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| 1 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 2 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 3 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 4 | Ca. 2.5 Ga TTG rocks in the western Alxa Block and their implications显示文摘The Alxa Block is considered part of the North China Craton, but the unambiguous Archean basement has not been reported. In this study, we present the first evidence of the Neoarchean rocks in the Beidashan area of the western Alxa Block. The petrographic and geochemical data show that these rocks are granodiorite with TTG (tonalite-trondhjemite-granodiorite) characteristics. Zircon U-Pb dating gave an age of 2522±30 Ma for the magmatic core and 2496±11 Ma for the metamorphic recrystallized rim. The near-identical age between the Latest Neoarchean magmatism and the high-grade metamorphism shows that these features were related to the same Latest Neoarchean-Earliest Paleoproterozoic tectonothermal event. The age-corrected Hf (t) value is mainly between 0.4 and 4.9. The two-stage zircon Hf model age ranges from 2.7 to 3.0 Ga, suggesting that the Mesoarchean- Neoarchean (2.7-3.0 Ga) juvenile crust was reworked at the end of the Neoarchean in the western Alxa Block. These data suggest that the western Alxa Block experienced a Mesoarchean-Neoarchean crust growth and Latest Neoarchean-Earliest Paleoproterozoic tectonothermal event similar to the North China Craton. | GONG JiangHua ZHANG JianXin YU ShengYao LI HuaiKun HOU KeJun | 2012 | Chinese Science Bulletin2012，57，31： | 21 |
| 5 | Timing of Holocene sea-level highstands by mass spectro-metric U-series ages of a coral reef from Leizhou Peninsula, South China Sea显示文摘Systematic mass spectrometric 230Th ages are reported for a Ponies coral reef terrace from Dengloujiao, Leizhou Peninsula, South China Sea. Seven episodes of coral growth were recognized in this terrace: 7125±96, 6764±29, 5826±37, 5006±54, 2543±24, 1915±15, and 1513±22 calendar years before present (cal. aBP). 50% of the coral age popula-tion fall between 7200 and 6600 cal. aBP, marking post-glacial stabilization of global sea level. Considering the facts that (i) Dengloujiao reef flat was measured at 1.6-2.5 m above modern tidal datum plane; (ii) modern Parties corals in the South China Sea are living at least ~1 m below the modern tidal datum plane; (iii) the top 20-30 cm of the reef was eroded; and (iv) crustal subsidence in the region since mid-Holocene was negligible, we conclude that the above age groups record at least two major periods (7200-5000 and 2500-1500 cal. aBP) of high sea-level at least 2.9-3.8 m above the present-day level. | ZHAO Jianxin & YU KefuDepartment of Earth Sciences, University of Queensland, Brisbane, Qld 4072, Australia (e-mail: j.zhao@earth.uq.edu.au) South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 501301, China (e-mail: kefuyu@scsi | 2002 | Chinese Science Bulletin2002，47，4： | 18 |
| 6 | High-sum-rate beamformers for multi-pair two-way relay networks with amplify-and-forward relaying strategy显示文摘In multi-pair two-way relay networks,the control over inter-pair-interference is a challenging problem.When mobile stations(MSs)cooperate fully,to achieve the sum capacity of networks and at the same time completely remove the inter-pair-interference,a singular value decomposition(SVD)based beamforming scheme at relay station(RS)is established where SVD beamformers are applied over both uplink and downlink channels,respectively.To avoid any cooperation among users,an efcient beamforming scheme is proposed.This scheme uses the Max-SINR based receive beamformer at RS in uplink channel and the Max-SLNR based transmit precoder at RS in downlink channel.It omits interference(uplink)and leakage(donwlink)inside each pair of users due to their abilities of self-interference cancellation.This beamforming scheme provides an analytical solution like some well-known linear beamformers such as zero-forcing,block diagonalization,etc.From simulation,we find:the proposed SVD shows an excellent sum-rate performance at the expense of a large cooperation overhead at MSs and can be used as a tighter upper bound of sum-rate;the proposed scheme of Max-SINR beamformer plus Max-SLNR precoder performs much better on sum-rate than the ZF-based and the BD-based schemes by using almost the same computational amount. | SHU Feng LU YaZhe CHEN Yu YOU XiaoHu WANG JianXin WANG Mao SHENG WeiXing CHEN Qian | 2014 | Science China(Information Sciences)2014，57，2： | 15 |
| 7 | Hydrothermal synthesis of xonotlite from carbide slag显示文摘Carbide slag was used as the calcareous materials for the first time to prepare xonotlite via dynamic hydrothermal synthesis.The efiects of infiuential factors including difierent calcination temperatures, pretreatment methods of the carbide slag and process param-eters of hydrothermal synthesis on the microstructure and morphology of xonotlite were explored using XRD and SEM techniques.The results indicate that the carbide slag after proper calcination could be used to prepare pure xonotlite;and difierent calcination tem-peratures have little efiect on the crystallinity of synthesized xonotlite, but have great impact on the morphology of secondary particles.The difierent pretreatment methods of the carbide slag pose great impact on the crystallinity and morphology of secondary particles of xonotlite.Xonotlite was also synthesized from pure CaO under the same experimental conditions as that prepared from calcined carbide slag for comparison.Little amount of impurities in carbide slag has no efiect on the mechanism of hydrothermal synthesizing xonotlite from carbide slag. | Jianxin Cao Fei Liu Qian Lin Yu Zhang | 2008 | Progress in Natural Science:Materials International2008，18，9： | 15 |
| 8 | Direct conversion of astrocytes into neuronal cells by drug cocktail显示文摘 | Lin Cheng Longfei Gao Wuqiang Guan Jianxin Mao Wenxiang Hu Binlong- Qiu Jian Zhao Yongchun Yu Gang Pei | 2015 | Cell Research2015，25，11： | 14 |
| 9 | Early Paleozoic granulite-facies metamorphism and anatexis in the northern West Qinling orogen: Monazite and zircon U-Pb geochronological constraints显示文摘In the northern West Qinling orogen(WQO), granulite-facies metamorphic rocks are recognized within the Qinling Complex. These rocks are composed of amphibole-bearing two-pyroxene granulite and garnet-sillimanite gneiss with widespread migmatitization. We investigate three granulite-facies samples and one leucosome sample from the Qinling Complex, which are suitable for U-Pb analyses of zircon and monazite. SHRIMP and LA-ICPMS U-Pb age dating of zircon and monazite from two pelitic granulites provides weighted mean ages of 430±4 Ma(MSWD=0.88) and 433±4 Ma(MSWD=0.27), respectively.Based on the petrographic characteristics and zircon CL imagery, we postulated a ca. 430 Ma metamorphic timing for the pelitic granulites. LA-ICPMS zircon U-Pb data from an amphibole two-pyroxene granulite sample reports two weighted mean age groups:424±3 Ma(MSWD=0.45) and 402±3 Ma(MSWD=1.4), which were interpreted as granulite-facies metamorphic and retrograde ages, respectively. LA-ICPMS U-Pb dating of zircons from the leucosome sample yields a weighted mean age of 426±2 Ma(MSWD=0.3), which is interpreted as the crystallization age of the leucosome. These data indicate that the West QOB experienced early Paleozoic granulite-facies metamorphism and anatexis similar to the East QOB. However, it remains unclear whether the early Paleozoic granulite facies metamorphism resulted from an arc setting created by the northward subduction of the Shangdan ocean or from a continental collisional orogenic event. | MAO XiaoHong ZHANG JianXin YU ShengYao LI YunShuai YU XingXing LU ZengLong | 2017 | Science China Earth Sciences2017，60，5： | 12 |
| 10 | Precipitation and hot deformation behavior of austenitic heat-resistant steels: A review显示文摘The austenitic heat resistant-steels have been considered as important candidate materials for advanced supercritical boilers, nuclear reactors, super heaters and chemical reactors, due to their favorable combination of high strength, corrosion resistance, perfect mechanical properties, workability and low cost.Since the precipitation behavior of the steels during long-term service at elevated temperature would lead to the deterioration of mechanical properties, it is essential to clarify the evolution of secondary phases in the microstructure of the steels. Here, a summary of recent progress in the precipitation behavior and the coarsening mechanism of various precipitates during aging in austenitic steels is made. Various secondary phases are formed under service conditions, like MX carbonitrides, M_(23)C_6 carbides, Z phase, sigma phase and Laves phase. It is found that the coarsening rate of M_(23)C_6 carbides is much higher than that of MX carbonitrides. In order to understand the thermal deformation mechanism, a constitutive equation can be established, and thus obtained processing maps are beneficial to optimizing thermal processing parameters, leading to improved thermal processing properties of steels. | Yinghui Zhou Yongchang Liu Xiaosheng Zhou Chenxi Liu Jianxin Yu Yuan Huang Huijun Li Wenya Li | 2017 | Journal of Materials Science & Technology2017，33，12： | 12 |
| 11 | Interspecies and spatial diversity in the symbiotic zooxanthellae density in corals from northern South China Sea and its relationship to coral reef bleaching显示文摘珊瑚礁石漂白被共生 zooxanthellae, zooxanthellae 色素沉着的损失,或两个的逐出通常描绘。我们收集了分别地,在海南岛的 Sanya 和广东省的 Daya 海湾从 Luhuitou 和 Xiaodonghai 包括礁石大楼珊瑚的 21 个类的 39 种类的 128 件样品并且分析了共生 zooxanthellae 人口密度。结果显示出那:( 1 )共生 zooxanthella 密度从 0.67x10 ( 6 )变化,显示 8.48x10 ( 6 )房间/厘米( 2 )重要内部种可变性,与通常相对有更少的 zooxanthellae 的分支珊瑚(从 0.67x10 ( 6 ) 到 2.47x10 ( 6 )房间/厘米( 2 ))比巨大的种类(从 1.0x10 ( 6 )到 8.48x10 ( 6 )房间/厘米( 2 ));(2 ) 在 4 m 水深度以内住在的珊瑚比那些生活在底部有共生 zooxanthellae 的高水平(类似于 7 m 深度) 礁石区域;(3 ) 在在从相对高的纬度 Daya 海湾的珊瑚之间的 zooxanthellae 密度没有可辨别的差别(类似于 22 度 N ) 并且那些从相对低的纬度 Sanya (类似于 18 度 N ) 在可比较的海表面温度(SST ) ;(4 ) 在里面部分 -- 漂白珊瑚, zooxanthellae 的密度显示出下列顺序:看似健康的部分 > 漂白半的部分 > 漂白部分。基于上述结果,我们建议(1 ) 分叉之间的 zooxanthellae 密度差别和巨大的珊瑚种类是分叉的珊瑚对比巨大的珊瑚漂白更脆弱的主要原因。例如,共生 zooxanthellae 层次在分叉的 Acropora 和 Pocillopora 珊瑚并且这样是低的这些珊瑚更产生漂白和死亡;(2 ) 共生 zooxanthellae 密度能被环境条件也影响,例如沉积负担,潜水相关的混浊,和水产业相关的硝酸盐和磷酸盐输入,并且他们的增加可以在珊瑚减少共生 zooxanthellae 密度。 | LI Shu YU KeFu SHI Qi CHEN TianRan ZHAO MeiXia ZHAO JianXin | 2008 | Chinese Science Bulletin2008，53，2： | 12 |
| 12 | Effects of subchronic oral toxic metal exposure on the intestinal microbiota of mice显示文摘Oral exposure to toxic metals such as cadmium(Cd), lead(Pb), copper(Cu) and aluminum(Al) can induce various adverse health effects in humans and animals. However, the effects of these metals on the gut microbiota have received limited attention. The present study demonstrated that long-term toxic metal exposure altered the intestinal microbiota of mice in a metal-specific and time-dependent manner.Subchronic oral Cu exposure for eight weeks caused a profound decline in gut microbial diversity in mice,whereas no significant changes were observed in groups treated with other metals. Cd exposure significantly increased the relative abundances of organisms from the genera Alistipes and Odoribacter and caused marked decreases in Mollicutes and unclassified Ruminococcaceae. Pb exposure significantly decreased the abundances of eight genera: unclassified and uncultured Ruminococcaceae, unclassified Lachnospiraceae, Ruminiclostridium_9, Rikenellaceae_RC9_gut_group, Oscillibacter, Anaerotruncus and Lachnoclostridium. Cu exposure affected abundances of the genera Alistipes, Bacteroides,Ruminococcaceae_UCG-014, Allobaculum, Mollicutes_RF9_norank, Rikenellaceae_RC9_gut_group,Ruminococcaceae_unclassified and Turicibacter. Al exposure increased the abundance of Odoribacter and decreased that of Anaerotruncus. Exposure to any metal for eight weeks significantly decreased the abundance of Akkermansia. These results provide a new understanding regarding the role of toxic metals in the pathogenesis of intestinal and systemic disorders in the host within the gut microbiota framework. | Qixiao Zhai Tianqi Li Leilei Yu Yue Xiao Saisai Feng Jiangping Wu Jianxin Zhao Hao Zhang Wei Chen | 2017 | Science Bulletin2017，62，12： | 12 |
| 13 | The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice显示文摘Lipid and phenolic metabolism are important for pollen exine formation. In Arabidopsis, polyketide synthases(PKSs) are essential for both sporopollenin biosynthesis and exine formation. Here, we characterized the role of a polyketide synthase(OsPKS2) in male reproduction of rice(Oryza sativa). Recombinant OsPKS2 catalyzed the condensation of fatty acyl-CoA with malonyl-CoA to generate triketide and tetraketide α-pyrones, the main components of pollen exine. Indeed, the ospks2 mutant had defective exine patterning and was male sterile. However, the mutant showed no significant reduction in sporopollenin accumulation. Compared with the WT(wild type), ospks2 displayed unconfined and amorphous tectum and nexine layers in the exine, and less organized Ubisch bodies. Like the pksb/lap5 mutant of the Arabidopsis ortholog, ospks2 showed broad alterations in the profiles of anther-related phenolic compounds.However, unlike pksb/lap5, in which most detected phenolics were substantially decreased, ospks2 accumulated higher levels of phenolics. Based on these results and our observation that OsPKS2 is unable to fully restore the exine defects in the pksb/lap5, we propose that PKS proteins have functionally diversified during evolution.Collectively, our results suggest that PKSs represent a conserved and diversified biochemical pathway for anther and pollen development in higher plants. | Xiaolei Zhu Jing Yu Jianxin Shi Takayuki Tohge Alisdair R.Fernie Sagit Meir Asaph Aharoni Dawei Xu Dabing Zhang Wanqi Liang | 2017 | Journal of Integrative Plant Biology2017，59，9： | 9 |
| 14 | Transcriptomic and genetic approaches reveal an essential role of the NAC transcription factor SlNAP1 in the growth and defense response of tomato显示文摘With global climate change,plants are frequently being exposed to various stresses,such as pathogen attack,drought,and extreme temperatures.Transcription factors(TFs)play crucial roles in numerous plant biological processes;however,the functions of many tomato(Solanum lycopersicum L.)TFs that regulate plant responses to multiple stresses are largely unknown.Here,using an RNA-seq approach,we identified SlNAP1,a NAC TF-encoding gene,which was strongly induced by various stresses.By generating SlNAP1 transgenic lines and evaluating their responses to biotic and abiotic stresses in tomato,we found that SlNAP1-overexpressing plants showed significantly enhanced defense against two widespread bacterial diseases,leaf speck disease,caused by Pseudomonas syringae pv.tomato(Pst)DC3000,and root-borne bacterial wilt disease,caused by Ralstonia solanacearum.In addition,SlNAP1 overexpression dramatically improved drought tolerance in tomato.Although the SlNAP1-overexpressing plants were shorter than the wild-type plants during the early vegetative stage,eventually,their fruit yield increased by 10.7%.Analysis of different hormone contents revealed a reduced level of physiologically active gibberellins(GAs)and an increased level of salicylic acid(SA)and abscisic acid(ABA)in the SlNAP1-overexpressing plants.Moreover,EMSAs and ChIP-qPCR assays showed that SlNAP1 directly activated the transcription of multiple genes involved in GA deactivation and both SA and ABA biosynthesis.Our findings reveal that SlNAP1 is a positive regulator of the tomato defense response against multiple stresses and thus may be a potential breeding target for improving crop yield and stress resistance. | Jiao Wang Chenfei Zheng Xiangqi Shao Zhangjian Hu Jianxin Li Ping Wang Anran Wang Jingquan Yu Kai Shi | 2020 | Horticulture Research2020，7，1： | 9 |
| 15 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 16 | Paleo-productivity evolution across the Permian-Triassic boundary and quantitative calculation of primary productivity of black rock series from the Dalong Formation, South China显示文摘The change of the primary productivity across the Permian-Triassic boundary(PTB)remains controversial.In this study,records from two deep-water sections in South China(Xiakou and Xinmin sections)show the primary productivity decreased gradually from the latest Permian to the earliest Triassic,and five evolutionary stages Increase-Decrease-Recovery-RecessionStagnation)can be observed from Clarkina changxingensis-C.deflecta to Hindeodus parvus-Isarcicella isarcica zones.Primary productivity decreased abruptly from the base of C.meishanensis zone.Besides,for adjusting to the deterioration of the oceanic environment,the primary producers in the oceanic surface had changed to acritarch and cyanobacteria,which were more tolerant of stressful environment.Then the producers were under huge stagnation in the H.parvus-I.isarcica zone.The values of quantitative calculation of the primary productivity from the black rock series in the Dalong Formation were very high,corresponding to that of an upwelling area in modern ocean,which shows that the strata of the Dalong Formation in the study region are potential hydrocarbon source-rocks.This result may come from the fact that South China craton was located at the equatorial upwelling area during the Permian-Triassic transitions.But organic matter contents were different in various sections because they could be affected by redox conditions and diagenesis process after burial. | SHEN Jun ZHOU Lian FENG QingLai ZHANG MuHui LEI Yong ZHANG Ning YU JianXin GU SongZhu | 2014 | Science China Earth Sciences2014，57，7： | 8 |
| 17 | Associations of egg consumption with incident cardiovascular disease and all-cause mortality显示文摘Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about their consumption.We conducted the study to investigate if egg consumption is associated with incident cardiovascular disease(CVD) and all-cause mortality. Using the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China, we included 102,136 adults free of CVD and assessed their egg consumption with food-frequency questionnaires. CVD endpoints and all-cause mortality were confirmed during follow-ups by interviewing participants or their proxies and checking hospital records/death certificates.The HRs(95% CIs) were calculated using the cohort-stratified Cox regression models. During 777,163 person-years of followup, we identified 4,848 incident CVD and 5,511 deaths. U-shaped associations of egg consumption with incident CVD and allcause mortality were observed. Compared with consumption of 3–<6/week, the multivariable-adjusted HRs(95% CIs) of <1/week and ≥10/week for incident CVD were 1.22(1.11 to 1.35) and 1.39(1.28 to 1.52), respectively. The corresponding HRs(95% CIs) for all-cause mortality were 1.29(1.18 to 1.41) and 1.13(1.04 to 1.24). Our findings identified that both low and high consumption were associated with increased risk of incident CVD and all-cause mortality, highlighting that moderate egg consumption of 3–<6/week should be recommended for CVD prevention in China. | Xue Xia Fangchao Liu Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Jianfeng Huang Xiangfeng Lu Dongfeng Gu | 2020 | Science China(Life Sciences)2020，63，9： | 7 |
| 18 | Mitochondrial tRNA^(Glu) A14693G variant may modulate the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in a Han Chinese family显示文摘Mutations in mitochondrial 12S rRNA gene are one of the most important causes of aminoglycoside-induced and nonsyndromic hear- ing loss. Here we report the characterization of one Han Chinese pedigree with aminoglycoside-induced and nonsyndromic hearing loss. This Chinese family carrying the 12S rRNA A1555G mutation exhibited high penetrance and expressivity of hearing impairment. In par- ticular, penetrances of hearing loss in this family pedigree were 43.8% and 25%, respectively, when aminoglycoside-induced hearing loss was included or excluded. Mutational analysis of entire mitochondrial genomes in this family showed the homoplasmic A1555G mutation and a set of variants belonging to haplogroup Y2. Of these, the A14693G variant occurred at the extremely conserved nucleotide (conven- tional position 54) of the TΨC-loop of tRNAGlu and was absent in 156 Chinese controls. Nucleotides at position 54 of tRNAs are often modified, thereby contributing to the structural formation and stabilization of functional tRNAs. Thus, the structural alteration of tRNA by the A14693G variant may lead to a failure in tRNA metabolism and impair mitochondrial protein synthesis, thereby worsening mito- chondrial dysfunctions altered by the A1555G mutation. Therefore, the tRNAGlu A14693G variant may have a potential modifier role in increasing the penetrance and expressivity of the deafness-associated A1555G mutation in this Chinese pedigree. | Yu Ding Yongyan Li Junyan You Li Yang Bobei Chen Jianxin Lu Min-Xin Guan | 2009 | Journal of Genetics and Genomics2009，36，4： | 7 |
| 19 | Strengthening effect of Cu-rich phase precipitation in 18Cr9Ni3CuNbN austenitic heat-resisting steel显示文摘The Cu-containing austenitic heat-resistant steel 18Cr9Ni3CuNbN, which is being used as superheater and reheater tube material for modern ultra-super-critical (USC) power plants all over the world, has been investigated at 650 ℃ long time aging till 10 000 h. SEM, TEM and 3DAP (three dimensional atom probe) have been used to follow microstructural changes with mechanical property variations. Experimental results show that Cu-rich phase and MX precipitate in the grains as well as M 23 C 6 precipitates at grain boundaries are the main precipitation strengthening phases in this steel. Among them Cu-rich phase is the most important strengthening phase. Homogeneous distribution of very fine nano-size Cu-rich phase has been formed at very early stage of 650 ℃ aging (less than 1 h). Cu atoms gradually concentrate to Cu-rich particles and the other elements (such as Fe, Cr, Ni etc) diffuse away from Curich particles to γ-matrix with the increasing of aging time at 650 ? C. The growth rate of Cu-rich phase at 650 ℃ long time aging is very slow and the average diameters of Cu-rich phase have been determined by TEM method. Cu-rich phase keeps in about 30 nm till 650 ℃ aging for 10 000 h. It shows that nano-size Cu-rich phase precipitation strengthening can be kept for long time aging at 650 ℃ because of its excellent stability at high temperatures. According to structure stability study and mechanical properties determination results the Cu-rich phase precipitation sequence and its strengthening mechanism model have been suggested and discussed. | Chengyu CHI Hongyao YU Jianxin DONG Xishan XIE Zhengqiang CUI Xiaofang CHEN Fusheng LIN | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，2： | 6 |
| 20 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
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