occlusion显示文摘 | Xiao Luan Bin Fang Linghui Liu Weibin Yang Jiye Qian | 2014 | Pattern Recognition2014，，2： | 1 |
| 6 | Full-field analysis of shear test on 3D orthogonal woven C/C composites显示文摘 | Lijun Qin Zhongwei Zhang Xiaofeng Li Xiaoguang Yang Zhihai Feng Yang Wang Hong Miao Linghui He Xinglong Gong | 2011 | Composites Part A2011，，2： | 1 |
| 7 | A Programmable Hybrid DNA Nanogel for Enhanced Photodynamic Therapy of Hypoxic Glioma显示文摘Photodynamic therapy(PDT)is a promising cancer therapy due to the evident advantages of a rapid curative eff ect,minimal or non-invasiveness,and circumvention of drug resistance.However,the hydrophobicity of photosensitizers and the hypoxic tumor microenvironment in solid tumors reduce the therapeutic eff ect of PDT immensely.Herein,we construct a programmable hybrid mesoporous silica nanoparticle/DNA nanogel(H-DNA nanogel)for enhanced PDT.The H-DNA nanogel is constituted with a virus-like mesoporous silica nanoparticle(VMSN)as the core to provide an appropriate nano-interface and a self-assembly programmable DNA hydrogel layer based on rolling circle amplifi cation(RCA)as the shell.Two kinds of G-quadruplex structures inserted with a hemin and zinc phthalocyanine(ZnPc)photosensitizer are introduced into the H-DNA nanogel by base pairing.The two modules of G-quadruplex structure work as an oxygen supplement in the hypoxic tumor microenvironment and increase the yield of singlet oxygen,respectively.Our hybrid DNA nanogel system provides a modular platform for effi cient cancer PDT and has great potential in the broader biomedical fi eld. | Ye Yuan Huiting Zhao Yunhua Guo Jianpu Tang Chunxia Liu Linghui Li Chi Yao Dayong Yang | 2020 | Transactions of Tianjin University2020，26，6： | 1 |
| 8 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
| 9 | Brain injury due to acute organophosphate poisoning Magnetic resonance imaging manifestation and pathological characteristics显示文摘BACKGROUND: Acute organophosphate poisoning can cause injuries of multiple visceras; especially, central nervous system injury can increase risk factors of patients with severe acute organophosphate poisoning. An application of modern image may increase diagnostic rate of brain injury in an earlier period and provide evidences for clinical treatment. OBJECTIVE: To reveal imaging manifestations, pathological characteristics and multi-ways injured mechanism of brain injury due to acute organophosphate poisoning. DESIGN: Contrast observational study. SETTING: Department of Medical Image, the Second Hospital of Hebei Medical University. MATERIALS: The experiment was carried out in the Department of Nerve Molecule Imaging Medicine and Laboratory of Neurology, the Second Hospital of Hebei Medical University from August 2003 to February 2004. A total of 30 healthy cats weighing 2.8–3.5 g and of both genders were selected from Animal Experimental Center of Hebei Medical University. METHODS: Thirty healthy cats were randomly divided into control group (n =5) and intoxication group (n =25). Cats in the control group were subcutaneously injected with 0.3 mL/kg saline at four points; while, cats in the intoxication group were subcutaneously injected with 400 g/L 0.3 mL/kg O,O-dimethyl-S-(methoxycarbonylmethyl) thiophosphate at four points. Two minutes after intoxication, cats received muscular injection with 0.5 mg/kg atropine sulfate, and then, brain tissues were collected from parietal lobe, basal ganglia, hippocampus, cerebellum and brain stem were observed at 3, 6, 24 hours, 3 and 7 days after intoxication respectively under optic microscope and electron microscope and expressions of acetylcholinesterase (AChE), choline acetyltransferase (ChAT), glial fibrillary acidic protein (GFAP), glutamic acid (Glu) and γ-amino butyric acid after immunohistochemical staining. MAIN OUTCOME MEASURES: Results of MRI examinations; histological changes under optic microscope and electron microscope; expressions of AChE, ChAT, GFAP, Glu and γ-amino butyric acid after immunohistochemical staining. RESULTS: All 30 healthy cats were involved in the final analysis. ① Imaging and pathological observation: Image manifestations of brain injury induced by acute organophosphate poisoning showed as cerebral edema and symmetry signal abnormality of bilateral basal ganglia; while, pathological manifestations also showed as cerebral edema. ② Observation of immunohistochemical staining: As compared with the control group, after organophosphate poisoning, area of AChE immune-positive cells was decreased obviously (P < 0.01), but area of ChAT immune-positive cells was not changed (P > 0.05); in addition, positive cells of GFAP were increased remarkably (P < 0.01), positive cells of γ-amino butyric acid in cerebral cortex were increased obviously (P < 0.05), but numbers of positive cells of Glu were not changed (P < 0.05). CONCLUSION: Multi-ways injured mechanism invovled in acute organophosphate poisoning. An application of modern image can increase diagnostic rate of brain injury in an earlier period and provide evidences for clinical treatment. | Huaijun Liu Yanmei Yang Jiping Yang Linghui Meng | 2007 | Neural Regeneration Research2007，2，7： | 1 |
| 10 | Optical Frequency Comb Frequency-division Multiplexing Dispersive Interference Multichannel Distance Measurement显示文摘An optical frequency comb(OFC)frequency-division multiplexing dispersive interference multichannel distance measurement method is proposed.Based on the OFC dispersive interference,the wide OFC spectrum is divided into multiple channels using a wavelength-division multiplexer.Under the existing light source and spectrometer,a single interference system can realize six channels of the high-precision parallel absolute distance measurement.The influence of the spectrum width and shape on the performance of the distance measurement channel is analyzed.The ranging accuracy of six channels is higher than±4μm under the optimization of a nonuniform discrete Fourier transform and Hanning window. | Xu Liang Tengfei Wu Jiarui Lin Linghui Yang Jigui Zhu | 2023 | Nanomanufacturing and Metrology2023，6，1： | 1 |
| 11 | Mg2+-Triggered and pH-Tuned in vitro Assembly of Trehalose-6-Phosphate Synthase显示文摘 | ZHANG Shanshan YANG Fan ZHANG Yuping LIU Zaiman YU Linghui CHEN Ximing XIAO Jianxi | 2018 | Wuhan University Journal of Natural Sciences2018，23，5： | 0 |
| 12 | TKCA:a timely keystroke-based continuous user authentication with short keystroke sequence in uncontrolled settings显示文摘Keystroke-based behavioral biometrics have been proven effective for continuous user authentication.Current state-of-the-art algorithms have achieved outstanding results in long text or short text collected by doing some tasks.It remains a considerable challenge to authenticate users continuously and accurately with short keystroke inputs collected in uncontrolled settings.In this work,we propose a Timely Keystroke-based method for Continuous user Authentication,named TKCA.It integrates the key name and two kinds of timing features through an embedding mechanism.And it captures the relationship between context keystrokes by the Bidirectional Long Short-Term Memory(Bi-LSTM)network.We conduct a series of experiments to validate it on a public dataset-the Clarkson II dataset collected in a completely uncontrolled and natural setting.Experiment results show that the proposed TKCA achieves state-of-the-art performance with 8.28%of EER when using only 30 keystrokes and 2.78%of EER when using 190 keystrokes. | Lulu Yang Chen Li Ruibang You Bibo Tu Linghui Li | 2021 | Cybersecurity2021，4，1： | 0 |
| 13 | Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells显示文摘Background:Diminished sensitivity towards chemotherapy remains the major impediment to the clinical treatment of bladder cancer.However,the critical elements in control of chemotherapy resistance remain obscure.Methods:We adopted improved collagen gels and performed cytotoxicity analysis of doxorubicin(DOX)and mitomycin C(MMC)of bladder cancer cells in a 3D culture system.We then detected the expression of multidrug resistant gene ABCB1,dormancy-associated functional protein chicken ovalbumin upstream-transcription factor 1(COUPTF1),cell proliferation marker Ki-67,and cellular senescence marker senescence-associatedβ-galactosidase(SA-β-Gal)in these cells.We further tested the effects of integrin blockade or protein kinase B(AKT)inhibitor on the senescent state of bladder cancer.Also,we examined the tumor growth and survival time of bladder cancer mouse models given the combination treatment of chemotherapeutic agents and integrinα2β1 ligand peptide TFA(TFA).Results:Collagen gels played a repressive role in bladder cancer cell apoptosis induced by DOX and MMC.In mechanism,collagen activated the integrinβ1/AKT cascade to drive bladder cancer cells into a premature senescence state via the p21/p53 pathway,thus attenuating chemotherapy-induced apoptosis.In addition,TFA had the ability to mediate the switch from senescence to apoptosis of bladder cancer cells in xenograft mice.Meanwhile,TFA combined with chemotherapeutic drugs produced a substantial suppression of tumor growth as well as an extension of survival time in vivo.Conclusions:Based on our finding that integrinβ1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel,we suggest that integrinβ1 might be a feasible target for bladder cancer eradication. | Linghui Deng Kun Jin Xianghong Zhou Zilong Zhang Liming Ge Xingyu Xiong Xingyang Su Di Jin Qiming Yuan Chichen Zhang Yifan Li Haochen Zhao Qiang Wei Lu Yang Shi Qiu | 2022 | Precision Clinical Medicine2022，5，2： | 0 |
| 14 | CMT2D neuropathy is influenced by vitamin D-mediated environmental pathway显示文摘Dear Editor,Peripheral neuropathy is a group of devastating diseases affecting periphe-ral nerves and may cause symptoms such as extreme numbness,muscle weakness,and paralysis.Currently,there are no effective therapies for these diseases.Great progress has been made in identifying genetic causes for peripheral neuropathy owing to the advances in genetic testing in the last decade.For example,>100 genes have been identified to be associated with Charcot–Marie–Tooth(CMT)neuropathy,a group of disorders among the most common forms of inherited peripheral neuropathy. | Huaqing Liu Mingmin Tang Hualin Yu Tongfei Liu Qinqin Cui Linfan Gu Zhi-Ying Wu Nengyin Sheng Xiang-Lei Yang Linghui Zeng Ge Bai | 2023 | Journal of Molecular Cell Biology2023，15，4： | 0 |
| 15 | Offline Pre-trained Multi-agent Decision Transformer显示文摘Offline reinforcement learning leverages previously collected offline datasets to learn optimal policies with no necessity to access the real environment.Such a paradigm is also desirable for multi-agent reinforcement learning(MARL)tasks,given the combinatorially increased interactions among agents and with the environment.However,in MARL,the paradigm of offline pre-training with online fine-tuning has not been studied,nor even datasets or benchmarks for offline MARL research are available.In this paper,we facilitate the research by providing large-scale datasets and using them to examine the usage of the decision transformer in the context of MARL.We investigate the generalization of MARL offline pre-training in the following three aspects:1)between single agents and multiple agents,2)from offline pretraining to online fine tuning,and 3)to that of multiple downstream tasks with few-shot and zero-shot capabilities.We start by introducing the first offline MARL dataset with diverse quality levels based on the StarCraftII environment,and then propose the novel architecture of multi-agent decision transformer(MADT)for effective offline learning.MADT leverages the transformer′s modelling ability for sequence modelling and integrates it seamlessly with both offline and online MARL tasks.A significant benefit of MADT is that it learns generalizable policies that can transfer between different types of agents under different task scenarios.On the StarCraft II offline dataset,MADT outperforms the state-of-the-art offline reinforcement learning(RL)baselines,including BCQ and CQL.When applied to online tasks,the pre-trained MADT significantly improves sample efficiency and enjoys strong performance in both few-short and zero-shot cases.To the best of our knowledge,this is the first work that studies and demonstrates the effectiveness of offline pre-trained models in terms of sample efficiency and generalizability enhancements for MARL. | Linghui Meng Muning Wen Chenyang Le Xiyun Li Dengpeng Xing Weinan Zhang Ying Wen Haifeng Zhang Jun Wang Yaodong Yang Bo Xu | 2023 | Machine Intelligence Research2023，20，2： | 0 |
| 16 | Selective recognition of methyl viologen by an endo-functionalized naphthobox显示文摘Highly selective binding of structurally similar substrates is common for biomolecular recognition,but is often challenging to realize in synthetic hosts.Herein,we report highly selective binding of methyl viologen over other analogues by an endo-functionalized naphthobox.X-ray single crystal structure and Density Functional Theory(DFT)calculations revealed that the endo-functionalized groups in the cavity of the naphthobox is important for the high binding selectivity through the formation of multiple C-H…N,C-H…π,andπ…πinteractions with methyl viologen. | Weier Liu Linghui Kong Mao Quan Huan Yao Liupan Yang Ho Yu Au-Yeung Wei Jiang | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员