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| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | Clinical and Laboratory Findings of Nonacute Neurobrucellosis显示文摘INTRODUCTION Brucellosis is the most common zoonotic infection in the world.It is an endemic disease in many areas throughout the world.Human brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations.The central nervous system (CNS) involvement is a rare but serious neurological complication of brucellosis.Neurobrucellosis (NB) often is underdiagnosed,which is partly because of unawareness about the disease among the treating physicians.Clinically nonacute NB is more common than acute NB.Therefore,in order to better understand the nonacute NB,we summarized 14 cases,aimed to shed light to detailed neurologic features of nonacute NB,as well as their laboratory findings. | Li-Dong Jiao Chang-Biao Chu Chhetri Jagadish Kumar Jie Cui Xian-Ling Wang Li-Yong Wu Cun-Jiang Li Xiang-Bo Wang | 2015 | Chinese Medical Journal2015，，13： | 24 |
| 3 | Assessment and sequencing of air target threat based on intuitionistic fuzzy entropy and dynamic VIKOR显示文摘In view of the fact that traditional air target threat assessment methods are difficult to reflect the combat characteristics of uncertain, dynamic and hybrid formation, an algorithm is proposed to solve the multi-target threat assessment problems. The target attribute weight is calculated by the intuitionistic fuzzy entropy(IFE) algorithm and the time series weight is gained by the Poisson distribution method based on multi-times data. Finally,assessment and sequencing of the air multi-target threat model based on IFE and dynamic Vlse Kriterijumska Optimizacija I Kompromisno Resenje(VIKOR) is established with an example which indicates that the method is reasonable and effective. | ZHANG Kun KONG Weiren LIU Peipei SHI Jiao LEI Yu ZOU Jie | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 24 |
| 4 | Mitochondrial transcription termination factor 2 binds to entire mitochondrial DNA and negatively regulates mitochondrial gene expression显示文摘(mTERF2 ) Mitochondrial 抄写结束因素 2 是绑在 mitochondrial DNA 的 mitochondrial 矩阵蛋白质。以前的研究证明了 mTERF2 的 overexpression 能禁止房间增长,但是机制到目前为止一直不是明确的。这研究试图在 vivo 介绍 mTERF2 的有约束力的模式给 mitochondrial DNA (mtDNA ) ,并且在 mtDNA, mRNA 抄写,和蛋白质翻译的复制上调查了 mTERF2 的生物功能。到全部 mtDNA 的 mTERF2 绑定经由染色质 immunoprecipitation 分析被识别。当 mTERF2 是在 HeLa 房间的 overexpressed 时,线粒体基因的 mtDNA 复制效率和表示层次显著地被禁止。mtDNA 内容的抑制水平是有 mRNA 和 mitochondrial 蛋白质表示的减少的层次的一样。总的来说, mTERF2 可能基于它 mtDNA 复制上的否定效果是一个细胞生长禁止者,它最后下面调整在是必要的为的线粒体的氧化 phosphorylation 部件,细胞是的所有精力新陈代谢。 | Weiwei Huang Min Yu Yang Jiao Jie Ma Mingxing Ma Zehua Wang Hong Wu Deyong Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 17 |
| 5 | Memetic computation based on regulation between neural and immune systems: the framework and a case study显示文摘Lamarckian learning has been introduced into evolutionary computation to enhance the ability of local search. The relevant research topic, memetic computation, has received significant amount of interest. In this study, a novel memetic computational framework is proposed by simulating the integrated regulation between neural and immune systems. The Lamarckian learning strategy of simulating the unidirectional regulation of neural system on immune system is designed. Consequently, an immune memetic algorithm based on the Lamarckian learning is proposed for numerical optimization. The proposed algorithm combines the advantages of immune algorithms and mathematical programming, and performs well in both global and local search. The simulation results based on ten low-dimensional and ten high-dimensional benchmark problems show that the immune memetic algorithm outperforms the basic genetic algorithm-based memetic algorithm in solving most of the test problems. | GONG MaoGuo , JIAO LiCheng, LIU Fang & YANG Jie Key Lab of Intelligent Perception and Image Understanding of Ministry of Education of China, Institute of Intelligent Information Processing, Xidian University, Xi’an 710071, China | 2010 | Science China(Information Sciences)2010，53，8： | 16 |
| 6 | IL-37b gene transfer enhances the therapeutic efficacy of mesenchumal stromal cells in DSS- induced colitis mice显示文摘瞄准:调查是否 IL-37b 基因的转移,天生、适应的免疫的一个最新识别的禁止者,能在煽动性的肠疾病( IBD )改进 mesenchumal stromal 房间( MSC )的治疗学的功效 .Methods :在有活跃 ulcerative 大肠炎( UC )的病人的 biopsied 标本的 IL-37 的表示用 RT-PCR 和 immunohistochemistry 被检测。老鼠与 3% 葡聚糖硫酸盐钠(决策支持系统) 被对待 8 天导致大肠炎。在决策支持系统治疗前,老鼠与 MSC, MSC-eGFP 或 MSC-IL37b 被注射。他们的身体重量每天被测量,并且结肠和脾在 d 上被收获 10 为病理学、生物化学的 analyses.Results : 在有活跃 UC 的病人,的 biopsied 标本, IL-37 的表示戏剧性地在煽动的 mucosa 被提高,主要在上皮的房间和渗透的有免疫力的房间。比作 MSC-eGFP 或 MSC, MSC-IL37b 管理显著地稀释了身体重量和冒号长度减小,并且减少在导致决策支持系统的大肠炎老鼠的组织学的分数。而且, MSC-IL37b 管理在老鼠在脾的 CD4+ T 房间之中象规章的 T 房间(Tregs ) 的百分比一样在全部的脾的 mononuclear 房间之中增加了导出 myeloid 的 suppressor 房间(MDSC ) 的百分比。而且, MSC-IL37b 管理增加了 IL-2+ 房间并且减少 IFN-γ在脾的 CD4+ T cells.Conclusion 之中的 + 房间: IL-37 涉及 UC 的 pathophysiology。IL-37b 基因转移由导致 Tregs 和 MDSC 并且调整 cytokine 生产在导致决策支持系统的大肠炎老鼠提高 MSC 的治疗学的功效。 | Wei-qiang WANG Kui DONG Lu ZHOU Guo-hui JIAO Cong-zhong ZHU Wen-wen LI Gang YU Wan-tong WU Song CHEN Zhi-na SUN Yu-ming WANG Wen-tian LIU Jie ZHANG Bang-mao WANG Xiao-ming FENG | 2015 | Acta Pharmacologica Sinica2015，36，11： | 13 |
| 7 | Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart F ailure Rats via Inhibiting P38 MA PK Pathway显示文摘Paconiflorin(Pae)is a monoterpenoid glycoside compound and has many biological activitics,such as immunosuppression,anti-inflammation and anti-cell proliferation.However,the effects and mechanisms of Pae on chronic heart failure(CHF)remain unclear.This study was conducted to assess the effects and mechanisms of Pae on myocardial fibrosis in isoprenaline(Iso)-induced CHF rats.Pae(20 mgkg)was intragastrically administrated to CHF rats for 6 weeks.Cardiac structure and function were assessed.The protein and mRNA levels of transforming growth factorβ1(TGF-β1)and p38 were detected.C ompared to Iso group,Pae could alleviate myocardial fbrosis and improve cardiac function in CHF rats.The levels of collagen volume fraction(13.75%+3.77%vs.30.97%+4.22%,P<0.001)and perivascular collagen volume area(14.32%+2.50%v8.28.31%+3.16%,P<0.001)were significantly reduced in Pae group as compared with those in Iso group.The expression of TGF-BI protein(0.30+0.07 vs.0.66+0.07,P<0.05)and mRNA(3.51+0.44 vs.7.58+0.58,P<0.05)decreased significantly in Pac group as compared with that in Iso group.The expression of p38 protein(0.36+0.12 vs.0.81+0.38,P<0.05)and mRNA(3.84+0.05 vs.4.40+0.17,P<0.05)also decreased markedly in Pae group as compared with that in Iso group.Pae could attenuate myocardial fibrosis and improve cardiac function in CHF rats by down-regulating the p38 MAPK signaling pathway. | Mao LIU Jie FENG Qian DU Jiao AI Zhan LV | 2020 | Current Medical Science2020，40，2： | 11 |
| 8 | Alginate oligosaccharide-induced intestinal morphology, barrier function and epithelium apoptosis modifications have beneficial effects on the growth performance of weaned pigs显示文摘Background: Alginate oligosaccharide(AOS), produced from alginate by alginate lyase-mediated depolymerisation, is a potential substitute for antibiotics and possesses growth-enhancing effects. Nevertheless, the mechanisms by which AOS regulates porcine growth remain to be elucidated. Therefore, we investigated the AOS-mediated changes in the growth performance of weaned pigs by determining the intestinal morphology, barrier function,as well as epithelium apoptosis.Methods: Twenty-four weaned pigs were distributed into two groups(n = 12) and received either a basal diet(control group) or the same diet supplemented with 100 mg/kg AOS. On d 15, D-xylose(0.1 g/kg body weight)was orally administrated to eight randomly selected pigs per treatment, and their serum and intestinal mucosa samples were collected 1 h later.Results: Our results showed that inclusion of AOS in the diet for 2 wk increased(P < 0.05) the average daily body weight gain in weaned pigs. Notably, AOS supplementation ameliorated the intestinal morphology and barrier function, as suggested by the enhanced(P < 0.05) intestinal villus height, secretory immunoglobulin A content and goblet cell counts. Compared to the control group, AOS ingestion both decreased(P < 0.05) the total apoptotic percentage and increased(P < 0.05) the proportion of S phase in the intestinal epithelial cells. Furthermore, AOS not only up-regulated(P < 0.05) the B-cell lymphoma-2(BCL2) transcriptional level but also down-regulated(P < 0.05) the B-cell lymphoma-2-associated X protein(BAX), cysteinyl aspartate-specific proteinase-3(caspase-3) and caspase-9 transcriptional levels in the small intestine.Conclusions: In summary, this study provides evidence that supplemental AOS beneficially affects the growth performance of weaned pigs, which may result from the improved intestinal morphology and barrier function,as well as the inhibited enterocyte death, through reducing apoptosis via mitochondria-dependent apoptosis. | Jin Wan Jiao Zhang Daiwen Chen Bing Yu Xiangbing Mao Ping Zheng Jie Yu Junqiu Luo Jun He | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 10 |
| 9 | Protective Effects of Chaihu Shugan San(柴胡疏肝散) on Nonalcoholic Fatty Liver Disease in Rats with Insulin Resistance显示文摘Objective: To investigate the protective effects of Chinese medicine formulation Chaihu Shugan San(柴胡疏肝散, CHSGS) on nonalcoholic fatty liver disease(NAFLD) in rats with insulin resistance(IR) and its molecular mechanisms. Methods: Male Sprague-Dawley rats were randomly divided into six groups: the control group, the model group, Dongbao Gantai group(东宝肝泰, DBGT, 0.09 g methionine/kg), CHSGS high-dose group(CHSG-H, 12.6 g crude drug/kg), CHSGS medium-dose group(CHSG-M, 6.3 g crude drug/kg), and CHSGS low-dose group(CHSG-L, 3.15 g crude drug/kg). After establishing the NAFLD rat model and treatment for 8 weeks, total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), free fatty acid(FFA), fasting blood glucose(FBG), fasting insulin(FINS) contents in blood serum, and TC, TG contents in the hepatic homogenate were measured by an automatic biochemical analyzer, and a homeostasis model assessment was applied to assess the status of IR, insulin sensitivity index(ISI), and homeostasis model assessment for insulin secretion(HOMA-IS). The expression levels of adiponectin and leptin mRNA in liver tissue were analyzed by reverse transcription polymerase chain reaction. Pathological changes of livers were observed by hematoxylineosin staining of paraffin section. Results: Compared with the model group, the serum levels of TC, TG, FFA, FBG, FINS, IRI, ISI, and the liver levels of TC and TG in CHSG-H, CHSG-M, CHSG-L groups showed significant declines(P<0.01 or P<0.05); the serum levels of HDL-C, HOMA-IS were significantly increased(P<0.01 or P<0.05); the expression of leptin mRNA was dramatically decreased and the expression of adiponectin mRNA was increased in the hepatic tissue(P<0.01 or P<0.05). The fatty deposition of liver cells could also be alleviated. Conclusion: CHSGS could up-regulate the expression of adiponectin mRNA and down-regulate the expression of leptin mRNA on the liver, suggesting the CHSGS had positive therapeutic effect on NAFLD in rats with IR. | JIANG Wei-ning LI Dan JIANG Tao GUO Jiao CHEN Yan-fen WANG Jie ZHOU Yun YANG Chao-yan TANG Chun-ping | 2018 | Chinese Journal of Integrative Medicine2018，24，2： | 10 |
| 10 | Preparation and characterization of a mixing soft-segment waterborne polyurethane polymer electrolyte显示文摘混合软片断的 WPU (水运的聚氨酯) 聚合物电解质被使用 PEO 综合(poly (乙烯氧化物)) 并且 PDMS (polydimethylsiloxane ) 作为软片断。这些聚合物电解质展出好热、电气化学的稳定性。胶化聚合物电解质的传导性是 2.52 ×在 25 ° 的 10 −3 S/cm;有 LiTFSI/( 直接数字控制 + EC ) 的 C 130% 的内容。 | Feng Wu Yue Jiao Li Ren Jie Chen Shi Chen | 2009 | Chinese Chemical Letters2009，20，1： | 10 |
| 11 | Sumoylation of hypoxia inducible factor-1α and its significance in cancer显示文摘Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia,a common feature of the microenvironment in solid tumors.The transcriptional activity,protein stabilization,protein-protein interactions and cellular localization of HIF-1α,an oxygen-sensitive subunit of HIF-1,are mainly modulated by various post-translational modifications.Recently,we reported that polycomb chromobox 4(Cbx4)governs the transcriptional activity of HIF-1αby enhancing its sumoylation at K391 and K477,through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma.This review summarizes the current knowledge of HIF-1α sumoylation and its roles in the pathogenesis of cancer. | LI Jie XU Ying JIAO HuiKe WANG Wei MEI Zhu CHEN GuoQiang | 2014 | Science China(Life Sciences)2014，57，7： | 9 |
| 12 | The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population显示文摘导致噪音的听觉损失(NIHL ) 是在环境、基因的因素之间的相互作用引起的复杂疾病。这研究调查了在 protocadherin 的基因可变性是否联系了 15 (PCDH15 ) 在一张中国人口位于增加的危险性下面到 NIHL 的发展。结果证明与 rs11004085 的 TT 遗传型相比, CT/CC 遗传型与 NIHL 的增加的风险被联系[调整机会比率(或)= 2.64;95% 信心间隔(CI ) :1.14-6.11, P = 0.024 ] 。另外,在 rs11004085 和 rs978842 之间的重要相互作用基因变化和噪音暴露在高级暴露组被观察(P < 0.05 ) 。而且,当与噪音暴露的高水平结合了时,风险 haplotype TAGCC 被观察(P < 0.05 ) 。因此,我们的学习证实在 PCDH15 的基因变化在人修改危险性到 NIHL 开发。 | XU Xiang Rong WANG Jing Jing YANG Qiu Yue JIAO Jie HE Li Hua YU Shan Fa GU Gui Zhen CHEN Guo Shun ZHOU Wen Hui WU Hui LI Yan Hong ZHANG Huan Ling ZHANG Zeng Rui JIN Xian Ning | 2017 | Biomedical and Environmental Sciences2017，30，2： | 9 |
| 13 | Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L显示文摘We recently report that the expression of polycomb chromobox 4(Cbx4)is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma(HCC)patients and it enhances hypoxia-induced vascular endothelial growth factor(VEGF)expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha(HIF-1α).Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell line MHCC97L.Our results show that Cbx4 overexpression in the cell line increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner,and promotes the in vitro migration of the cancer cell,which can be effectively abrogated by anti-VEGF antibody.Although Cbx4 expression does not impact the in vitro growth of MHCC97L cells,it still promotes the progression and metastasis of orthotopically transplanted tumors in nude mice.These results further support the role of Cbx4 as a SUMO E3 ligase in the progression and metastasis of HCC. | MEI Zhu JIAO HuiKe WANG Wei LI Jie CHEN GuoQiang XU Ying | 2014 | Science China(Life Sciences)2014，57，6： | 9 |
| 14 | Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects显示文摘For large segmental bone defects,porous titanium scaffolds have some advantages,however,they lack electrical activity which hinders their further use.In this study,a barium titanate(BaTiO3)piezoelectric ceramic was used to modify the surface of a porous Ti6Al4V scaffold(pTi),which was characterized by scanning electron microscopy,energy dispersive spectroscopy,X-ray photoelectron spectroscopy,and roughness and water contact angle analyses.Low intensity pulsed ultrasound(LIPUS)was applied in vitro and in vivo study.The activity of bone marrow mesenchymal stem cells,including adhesion,proliferation,and gene expression,was significantly superior in the BaTiO3/pTi,pTi+LIPUS,and BaTiO3/pTi+LIPUS groups than in the pTi group.The activity was also higher in the BaTiO3/pTi+LIPUS group than in the BaTiO3/pTi and pTi+LIPUS groups.Additionally,micro-computed tomography,the mineral apposition rate,histomorphology,and the peak pull-out load showed that these scaffold conditions significantly enhanced osteogenesis and osseointegration 6 and 12 weeks after implantation in large segmental bone defects in the radius of rabbits compared with those resulting from the pTi condition.Consequently,the improved osteogenesis and osseointegration make the BaTiO3/pTi+LIPUS a promising method to promote bone regeneration in large segmental bone defects for clinical application. | Bo Fan Zheng Guo Xiaokang Li Songkai Li Peng Gao Xin Xiao Jie Wu Chao Shen Yilai Jiao Wentao Hou | 2020 | Bioactive Materials2020，5，4： | 9 |
| 15 | hMTERF4 knockdown in HeLa cells results in sub-G1 cell accumulation and cell death显示文摘Mitochondrial 活动和房间精力地位在房间周期和房间增长的规定起重要作用。mitochondrial 基因表示的规定为 mitochondrial 活动规定是关键的。mitochondrial 抄写结束因素(MTERF ) 家庭是一组重要 mitochondrial 抄写规章的因素。MTERF13 涉及 mitochondrial 基因抄写和氧化 phosphorylation 的规定,这被表明了。然而,最新的成员 MTERF4 的功能没被描绘。在这研究,人的 MTERF4 全身的开的读物框架被克隆,并且蛋白质结构预言表明那 hMTERF4 蛋白质包含了白氨酸拉链主题,它类似于人的 MTERF13。在 HeLa 房间的表示 pMTERF4 绿的荧光熔化蛋白质局部性线粒体。(3 (4,5 ) dimethylthiahiazo (zy1 ) 3,5diphenytetrazoliumromide )(MTT ) 增长试金和流动 cytometry 分析显示出那 hMTERF4 击倒的导致的 sub-G1 阶段房间累积,而它的 overexpression 支持了房间增长。而且,两倍与 Annexin V 和 PI 染色揭示了那 hMTERF4 击倒的增加的坏死然而并非 apoptosis。在结论,我们的数据建议 hMTERF4 是为房间增长的一个必要因素,它被 mitochondrial 抄写可能调制支持房间增长。 | Min Yu Jie Dai Weiwei Huang Yang Jiao Liang Liu Min Wu Deyong Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 9 |
| 16 | Associations between Mycobacterium tuberculosis Beijing geno- type and drug resistance to four first-line drugs: a survey in China显示文摘在中国的 Mycobacterium 肺结核的基因差异上的调查证明了北京遗传型紧张起一个主导的作用。学习在 M. 之间的协会 ? 肺结核北京遗传型和药抵抗显型, 1286 M。肺结核临床和病人的流行病学、临床的信息孤立从肺结核(TB ) 的中心被收集在在中国的北京自治市和九个省或自治区域的预防和控制或 TB 医院。测试的药抵抗在所有 isolates 上被进行到四首要的 anti-TB 药(异菸肼, rifampicin,链球菌,和 ethambutol ) 。585 紧张的一个总数被发现对四 anti-TB 药中的至少一个抵抗。北京家庭紧张由 499 组成了(53.20%) 药敏感的紧张并且 439 (46.80%) 药抵抗的紧张,而非北京家庭紧张包括了 202 (58.05%) 药敏感的紧张并且 146 (41.95%) 药抵抗的紧张。没有重要差别在流行被观察(c 2=2.41, P > 0.05 ) 在在北京家庭紧张之中的药抵抗、药敏感的紧张之间。药抵抗的 monoresistance, multidrug 抵抗的 TB,和地理分发的分析没发现在 M. 之间的任何关系 ? 在中国的肺结核北京遗传型和药抵抗显型。结果证实了北京遗传型,占优势的 M。在中国的肺结核遗传型,没与药抵抗被联系。 | Haican Liu Yuanyuan Zhang Zhiguang Liu Jinghua Liu Yolande Hauck Jiao Liu Haiyan Dong Jie Liu Xiuqin Zhao Bing Lu Yi Jiang Gilles Vergnaud Christine Pource Kanglin Wan | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 17 | Aligned Graphene Nanoribbons and Crossbars from Unzipped Carbon Nanotubes显示文摘Aligned graphene nanoribbon (GNR) arrays have been made by unzipping of aligned single-walled and few-walled carbon nanotube (CNT) arrays. Nanotube unzipping was achieved by a polymer-protected Ar plasma etching method, and the resulting nanoribbon array can be transferred onto any chosen substrate. Atomic force microscope (AFM) imaging and Raman mapping on the same CNTs before and after unzipping confirmed that ~80% of CNTs were opened up to form single layer sub-10 nm GNRs. Electrical devices made from the GNRs (after annealing in H2 at high temperature) showed on/off current (Ion/Ioff) ratios up to 103 at room temperature, suggesting the semiconducting nature of the narrow GNRs. Novel GNR-GNR and GNR-CNT crossbars were fabricated by transferring GNR arrays across GNR and CNT arrays, respectively. The production of such ordered graphene nanoribbon architectures may allow for large scale integration of GNRs into nanoelectronics or optoelectronics. | Liying Jiao Li Zhang Lei Ding Jie Liu Hongjie Dai | 2010 | Nano Research2010，3，6： | 9 |
| 18 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 19 | 15-Deoxy-△12,14 -prostaglandtn J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy显示文摘肝的 ischemia-reperfusion (I/R ) 损害是在许多情形发生并且导致差的预后的一个普通临床的缺陷。apoptosis 和 autophagy 被显示了在肝的 I/R 损害贡献房间死亡。15-Deoxy-12,14-prostaglandin J 2(15d-PGJ2 ) 是学习最好的反煽动性的前列腺素之一,它被验证了在细胞和动物模型的各种各样的类型施加反煽动性、房间保护的功能。在这研究,我们在老鼠在 apoptosis 和 autophagy 上探索了 15d-PGJ2 的效果肝的 I/R 损害和它的可能的机制。一个模型部分(70%)肝的温暖的局部缺血在 Balb/c 老鼠被建立,并且在浆液的病理学的变化和肝纸巾在 6 , 12 ,和 24 h 被检测外科以后 15d-PGJ2 ( 2.5 , 7.5 , 15 g , iv )被管理 30 min 优先外科。有 15d-PGJ2 的预告的处理(7.5, 15 g ) 浆液中高音和著名计算机生产厂商层次的剂量依赖者减小象减轻的织物一样证实的显著地改善的 I/R-induced 肝的损害损坏。15d-PGJ2 预告的处理显著地减少了浆液 TNF-1 和 IL-1 层次和 F4/80 的肝的表示,巨噬细胞的主要 biomarker。15d-PGJ2 预告的处理 upregulated Bcl-2/Bax 比率,因此在肝减少 apoptotic 房间的数字。15d-PGJ2 预告的处理更加压制了 Beclin-1 和 LC3 的表示,因此减少在肝的 autophagosomes 的数字。而且, 15d-PGJ2 预告的处理激活 Nrf2 并且在肝禁止了一条 ROS/HIF1/BNIP3 小径。有 PPAR 受体 blocker GW9662 的预告的处理(2 g, ip ) 部分在肝的 I/R 损害上颠倒了 15d-PGJ2 的保护的效果。在结论,我们的结果在肝的 I/R 损害,可以在 Kupffer 房间并且在 Nrf2 小径的激活上的激活依靠减小的效果,它导致 ROS 产生的抑制, apoptosis,和 autophagy 上证实 15d-PGJ2 的保护的效果。 | Kan CHEN Jing-jing LI Sai-nan LI Jiao FENG Tong LIU Fan WANG Wei-qi DAI Yu-jing XIA Jie LU Ying-qun ZHOU Chuan-yong GUO | 2017 | Acta Pharmacologica Sinica2017，38，5： | 8 |
| 20 | Zinc finger protein A20 protects rats against chronic liver allograft dysfunction显示文摘AIM:To investigate the effect of zinc finger protein A20 on chronic liver allograft dysfunction in rats.METHODS:Allogeneic liver transplantation from DA rats to Lewis rats was performed.Chronic liver allograft dysfunction was induced in the rats by administering low-dose tacrolimus at postoperative day (POD) 5.Hepatic overexpression of A20 was achieved by recombinant adenovirus (rAd.)-mediated gene transfer administered intravenously every 10 d starting from POD 10.The recipient rats were injected with physiological saline,rAdEasy-A20 (1 × 109 pfu/30 g weight) or rAdEasy (1 × 109 pfu/30 g weight) every 10 d through the tail vein for 3 mo starting from POD 10.Liver tissue samples were harvested on POD 30 and POD 60.RESULTS:Liver-transplanted rats treated with only tacrolimus showed chronic allograft dysfunction with severe hepatic fibrosis.A20 overexpression ameliorated the effects on liver function,attenuated liver allograft fibrosis and prolonged the survival of the recipient rats.Treatment with A20 suppressed hepatic protein production of tumor growth factor (TGF)1,interleukin1 ,caspase-8,CD40,CD40L,intercellular adhesion molecule-1,vascular cell adhesion molecule-1 and E-selectin.A20 treatment suppressed liver cell apoptosis and inhibited nuclear factorB activation of Kupffer cells (KCs),liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs),and it subsequently decreased cytokine mRNA expression in KCs and LSECs and reduced the production of TGF1 in HSCs.CONCLUSION:A20 might prevent chronic liver allograft dysfunction by re-establishing functional homeostasis of KCs,LSECs and HSCs. | Jie Yang Ming-Qing Xu Lu-Nan Yan Xiao-Bo Chen Jiao Liu | 2012 | World Journal of Gastroenterology2012，18，27： | 6 |
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