|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 2 | State of the Art and Prospects in Metal-Organic Framework-Derived Microwave Absorption Materials显示文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed. | Shuning Ren Haojie Yu Li Wang Zhikun Huang Tengfei Lin Yudi Huang Jian Yang Yichuan Hong Jinyi Liu | 2022 | Nano-Micro Letters2022，14，4： | 6 |
| 3 | Unveiling the Effects of Interchain Hydrogen Bonds on Solution Gelation and Mechanical Properties of Diarylfluorene-Based Semiconductor Polymers显示文摘The intrinsically rigid and limited strain of most conjugated polymers has encouraged us to optimize the extensible properties of conjugated polymers.Herein,learning from the hydrogen bonds in glucose,which were facilitated to the toughness enhancement of cellulose,we introduced interchain hydrogen bonds to polydiarylfluorene by amide-containing side chains.Through tuning the copolymerization ratio,we systematically investigated their influence on the hierarchical condensed structures,rheology behavior,tensile performances,and optoelectronic properties of conjugated polymers.Compared to the reference copolymers with a low ratio of amide units,copolymers with 30%and 40%amide units present a feature of the shearthinning process that resembled the non-Newtonian fluid,which was enabled by the interchain dynamic hydrogen bonds.Besides,we developed a practical and universal method for measuring the intrinsic mechanical properties of conjugated polymers.We demonstrated the significant impact of hydrogen bonds in solution gelation,material crystallization,and thin film stretchability.Impressively,the breaking elongation for P4 was even up to~30%,which confirmed the partially enhanced film ductility and toughness due to the increased amide groups.Furthermore,polymer light-emitting devices(PLEDs)based on these copolymers presented comparable performances and stable electroluminescence(EL).Thin films of these copolymers also exhibited random laser emission with the threshold as low as 0.52μJ/cm^(2),suggesting the wide prospective application in the field of flexible optoelectronic devices. | Lubing Bai Yamin Han Chen Sun Xiang An Chuanxin Wei Wei Liu Man Xu Lili Sun Ning Sun Mengna Yu He Zhang Qi Wei Chunxiang Xu Yingguo Yang Tianshi Qin Linghai Xie Jinyi Lin Wei Huang | 2020 | Research2020，，1： | 2 |
| 4 | Alkyl-chain branched effect on the aggregation and photophysical behavior of polydiarylfluorenes toward stable deep-blue electroluminescence and efficient amplified spontaneous emission显示文摘The control of the condensed superstructure of light-emitting conjugated polymers(LCPs)is a crucial factor to obtain high performance and stable organic optoelectronic devices.Side-chain engineering strategy is an effective platform to tune inter chain aggregation and photophysical behaviour of LCPs.Herein,we systematically investigated the alkyl-chain branched effecton the conformational transition and photophysical behaviour of polydiarylfluorenes toward efficient blue optoelectronic devices.The branched side chain will improve materials solubility to inhibit interchain aggregation in solution according to DLS and optical analysis,which is useful to obtain high quality film.Therefore,our branched PEODPF,POYDPF pristine film present high luminance efficiency of 36.1%and 39.6%,enhanced about 20%relative to that of PODPF.Compared to the liner-type sides'chain,these branched chains also suppress chain planarization and improve film morphological stability effectively.Interestingly,the branched polymer also had excellent stable amplified spontaneous emission(ASE)behaviour with low threshold(4.72μJ/cm2)and a center peak of 465 nm,even thermal annealing at 220℃in the air atmosphere.Therefore,side-chain branched strategy for LCPs is an effective means to control interchain aggregation,film morphology and photophysical property of LCPs. | Lili Sun Ning Sun Lubing Bai Xiang An Bin Liu Chen Sun Lixiang Fan Chuanxin Wei Yamin Han Mengna Yu Jinyi Lin Dan Lu Ning Wang Linghai Xie Kang Shen Xinwen Zhang Yanan Xu Juan Cabanillas-Gonzalez Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 5 | Stretchable organic electrochemical transistors via threedimensional porous elastic semiconducting films for artificial synaptic applications显示文摘Neuromorphic computing targets realizing biomimetic or intelligence systems capable of processing abundant tasks in parallel analogously to our brain,and organic electrochemical transistors(OECTs)that rely on the mixed ionic-electronic synergistic couple possess significant similarity to biological systems for implementing synaptic functions.However,the lack of reliable stretchability for synaptic OECTs,where mechanical deformation occurs,leads to consequent degradation of electrical performance.Herein,we demonstrate stretchable synaptic OECTs by adopting a three-dimensional poly(3-hexylthiophene)(P3HT)/styrene-ethylene-butylene-styrene(SEBS)blend porous elastic film for neuromorphic computing.Such architecture shows the full capability to emulate biological synaptic behaviors.Adjusting the accumulated layer numbers of porous film enables tunable OECT output and hysteresis,resulting in transition in plasticity.Especially,with a trilayer porous film,large-scale conductance and hysteresis are endorsed for efficient mimicking of memory-dependent synapse behavior.Benefitted from the interconnected three-dimensional porous structures,corresponding stretchable synaptic OECTs exhibit excellent mechanical robustness when stretched at a 30%strain,and maintain reliable electrical characteristics after 500 stretching cycles.Furthermore,near-ideal weight updates with near-zero nonlinearities,symmetricity in long-term potentiation(LTP)and depression,and applications for image simulation are validated.This work paves a universal design strategy toward highperformance stretchable neuromorphic computing architecture and could be extended to other flexible/stretchable electronics. | Yujie Peng Lin Gao Changjian Liu Jinyi Deng Miao Xie Libing Bai Gang Wang Yuhua Cheng Wei Huang Junsheng Yu | 2023 | Nano Research2023，16，7： | 1 |
| 6 | Synthesis of submicrome- ter sized Cu2 0 crystals with morphological evolution from cubic to hexapod structures and their comparative photo- catalytic activity显示文摘 | HO Jinyi HUANG Michael H | 2009 | J Phys Chem C2009，113，14： | 1 |
| 7 | Prebiotic effect of diosgenin, an immunoactive pogenin of the Chinese yam显示文摘 | Huang Chunghsiung Cheng Jinyi Deng Mingchung | 2012 | Food Chemistry2012，132，1： | 1 |
| 8 | Comparison Test on Adaptability of Six Medicago sativa (Alfalfa) Varieties in Guangxi显示文摘In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were selected and tested for growth performance,nutritional value and over-summer rate by the random block method.The results showed that the alfalfa varieties with better plant height and fresh grass yield were 59N59 and WL903,which showed the plant heights reaching 62.01 and 62.53 cm,respectively,and the fresh grass yields up to 40.93 and 38.38 t/hm 2,respectively,exhibiting extremely significant differences from the poorly performing Longwei 6010(P<0.01).The nutritional value of each tested variety was good,and the crude protein content was more than 20%.Among them,Elite 9 had a crude protein content as high as 28.43%.The over-summer rates of the six alfalfa varieties were all higher than 75%.It showed that the alfalfa varieties with fast growth,high yield,high nutritional value and high over-summer rate in this experimental area were 59N59 and WL903,which are suitable as the first varieties for planting in Guangxi. | Jinhua QIU Yilong HUANG Fanquan ZENG Jinyi WEI Na YAO | 2020 | Agricultural Biotechnology2020，9，4： | 1 |
| 9 | Hierarchical structures,surface morphology and mechanical elasticity of lamellar crystals dominated by halogen effects显示文摘To understand the deformation mechanism of molecular crystals under mechanical forces will accelerate the molecular design and preparation of deformable crystals.Herein,the relationship between structural halogenation and molecular-level stacking,micro/nanoscale surface morphology,and macroscopic mechanical properties are investigated.Elastic crystals of halo-pyrimidinyl carbazoles(CzM-Cl,CzM-Br and CzM-I)with lamellar structure and brittle crystal(CzM-F)were quantitatively analyzed by crystal energy framework(CEF)providing the inter/intralayer interaction energy(Inter/Intra-IE).It is revealed that the elastic crystals bend under external force as a result from stronger Intra-IE to prevent cleavage and weaker Inter-IE for the short-range movement of molecules on the slip plane.This research will provide an insight for the molecular design of flexible crystals and facilitate the development of next-generation smart crystal materials. | Chuanxin Wei Jianfeng Wang Yanni Zhang Xuehua Ding Yanze Jiang Qiang Zhao Jinyi Lin Jianfeng Zhao Linghai Xie Wei Huang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 10 | Salicylic acid sensitizes cervical cancer cells to radiotherapy by activating AMPK/TSC2/mTOR pathway显示文摘Objective:To investigate the radio-sensitizing effect of salicylic acid(SA)on human cervical cancer cells and its potential molecular mechanism.Methods:Cervical cancer cells were treated with SA and ionizing radiation.The expression ofγ-H2AX was evaluated by immunofluorescence(IF)assay.Cell cycle and apoptosis were analyzed by flow cytometry.Western blot was performed to detect the protein level of AMPK/TSC2/mTOR pathway.Results:SA inhibited basal proliferation of cervical cancer cells in a dose and time dependent manner.In addition,SA increased radiation-induced DNA damage,promoted apoptosis,triggered a redistribution of cell cycle from G2-M phase to G1-S phase of cervical cancer cells,and hence increased cell sensitivity to radiation.Moreover,SA treatment elevated the expression levels of p-AMPKα(t=3.996,P<0.05)and p-TSC2(t=5.308,P<0.05),whereas the level of p-mTOR(t=10.160,P<0.05)was significantly decreased.Conclusion:SA enhances the radiosensitivity of cervical cancer cells by targeting AMPK/TSC2/mTOR signaling pathway,and might serve as a promising therapeutic strategy to improve the efficacy of radiotherapy for cervical cancer. | Shun Lu Wenjing Ye Jie Zhou Guangming Yi Jianming Huang Siyao Deng Minglun Li Yimin Li Yanqiong Song Jiayu Zhang Lichun Wei Guiquan Zhu Jinyi Lang | 2022 | Radiation Medicine and Protection2022，3，1： | 0 |
| 11 | Erratum to:Forecasts on CMB lensing observations with AliCPT-1显示文摘One of the authors regrets that there was an omission of affiliation in this published article[1].The affiliation information of author Yi-WenWu only included the institution name for the author,and it is advised to add the university as the author’s second affiliation,which is the 16th affiliation of this article. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 12 | Fluorene pendant-functionalization of poly(N-vinylcarbazole)as deep-blue fluorescent and host materials for polymer light-emitting diodes显示文摘π-Electron coupling of pendant conjugated segment inπ-stacked semiconducting polymers always causes the formation of defect trapped sites and further quenched high-band excitons,which is harmful to the performance and stability of deep-blue polymer light-emitting diodes(PLEDs).Herein,considerate of“defect”carbazole(Cz)electromers in poly(N-vinylcarbazole)(PVK),a series of fluorene units are introduced into pendant segments(PVCz-DMeF,PVCz-FMeNPh and PVCz-DFMeNPh)to suppress the strongπ-electron coupling of pendant Cz units and enhance radiative transition toward fabricating sable PLEDs.Compared to PVCz-FMeNPh and PVCz-DFMeNPh,PVCz-DMeF spin-coated films show a relatively efficient deep-blue emission,completely similar to its single pendant chromophore,confirmed an extremely weak charge-transfer and electron coupling between adjacent pendant segments.Therefore,PLEDs based on PVCz-DMeF present stable and deep-blue emission with a high color purity(0.17,0.08),associated with extremely weak defect emission at 600∼700nm(induced by carbazole electromers).Finally,PLEDs based on PVCz-DMeF/F8BT blended films(1:1)also present the high maximum luminance(Lmax)of 6261 cd/m2 and current efficiency(CE_(max))of 2.03 cd/A,confirmed slightly trapped sites formation.Therefore,precisely control the arrangement and packing model of pendant units inπ-stacked polymer is an essential prerequisite for building efficient and stable emitter for optoelectronic devices. | Ning Sun Qin Zou Wenyu Chen Yingying Zheng Kai Sun Chunbin Li Yamin Han Lubing Bai Chuanxin Wei Jinyi Lin Chengrong Yin Jianguo Wang Wei Huang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 13 | DSEMR: A database for special environment microorganisms resource and associating them with synthetic biological parts显示文摘Special environmental microorganisms are considered to be of great industrial application value because of their special genotypes,physiological functions and metabolites.The research and development of special environmental microorganisms will certainly bring about some innovations in biotechnology processes and change the face of bioengineering.The Special Environmental Microbial Database(DSEMR)is a comprehensive database that provides information on special environmental microbial resources and correlates them with synthetic biological parts.DSEMR aggregates information on specific environmental microbial genomes,physiological properties,culture media,biological parts,and metabolic pathways,and provides online tool analysis data,including 5268 strains from 620 genera,31 media,and 42,126 biological parts.In short,DSEMR will become an important resource for the study of microorganisms in special environments and actively promote the development of synthetic biology. | Yuzhou Wang Jinyi Qian Fang Yan Yuetong Wang Tianqiong Shi Zhidong Zhang Chao Ye He Huang | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 14 | Enhancement of morphological and emission stability of deep-blue small molecular emitter via a universal side-chain coupling strategy for optoelectronic device显示文摘Film morphology of emissive layers is crucial to the performance and stability of solution-processable organic light-emitting diodes(OLEDs). Compared to the interpenetration of conjugated polymer chain,small molecular emitter with a flexible side chain always presents easily aggregation upon external treatment, and caused π-electronic coupling, which is undesirable for the efficiency and stability of deep-blue OLEDs. Herein, we proposed a side-chain coupling strategy to enhance the film morphological an emission stability of solution-processable small molecular deep-blue emitter. In contrary to “parent” MC8 TPA,the crosslinkable styryl and vinyl units were introduced as ended unit at the side-chain of Cm TPA and OEYTPA. Interestingly, Cm TPA and OEYTPA films present a relatively stable morphology and uniform deep-blue emission after thermal annealing(160 ℃) in the atmosphere, different to the discontinuous MC8 TPA annealed film. Besides, compared to the Cm TPA and OEYTPA ones, serious polaron formation in the MC8 TPA annealed film also negative to the deep-blue emission, according to transient absorption analysis. Therefore, both Cm TPA and OEYTPA annealed film obtained at 140 ℃ present an excellent deep-blue ASE behavior with a 445 nm, but absence for MC8 TPA ones, associated with the disruption of annealed films. Finally, enhancement of device performance based on Cm TPA and OEYTPA film(~40%)after thermal annealing with a similar performance curves also confirmed the assumption above. Therefore, these results also supported the effectiveness of our side-chain coupling strategy for optoelectronic applications. | Ning Sun Han Gao Lili Sun Jingxi An Man Xu Chen Sun Yamin Han Jinyi Lin Jiangli Cai Mingjian Ni Liangliang He Jinghao Yang Zhoulu Wang Lubing Bai Xinwen Zhang Qi Wei Xuehua Ding Chengrong Yin Linghai Xie Wei Huang | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 15 | Recent progress on electro-sorption technology for lithium recovery from aqueous sources显示文摘Lithium is known as the“white petroleum”of the electrification era,and the global demand for lithium grows rapidly with the quick development of new energy industry.The aqueous solutions,such as salt lake brine,underground brine,and seawater,have large lithium reserves,thus this kind of lithium resource has become a research hotspot recently.Compared with other lithium extraction technologies,electro-sorption method shows good prospects for practical applications with advantages in the aspects of efficiency,recovery ratio,cost,and environment.Herein,this review covers recent progress on electro-sorption technology for lithium recovery from aqueous solutions,including the concept illustration,research progress of the applied working electrodes and counter electrodes,and the evaluation indicators of electro-sorption system.Meanwhile,some prospects for the development of this technology are also proposed.We hope this review is beneficial for the construction of high-efficient electrochemical lithium recovery system to achieve an adequate lithium supply in the future. | Qichen Lu Peng Liu Tianyi Zhou Ruling Huang Kexin Zhang Lin Hu Rong Liu Zhibo Ren Jinyi Wang Xiaolong Wang | 2024 | Nano Research2024，17，4： | 0 |
| 16 | Universal 4-qualifiable fluorene-based building blocks for potential optoelectronic applications显示文摘In the design of conjugated molecules,modular production enables materials to easily realize structure modification and precisely tune their photoelectrical property.Construction of a novel and universal building block is crucial to design and manufacture high performance and stable conjugated molecules for optoelectronic application.Herein,we originally demonstrated a universal 4-qualifiable fluorene-based building block,which is a fundamental molecular segment to functionalize and obtain novel conjugated materials.Compared to the traditional modification at 9-site,additional 4-position functionalization provided an exciting blueprint to not only tune electronic structure and excited state via p-n molecular design engineering and space charge-transfer strategy,but also allow for optimizing intermolecular arrangement and obtaining solution-processing ability.The introduction of the 4-site substituent in fluorene based semiconductors may endow materials with unique properties.Finally,we successfully prepared two stable deep-blue light-emitting conjugated polymer,PODOPF and PODOF,by utilizing the 4-substituent fluorene based building block.It is believable that the performance,stability and processibility of reported outstanding fluorene-based conjugated molecules can be further optimized based on this universal building block. | Xiang An Jinghao Yang Man Xu Lili Sun Lubing Bai Kai Wang Zhiqiang Zhuo Yingying Zheng Jinyi Lin Xuehua Ding Yuyu Liu Linghai Xie Chengrong Yin Wei Huang | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 17 | Photoexcitation dynamics and energy engineering in supramolecular doping of organic conjugated molecules显示文摘Doping and blending strategies are crucial means to precisely control the excited states and energy level in conjugated molecular systems.However,effective models and platforms are rarely proposed to systematically explore the effects of the formation of trapped doped centers on heterogeneous structures,energy level and ultrafast photophysical process.Herein,for deeply understanding the impact of molecular doping in film energy levels and photoexcitation dynamics,we set a supramolecular N-B coordination composed by the conjugated molecules of pyridine functionalized diarylfluorene(host material),named as ODPF-Phpy and ODPF-(Phpy)2,and the molecule of tris(perfluorophenyl)borane(BCF)(guest material).The generation of the molecular-level coordination bond increased the binding energy of N atoms and tuned the band-gap,leading to a new fluorescent emission center with longer excitation wavelength and emission wavelength.The intermolecular Forster resonance energy transfer(FRET)in blending flms make it present inconsistent fluorescent behaviors compared to that in solution.The charge transfer(CT)state of N-B coordinated compounds and the changed dielectric constant of blending films resulted in a large PL spectra red-shift with the increased dopant ratio,causing a wide-tunable fluorescent color.The excited state behaviors of two compounds in blending system was further investigated by the transient absorption(TA)spectroscopy.Finally,we found supramolecular coordination blending can effectively improve the films'photoluminescence quantum yield(PLQY)and conductivity.We believe this exploration in the internal coordination mechanisms would deepen the insights about doped semiconductors and is helpful in developing novel high-efficient fluorescent systems. | Xiang An Chuanxin Wei Lubing Bai Jun Zhou Le Wang Yamin Han Lili Sun Jinyi Lin Heyuan Liu Jiewei Lil Man Xu Haifeng Ling Linghai Xie Wei Huang | 2023 | Light(Science & Applications)2023，12，2： | 0 |
| 18 | Forecasts on CMB lensing observations with AliCPT-1显示文摘Ali CPT-1 is the first Chinese cosmic microwave background(CMB) experiment aiming for the high-precision measurement of CMB B-mode polarization. The telescope, currently under deployment in Tibet, will observe in two frequency bands centered at 90 and 150 GHz. We forecast the CMB lensing reconstruction, lensing-galaxy, and lensing-cosmic infrared background(CIB) cross-correlation signal-to-noise ratio(SNR) for Ali CPT-1. We consider two stages with different integrated observation times, namely “4 module*yr”(first stage) and “48 module*yr”(final stage). For lensing reconstruction, we use three different quadratic estimators, namely temperature-only, polarization-only and minimum-variance(MV) estimators, using curved sky geometry. We take into account the impacts of inhomogeneous hit counts and mean-field bias due to incomplete sky coverage.In the first stage, our results show that the 150 GHz channel can measure the lensing signals at 15σ significance with the MV estimator. In the final stage, the measurement significance will increase to 31σ. We also combine the two frequency data in the harmonic domain to optimize the SNR. Our results show that the coadding procedure can significantly reduce the reconstruction bias in the high multiple range. Owning to the high quality of the polarization data in the final stage of Ali CPT-1, the EB estimator will dominate the lensing reconstruction in this stage. We also estimate the SNR of cross-correlations between Ali CPT-1 CMB lensing and other tracers of the large scale structure of the universe. For its cross-correlation with Dark Energy Spectroscopic Instrument(DESI) galaxies/quasars, we report the cross-correlation SNR = 10-20 for the four redshift bins at 0.05 < z < 2.1. In the first stage, the total SNR is approximately 32. In the final stage, the lensing-galaxy cross-correlation can reach SNR = 52. For lensing-CIB cross-correlation, in the first stage, the cross-correlations between Ali CPT-1 lensing and Planck CIB 353, 545 and857 GHz channels are approximately SNR = 18, 19, and 23, respectively. In the final stage, the cross-correlations can reach SNR = 25, 33 and 42. Due to the strong correlations between frequency bands, the total lensing-CIB cross-correlations by combining the three frequencies in Planck CIBs are SNR = 23 and 43 for the Ali CPT-1 first and final stages, respectively. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 0 |
| 19 | Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer显示文摘Background:Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer(TNBC).One of the immunosuppressive pathways involves programmed cell death-1(PD-1)and programmed cell death ligand-1(PD-L1),but many patients derived little benefit from PD-1/PD-L1 checkpoint blockades treatment.Prior research has shown that MYC,a master transcription amplifier highly expressed in TNBC cells,can regulate the tumor immune microenvironment and constrain the efficacy of immunotherapy.This study aims to investigate the regulatory relationship between MYC and PD-L1,and whether a cyclin-dependent kinase(CDK)inhibitor that inhibits MYC expression in combination with anti-PD-L1 antibodies can enhance the response to immunotherapy.Methods:Public databases and TNBC tissue microarrays were used to study the correlation between MYC and PD-L1.The expression of MYC and PD-L1 in TNBCs was examined by quantitative real-time polymerase chain reaction and Western blotting.A patient-derived tumor xenograft(PDTX)model was used to evaluate the influence of a CDK7 inhibitor THZ1 on PD-L1 expression.Cell proliferation and migration were detected by 5-ethynyl-2′-deoxyuridine(EdU)cell proliferation and cell migration assays.Tumor xenograft models were established for in vivo verification.Results:A high MYC expression level was associated with a poor prognosis and could alter the proportion of tumor-infiltrating immune cells(TIICs).The positive correlation between MYC and PD-L1 was confirmed by immunostaining samples from 165 TNBC patients.Suppression of MYC in TNBC caused a reduction in the levels of both PD-L1 messenger RNA and protein.In addition,antitumor immune response was enhanced in the TNBC cancer xenograft mouse model with suppression of MYC by CDK7 inhibitor THZ1.Conclusions:The combined therapy of CDK7 inhibitor THZ1 and anti-PD-L1 antibody appeared to have a synergistic effect,which might offer new insight for enhancing immunotherapy in TNBC. | Xintong Li Lin Tang Qin Chen Xumin Cheng Yiqiu Liu Cenzhu Wang Chengjun Zhu Kun Xu Fangyan Gao Jinyi Huang Runtian Wang Xiaoxiang Guan | 2022 | Chinese Medical Journal2022，135，20： | 0 |
| 20 | Feeding Effect of Codariocalyx gyroides on Meat Rabbits显示文摘To explore the feeding effect of Codariocalyx gyroides on meat rabbits, 30 healthy meat rabbits at the age of 50 days were randomly divided into five groups(Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ), six rabbits each group. Rabbits in experimental groups Ⅰ,Ⅱ,Ⅲ and Ⅳ were fed with different quantita-tive complete formula feed and unlimited fresh grass of C. gyroides, and those in group Ⅴ(control group) were fed with complete formula feed. The indicators such as feed intake and growth performance were measured after 60 d. The results showed that the gaining effects of meat rabbits in ex-perimental groups Ⅳ and Ⅲ were most obvious, and the daily gain reached(25.75 ±3.00) and(24.50±1.95) g, 20.72% and 14.86% higher than those in control group, respectively. The conversion efficiency of dry matter in experimental group Ⅲ was the highest, and only 2.99 g of C. gyroides and compound feed dry matter was consumed for the growth of 1 g of rabbit meat, receiving significant economic benefit. | Yao Na Huang Yilong Zeng Fanquan Deng Suyuan Lai Dawei Wei Jinyi | 2019 | Animal Husbandry and Feed Science2019，11，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员