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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Zircon SHRIMP U-Pb dating for olivine gabbro at Wangmuguan in the Beihuaiyang zone and its geological significance显示文摘Zircon SHRIMP U-Pb dating was per- formed for olivine gabbro at Wangmuguan in the Beihuaiyang zone of the Dabie orogen and its coun- try rock (garnet-bearing epidote-mica-quartz schist). The results show that the gabbro was crystallized at 635 ± 5 Ma, in the late Neoproterozoic rather than in the late Paleozoic as previously suggested; its coun- try rocks formed at 464±7 Ma, younger than the en- closed gabbro. The U-Pb age for the gabbro is in good agreement with ages for tuff interbedded with sediments from the Doushantuo Formation in the South China Block and late-Neoproterozoic basic dyke swarms distributed on a large scale over areas of Suizhou to Zaoyang of Hubei Province in the northern margin of the South China Block. This sug- gests a large-scale magmatic activity occurred at the late Neoproterozoic in the South China Block, so that the gabbro at Wangmuguan in the western segment of the Beihuaiyang zone is geotectonic affinity to the northern margin of the South China Block. Since the olivine gabbro occurs within the schist of Ordovician protolith with tectonic contact between them but forming in different tectonic settings, it is concluded that the late-Neoproterozoic gabbro was detached from the Precambrian basement of the South China Block during the Triassic subduction of the South China Block, and tectonically thrusted over the metamorphosed rocks in the southern margin of the North China Block. | LIU Yican LI Shuguang GU Xiaofeng HOU Zhenhui | 2006 | Chinese Science Bulletin2006，51，20： | 16 |
| 3 | CPSF30-L-mediated recognition of mRNA m^(6)A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis显示文摘N6-methyladenosine(m^(6)A),a ubiquitous internal modification of eukaryotic mRNAs,plays a vital role in almost every aspect of mRNA metabolism.However,there is little evidence documenting the role of m^(6)A in regulating alternative polyadenylation(APA)in plants.APA is controlled by a large protein-RNA complex with many components,including CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30(CPSF30).In Arabidopsis,CPSF30 has two isoforms and the longer isoform(CPSF30-L)contains a YT512-B Homology(YTH)domain,which is unique to plants.In this study,we showed that CPSF30-L YTH domain binds to m^(6)A in v itro.In the cpsf30-2 mutant,the transcripts of many genes including several important nitrate signaling-related genes had shifts in polyadenylation sites that were correlated with m^(6)A peaks,indicating that these gene transcripts carrying m^(6)A tend to be regulated by APA.Wild-type CPSF30-L could rescue the defects in APA and nitrate metabolism in cpsf30-2,but m^(6)A-binding-defective mutants of CPSF30-L could not.Taken together,our results demonstrated that m^(6)A modification regulates APA in Arabidops is and revealed that the m^(6)A reader CPSF30-L affects nitrate signaling by controlling APA,shedding new light on the roles of the m^(6)A modification during RNA 3-end processing in nitrate metabolism. | Yiteng Hou Jing Sun Baixing Wu Yangyang Gao Hongbo Nie Zhentian Nie Shuxuan Quan Yong Wang Xiaofeng Cao Sisi Li | 2021 | Molecular Plant2021，14，4： | 12 |
| 4 | Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation显示文摘 | Yong Zhang Lianfeng Gu Yifeng Hou Lulu Wang Xian Deng Runlai Hang Dong Chen Xiansheng Zhang Yi Zhang Chunyan Liu Xiaofeng Cao | 2015 | Cell Research2015，25，7： | 11 |
| 5 | The mechanism of barrier river reaches in the middle and lower Yangtze River显示文摘在它人工地或自然地被扰乱以后,冲积隧道总是以沉积运输的平衡国家调整了自己。怎么维持沉积运输的平衡国家并且使河政体稳定总是是河的 geomorphologists 的担心。在长江的中间、更低的活动范围的隧道被区分的河和单个线的河的蹒跚的分发描绘。河政体的变化比在单个线的河里在区分的河里猛烈地是更多。区分的河里的河政体的调整是否能通过单个线的河并且宣传到下游的活动范围,影响全面的河政体的稳定性。研究证明障碍河活动范围能阻止宣传到下游的活动范围接近在上游的隧道调整;因此,它在稳定河政体起一个关键作用。这研究在长江的中间、更低的活动范围调查 34 个单个线的河活动范围。根据长江的中间、更低的活动范围的河的进程的系统的摘要,障碍河活动范围的控制因素被总结并且提取:平面形态学单个线、蜿蜒地流;没有流动偏斜,节点在河活动范围的上面或中间的部分散布了;水力的几何系数是不到 4;纵的坡度比 12 大,凹面河岸的泥土内容比 9.5% 大,并且床沉积的中部的直径比 0.158 公里大。从海军司烧方程,流动的弯曲半径的计算公式动态轴被推出,然后这些的角色在限制流动的迁居上控制因素动态轴和障碍河活动范围的形成被分析。当时,障碍河活动范围被看作这到隧道边界的限制力量的动态轴是的流动的迁居力量的比率不到 1 在不同流动层次下面。障碍河活动范围的机制是以便甚至当在上游的河政体调整时,这个活动范围的隧道边界能总是抑制流动的移植振幅动态轴并且在不同的在上游的河政体条件下面集中主要的流线的平面位置,提供相对稳定的到来的流动为下游的活动范围调节,从而阻止宣传到下游的活动范围接近在上游的河政体调整。 | YOU Xingying TANG Jinwu ZHANG Xiaofeng HOU Weiguo YANG Yunping SUN Zhaohua WENG Zhaohui | 2017 | Journal of Geographical Sciences2017，27，10： | 9 |
| 6 | Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize显示文摘Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed production.Although GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther development.In this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic pathway.We found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther development.ZmMs33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late stages.Chloroplasts in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate supply.Loss of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch granules.Further analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP ratio.The energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant anthers.Taken together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic activities of En chloroplasts at different developmental stages are essential for normal anther development.These findings provide novel insights for understanding how lipid biosynthesis in the tapetum,the structure and function of En chloroplasts,and energy and substance metabolism are coordinated to maintain maize anther development. | Taotao Zhu Ziwen Li Xueli An Yan Long Xiaofeng Xue Ke Xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou Lina Zhao Suowei Wu Jinping Li Weiwei Jin Xiangyuan Wan | 2020 | Molecular Plant2020，13，11： | 9 |
| 7 | SDN Based Next Generation Mobile Network With Service Slicing and Trials显示文摘Software-Defined Network(SDN)empowers the evolution of Internet with the OpenFlow,Network Virtualization and Service Slicing strategies.With the fast increasing requirements of Mobile Internet services,the Internet and Mobile Networks go to the convergence.Mobile Networks can also get benefits from the SDN evolution to fulfill the Sth Generation(5G) capacity booming.The article implements SDN into Frameless Network Architecture(FNA) for5G Mobile Network evolution with proposed Mobile-oriented OpenFlow Protocol(MOFP).The Control Plane/User Plane(CP/UP)separation and adaptation strategy is proposed to support the User-Centric scenario in FNA.The traditional Base Station is separated with Central Processing Entity(CPE) and Antenna Element(AE) to perform the OpenFlow and Network Virtualization.The AEs are released as new resources for serving users.The mobile-oriented Service Slicing with different Quality of Service(QoS) classification is proposed and Resource Pooling based Virtualized Radio Resource Management(VRRM) is optimized for the Service Slicing strategy with resource-limited feature in Mobile Networks.The capacity gains are provided to show the merits of SDN based FNA.And the MiniNet based Trial Network with Service Slicing is implemented with experimental results. | XU Xiaodong ZHANG Huixin DAI Xun HOU Yanzhao TAO Xiaofeng ZHANG Ping | 2014 | China Communications2014，11，2： | 7 |
| 8 | Laparoscopic treatment for suspected gallbladder cancer confined to the wall: a 10-year study from a single institution显示文摘Objective: Although laparoscopic treatment of gallbladder cancer(GBC) has been explored in the last decade,long-term results are still rare. This study evaluates long-term results of intended laparoscopic treatment for suspected GBC confined to the gallbladder wall, based on our experience over 10 years.Methods: Between August 2006 and December 2015, 164 patients with suspected GBC confined to the wall were enrolled in the protocol for laparoscopic surgery. The process for GBC treatment was analyzed to evaluate the feasibility of computed tomography(CT) and/or magnetic resonance imaging(MRI) combined with frozen-section examination in identifying GBC confined to the wall. Of 159 patients who underwent the intended laparoscopic radical treatment, 47 with pathologically proven GBC were investigated to determine the safety and oncologic outcomes of a laparoscopic approach to GBC.Results: Among the 164 patients, 5 patients avoided further radical surgery because of unresectable disease and12 were converted to open surgery; in the remaining 147 patients, totally laparoscopic treatment was successfully accomplished. Extended cholecystectomy was performed in 37 patients and simple cholecystectomy in 10. The T stages based on final pathology were Tis(n=6), T1 a(n=2), T1 b(n=9), T2(n=26), and T3(n=4). Recurrence was detected in 11 patients over a median follow-up of 51 months. The disease-specific 5-year survival rate of these 47 patients was 68.8%, and rose to 85% for patients with a normal cancer antigen 19-9(CA19-9) level.Conclusions: The favorable long-term outcomes demonstrate the feasibility of combined CT/MRI and frozensection examination in the selection of patients with GBC confined to the gallbladder wall, confirm the oncologic safety of laparoscopic treatment in selected GBC patients, and favor measurement of preoperative CA19-9 in the selection of GBCs suitable for laparoscopic treatment. | Lingfu Zhang Chunsheng Hou Zhi Xu Lixin Wang Xiaofeng Ling Dianrong Xiu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 6 |
| 9 | Joint Allocation of Wireless Resource and Computing Capability in MEC-Enabled Vehicular Network显示文摘In MEC-enabled vehicular network with limited wireless resource and computation resource,stringent delay and high reliability requirements are challenging issues.In order to reduce the total delay in the network as well as ensure the reliability of Vehicular UE(VUE),a Joint Allocation of Wireless resource and MEC Computing resource(JAWC)algorithm is proposed.The JAWC algorithm includes two steps:V2X links clustering and MEC computation resource scheduling.In the V2X links clustering,a Spectral Radius based Interference Cancellation scheme(SR-IC)is proposed to obtain the optimal resource allocation matrix.By converting the calculation of SINR into the calculation of matrix maximum row sum,the accumulated interference of VUE can be constrained and the the SINR calculation complexity can be effectively reduced.In the MEC computation resource scheduling,by transforming the original optimization problem into a convex problem,the optimal task offloading proportion of VUE and MEC computation resource allocation can be obtained.The simulation further demonstrates that the JAWC algorithm can significantly reduce the total delay as well as ensure the communication reliability of VUE in the MEC-enabled vehicular network. | Yanzhao Hou Chengrui Wang Min Zhu Xiaodong Xu Xiaofeng Tao Xunchao Wu | 2021 | China Communications2021，18，6： | 4 |
| 10 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 11 | Numerical simulation of nonlinear propagation of sound waves in a finite horn显示文摘Nonlinear acoustic propagation generated by a piston in a finite horn is numerically studied.A quasi-one-dimensional nonlinear model with varying cross-section uses high-order low-dispersion numerical schemes to solve the governing equation.Because of the nonlinear wave distortion and reflected sound waves at the mouth,broadband time-domain impedance boundary conditions are employed.The impedance approximation can be optimized to identify the complex-conjugate pole-residue pairs of the impedance functions,which can be calculated by fast and efficient recursive convolution.The numerical results agree very well with experimental data in the situations of weak nonlinear wave propagation in an exponential horn,it is shown that the model can describe the broadband characteristics caused by nonlinear distortion.Moreover,finite-amplitude acoustic propagation in types of horns is simulated,including hyperbolic,conical,exponential and sinusoidal horns.It is found that sound pressure levels at the horn mouth are strongly affected by the horn profiles,the driving velocity and frequency of the piston.The paper also discusses the influence of the horn geometry on nonlinear waveform distortion. | HOU Wei PAN Haoran SONG Weihua JING Xiaodong SUN Xiaofeng | 2015 | Chinese Journal of Acoustics2015，34，2： | 4 |
| 12 | On the γ' precipitates of the normal and inverse Portevin-Le Chatelier effect in a wrought Ni-base superalloy显示文摘The Portevin-Le Chatelier(PLC) effects in a wrought Ni-base superalloy with different γ' precipitates contents have been investigated. Detailed analysis on the serration type of the tensile curves indicates that the γ' precipitates have a decisive influence on the transformation from normal to inverse PLC behavior, which is rarely proposed in other works. It is considered that the γ' precipitates play the same role in PLC effect as temperature and strain rate for the investigated wrought Ni-base superalloy. | Xinguang Wang Guoming Han Chuanyong Cui Shuai Guan Jinguo Li Guichen Hou Yizhou Zhou Xiaofeng Sun | 2019 | Journal of Materials Science & Technology2019，35，1： | 3 |
| 13 | Predicting mobile users’behaviors and locations using dynamic Bayesian networks显示文摘This paper studies the traveling location prediction problem for detecting whether mobile users will leave their living area and where they will go.We investigate the hidden connections between users’behaviors in different locations and online social interactions.We combine dynamic Bayesian networks with a majority voting model which is based on social interaction information to estimate the users’behaviors and predict the locations.By analyzing Instagram media records,spanning a period of 3 months,we explore rarely visited locations,which are often ignored as noise in previous research.In comparison,our model,using Instagram data with two existing location prediction models,shows that(1)our location prediction is more accurate and robust in both the general location and the location outside the living area;(2)social relations are instrumental in the location prediction as social interaction information can increase the accuracy of the prediction. | Jianrong Hou Hui Zhao Xiaofeng Zhao Jie Zhang | 2016 | Journal of Management Analytics2016，3，3： | 3 |
| 14 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 15 | Ethylene Production and 1-Aminocyclopropane-l-Carboxylate (ACC) Synthase Gene Expression in Tomato ( L ycopsicon esculentum Mill.) Leaves Under Enhanced UV-B Radiation显示文摘西红柿(Lycopsicon esculentum 米尔) 在一个温室种的植物与 UV-B 的二个不同层次被照耀,也就是 8.82 (T1 ) 并且 12.6 kJ/m2 每天(T2 ) 。乙烯生产, 1-aminocyclopropane-1-carboxylate (ACC ) 内容, 1-(malonylamino ) cyclopvopane-1-carboxylic 酸(MACC ) 内容, ACC synthase (EC 4.4.1.14 ) 的基因表示,和在西红柿叶子的 ACC oxidase 活动是坚定的。结果显示了那个 ACC 内容, ACC synthase 的活动和 ACC oxidase,并且乙烯生产在 UV-B 放射的低剂量下面连续地增加了,而在放射的高剂量这些参数在开始的 12 d 期间增加了然后开始减少。MACC 内容在 UV-B 照耀的两剂量下面在 18 d 上连续地增加了。在 ACC 内容, ACC synthase 活动, ACC oxidase 活动, ACC synthase 基因的 transcriptional 水平,和乙烯生产的变化与对方一致,建议 ACC synthase 在在 UV-B 放射下面的西红柿叶纸巾是在乙烯生合成和那乙烯生产的关键酶能被 ACC synthase 基因的表示调整。结果也显示在乙烯新陈代谢的变化可以是到提高的 UV-B 放射的适应机制。 | Lizhe An Xiaofeng Xu Hongguan Tang Manxiao Zhang Zongdong HOU Yanhong Liu Zhiguang Zhao Huyuan Feng Shijian Xu Xunling Wang | 2006 | Journal of Integrative Plant Biology2006，48，10： | 2 |
| 16 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 17 | Analyzing the time buffer in the Theory of Constraints based lean operations显示文摘This paper uses quantitative methods to estimate the size of the time buffer in lean operations controlled by the Theory of Constraints(TOC).The main focus of the operations system of TOC is the identification and management of constraints.To protect the constraints,they should be buffered with time buffers,which protecting the system’s output from disruptions and fluctuations.Despite the importance of time buffers,the approaches to identifying the size of the time buffer in literature are very empirical.In this paper,a queuing-theory based method is applied to calculate the time buffer sizes.It provides a mathematically exact expression for the coefficient of variation of waiting time for Markov queues.It then applies the concept of isomorphism to approximate the variance of customer waiting time in a general queue.Simulation experiments are conducted to verify the accuracy of approximation. | Xiaofeng Zhao Jianrong Hou | 2014 | Journal of Management Analytics2014，1，3： | 2 |
| 18 | Amelioration of weld-crack resistance of the M951 superalloy by engineering grain boundaries显示文摘Fusion weld is a portable and economical joining and repairing method of metals.However,weld cracks often occur during the fusion weld of Ni-base superalloys,which hinder the applications of fusion weld on this kind of materials.In this work,the effects of microstructures of grain boundaries(GBs)of the prototype M951 superalloy on its weldability were investigated.The precipitated phases,the elemental segregations on GBs,and the morphologies of GBs can be largely altered by regulating the cooling rates of pre-weld heat treatments.With decreasing the cooling rate,chain-like M_(23)X_(6)phase precipitates along the GBs,accompanying segregations of B,and GBs becomes more serrated in morphology.During fusion weld,the engineered GBs in the M951 superalloy with a low cooling rate favor the formation of the continuous liquid films on GBs,which together with the serrated GB morphology significantly prevents the formation of weld cracks.Our findings imply that the weld-crack resistance of the superalloys can be ameliorated by engineering GBs. | Mingyue Wen Yuan Sun Jinjiang Yu Shulin Yang Xingyu Hou Yanhong Yang Xiaofeng Sun Yi Zhou Zhou | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
| 19 | Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells显示文摘Our previous studies showed that resveratrol could inhibit the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2).This study further explored the potential mechanisms whereby resveratrol inhibits the proliferation of rat VSMCs.Lentiviral vectors that incorporated NQO2 small interfering RNA (siRNA) were constructed and transduced into rat VSMCs.The cell proliferation was detected using the bromodeoxyuridine (BrdU) assay.Cultured rat VSMCs were stimulated with angiotensin II and the level of reactive oxygen species (ROS) was measured using a ROS assay kit.A realtime quantitative PCR was used to detect NQO2 mRNA levels.Extracellular signal-regulated kinase (ERK1/2) and NQO2 protein expression were determined by Western blotting analysis.The inhibitory effect of resveratrol (10 and 50 μmol/L) on the proliferation of rat VSMCs in the NQO2 siRNA group was significantly weaker than that in the normal and scrambled siRNA group (P < 0.01).The ROS level in the NQO2 siRNA and resveratrol (50 μmol/L) treatment groups were lower than that in the normal and scrambled siRNA groups (P < 0.01 in both).Compared with the normal and scrambled siRNA group,the phosphorylation of ERK1/2 was significantly decreased in the NQO2 siRNA and resveratrol (50 μmol/L) treatment group (P < 0.01 in both).In conclusion,high concentration of resveratrol inhibits angiotensin II-induced ERK1/2 phosphorylation and subsequent proliferation by down-regulation of NQO2 in cultured rat VSMCs. | Xiwen Zhang Yao Wang Weiwei Yang Xiaofeng Hou Jiangang Zou Kejiang Cao | 2012 | The Journal of Biomedical Research2012，26，2： | 2 |
| 20 | Global spherically symmetric classical solution to the Navier-Stokes-Maxwell system with large initial data and vacuum显示文摘We study the initial boundary value problem to the system of the compressible Navier-Stokes equations coupled with the Maxwell equations through the Lorentz force in a bounded annulus Ω of R3. And a result on the existence and uniqueness of global spherically symmetric classical solutions is obtained. Here the initial data could be large and initial vacuum is allowed. | HONG GuangYi HOU XiaoFeng PENG HongYun ZHU ChangJiang | 2014 | Science China Mathematics2014，57，12： | 2 |
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