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| 1 | Time-domain analysis methodology for large-scale RLC circuits and its applications显示文摘With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts: 1) An approach is proposed to delete all intermediate nodes of RL branches. 2) An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3) The Y toπtransformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground (P/G) networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks. | LUO Zuying CAI Yici Sheldon X.-D Tan HONG Xianlong WANG Xiaoyi PAN Zhu FU Jingjing | 2006 | Science in China(Series F)2006，49，5： | 13 |
| 2 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 3 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 4 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018，9，8： | 9 |
| 5 | Four Closely-related RING-type E3 Ligases,APD1-4,are Involved in Pollen Mitosis II Regulation in Arabidopsis显示文摘Ubiquitination of proteins is one of the critical regulatory mechanisms in eukaryotes.In higher plants,protein ubiquitination plays an essential role in many biological processes,including hormone signaling,photomorphogenesis,and pathogen defense.However,the roles of protein ubiquitination in the repro-ductive process are not clear.In this study,we identified four plant-specific RING-finger genes designated Aberrant Pollen Development 1 (APD1) to APD4,as regulators of pollen mitosis Ⅱ (PMⅡ) in Arabidopsis thaliana (L.).The apd1 apd2 double mutant showed a significantly increased percentage of bicellular-like pollen at the mature pollen stage.Further downregulation of the APD3 and APD4 transcripts in apd1 apd2 by RNA interference (RNAi) resulted in more severe abnormal bicellular-like pollen phenotypes than in apd1 apd2,suggesting that cell division was defective in male gametogenesis.All of the four genes were expressed in multiple stages at different levels during male gametophyte development.Confocal analysis using green florescence fusion proteins (GFP) GFP-APD1 and GFP-APD2 showed that APDs are associated with intracellular membranes.Furthermore,APD2 had E2-dependent E3 ligase activity in vitro,and five APD2-interacting proteins were identified.Our results suggest that these four genes may be involved,redundantly,in regulating the PMⅡ process during male gametogenesis. | Guo Luo Hongya Gu Jingjing Liu Li-Jia Qu | 2012 | Journal of Integrative Plant Biology2012，54，10： | 8 |
| 6 | Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway显示文摘As an important component of the tumor microenvironment,cancer-associated fibroblasts(CAFs)secrete energy metabolites to supply energy for tumor progression.Abnormal regulation of long noncoding RNAs(lncRNAs)is thought to contribute to glucose metabolism,but the role of lncRNAs in glycolysis in oral CAFs has not been systematically examined.In the present study,by using RNA sequencing and bioinformatics analysis,we analyzed the lncRNA/mRNA profiles of normal fibroblasts(NFs)derived from normal tissues and CAFs derived from patients with oral squamous cell carcinoma(OSCC).LncRNA H19 was identified as a key lncRNA in oral CAFs and was synchronously upregulated in both oral cancer cell lines and CAFs.Using small interfering RNA(siRNA)strategies,we determined that lncRNA H19 knockdown affected proliferation,migration,and glycolysis in oral CAFs.We found that knockdown of lncRNA H19 by siRNA suppressed the MAPK signaling pathway,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3)and miR-675-5p.Furthermore,the lncRNA H19/miR-675-5p/PFKFB3 axis was involved in promoting the glycolysis pathway in oral CAFs,as demonstrated by a luciferase reporter system assay and treatment with a miRNA-specific inhibitor.Our study presents a new way to understand glucose metabolism in oral CAFs,theoretically providing a novel biomarker for OSCC molecular diagnosis and a new target for antitumor therapy. | Jin Yang Xueke Shi Miao Yang Jingjing Luo Qinghong Gao Xiangjian Wang Yang Wu Yuan Tian Fanglong Wu Hongmei Zhou | 2021 | International Journal of Oral Science2021，13，1： | 8 |
| 7 | Active digital spoof plasmonics显示文摘Digital coding and digital modulation are the foundation of modern information science.The combination of digital technology with metamaterials provides a powerful scheme for spatial and temporal controls of electromagnetic waves.Such a technique,however,has thus far been limited to the control of free-space light.Its application to plasmonics to shape subwavelength fields still remains elusive.Here,we report the design and experimental realization of a tunable conformal plasmonic metasurface;which is capable of digitally coding and modulating designer surface plasmons at the deep-subwavelength scale.Based on dynamical switching between two discrete dispersion states in a controlled manner;we achieve digital modulations ofboth amplitude and phase of surface waves with nearly 100%modulation depth on a single device.Our study not only introduces a new approach for active dispersion engineering,but also constitutes an important step towards the realization of subwavelength integrated plasmonic circuits. | Hao Chi Zhang Tie Jun Cui Yu Luo Jingjing Zhang Jie Xu Pei Hang He Le Peng Zhang | 2020 | National Science Review2020，7，2： | 5 |
| 8 | Gene characterization and molecular pathway analysis of reverse thermosensitive genic male sterility in eggplant(Solanum melongena L.)显示文摘The naturally occurring mutant eggplant line 05ms was identified with reverse thermosensitive genic male sterility(rTGMS),but its temperature-responsive fertility mechanisms remain largely unknown.Here,we studied the flower morphology,anther cellular structure,and genome-wide gene expression of this rTGMS line.Candidate genes for thermosensitive male sterility during the microspore development of 05ms and the temperature-insensitive line S63 under low-temperature(LT)and high-temperature(HT)conditions were identified.Under LT,tapetum cells were vacuolated and had delayed disintegration in 05ms.RNA-seq analysis indicated that DEGs were enriched in the KEGG pathways‘plant hormone signal transduction’,‘starch and sucrose metabolism’,and‘phenylpropanoid biosynthesis’.We identified two genes,4CLL1(Sme2.5_00368.1_g00010.1)and CKI1(Sme2.5_10056.1_g00002.1),which could potentially regulate eggplant anther development and may be candidate genes for rTGMS.Finally,we propose a working model of anther abortion for rTGMS in eggplant.CKI1 responds to LT stress and causes expression changes in genes related to anther development,such as 4CLL1,and the cellular structure of the tapetum becomes abnormal,causing male sterility.The findings of this study explain the underlying molecular mechanisms of male sterility in eggplant rTGMS lines. | Bing Li Xueping Chen Yanrong Wu Aixia Gu Jingjing Zhang Shuangxia Luo Xiurui Gao Jianjun Zhao Xiuqing Pan Shuxing Shen | 2019 | Horticulture Research2019，6，1： | 5 |
| 9 | Radiotherapy targeting cancer stem cells “awakens” them to induce tumour relapse and metastasis in oral cancer显示文摘Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic, recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying mechanism remains unclear. Cancer stem cells(CSCs), considered the 'seeds'of cancer, have been confirmed to be in a quiescent state in most established tumours, with their innate radioresistance helping them survive more easily when exposed to radiation than differentiated cancer cells. There is increasing evidence that CSCs play an important role in recurrence and metastasis post-radiotherapy in many cancers. However, little is known about how oral CSCs cause tumour recurrence and metastasis post-radiotherapy. In this review article, we will first summarise methods for the identification of oral CSCs and then focus on the characteristics of a CSC subpopulation induced by radiation, hereafter referred to as 'awakened'CSCs, to highlight their response to radiotherapy and potential role in tumour recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting CSCs. In addition, we explore potential therapeutic strategies targeting these 'awakened' CSCs to solve the serious clinical challenges of recurrence and metastasis in oral cancer after radiotherapy. | Yangfan Liu Miao Yang Jingjing Luo Hongmei Zhou | 2020 | International Journal of Oral Science2020，12，2： | 4 |
| 10 | Transformation optics from macroscopic to nanoscale regimes:a review显示文摘Transformation optics is a mathematical method that is based on the geometric interpretation of Maxwell’s equations.This technique enables a direct link between a desired electromagnetic(EM)phenomenon and the material response required for its occurrence,providing a powerful and intuitive design tool for the control of EM fields on all length scales.With the unprecedented design flexibility offered by transformation optics(TO),researchers have demonstrated a host of interesting devices,such as invisibility cloaks,field concentrators,and optical illusion devices.Recently,the applications of TO have been extended to the subwavelength scale to study surface plasmon-assisted phenomena,where a general strategy has been suggested to design and study analytically various plasmonic devices and investigate the associated phenomena,such as nonlocal effects,Casimir interactions,and compact dimensions.We review the basic concept of TO and its advances from macroscopic to the nanoscale regimes. | Jingjing Zhang John BPendry Yu Luo | 2019 | Advanced Photonics2019，1，1： | 4 |
| 11 | The biosorption of Cr(VI) ions by dried biomass obtained from a chromium-resistant bacterium显示文摘biomaterials 的许多不同类型的 biosorption 潜力广泛地被学习了。然而,几乎由弄干的生物资源 Cr (VI ) 的 biosorption 机制上没有很少数据。从水的溶液的 Cr (VI ) 离子的简历移动因此从一个铬抵抗的细菌用弄干的生物资源被调查。细菌从从污水处理植物被获得的除去的污泥样品被孤立。平衡和运动实验在不同金属集中, pH 价值,和 biosorbents 剂量被执行。生物资源用扫描电子显微镜学和精力散的 X 光检查光谱学被描绘。在可以在 biosorption 过程起一个作用的杆菌仙影拳生物资源的功能的组被 Fourier 变换识别红外线的光谱学。biosorption 过程被发现是高度依赖的 pH 和为 Cr (VI ) 的吸附的最佳 pH 是 2.0 吗? | Paul Fabrice NGUEMA Zejiao LUO Jingjing LIAN | 2014 | Frontiers of Chemical Science and Engineering2014，8，4： | 4 |
| 12 | High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice显示文摘Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease(AD).However,systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare.Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST)data,we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1)mouse model of AD.In addition to distinct vascular patterns in different brain regions,we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml)undergo abrupt changes in both diameter and branch angle,spreading a unique comb-like pattern of capillaries.By using a quantitative analysis workflow,we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter,volume fraction and branch angle,with most significant impairment in the DG-ml.In addition,virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice,potentially contributing to the impairment of blood flow.Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis. | Xiaochuan Zhang Xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang | 2019 | National Science Review2019，6，6： | 4 |
| 13 | Detection sensitivity of ultrasound scanning vs.clinical examination for insulin injection-related lipohypertrophy显示文摘To the Editor:Lipohypertrophy(LH)is the most common local complication caused by multiple overlapping insulin injections.Clinically,LH manifests as prominent and/or thickened tissue at injection or infusion sites,sometimes resulting in lump formation under the skin.Histologically,LH is characterized by decreased vascularity,fibrosis,and adipocyte enlargement and proliferation in the subcutaneous tissue at insulin injection sites.Because of this,the existing screening methods for LH are mainly based on clinical examination and ultrasound scanning(USS).A recent systematic review revealed that only limited information is available for detection sensitivity among the different methods used to identify LH to date.Thus far,the gold standard examination for LH diagnosis remains debatable and there has been insufficient research on which patients require both kinds of examination.Currently,the detection sensitivity of USS vs.clinical examination for LH has not been reported in large sample-based studies.The present study aimed to compare the detection accuracy between USS and clinical examination using a large patient cohort and to determine the influencing factors for inconsistent detection results of LH between the two methods. | Jian Yu Hong Wang Min Zhu Dan Yan Boqiang Fan Yun Shi Min Shen Xiaoyun Liu Wei He Dan Luo Jingjing Xu | 2022 | Chinese Medical Journal2022，，3： | 3 |
| 14 | Ultra-reliable and low-latency communications:applications,opportunities and challenges显示文摘In the upcoming 5G and beyond systems,ultra-reliable and low latency communication(URLLC)has been considered as the key enabler to support diverse mission-critical services,such as industrial automation,remote healthcare,and intelligent transportation.However,the two stringent requirements of URLLC:extremely low latency and ultra-strict reliability have posed great challenges in system designing.In this article,the basic concepts and the potential applications of URLLC are first introduced.Then,the state-ofthe-art research of URLLC in the physical layer,link layer and the network layer are overviewed.In addition,some potential research topics and challenges are also identified. | Daquan FENG Lifeng LAI Jingjing LUO Yi ZHONG Canjian ZHENG Kai YING | 2021 | Science China(Information Sciences)2021，64，2： | 3 |
| 15 | Comparison of surgical indications for hysterectomy by age and approach in 4653 Chinese women显示文摘约 100 万子宫切除每年在中国被执行。然而,关于指示的国家数据和为子宫切除的外科的途径正在缺乏。这研究的目的是在中国女人为子宫切除在不同年龄组和不同外科的途径的相对优点为子宫切除检验外科的指示。从从 2004 ~ 2009 在 Tongji 医院里执行的子宫切除的 4653 个盒子的临床的数据被分析。子宫切除最通常 4049 年在女人之中被执行(2299;49.4%) 。总的来说, colporrhagia 和腹的疼痛是为子宫切除的二个很普通的指示。由年龄组的最普通的指示如下:恶意的卵巢的瘤, 70 年。恶意的原因论的比例也到年龄变化了,在女人是最高的变老 P < 0.05 ) 。两个都,流血和输血体积的数量要求了在阴道途径是更小的,没有其它之间的重要差别。使用的外科的途径也与外科的范围有关。外科的指示和双边的 oophorectomy 的率到年龄变化了。以两个都操作时间和流血和要求的输血体积的数量,阴道途径比所有另外的外科的途径优异。 | Jingjing Jiang Ting Ding Aiyue Luo Yunping Lu Ding Ma Shixuan Wang | 2014 | Frontiers of Medicine2014，8，4： | 2 |
| 16 | Neural-Fuzzy-Based Adaptive Sliding Mode Automatic Steering Control of Vision-based Unmanned Electric Vehicles显示文摘This paper presents a novel neural-fuzzy-based adaptive sliding mode automatic steering control strategy to improve the driving performance of vision-based unmanned electric vehicles with time-varying and uncertain parameters.Primarily,the kinematic and dynamic models which accurately express the steering behaviors of vehicles are constructed,and in which the relationship between the look-ahead time and vehicle velocity is revealed.Then,in order to overcome the external disturbances,parametric uncertainties and time-varying features of vehicles,a neural-fuzzy-based adaptive sliding mode automatic steering controller is proposed to supervise the lateral dynamic behavior of unmanned electric vehicles,which includes an equivalent control law and an adaptive variable structure control law.In this novel automatic steering control system of vehicles,a neural network system is utilized for approximating the switching control gain of variable structure control law,and a fuzzy inference system is presented to adjust the thickness of boundary layer in real-time.The stability of closed-loop neural-fuzzy-based adaptive sliding mode automatic steering control system is proven using the Lyapunov theory.Finally,the results illustrate that the presented control scheme has the excellent properties in term of error convergence and robustness. | Jinghua Guo Keqiang Li Jingjing Fan Yugong Luo Jingyao Wang | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 17 | Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G_1 cell cycle arrest and apoptosis: A quantitative proteomic study显示文摘Objective: The present study aimed to investigate the molecular events in alisol B 23-acetate(ABA) cytotoxic activity against a liver cancer cell line.Methods: First, we employed a quantitative proteomics approach based on stable isotope labeling by amino acids in cell culture(SILAC) to identify the different proteins expressed in HepG2 liver cancer cells upon exposure to ABA. Next, bioinformatics analyses through DAVID and STRING on-line tools were used to predict the pathways involved. Finally, we applied functional validation including cell cycle analysis and Western blotting for apoptosis and mTOR pathway-related proteins to confirm the bioinformatics predictions.Results: We identified 330 different proteins with the SILAC-based quantitative proteomics approach. The bioinformatics analysis and the functional validation revealed that the mTOR pathway, ribosome biogenesis, cell cycle, and apoptosis pathways were differentially regulated by ABA. G1 cell cycle arrest, apoptosis and mTOR inhibition were confirmed.Conclusions: ABA, a potential mTOR inhibitor, induces the disruption of ribosomal biogenesis. It also affects the mTOR-MRP axis to cause G1 cell cycle arrest and finally leads to cancer cell apoptosis. | Ji Xia Qiang Luo Shengbin Huang Fuquan Jiang Lin Wang Guanghui Wang Jingjing Xie Jie Liu Yang Xu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
| 18 | Recruited CD68^(+)CD206^(+)macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration显示文摘Successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation,fibrosis,and remodeling process.Adaptive macrophage subsets have been identified to modulate inflammation and orchestrate the repair of neighboring parenchymal tissues.This study fabricated PPARγ-primed CD68+CD206+M2 phenotype(M2γ),and firstly verified their anti-inflammatory and tissue-regenerating roles in xenogeneic bioengineered organ regeneration.Our results showed that Th1-type CD3^(+)CD8^(+)T cell response to xenogeneic-dentin matrix-based bioengineered root complex(xeno-complex)was significantly inhibited by M2γmacrophage in vitro.PPARγactivation also timely recruited CD68^(+)CD206^(+)tissue macrophage polarization to xeno-complex in vivo.These subsets alleviated proinflammatory cytokines(TNF-α,IFN-γ)at the inflammation site and decreased CD3^(+)CD8^(+)T lymphocytes in the periphery system.When translated to an orthotopic nonhuman primate model,PPARγ-primed M2 macrophages immunosuppressed IL-1β,IL-6,TNF-α,MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity.These collective activities promoted the differentiation of odontoblast-like and periodontal-like cells to guide pulp-dentin and cementum-PDLs-bone regeneration and rescued partially injured odontogenesis such as DSPP and periostin expression.Finally,the regenerated root showed structure-biomechanical and functional equivalency to the native tooth.The timely conversion of M1-to-M2 macrophage mainly orchestrated odontogenesis,fibrogenesis,and osteogenesis,which represents a potential modulator for intact parenchymal-stromal tissue regeneration of targeted organs. | Hui Li Jingjing Sun Hefeng Yang Xue Han Xiangyou Luo LiJun Liao Bo Yang Tian Zhu Fangjun Huo Weihua Guo Weidong Tian | 2021 | Bioactive Materials2021，6，4： | 2 |
| 19 | Wireless recommendations for internet of vehicles:Recent advances,challenges,and opportunities显示文摘Internet of Vehicles(IoV)is a distributed network of connected cars,roadside infrastructure,wireless communication networks,and central cloud platforms.Wireless recommendations play an important role in the IoV network,for example,recommending appropriate routes,recommending driving strategies,and recommending content.In this paper,we review some of the key techniques in recommendations and discuss what are the opportunities and challenges to deploy these wireless recommendations in the IoV. | Tan Li Congduan Li Jingjing Luo Linqi Song | 2020 | Intelligent and Converged Networks2020，1，1： | 2 |
| 20 | The diagnostic value of computed tomography histogram analysis in thyroid malignant solitary nodules showing coarse calcifications显示文摘 | Zhang Lexing Wei Peiying Han Zhijiang Xiang Jingjing Ding Jinwang Luo Dingcun Li Mingkui | 2018 | 中华内分泌外科杂志2018，12，4： | 2 |
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