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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Dualistic water cycle pattern and its evolution in Haihe River basin显示文摘The Haihe River basin is widely recognized as an area in China which is most severely affected by human activities.The water resources utilization and recycling in the basin is very complex, and the characteristic of the dualistic water cycle is becoming more and more prominent.The ever-growing demand of water for modern industry and domestic life nearly dries up all the natu-ral runoff.Meanwhile, industrial, agricultural and domestic wastewater discharges cause severe deterioration in water quality.Consequently, many of water courses are either dried out or being heavily polluted.Modern water resources management can no longer rely on the 'monitoring-rehabilitation' model which was originally developed based on the natural water cycle.This paper analyzes the critical characteristics, water balance, and evolution of water flux process based on the theory of dualistic water cycle.Referring to the water cycle in the Haihe River basin, a schematic diagram was drawn to describe the dualistic water cycle pattern.Ten different parameters affecting mainly the evolution of water flux in the 'dualistic water cycle' are closely examined using the newly-collected data.As a result, this paper proposes several water management and control strategies to achieve healthy wa-ter status for the Haihe River basin. | LIU JiaHong QIN DaYong WANG Hao WANG MingNa YANG ZhiYong | 2010 | Chinese Science Bulletin2010，55，16： | 18 |
| 3 | Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization显示文摘This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of recombinant DNA(pCCMp24) and recombinant attenuated vaccinia virus Tian Tan(rddVTT-CCMp24).Intramuscular immunization was performed on days 0(prime) and 21(boost).The immunogenicity of the vaccine schedules was determined by measuring human immunodeficiency virus(HIV)-specific binding antibody levels and cytokine(interleukin-2 and interleukin-4) concentrations in peripheral blood,analyzing lymphocyte proliferation capacity against HIV epitopes and CD4 + /CD8 + cell ratio,and monitoring interferon-gamma levels at different times post-immunization.The results showed that pCCMp24,rddVTT-CCMp24 and their prime-boost immunization induced humoral and cellular immune responses.The pCCMp24/rddVTT-CCMp24 immunization strategy increased CD8 + T cells and induced more IFN-γ-secreting cells compared with single-shot rDNA.The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides.These results demonstrated that prime-boost immunization with rDNA and rddVTT-CCMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations,especially IFN-γ response,providing a basis for further studies. | LIU CunXia DU ShouWen LI Chang WANG YuHang WANG MaoPeng LI Yi YIN RongLan LI Xiao REN DaYong QIN YanQing REN JingQiang JIN NingYi | 2013 | Science China(Life Sciences)2013，56，6： | 7 |
| 4 | Necessity and feasibility for an ET-based modern water resources management strategy: A case study of soil water resources in the Yellow River Basin显示文摘The necessity and feasibility of an ET-based modern water resources management was analyzed to improve assessment of critical water resources scarcity in the region/basin. This analysis was based on the whole water cycle process and its analysis object is evapotranspiration (ET), a main consumption component in the water resources dynamic transformation process. A case study was undertaken by selecting soil water resources in the Yellow River Basin and employing the WEP-L distributed hydrological model with physics mechanisms. This paper discusses the amount and consumption efficiency of soil-water resources according to completely simulated results of water cycle elements throughout the basin. Results indicate that it is important for the ET-based modern water resources management strategy to alleviate water resources scarcity because it may not only avoid unused water wasting but also improve water use efficiency. Therefore, an ET-based modern water resources management scheme is a good complement to the traditional water resources demand management system. | WANG Hao YANG GuiYu JIA YangWen QIN DaYong GAN Hong WANG JianHua HAN ChunMiao | 2009 | Science China(Technological Sciences)2009，52，10： | 6 |
| 5 | Theoretical framework of dualistic nature–social water cycle显示文摘The global climate change and intensification of human activities in recent decades have made profound changes in hydrological cycle processes and water resources,and produced serious water problems and water crisis in many areas.The main reason is that the driving force of water cycle,the structure of water cycle,and the parameters of water cycle have dualistically evolved under the influence of human activities,and consequently resulted in reduction of runoff water resources,water pollution,and degradation of natural ecosystems.In order to realize of the safety aim of water supply,water environment,and ecosystem in area which is short of water resources,scientific regulation of water resources must take basin water cycle system as the unified base,and the first scientific basis is the awareness of the internal mechanism and law of water cycle evolution under highly intensive human activities.This article discussed four aspects of dualistic water cycle evolution,including its history in China,its theory,its characteristics in a typical basin,and its description of integral structure,along with the conceptive model system to quantify it.This article can be a reference to the basic cognition of water cycle evolution in a changing environment,and the study of water resources reduction reasons in the contemporary age. | Dayong Qin Chuiyu Lu Jiahong Liu Hao Wang Jianhua Wang Haihong Li Junyin Chu Genfa Chen | 2014 | Chinese Science Bulletin2014，59，8： | 5 |
| 6 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 7 | Theories and calculation methods for regional objective ET显示文摘The regional objective ET (Evapotranspiration) is a new concept in water resources research,which refers to the total amount of water that could be exhausted from a region in the form of vapor per year. The objective-ET based water resources management allocates water to different regions in terms of ET. It controls the water exhausted from a region to meet the objective ET. The regional objective ET must be adapted to fit the region’s local available water resources. By improving the water utilization effi-ciency and reducing the unrecoverable water in the social water circle,it is saved so that water related production is maintained or even increased under the same water consumption conditions. Regional water balance is realized by rationally deploying the available water among different industries,adjusting industrial structures,and adopting new water-saving technologies,therefore to meeting the requirements for groundwater conservation,agricultural income stability,and avoiding environmental damages. Furthermore,water competition among various departments and industries (including envi-ronmental and ecological water use) may be avoided. This paper proposes an innovative definition of objective ET,and its principles,sub-index systems. Besides,a computational method for regional ob-jective ET is developed by combining the distributed hydrological model and the soil moisture model. | QIN DaYong LU JinYan LIU JiaHong WANG MingNa | 2009 | Chinese Science Bulletin2009，54，1： | 3 |
| 8 | Water cycle evolution in the Haihe River Basin in the past 10000 years显示文摘The water shortage problem in the Haihe River Basin is the most severe in China, and has restricted its economic development. Over-extraction of groundwater has been very severe in the past 30 years. To solve this problem, scientific decisions should be made from a historical perspective. It is important to describe water cycle evolution in the Haihe River basin over the past 10000 years. Datasets of paleoclimate, paleogeography, palynoflora, historical record, isotopic abundance ratio and content were collected for research on different time scales. Some interesting conclusions were drawn by a comprehensive analysis method. First, radiation was the intrinsic force driving the evolution of water cycle. Generally, precipitation increased with temperature. Second, precipitation was high during 8 ka-5 ka B.P., the so-called Yangshao warm period of the Middle Holocene, which recharged the major part of the Quaternary groundwater. Third, heavy floods during this period transported sediment to the seaside, forming the Coastal Plain where cities such as Tianjin, Huanghua, Cangzhou are now located. In the last 3000 years, intermittent moderate floods did not have enough energy to transport sediment to the sea. Rivers usually overflowed in the piedmont region of the Taihang Mountains, and sediment deposited there formed the Piedmont Plain, where locate Shijiazhuang, Xingtai, Handan, Baoding and other cities. Precipitation had a high correlation with temperature in Haihe River Basin in the past 10000 years: the high temperature usually coupled with high precipitation. Today precipitation in the Haihe River Basin is relatively low, owing to low temperature. This study reveals the relationship between temperature, precipitation and river networks in the past 10000 years in Haihe River Basin, which has great scientific and practical importance in understanding the current water circulation and water shortage. | LIU JiaHong XU He QIN DaYong WANG Hao WANG JianHua LI HaiHong BAO ShuJun | 2013 | Chinese Science Bulletin2013，58，27： | 3 |
| 9 | Study on consumption efficiency of soil water resources in the Yellow River Basin based on regional ET structure显示文摘Based on the regional water resources character, the concept of soil water resources is first redefined, and then associated with their transfer relationship in the hydrological cycle, Evapotranspiration (ET)-based consumption structure and consumption efficiency of soil water resources are analyzed. According to ET 's function in productivity, the consumption efficiency of soil water resources is di- vided into three classes: high efficient consumption from vegetation transpiration, low efficient con- sumption from soil evaporation among plants with high vegetation coverage and inefficient consump- tion from soil evaporation among plants with low vegetation coverage and bare soil evaporation. The high efficient and low efficient consumption were further classified as productive consumption. The ineffi- cient consumption is considered non-productive consumption because it is significant in the whole hydrological cycle process. Finally, according to these categories, and employing a WEP-L dis- tributed hydrological model, this paper analyzes the consumption efficiency of soil water resources in the Yel- low River Basin. The results show that there are 2078.89×108 m3 soil water resources in the whole basin. From the viewpoint of consumption structure, the soil water resources are comprised of 381.89×108 m3 transpiration consumption from vegetation and 1697.09×108 m3 evaporation consumption from soil among plants and bare soil. From the viewpoint of consumption efficiency, soil water re- sources are composed of 920.11×108 m3 efficient consumption and 1158.86×108 m3 of inefficient con- sumption. High efficient consumption accounts for 41.5 percent of the total efficient consumption of the whole basin, low efficient for 58.5 percent. Furthermore, consumption efficiency varies by region. Compared with ET from different land use conditions, the whole basin appears to follow the trend of having the greatest proportion of consumption as inefficient consumption, followed by low efficient consumption, and then the least proportion as high efficient consumption. The amount of inefficient consumption in some regions with vegetation is less than in other regions without vegetation. The amount of inefficient consumption in grasslands is much greater than in forestlands. However, the proportion of low efficient consumption is the greatest in crop fields. The amount of high efficient con- sumption in grasslands and forelands is similar to the corresponding low efficient consumption. However, the low efficient consumption in grasslands is larger than in the forelands. Therefore, when adjusting the utilization efficiency of soil water resources, vegetation coverage and plant structure should be modulated in terms of the principle of decreasing inefficient consumption, improving low efficiency ET and increasing high efficiency ET according to area character. | WANG Hao YANG GuiYu JIA YangWen QIN DaYong | 2008 | Science China Earth Sciences2008，51，3： | 3 |
| 10 | Theories and calculation methods for regional objective ET(evapotranspiration):Applications显示文摘The regional objective ET(evapotranspiration) is defined as the quantity of water that could be con-sumed in a particular region.It varies with the water conditions and economic development stages in the region.It is also constrained by the requirement of benign environment cycle.At the same time,it must meet the demands of sustainable economic growth and the construction of harmony society.Objective ET based water resources distribution will replace the conventional method,which empha-sizes the balance between the water demand and the water supply.It puts focus on the reasonable water consumption instead of the forecasted water demand,which is usually greater than the actual one.In this paper,we calculated the objective ET of 2010 year level in Tianjin by an analysis-integra-tion-assessment method.Objective ET can be classified into two parts:controllable ET and uncontrol-lable ET.Controllable ET includes the ET from irrigation land and the ET from resident land,among which the former can be calculated with soil moisture model and evapotranspiration model,while the latter can be calculated by water use ration and water consumption rate.The uncontrollable ET can be calculated with the distributed hydrological model and the remote sensing monitoring model.The two models can be mutually calibrated.In this paper,eight schemes are put forward based on different portfolios of water resources.The objective ET of each scheme was calculated and the results were assessed and analyzed.Finally,an optimal scheme was recommended. | LIU JiaHong QIN DaYong WANG MingNa LüJinYan SANG XueFeng ZHANG RuiMei | 2009 | Science China(Technological Sciences)2009，52，5： | 2 |
| 11 | Room-temperature NH_3 sensors with high sensitivity and short response/recovery times显示文摘Micro-sensors are fabricated by co-electrospinning In2O3and SnO2nanofibers on the substrates of SiO2/Si with interdigitated Pt signal electrodes.The total sensor area is 1.36 mm 9 0.55 mm and the active area is only0.63 mm 9 0.55 mm.Excellent NH3sensing properties are obtained based on the sensors at room temperature.The sensitivity is at most 28 when the sensors are exposed to NH3of 10 ppm.The response time is 8 s or so and the recovery time is nearly 2 s.Not only fine selectivity,but also longtime stability is obtained.The results not only demonstrate the obtained micro-sensors are very promising devices for NH3detection,but also show a possible route for large-scale NH3sensor fabrication at the industrial level. | Qingcheng Liang Di Li Shang Gao Dayong Jiang Jianxun Zhao Jieming Qin Jianhua Hou | 2014 | Chinese Science Bulletin2014，59，4： | 2 |
| 12 | Extraction and antioxidant property of polyhydroxylatcd naphthoquinonc pigments from spines of purple sea urchin Strongylocentrotus nudus显示文摘 | ZHOU Dayong QIN Lei ZHU Bciwci ct al | 2011 | Food Chore2011，129，4： | 1 |
| 13 | Risk Identification of Sudden Water Pollution on Fuzzy Fault Tree in Beibu-Gulf Economic Zone显示文摘 | HU Jian Chu Junying Liu Jiahong Qin Dayong | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 14 | Spectroscopic properties in Era+/Yb3+ Co-doped fluorophosphate glass显示文摘 | ZHENG Tao QIN Jieming JIANG Dayong | 2012 | Chin Phys B2012，21，4： | 1 |
| 15 | Feasibility analysis of solar irrigation system for pastures conservation in a demonstra- tion area in Inner Mongolia显示文摘 | He Xu Jiahong Liu Dayong Qin | 2013 | Applied Energy2013，，69： | 1 |
| 16 | Molecular correlation of crude oils and oil components from reservoir rocks in the Tazhong and Tabei uplifts of the Tarim Basin, China 显示文摘 | Yu Shuang Pan Changchun Wang Jinji Jin Xiaodong Jiang Lanlan Liu Dayong LiJ Xiuxiang Qin Jianzhong Qian Yixiong Ding Yong Chen | 2011 | Org Geochem2011，42，10： | 1 |
| 17 | The Treatment of Digital River System in Flat Areas Affected by Human Activities 显示文摘 | Xuefeng Sang Hao Wang Dayong Qin | 2008 | Proceedings of Information Technology and Environmental System Sciences 20082008，，： | 1 |
| 18 | In vitro e- valuation of the probiotic and functional potential of Lacto-bacill~ strains isolated from fermented food and human in- testine 显示文摘 | Dayong Ren Chang Lia Yanqing Qin | 2014 | Anaerobe2014，30，： | 1 |
| 19 | An analysis of clinico-pathologic features of intraductal papillary mucinous neoplasm of the pancreas显示文摘The natural history and clinical manifestation of resected intraductal papillary mucinous neoplasm(IPMN)of the pancreas were elucidated,and based on this,a retrospective pancreatic database was reviewed to identify patients with IPMN who were surgically managed in our department from 1999 to June 2006.Pathologic rereview of each case was performed,and the clinico-pathologic features were examined.Student’s T test and x2 analysis were used to identify factors associated with malignancy.Fifty-one patients were identified.There were 33 males and 18 females.One patient’s pancreas was unresectable,two patients underwent a total pancreatectomy,42 patients had a pancreatecoduodenectomy and five patients had distal pancreatectomy.Main-duct type carcinoma was identified in 24 patients;branch-duct type in 15 patients,and mixed type in 12 patients.Invasive carcinoma was present in 35 patients.Weight loss and jaundice occurred more commonly in the invasive group.The average serum CA19-9 level was significantly higher in the invasive group(1542μ vs 94.5μ).The average diameter of the pancreatic duct was also wider in the invasive group(8.7 mm vs 4.3 mm).Significant predictors of malignant IPMNs included weight loss,jaundice,a high level of serum CA19-9,a large pancreatic duct and main-duct type carcinoma. | LOU Wenhui JIN Dayong WANG Dansong XU Xuefeng KUANG Tiantao QIN Xinyu | 2007 | Frontiers of Medicine2007，1，2： | 0 |
| 20 | Administration with Bushenkangshuai Tang alleviates UV irradiation- and oxidative stress-induced lifespan defects in nematode Caenorhabditis elegans显示文摘During normal metabolism,oxidative bypro-ducts will inevitably generate and damage molecules thereby impairing their biological functions,including the aging process.Bushenkangshuai Tang(补肾抗衰方,BT)is a traditional Chinese medicine widely used for clini-cally treating premature ovarian failure.In the present study,BT administration at high concentrations signifi-cantly increased lifespan,slowed aging-related decline,and delayed accumulation of aging-related cellular damage in wild-type Caenorhabditis elegans.BT admin-istration could further largely alleviate the aging defects induced by UV and oxidative stresses,and BT administra-tion at different concentrations could largely rescue the aging defects in mev-1 mutant animals.The protective effects of BT administration on aging process were at least partially dependent on the Ins/IGF-like signaling pathway.Moreover,BT administration at different concentrations obviously altered the expression patterns of antioxidant genes and suppressed the severe stress responses induced by UV and oxidative stresses,suggesting that BT-induced tolerance to UV or oxidative stress might result from reactive oxygen species scavenging.BT administration during development was not necessarily a requirement for UV and oxidative stress resistance,and the concentrations of administrated BT examined were not toxic for nematodes.Therefore,BT administration could effectively retrieve the aging defects induced by UV irradiation and oxidative stress in Caenorhabditis elegans. | Qi RUI Qin LU Dayong WANG | 2009 | Frontiers of Medicine2009，3，1： | 0 |
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