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| 1 | A new strategy for integrated urban water management in China:Sponge city显示文摘Urban water-related problems associated with rapid urbanization, including waterlogging, water pollution, the ecological degradation of water, and water shortages, have caused global concerns in recent years. In 2013, in order to mitigate increasingly severe urban water-related problems, China set forth a new strategy for integrated urban water management(IUWM) called the 'Sponge City'. This is the first holistic IUWM strategy implemented in a developing country that is still undergoing rapid urbanization, and holds promise for application in other developing countries. This paper aims to comprehensively summarize the sponge city. First, this paper reviews prior studies and policies on urban water management in China as important background for the sponge city proposal. Then, the connotations, goals, and features of the sponge city are summarized and discussed.Finally, the challenges, research needs, and development directions pertinent to the sponge city are discussed based on investigations and studies conducted by the authors. The sponge city in China has a short history—given this, there are many issues that should be examined with regard to the stepwise implementation of the Sponge City Programme(SCP). Accordingly, the authors perceive this study as only the beginning of abundant studies on the sponge city. | WANG Hao MEI Chao LIU JiaHong SHAO WeiWei | 2018 | Science China(Technological Sciences)2018，61，3： | 25 |
| 2 | Dualistic water cycle pattern and its evolution in Haihe River basin显示文摘The Haihe River basin is widely recognized as an area in China which is most severely affected by human activities.The water resources utilization and recycling in the basin is very complex, and the characteristic of the dualistic water cycle is becoming more and more prominent.The ever-growing demand of water for modern industry and domestic life nearly dries up all the natu-ral runoff.Meanwhile, industrial, agricultural and domestic wastewater discharges cause severe deterioration in water quality.Consequently, many of water courses are either dried out or being heavily polluted.Modern water resources management can no longer rely on the 'monitoring-rehabilitation' model which was originally developed based on the natural water cycle.This paper analyzes the critical characteristics, water balance, and evolution of water flux process based on the theory of dualistic water cycle.Referring to the water cycle in the Haihe River basin, a schematic diagram was drawn to describe the dualistic water cycle pattern.Ten different parameters affecting mainly the evolution of water flux in the 'dualistic water cycle' are closely examined using the newly-collected data.As a result, this paper proposes several water management and control strategies to achieve healthy wa-ter status for the Haihe River basin. | LIU JiaHong QIN DaYong WANG Hao WANG MingNa YANG ZhiYong | 2010 | Chinese Science Bulletin2010，55，16： | 18 |
| 3 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 4 | Influence of different extrusion processes on mechanical properties of magnesium alloy显示文摘AZ31 Mg alloy sheets were processed by the conventional symmetrical extrusion(CSE)and the asymmetric extrusion(ASE).Progressive-asymmetric extrusion(PASE)and severe strain-asymmetric extrusion(SASE)were employed for ASE processes.The texture at near-surface and mid-layer zones of ASE sheets was diverse penetrating the normal direction(ND).This was attributed to an additional asymmetric shear strain deformation during the ASE process.(0002)basal planes of PASE sheets tilt to the shear deformation direction.Meanwhile,the basal texture intensity of PASE sheets has been weakened compared with one in CSE sheets.Grain refinement and tilted weak basal texture obtained by SASE process dramatically enhances the room temperature strength and plasticity of the extruded AZ31 magnesium alloy sheets.The microstructure and mechanical responses were examined and discussed. | Qingshan Yang Bin Jiang Hucheng Pan Bo Song Zhongtao Jiang Jiahong Dai Lifei Wang Fusheng Pan | 2014 | Journal of Magnesium and Alloys2014，2，3： | 11 |
| 5 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 6 | Adsorption and Desorption Behavior of Tannic Acid in Aqueous Solution on Polyaniline Adsorbent显示文摘Tannic acid is generally considered as one of polyphenolic pollutants, which may cause severe threats to the environment. In this study, polyaniline adsorbent was synthesized by chemical oxidation to remove tannic acid in aqueous solutions. The adsorption amount of tannic acid varied greatly with pH of solution and strong adsorption was at pH 5.8-6.7. Coexisting cations, such as Na+, K+, and Ca2+, can enhance the adsorption of tannic acid on poly-aniline, which may be contributed to the electrostatic interaction between tannic acid and polyaniline. The adsorp-tion process could be well described by Langmuir model and the maximum adsorption capacity was 117.65 mg·g-1 at 35 ℃ and pH 6.0. The thermodynamic parameters calculated from the adsorption isotherms indicate that the ad-sorption of tannic acid is spontaneous and endothermic process. The polyaniline saturated with tannic acid can be desorbed in alkaline solution and regenerated adsorbent can be used repeatedly with high adsorption capacity, which implies that polyaniline adsorbents have a great potential in water purification for the removal of tannic acid. | WANG Jiahong JI Yan fen DING Shaolan MA Hongrui HAN Xiaojing | 2013 | Chinese Journal of Chemical Engineering2013，21，6： | 7 |
| 7 | Zircon U-Pb Age and Geochemistry of the Ore-hosting Ultramafic Complex of Zhou'an PGE-Cu-Ni Deposit,Henan Province,Central China显示文摘The Zhou'an PGE-Cu-Ni deposit was recently discovered in the Qinling orogenic belt bound by the Yangtze and the North China Cratons. It is a blind deposit thoroughly covered by the Cenozoic alluvial sediments in the Nanyang Basin. As the first large PGE-Cu-Ni deposit discovered in the Qinling-Dabie-Sulu orogenic belt, its geological and geochemical characteristic, isotope age, genesis and tectonic setting are of wide concern in both scientific studies and ore exploration. In this contribution, we report the results obtained from a pioneering study. The Zhou'an ultramafic complex is ferruginous, with m/f=4.79-5.08, and shows the nature of tholeiite series. It is rich in light rare earth elements, Rb, Th, U, La, Sm, Zr and Hf, and poor in heavy rare earth elements, Nd and Ta, suggesting an intraplate setting. It has high 87Sr/86Sr and low 143Nd/144Nd ratios. The ratios of Zr/Nb, La/Nb, Ba/Nb, Rb/Nb, Th/Nb, Th/La and Ba/La, suggest the magma originated from lithosphere mantle. The Fo values of olivine and Pd/Ir-Ni/Cu diagram suggest primary magma was High Mg basalt. The laser ablation inductively coupled plasma atomic emission spectroscopy zircon U-Pb age is 641.5±3.7 Ma. | YAN Haiqing DING Ruiying TANG Zhongli WANG Yalei LIU Shuang MA Jiahong HU Yanqiang CHEN Kena | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 6 |
| 8 | Theoretical framework of dualistic nature–social water cycle显示文摘The global climate change and intensification of human activities in recent decades have made profound changes in hydrological cycle processes and water resources,and produced serious water problems and water crisis in many areas.The main reason is that the driving force of water cycle,the structure of water cycle,and the parameters of water cycle have dualistically evolved under the influence of human activities,and consequently resulted in reduction of runoff water resources,water pollution,and degradation of natural ecosystems.In order to realize of the safety aim of water supply,water environment,and ecosystem in area which is short of water resources,scientific regulation of water resources must take basin water cycle system as the unified base,and the first scientific basis is the awareness of the internal mechanism and law of water cycle evolution under highly intensive human activities.This article discussed four aspects of dualistic water cycle evolution,including its history in China,its theory,its characteristics in a typical basin,and its description of integral structure,along with the conceptive model system to quantify it.This article can be a reference to the basic cognition of water cycle evolution in a changing environment,and the study of water resources reduction reasons in the contemporary age. | Dayong Qin Chuiyu Lu Jiahong Liu Hao Wang Jianhua Wang Haihong Li Junyin Chu Genfa Chen | 2014 | Chinese Science Bulletin2014，59，8： | 5 |
| 9 | A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma显示文摘 | Kai Feng Jun Yan Xiaowu Li Feng Xia Kuansheng Ma Shuguang Wang Ping Bie Jiahong Dong | 2012 | Journal of Hepatology2012，，4： | 5 |
| 10 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 11 | Urban flood inundation and damage assessment based on numerical simulations of design rainstorms with different characteristics显示文摘In the context of global climate change and urbanization,urban flooding is an important type of natural disaster that affects urban development,especially in China,which is experiencing rapid urbanization.In the past 10 years,urban flooding events have caused huge disaster losses in Chinese cities.This has resulted in significant negative effects on the urban infrastructure,socioeconomic systems,and urban residents,thus causing widespread concern.Studies have confirmed the change in extreme rainstorms is due to the changing environments in many cities globally.Conducting studies on the impact of these rainstorms with different characteristics for urban flooding is valuable for coping with unfavorable situations.In addition,numerical simulations provide an economical and viable means to perform these studies.This paper presents a numerical model of Xiamen Island in China.Simulations were conducted for 12 design rainstorm events with different return periods,rain patterns,and durations.The results indicate that,in the case of an equal rainfall amount,the rainfall intensity is the key factor that affects the inundated area,depth,and damages.However,the rainfall intensity is not the only determining factor;the rainfall pattern also affects the inundations.In regard to the rainfall pattern,a higher rainfall peak coefficient usually leads to severe urban inundation and damage.As a result,the lag time would be shorter,which may further exacerbate the impact of urban flood disasters.The results of this study provide insights into managing flood risks,developing urban flood prevention strategies,and designing flood prevention measures. | MEI Chao LIU JiaHong WANG Hao LI ZeJin YANG ZhiYong SHAO WeiWei DING XiangYi WENG BaiSha YU YingDong YAN DianYi | 2020 | Science China(Technological Sciences)2020，63，11： | 5 |
| 12 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 13 | A 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene is associated with the red skin of“Zaosu Red”pear(Pyrus pyrifolia White Pear Group):a deletion in the PpBBX24 gene is associated with the red skin of pear显示文摘Red skin is an important quality trait for pear fruits and is determined by the concentration and composition of anthocyanins.The regulatory mechanism underlying anthocyanin accumulation is a popular topic in fruit research.Red mutants are ideal materials for studying the molecular mechanism of color diversity in pear.Although several red pear mutants have been cultivated and are in production,no exact locus containing the responsible genetic mutation has been identified.In this study,by combining the bulked segregant analysis with whole-genome sequencing,we identified a 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene from the red pear mutant“Zaosu Red”.We further verified that the deletion was present only in the red mutant of“Zaosu”and in its red offspring,which was different from that which occurred in other red pear fruits.This deletion results in a coding frame shift such that there is an early termination of the PpBBX24 gene and loss of key NLS and VP domains from PpBBX24.The lost domains may reduce or alter the normal function of PpBBX24.In addition,we found that the transcript levels of the PpMYB10 and PpHY5 genes in red samples were significantly higher than those in green samples,whereas the results for the normal-type PpBBX24 gene were the opposite.We ultimately revealed that the 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene is associated with the red skin of the“Zaosu Red”pear.This finding of somatic mutational events will be helpful for breeding new red pear cultivars and for understanding the regulatory mechanisms involved in pear skin pigmentation. | Chunqing Ou Xiaoli Zhang Fei Wang Liyi Zhang Yanjie Zhang Ming Fang Jiahong Wang Jixun Wang Shuling Jiang Zhihong Zhang | 2020 | Horticulture Research2020，7，1： | 4 |
| 14 | Synthesis of gold/rare-earth-vanadate core/shell nanorods for integrating plasmon resonance and fluorescence显示文摘nanoscale 核心 / 壳 heterostructure 是一个特别地有效的主题联合 plasmonic 材料和稀土元素的混合物的有希望的性质;然而,在那里由于在这二内在地无敌的材料之间的大界面的精力在合成控制仍然是重要挑战。此处,我们报导种 rare-earth-vanadate 的一条合成线路在金 nanorod (AuNR ) 上轰炸核心。在通过表面活化剂交换与油酸盐修改 AuNR 表面以后,包装得好的稀土元素的氧化物(例如, Gd 2 O 3:Eu) 壳由于油酸盐的多重角色在 AuNRs 上被种。而且,壳的作文从氧化物被改变了到 vanadate (用一个阴离子交换方法的 GdVO 4:Eu) 。由于小心地设计的策略, AuNR 核心在合成过程期间维持形态学;因此,最后的 Au/GdVO 4:Eu 核心 / 壳 NR 展出强壮的吸收乐队和高 photothermal 效率。另外, Au/GdVO 4:Eu NR 象 ~ 一样高与量产量展出明亮的 Eu 3+ 荧光 17% ;明亮的 Sm 3+ 和 Dy 3+ 荧光能被改变在氧化物形成做的 lanthanide 也获得。由于 plasmonic 和荧光性质的吸引人的集成,如此的核心 / 壳 heterostructures 将在区域的一个宽数组发现特别应用,从 biomedicine 到精力。 | Jiahong Wang Hao Huang Daquan Zhang Ming Chen Yafang Zhang Xuefeng Yu Li Zhou Ququan wang | 2015 | Nano Research2015，8，8： | 4 |
| 15 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 16 | Water dissipation mechanism of residential and office buildings in urban areas显示文摘Indoor humidity directly impacts the health of indoor populations. In arid and semi-arid cities, the buildings indoor humidity is typically higher than outdoors, and the presence of water vapor results from water dissipation inside the buildings. Few studies have explored indoor humidity features and vapor distribution or evaluated water dissipation inside buildings. This study examined temperature and relative humidity(RH) changes in typical residential and office buildings. The results indicate a relatively stable temperature with vary range of ±1°C and a fluctuation RH trend which is similarly to that of water use. We proposed the concept of building water dissipation to describe the transformation of liquid water into gaseous water during water consumption and to develop a building water dissipation model that involves two main parameters: indoor population and total floor area. The simulated values were verified by measuring water consumption and water drainage, and the resulting simulation errors were lower for residential than for office buildings. The results indicate that bathroom vapor accounts for 70% of water dissipation in residential buildings. We conclude that indoor humidity was largely a result of water dissipation indoors, and building water dissipation should be considered in urban hydrological cycles. | ZHOU JinJun LIU JiaHong WANG Hao WANG ZhongJing MEI Chao | 2018 | Science China(Technological Sciences)2018，61，7： | 3 |
| 17 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
| 18 | Enhanced adsorptive removal of Cr(VI)in aqueous solution by polyethyleneimine modified palygorskite显示文摘Polyethyleneimine(PEI)modified palygorskite(Pal)was used for the adsorption of Cr(VI)in aqueous solution.The absorbent was characterized by Fourier transform infrared spectroscopy(FT-IR)and thermogravimetric analysis(TGA).Characterized results confirmed that the Pal has been successfully modified by PEI.The modification of PEI increased the Cr(VI)adsorption performance of the Pal by the adsorption combined reduction mechanism,and amino groups of the adsorbent play the main role in the enhanced Cr(VI)adsorption.The maximum adsorption capacity was 51.10 mg·g^-1 at pH4.0 and 25°C.The adsorption kinetics of Cr(VI)on the adsorbent conforms to the Langmuir isotherm model.The maximum adsorption occurs at pH3,and then the adsorption capacity of PEI-Pal was decreased with the increase of p H values.The adsorption kinetics of Cr(VI)on PEI-Pal was modeled with pseudo-second-order model.The addition of Cl^-,SO4^2-and PO4^3-reduced the Cr(VI)adsorption by competition with Cr(VI)for the active sites of PEI-Pal.The Cr(VI)saturated PEI-Pal can be regenerated in alkaline solution,and the adsorption capacity can still be maintained at 30.44 mg·g^-1 after 4 cycles.The results demonstrate that PEI-Pal can be used as a potential adsorbent of Cr(VI)in aqueous solutions. | Jiahong Wang Tongtong Sun Atif Saleem Yao Chen | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 3 |
| 19 | Observation of double indirect interlayer exciton in MoSe_(2)/WSe_(2) heterostructure显示文摘Interlayer excitons(IXS)are electron–hole pairs bound in the spatial separation layer by the Coulomb effect,and their lifetime is several orders of magnitude longer than that of direct excitons,providing an essential platform for long-lived exciton devices.The recent emergence of the van der Waals heterostructure(HS),which combines two layers of different transitional metal dichalcogenides(TMDs),has created new opportunities for IX research.Herein,we demonstrate the observation of double indirect interlayer excitons in the MoSe_(2)/WSe_(2)HS using photoluminescence(PL)spectroscopy.The intensities of the two peaks are essentially the same,and the energy difference is 22 meV,which is perfectly in line with the calculation result of density functional theory.Furthermore,the experience of variable excitation power also proves that the splitting of the IXs originates from the conduction band spin-splitting of MoSe_(2).The observation results provide a promising platform for further exploring the new physical properties and optoelectronic phenomena of TMD HS. | Biao Wu Yunpeng Wang Jiahong Zhong Cheng Zeng Yassine Madoune Wanting Zhu Zongwen Liu Yanping Liu | 2022 | Nano Research2022，15，3： | 3 |
| 20 | Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N^(6)-Methyladenosine-Modified Yap Expression显示文摘Circular RNAs take crucial roles in several pathophysiological processes.The regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown.Here,we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion(I/R)remodeling.Knockdown of circ-ZNF609 protects against acute I/R injury and attenuates left ventricle dysfunction after I/R remodeling in vivo.In vitro,circ-ZNF609 regulates cardiomyocyte survival and proliferation via modulating the crosstalk between Hippo-YAP and Akt signaling.Mechanically,N6-methyladenosine-modification is involved in the regulatory role of circ-ZNF609 on YAP.An in-depth study indicates that knockdown of circ-ZNF609 decreases the expression of YTHDF3 and further fine-tuned the accessibility of Yap mRNA to YTHDF1 and YTHDF2 to regulate YAP expression.circ-ZNF609 knockdown represents a promising therapeutic strategy to combat the pathological process of myocardial I/R injury. | Lijun Wang Pujiao Yu Jiaqi Wang Guie Xu Tianhui Wang Jingyi Feng Yihua Bei Jiahong Xu Hongbao Wang Saumya Das Junjie Xiao | 2022 | Research2022，，3： | 3 |
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