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| 1 | ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13显示文摘这研究的目的是在房间增长和肺腺癌的 autophagy 调查 apelin 的角色。在肺腺癌的 APJ 的在表示上被 immunohistochemistry 检测,当在肺癌症病人的血浆 apelin 水平被连接酶的 immunosorbent 试金测量时。我们的调查结果表明 apelin-13 显著地增加了 ERK1/2 的 phosphorylation, cyclin D1 的表示,联系微导管的蛋白质 1 轻链 3A/B (LC3A/B ) ,和 beclin1,并且证实 apelin-13 支持了 A549 房间增长并且经由 ERK1/2 发信号导致了 A549 房间 autophagy。而且,人的肺腺癌房间线 A549 的表面和光滑、光滑的 apelin-13 原因房间表面上有毛孔是在原子力量下面观察了显微镜学。这些结果建议 ERK1/2 发信号小径调停 apelin-13-induced 肺腺癌房间增长和 autophagy。在我们的试验性的条件下面,与 3-methyladenine 联系的 autophagy 不涉及房间增长。 | Li Yang Tao Su Deguan Lv FengXie Wei Liu Jiangang Cao Irshad Ali Sheikh Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 15 |
| 2 | Comparisons in subcellular and biochemical behaviors of cadmium between Iow-Cd and high-Cd accumulation cultivars of pakchoi (Brassica chinensis L.)显示文摘 | Meng XUE Yihui ZHOU Zhongyi YANG Biyun LIN Jiangang YUAN Shanshan WU | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 14 |
| 3 | High cadmium pollution risk on vegetable amaranth and a selection for pollution-safe cultivars to lower the risk显示文摘一个壶实验被种蔬菜苋的 29 不同遗传型(Amaranthus spp ) 在下面执行低 --(0.12 mg 椠 ?? 牧潯敶吗? | YihuiZHOU Meng XUE Zhongyi YANG Yulian GONG Jiangang YUAN Chunyan ZHOU Baifei HUANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，2： | 10 |
| 4 | Genotype variations in accumulation of cadmium and lead in celery (Apium graveolens L.) and screening for low Cd and Pb accumulative cultivars显示文摘To help reduce risks of heavy metal pollution, two pot experiments were conducted to investigate the variations, transfer potential, and stability of Cadmium (Cd) and Lead (Pb) accumulations in celery (Apium graveolens L.) and to screen for low Cd and Pb accumulative cultivars. The maximum differences in shoot Cd concentration were 4.7-fold under low-Cd exposure and 3.3-fold under high-Cd exposure. These genotype variations in Cd accumulation are sufficiently large to help reduce Cd contamination risk in soil by using the Low-Cd-Accumulative genotypes. Cd accumulation of the Low-Cd-Accumulative genotypes is significantly positive correlated with Pb accumulation. Evidence obtained proves that Cd and Pb accumulations in celery are stable and genotype-dependent at the cultivar level. The presence of high-Pb contamination in soil promoted Cd accumulation in shoots of celery. Celery is considered a species with high risks in Cd pollution and low risks in Pb pollution. Among the tested cultivars, cv. Shuanggang- kangbing (SGKB) had the lowest shoot Cd and Pb accumulating abilities, and thus is the most important material for breeding of pollution-safe cultivars (PSCs) to minimize Cd and Pb accumulations in celery. | Kun ZHANG Jianbing WANG Zhongyi YANG Guorong XIN Jiangang YUAN Junliang XIN Charlie HUANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 9 |
| 5 | Spatio-temporal Pattern Characteristics of Relationship Between Urbanization and Economic Development at County Level in China显示文摘The relationship between China’s urbanization and economic development(RCUED) is an important concern nationwide. As important actors in regional strategy and policy, county-level regions have played an increasingly significant role in the development of China’s social economy. However, the existing research on the RCUED lacks the fine depiction of the county-level administrative units.Using 2000 and 2010 census data and the statistical analysis method, we uncovered the evolution characteristics of China’s urbanization and economic development and conducted a quantitative identification for the RCUED with improved methods using the quadrant map approach. In addition, we investigated the spatial correlation effect of the RCUED using the spatial autocorrelation analysis method. The results were as follows: 1) In general, a high degree of matching exists between China’s urbanization and economic development at the county level at the significance level of 0.01. The correlation coefficients between China’s urbanization and economic development in2000 and 2010 were 0.608 and 0.603, respectively. 2) A significant regional difference exists in the RCUED at the county level. Based on a comparative analysis of 2276 county units in China in the two years, we found that county units can be categorized as under-urbanized, basic coordination and over-urbanized in various areas. No situation was observed where urbanization seriously lagged behind the economic development level, so the levels of urbanization and economic development appear to be basically coordinated,and the coordination state may be gradually optimized over time. 3) Over time, the spatial dependency of the RCUED has weakened and the spatial heterogeneity has increased. Northeast China has always been an area characterized by over-urbanization. The number of county units classified as under-urbanized has begun to decline in eastern coastal urban agglomeration areas, while counties rich in resources have transformed from having point-shaped over-urbanization to plane-shaped under-urbanization along the northern border,and the number of over-urbanized county units has increased in the middle reaches of the Yangtze River. 4)’Lag-lag’ type and ’advance-advance’ type accounted for 68% of all counties in China, and these counties were shown to have obvious spatial differentiation characteristics. | YANG Zhen ZHANG Xiaolei LEI Jun DUAN Zuliang LI Jiangang | 2019 | Chinese Geographical Science2019，29，4： | 9 |
| 6 | Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF. | Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，3： | 5 |
| 7 | Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration显示文摘The functional changes of nucleus pulposus (NP) cells are considered to be the initiating factors of intervertebral disc degeneration (IDD), and the differentially expressed circRNAs in NP cells may play an important role in the process of IDD. To identify circular RNAs (circRNAs) associated with human IDD, we isolated the NP cells from human degenerated and non-degenerated intervertebral disc and identified NP cells by microscopy and cell proliferation. CircRNA microarray expression profiles were obtained from NP cells of degenerated and non-degenerated intervertebral disc and further validated by quantitative reverse transcription PCR (qRTPCR). The expression data were analyzed by bioinformatics. Microarray analysis identified 7294 circRNAs differentially expressed in degenerated human IDD NP cells. Among them, 3724 circRNAs were up-regulated and 3570 circRNAs were down-regulated by more than 2 folds. After validating by qRT-PCR, we predicted the possible miRNAs of the top dysregulated circRNAs using TargetScan, and miRanda. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the most modulated circRNAs regulate the viability, degradation, apoptosis and oxidative stress in NP cells, and the possible mechanism underlying IDD was discussed. These results revealed that circRNAs may play a role in IDD and might be a promisi ng can didate molecular target for gene therapy. | Shunmin Wang Jingchuan Sun Haisong Yang Weiguo Zou Bing Zheng Yu Chen Yongfei Guo Jiangang Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 8 | Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectivity显示文摘Majority of type 2 diabetes mellitus(T2DM)patients are highly susceptible to several forms of cognitive impairments,particularly dementia.However,the underlying neural mechanism of these cognitive impairments remains unclear.We aimed to investigate the correlation between whole brain resting state functional connections(RSFCs)and the cognitive status in 95 patients with T2DM.We constructed an elastic net model to estimate the Montreal Cognitive Assessment(MoCA)scores,which served as an index of the cognitive status of the patients,and to select the RSFCs for further prediction.Subsequently,we utilized a machine learning technique to evaluate the discriminative ability of the connectivity pattern associated with the selected RSFCs.The estimated and chronological MoCA scores were significantly correlated with R=0.81 and the mean absolute error(MAE)=1.20.Additionally,cognitive impairments of patients with T2DM can be identified using the RSFC pattern with classification accuracy of 90.54%and the area under the receiver operating characteristic(ROC)curve(AUC)of 0.9737.This connectivity pattern not only included the connections between regions within the default mode network(DMN),but also the functional connectivity between the task-positive networks and the DMN,as well as those within the task-positive networks.The results suggest that an RSFC pattern could be regarded as a potential biomarker to identify the cognitive status of patients with T2DM. | Zhenyu Liu Jiangang Liu Huijuan Yuan Taiyuan Liu Xingwei Cui Zhenchao Tang Yang Du Meiyun Wang Yusong Lin Jie Tian | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 4 |
| 9 | Review of the decomposition characteristics of eco-friendly insulation gas显示文摘As one of the major concerns of climate change,identifying a proper eco‐friendly insulation gas for replacing sulphur hexafluoride(SF_(6))becomes a prominent research topic in recent years.c-C_(4)F_(8),CF_(3)I,C_(5)F_(10O),C_(6)F_(12O)and C4F7N are some potential al-ternatives that are proved to have excellent characteristics,including high insulation strengths and low Global Warming Potentials(GWPs).Beyond these key factors,the decomposition products of these alternatives are closely related to the gases'insulation performance,as well as the safety of operators and the compatibility with other materials.In addition,the type and content of decomposition products can be used for fault diagnosis.Therefore,a number of studies were carried out to reveal the decomposition mechanism of these alternative gases,and then to explore the gases'application feasibility and strategy.The recent advances obtained in these studies,including theoretical calcu-lation methods,detection of gas decomposition products,decomposition mechanism are reviewed,and some perspectives for future works are proposed.It is concluded that the phenomenon of solid matter precipitation in c-C_(4)F_(8)and CF_(3)I gas decomposition cannot be ignored and that more research is needed to reveal the influence of buffer gases,micro‐aerobic,micro‐water and other impurities on the gas decomposition process. | Yuan Yang Keli Gao Lijian Ding Jiangang Bi Shuai Yuan Xianglian Yan | 2021 | High Voltage2021，6，5： | 3 |
| 10 | Histological and Ultrastructural Features for Proliferation Inhibition by Delivery of Exogenous p27^(Kip1) to Rabbit Models after Glaucoma Filtration Surgery显示文摘Purpose: To investigate postoperative inhibition of cell proliferation in animals treated with exogenous p27Kip1 during an experimental glaucoma filtration surgery (GFS) by histological and ultrastructural examinations. Methods:The primer was designed according to p27Kip1 gene sequence of GenBank..The p27Kip1-expressing adenovirus-mediated Ad-p27 was constructed according to standard techniques..Gene therapy was performed by subconjunctival delivery of Ad-p27,mitomycin C(MMC) and PBS served as controls..Histological and ultastructural changes at surgical sites were observed for 28 days postoperatively. Results: Histologically, evident cellular proliferation induced by Ad-p27 was observed on day 7,.with appreciable filtering cavity. However, thin conjunctival layers were noted, and the number of fibroblasts decreased in the Tenon's capsule on day 14. On day 28, the filtering cavity partially disappeared. The histological features of the animals with MMC delivery were similar to those treated by Ad-p27..In contrast,.in the PBS treatment group, thick conjunctival layers were observed, and the number of goblet cells and fibroblasts, increased markedly..The filtering cavity disappeared at postoperative day 21. Twenty eight day postoperatively,.ultrastructural findings showed that most conjunctival epithelial cells in the Ad-p27 treatment group were under static state,.and that organelles were inactive. The number of goblet cells,.and the secretion of mucin,.were decreased..The amount of fibroblasts also decreased with partial apoptotic cells. The ultrastructural features presented by rabbits with the MMC delivery resembled those treated with Ad-p27. In the PBS treatment group, the number of conjunctival epithelial cells increased; the amount of goblet cells increased as the secretion of mucin was strengthened, and a substantial amount of fibroblasts were observed with active and productive organelles. Conclusion: Ad-p27 inhibits the proliferation of Tenon's capsule fibroblasts at surgical sites, and suppresses the formation of scars, thereby promoting surgical efficacy. | Jiangang Yang Pengrui Sun Lingxiao Zhou Xiaoyan Li Yong Zhang Naixue Sun | 2012 | Eye Science2012，27，3： | 3 |
| 11 | The minimization of non-equilibrium plasma source at high pressure显示文摘The density of plasma produced by atmospheric non-equilibrium plasma source is the function of en-ergy dissipation rate in ionization electric field and gas particles momentum.The experiment shows that the plasma density highly rises with the increasing of energy dissipation rate and gas particles momentum.When the energy dissipation rate of activation field is 2.18 Wh/m3 and the average gas particles momentum is 109×10-22 g·m/s,the air throughput of plasma source whose volume is only 2.5 cm3 can be up to 12 m3/h and the density of plasma can be up to 1010 cm-3.The research can develop a method of producing minitype plasma source which is low energy consumption but high ion concen-tration used for chemical industry,environmental engineering and military. | BAI MinDi QIU XiuMei LIU Dong YANG Bo ZHOU JianGang XUE XiaoHong GU JianLong | 2008 | Chinese Science Bulletin2008，53，21： | 3 |
| 12 | Redefinition and Formation Age of the Tanjianshan Group in Xitieshan Region, Qinghai显示文摘The Tanjianshan Group, which was previously divided into a, b, c and d formations, has been controversial for a long time. It mainly distributes in the northern margin of Qaidam Basin and is an important early Paleozoic greenschist facies metamorphic volcanic sedimentary rock formation. Detailed field investigation and zircon LA-ICPMS U-Pb dating of the key strata suggest that the original lower part of a Formation(a-1) versus the original middle upper of d Formation(d-3 and d-4), the original upper part of a Formation(a-2) and b Formation versus the original lower part of d Formation(d-1 and d-2) of Tanjianshan Group are contemporaneous heterotopic facies volcanicclasolite deposit, respectively. The former formations formed during the middle-late Ordovician(463–458 Ma), while the latter ones formed in the late Ordovician(about 445 Ma). The original c formation of Tanjianshan Group, which formed after 430 Ma, is similar to the Maoniushan Formation of Kunlun Mountains and north Qaidam Basin. According to the rules of stratigraphic division and naming, new stratum formations of Tanjianshan Group are re-built and divided into Duancenggou(O1-2td), Zhongjiangou(O2-3tz) and Xitieshan(O3tx) formations. The original c Formation is separated from Tanjianshan Group and is renamed as the Wuminggou Formation(S3-D1w), which shows a discordant contact with underlying Tanjianshan Group and overlying Amunike Formation(D3a). The zircon U-Pb age frequency spectrogram of Tanjianshan Group indicates three prominent peaks of 430 Ma, 460 Ma and 908 Ma, which is consistent with the metamorphic and magmatic crystallization ages obtained from para- and orthogneisses in north Qaidam HP-UHP metamorphic belt, implying that strong Caledonian and Jinningian tectonic and magmatic events have ever happened in North Qaidam. | LIANG Xinquan FU Jiangang WANG Ce JIANG Ying ZHOU Yun YANG Yongqiang WANG Zeli PAN Chuanchu | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 3 |
| 13 | Cadmium accumulation in different rice cultivars and screening for pollution-safe cultivars of rice显示文摘 | Hui Yu Junli Wang Wei Fang Jiangang Yuan Zhongyi Yang | 2006 | Science of the Total Environment2006，，2： | 2 |
| 14 | Tpeak-Tend interval as a new risk factor for arrhythmic event in pa-tient with Brugada syndrome显示文摘Objective: To evaluate Tpeak- Tend ( Tp- e) interval in surface standard ECG as a new risk factor for arrhythmic event inpatient with Brugada syndrome. Methods: 23 male patients with Brugada syndrome and 20 male patients with paroxysmalsupraventricular tachycardia ( PSVT) as the control group were investigated in this study. Tp- e interval in surface standardECG was compared between BrS and PSVT patients. Results: Tp- e interval in BrS patients was significantly longer thanthat in PSVT patients ( 109.57±22.86 ms vs. 88.50±13.08ms, P<0.05) . There was significant difference in Tp- e interval be-tween 16 BrS patients with arrhythmic events ( including syncope, clinical ventricular fibrillation [ VF] and programmed elec-trical stimulation [ PES] - induced VF) and 7 BrS patients without arrhythmic events and PSVT patients ( 118.12±20.40ms vs.90.00±15.27ms, P<0.05; 118.12±20.40ms vs. 88.50±13.08ms, P<0.05). However, Tp- e interval was similar in BrS patients with-out arrhythmic events and PSVT patients (90.00±15.27ms vs 88.50±13.08ms, P>0.05). Conclusion: The prolongation of Tp- einterval could serve as a new noninvasive event predictor for arrhythmic events in patients with Brugada syndrome. | Jinfeng Wang Qijun Shan Bing Yang Minglong Chen Jiangang Zou Dongjie Xu Chun Chen Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，4： | 2 |
| 15 | Growth and optical properties of ytterbium and rare earth ions codoped CaF2-SrF2 eutectic solid-solution(RE=Y^(3+),Gd^(3+),La^(3+))显示文摘Ytterbium and rare earth ions(RE=Y,Gd,La)codoped CaF_(2)-SrF_(2)single crystals(3 at%Yb,6 at%RE:CaF_(2)-SrF_(2))were fabricated by temperature gradient technology(TGT).All the space groups remain the same Fm3m as that of Yb:CaF_(2)-SrF_(2).The lattice parameter a,unit cell volume V,as well as bond length of Ca/Sr-F and F-F increase in the sequence of rare-earth ions radius Y^(3+) | Binbin Jiang Lihe Zheng Dapeng Jiang Handi Yin Jiangang Zheng Qiuhong Yang Guofeng Cheng Liangbi Su | 2021 | Journal of Rare Earths2021，39，4： | 2 |
| 16 | Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells显示文摘Our previous studies showed that resveratrol could inhibit the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2).This study further explored the potential mechanisms whereby resveratrol inhibits the proliferation of rat VSMCs.Lentiviral vectors that incorporated NQO2 small interfering RNA (siRNA) were constructed and transduced into rat VSMCs.The cell proliferation was detected using the bromodeoxyuridine (BrdU) assay.Cultured rat VSMCs were stimulated with angiotensin II and the level of reactive oxygen species (ROS) was measured using a ROS assay kit.A realtime quantitative PCR was used to detect NQO2 mRNA levels.Extracellular signal-regulated kinase (ERK1/2) and NQO2 protein expression were determined by Western blotting analysis.The inhibitory effect of resveratrol (10 and 50 μmol/L) on the proliferation of rat VSMCs in the NQO2 siRNA group was significantly weaker than that in the normal and scrambled siRNA group (P < 0.01).The ROS level in the NQO2 siRNA and resveratrol (50 μmol/L) treatment groups were lower than that in the normal and scrambled siRNA groups (P < 0.01 in both).Compared with the normal and scrambled siRNA group,the phosphorylation of ERK1/2 was significantly decreased in the NQO2 siRNA and resveratrol (50 μmol/L) treatment group (P < 0.01 in both).In conclusion,high concentration of resveratrol inhibits angiotensin II-induced ERK1/2 phosphorylation and subsequent proliferation by down-regulation of NQO2 in cultured rat VSMCs. | Xiwen Zhang Yao Wang Weiwei Yang Xiaofeng Hou Jiangang Zou Kejiang Cao | 2012 | The Journal of Biomedical Research2012，26，2： | 2 |
| 17 | The coordinated relationship between vortex finder parameters and performance of hydrocyclones for separating light dispersed phase 显示文摘 | Yang Qiang Wang Hualin Wang Jiangang | 2011 | Separation and Purification Technology2011，79，3： | 1 |
| 18 | Responses of different water spinach cultivars and their hybrid to Cd, Pb and Cd–Pb exposures显示文摘 | Junliang Xin Baifei Huang Zhongyi Yang Jiangang Yuan Hongwen Dai Qiu Qiu | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 19 | Image Compression Method Lrsilg Improved PSO Vector Quantizaion 显示文摘 | Qian Chen Jiangang Yang Jin Gou | 2005 | Springer- Verlag Berlin Heidelberg 2005:490- 4952005，2005，： | 1 |
| 20 | Optical detection of single nanoparticles with a subwavelength fiber-taper 显示文摘 | Jiangang Zhu Sahin Kaya zdemir Lan Yang | 2011 | Photon Technol Lett2011，23，18： | 1 |
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