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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway显示文摘Neuritin is a member of the neurotrophic factor family,which plays an important role in the promotion and development of the nervous system.Neuritin is also involved in angiogenesis.Neuritin was recently found to be a negative regulatory factor of the Notch 1 signaling pathway.Notch signaling pathway is known as a regulatory pathway of angiogenesis.Thus,neuritin may play a role in angiogenesis through the Notch signaling pathway.In the present study,we investigated the expressions of neuritin and Notch signaling pathway factors in the pulmonary vascular tissue.The results showed that neuritin expression was increased in the paraneoplastic vascular tissue and decreased in the lung cancer vascular tissue.The neuritin expression was increased with the increase of vascular tissue density,and a negative correlation between neuritin expression and delta-like ligand 4(DLL4)was identified in vascular tissues of lung cancer.Overexpression of neuritin in human umbilical vein endothelial cells(HUVECs)inhibited the expressions of Notch signaling pathway-associated factors,including DLL4,NICD,and Hes-1,and promoted the migration and tubular formation of HUVECs.In conclusion,our results indicated that neuritin is involved in angiogenesis and may play a role in angiogenesis through the Notch signaling pathway.This study provides a theoretical basis for clinical anti-angiogenesis therapy. | Li Yang Xuhui Wang Jiawei Sun Chunyan Liu Guoxiang Li Jingling Zhu Jin Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 4 |
| 3 | Do trace metal(loid)s in road soils pose health risks to tourists?A case of a highly-visited national park in China显示文摘Nowadays,more people tend to spend their recreational time in large national parks,and trace metal(loid)s in soils have attracted long-term attention due to their possible harm to human health.To investigate the pollution levels,potential sources and health risks of trace metal(loid)s in road soils,a total of eight trace metal(loid)s(including As,Cd,Cr,Cu,Ni,Pb,Zn and Hg)from 47 soil samples along roads were studied in the Huangshan National Park in Southeast China.The results showed that the concentrations of As,Cd,Pb,Zn and Hg appeared different degrees of pollution compared with their corresponding background values.According to the pollution indices,Hg and Cd were recognized as significant pollutants presenting moderate to high ecological risk.Combining principal component analysis and positive matrix factorization model,the results showed that traffic,industrial,agricultural and natural sources were the potential origins of trace metal(loid)s in this area,with contribution rates of 39.93%,25.92%,10.53%and 23.62%,respectively.Non-carcinogenic risks were all negligible,while the carcinogenic risk of As was higher than the limit(1×10^(-6)).Moreover,children were more susceptible to trace metal(loid)s by ingestion which appeared to be a more important exposure pathway than dermal contact and inhalation.The contribution rates of different sources to non-carcinogenic risks and carcinogenic risks were similar among children and adults,while traffic and industrial sources have a significant impact on health risks.This study will give more insights to control the environmental risks of trace metal(loid)s in national parks. | Jingling Huang Yuying Wu Yanyao Li Jiaxun Sun Yujing Xie Zhengqiu Fan | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 4 | Determination of Volatile Constituents,Total Flavonoids and Total Polysaccharides in the Roots of Artemisia argyi Levl. et Van. var.argyi cv. Qiai显示文摘[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the comprehensive development and utilization of the resources.[Methods]The volatile components of the roots were extracted by solid phase micro-extraction( SPME),and its volatile components were analyzed by gas chromatography-mass spectrometry( GC-MS); the contents of total flavonoids and total polysaccharides in the samples were measured by UV-spectrophotometry. [Results] 44 peaks were isolated from the roots and 30 components were identified,accounting for 80. 9% of the total volatile components; the content of total flavonoids in the roots was 9. 42%; the content of total polysaccharides in the roots was 11. 05%.[Conclusions] After a comprehensive investigation,the olefins in the roots generally have antibacterial activity,the contents of the total flavonoids and total polysaccharides contained in the roots were relatively high,the roots of Artemisia argyi do have broad prospects for the development. | Min GONG Jinqing LU Yushuo XIAO Jiamin MENG Jingling HUANG Mengfei LIU Jiaxuan XIA Yi ZHOU | 2017 | Medicinal Plant2017，8，6： | 1 |
| 5 | Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals显示文摘Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos in vivo and in vitro.However,its role in preimplantation development is unclear.Here,we report that lactate is highly enriched in the nuclei of early embryos when major zygotic genome activation(ZGA)occurs in humans and mice.The inhibition of its production and uptake results in developmental arrest at the 2-cell stage,major ZGA failure,and loss of lactate-derived H3K18lac,which could be rescued by the addition of Lac-CoA and recapitulated by overexpression of H3K18R mutation.By profiling the landscape of H3K18lac during mouse preimplantation development,we show that H3K18lac is enriched on the promoter regions of most major ZGA genes and correlates with their expressions.In humans,H3K18lac is also enriched in ZGA markers and temporally concomitant with their expressions.Taken together,we profile the landscapes of H3K18lac in mouse and human preimplantation embryos,and demonstrate the important role for H3K18lac in major ZGA,showing that a conserved metabolic mechanism underlies preimplantation development of mammalian embryos. | Jingyu Li Weibo Hou Qi Zhao Wei Han Hongdi Cui Songling Xiao Ling Zhu Jiadan Qu Xiaoyu Liu Weitao Cong Jingling Shen Yuzheng Zhao Shaorong Gao Guoning Huang Qingran Kong | 2024 | National Science Review2024，11，2： | 0 |
| 6 | Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate显示文摘Neuritin plays a key role in neural development and regeneration by promoting neurite outgrowth and synapse maturation.Our previous research revealed the mechanism by which neuritin inhibits Notch signaling through interaction with neuralized-like 1(Neurl1)to promote neurite growth.However,how neuritin regulates Notch signaling through Neurl1 has not been elucidated.Here,we first confirm that neuritin is an upstream regulator of Neurl1 and inhibits Notch signaling through Neurl1.Neurl1 is an E3 ubiquitin ligase that can promote ubiquitination and endocytosis of the Notch1 ligand Jagged1.Therefore,we observe the effect of neuritin on the ligase activity of Neurl1.The results indicate that neuritin inhibits Neurl1 activity by reducing the ubiquitination level and endocytosis of the target protein Jagged1.Moreover,we find that decreased activity of Neurl1 results in reduced expression of Notch receptor Notch intracellular domain(NICD)and downstream target gene hairy and enhancer of split-1(HES1).Furthermore,we investigate how neuritin affects Neurl1 enzyme activity.The results show that neuritin not only weakens the affinity between Neurl1 and Jagged1 but also promotes the degradation of Neurl1 by the 26S proteasome pathway.Taken together,our results suggest that neuritin negatively regulates Notch signaling by inhibiting the activity of Neurl1,promoting the degradation of Neurl1 and weakening the affinity of Neurl1 for Jagged1.Our study clarifies the molecular mechanisms of neuritin in regulating the Notch signaling pathway and provides new clues about how neuritin mediates neural regeneration and plasticity. | Jingling Zhu Yu Li Chen Zhong Meiyi Zhu Yan Zheng Anying Xiong Pingping Meng Liya Shan Yang Li Jin Huang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 7 | Characteristic metabolic and microbial profiles in acute ischemic stroke patients with phlegm-heat pattern显示文摘Objective:To explore the characteristics of plasma metabolites,feces gut microbiota and the crosstalk between gut microbiota and host metabolism in patients with acute ischemic stroke and phlegm-heat pattern(AIS-PHP).Methods:The metabolic and microbiome profiles of 20 AIS-PHP patients and 20 healthy controls(HCs)were analyzed using liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based metabolomics and 16s rDNA sequencing,respectively.The covariation between LC-MS/MS-based metabolite data and 16s rDNA sequence data was presented.Results:Distinct alterations in the plasma metabolic phenotype of AIS-PHP patients were found,in which 16 metabolites differed significantly between the AIS-PHP patients and the HCs.These metabolites represented 17 different metabolic pathways,including amino acid metabolism,lipid metabolism,and nucleotide metabolism.Additionally,significant alterations of gut microbiota composition and taxon were revealed at the phylum level between the AIS-PHP patients and the HCs.In AIS-PHP,Bacteroidetes,Firmicutes,and Proteobacteria dominated.Moreover,some microbes that differed between the 2 groups manifested a sole association with certain metabolites,such as the connection between Bacteroides and inosine and between Lachnospiraceae_unclassified and hypoxanthine.Conclusion:The present study preliminarily investigated the metabolomic and gut microbiome characteristics of AIS-PHP patient indicators.The link between metabolic and microbial dysbiosis in AIS-PHP sheds new light on the function of gut microbiota and associated metabolomics in the pathogenesis of the disease. | Xing Huang Yun Cao Leyi Zhang Shuren Li Xin Shu Xiyan Xin Kazuo Sugimoto Jia Liu Ying Gao Jingling Chang | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，3： | 0 |
| 8 | STING-activating drug delivery systems:Design strategies and biomedical applications显示文摘The stimulator of interferon genes(STING)shows promising clinical activity in infectious diseases and tumors.However,the lack of targeting capability and intracellular stability of STING agonists severely limits the therapeutic efficacy.Recently,drug delivery systems(DDSs)overcome these delivery barriers of STING agonists via passive or active cell targeting,prolonged blood circulation and drug release,and lysosome escape,etc.In this review,we will describe in detail how existing DDSs are designed to overcome delivery barriers and activate the STING pathway,and the current biomedical applications of STING-activating DDSs in the treatments of infectious diseases and tumors.Finally,the prospects and challenges of DDSs in STING activation are discussed. | Chunying Li Yifan Zhang Yilin Wan Jingle Wang Jing Lin Zhiming Li Peng Huang | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
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