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| 1 | Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway显示文摘Acacetin(5,7-dihydroxy-4′-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions. However, whether acacetin has an effect on inflammatory corpuscle 3(NLRP3) after cerebral ischemia-reperfusion injury has not been fully determined. This study used an improved suture method to establish a cerebral ischemia-reperfusion injury model in C57BL/6 mice. After ischemia with middle cerebral artery occlusion for 1 hour, reperfusion with intraperitoneal injection of 25 mg/kg of acacetin(acacetin group) or an equal volume of saline(0.1 mL/10 g, middle cerebral artery occlusion group) was used to investigate the effect of acacetin on cerebral ischemia-reperfusion injury. Infarct volume and neurological function scores were determined by 2,3,5-triphenyltetrazolium chloride staining and the Zea-Longa scoring method. Compared with the middle cerebral artery occlusion group, neurological function scores and cerebral infarction volumes were significantly reduced in the acacetin group. To understand the effect of acacetin on microglia-mediated inflammatory response after cerebral ischemia-reperfusion injury, immunohistochemistry for the microglia marker calcium adapter protein ionized calcium-binding adaptor molecule 1(Iba1) was examined in the hippocampus of ischemic brain tissue. In addition, tumor necrosis factor-α, interleukin-1β, and interleukin-6 expression in ischemic brain tissue of mice was quantified by enzyme-linked immunosorbent assay. Expression of Iba1, tumor necrosis factor-α, interleukin-1β and interleukin-6 was significantly lower in the acacetin group compared with the middle cerebral artery occlusion group. Western blot assay results showed that expression of Toll-like receptor 4, nuclear factor kappa B, NLRP3, procaspase-1, caspase-1, pro-interleukin-1β, and interleukin-1β were significantly lower in the acacetin group compared with the middle cerebral artery occlusion group. Our findings indicate that acacetin has a protective effect on cerebral ischemia-reperfusion injury, and its mechanism of action is associated with inhibition of microglia-mediated inflammation and the NLRP3 signaling pathway. | Juan Bu Shen Shi Hui-Qin Wang Xiao-Shan Niu Zong-Feng Zhao Wei-Dong Wu Xiao-Ling Zhang Zhi Ma Yan-Jun Zhang Hui Zhang Yi Zhu | 2019 | Neural Regeneration Research2019，14，4： | 22 |
| 2 | Effect of repaglinide and gliclazide on glycaemic control, early-phase insulin secretion and lipid profiles in newly diagnosed type 2 diabetics显示文摘repaglinide 和 gliclazide 是的背景广泛地在类型 2 diabetes.They 的治疗使用的胰岛素促泌素通过不同机制刺激胰岛素分泌物并且可以从学习是在 glycaemic 控制上评估 repaglinide 或 gliclazide 的效果的在场的不同 aspects.The 有益于病人,胰岛素分泌物,并且类脂化合物在 47 全部的 A 最新诊断了的类型 2 糖尿病 patients.Methods 介绍打 2 个糖尿病病人被使随机化与 repagl 接受4星期的治疗的 | ZHANG Hong BU Ping XIE Yan-hong LUO Juan LEI Min-xiang MO Zhao-hui LIAO Er-yuan | 2011 | Chinese Medical Journal2011，，2： | 10 |
| 3 | Rapid Detection of Haemophilus influenzae and Haemophilus parainfluenzae in Nasopharyngeal Swabs by Multiplex PCR显示文摘Objective To establish multiplex PCR-based assays for detecting H.influenzae and H.parainfluenzae.And the PCR-based assays were applied to detect the carriage rates of H.influenzae and H.parainfluenzae in nasopharyngeal swab specimens which were collected from healthy children.Methods Multiplex primers for species-specific PCR were designed by using DNAstar soft based on the sequences of 16S rRNA genes from genus Haemophilus to detect H.influenzae and H.parainfluenzae.Results The sensitivity of the 16S rRNA PCR assay for detecting H.influenzae and H.parainfluenzae was 97.53% and 100% respectively,and the specificity was 95.89% and 96.63% respectively.Youden's Index on the ability to detect H.influenzae and H.parainfluenzae was 0.9342 and 0.9663 respectively.666 nasopharyngeal swab specimens were collected from healthy children.The detection rates of H.influenzae and H.parainfluenzae were 14.11% and 16.07% respectively by using isolation and culture methods.The detection rates of H.influenzae and H.parainfluenzae were 43.54% and 57.96% respectively by 16S rRNA PCR assays.The carriage rates of serotypes a,b,c,d,e,f and non-typeable isolates were 0% (0/666),0.15% (1/666),1.20% (8/666),0.15% (1/666),1.20% (8/666),1.80% (12/666),95.50% (636/666) respectively.Conclusion The multiplex PCR assays were very rapid,reliable and feasible methods for detection of H.influenzae and H.parainfluenzae in pharyngeal swab specimens which were compared to conventional isolation and culture methods.95.5% of H.influenzae strains in healthy children were nontypeable.The encapsulated or typable strains were mainly three serotypes which was c,e,and f serotype. | TIAN Guo Zhong ZHANG Li Juan WANG Xiao Lei ZHANG Li LI Shu Feng GU Chang Mei SUN Jian CUI Bu Yun | 2012 | Biomedical and Environmental Sciences2012，25，3： | 8 |
| 4 | Isolation and identification of Serratia marcescens Ha1 and herbicidal activity of Ha1 ‘pesta’ granular formulation显示文摘A total of 479 bacterial strains were isolated from brine(Bohai, Qinhuangdao City, Hebei Province, China). Bioassay results indicated that 4 strains named Ha1, Ha17, Ha38, and Ha384 had herbicidal activity. And strain Ha1 had the highest effective herbicidal activity. As a result, this study aims to identify strain Ha1, characterize its physiological and biological activities, evaluate the herbicidal activity of its metabolites, and develop a ‘pesta' formulation and assess its effectiveness on Digitaria sanguinalis. Ha1 was identified as Serratia marcescens based on 16 S r DNA sequencing. This strain has a flagellum, a diameter of 0.5 to 0.8 μm, and a length of 0.9 to 2.0 μm. The indole test shows positive results, and the catalase enzyme exhibits strong positive reactions. Results further showed that the inhibitory concentration(IC50) of the crude extracts to D. sanguinalis radicula and coleoptile were 3.332 and 2.828 mg m L–1, respectively. Both the suppression of D. sanguinalis and the cell viability of the Ha1 formulation in ‘pesta' were higher when stored at 4°C than at(25±2)°C. These results indicated that S. marcescens Ha1 can potentially be used as a biocontrol agent against D. sanguinalis. | YANG Juan WANG Wei YANG Peng TAO Bu YANG Zheng ZHANG Li-hui DONG Jin-gao | 2015 | Journal of Integrative Agriculture2015，14，7： | 8 |
| 5 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，14： | 6 |
| 6 | MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway显示文摘Apoptosis is an important programmed cell death process involved in ischemia/reperfusion injury.MicroRNAs are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion injury.However,whether miR-670 can regulate cell growth and death in cerebral ischemia/reperfusion and the underlying mechanism are poorly understood.In this study,we established mouse models of transient middle artery occlusion and Neuro 2a cell models of oxygen-glucose deprivation and reoxygenation to investigate the potential molecular mechanism by which miR-670 exhibits its effects during cerebral ischemia/reperfusion injury both in vitro and in vivo.Our results showed that after ischemia/reperfusion injury,miR-670 expression was obviously increased.After miR-670 expression was inhibited with an miR-670 antagomir,cerebral ischemia/reperfusion injury-induced neuronal death was obviously reduced.When miR-670 overexpression was induced by an miR-670 agomir,neuronal apoptosis was increased.In addition,we also found that miR-670 could promote Yap degradation via phosphorylation and worsen neuronal apoptosis and neurological deficits.Inhibition of miR-670 reduced neurological impairments after cerebral ischemia/reperfusion injury.These results suggest that microRNA-670 aggravates cerebral ischemia/reperfusion injury through the Yap pathway,which may be a potential target for treatment of cerebral ischemia/reperfusion injury.The present study was approved by the Institutional Animal Care and Use Committee of China Medical University on February 27,2017(IRB No.2017PS035K). | Shi-Jia Yu Ming-Jun Yu Zhong-Qi Bu Ping-Ping He Juan Feng | 2021 | Neural Regeneration Research2021，16，6： | 6 |
| 7 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part II显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，15： | 3 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | A fast and robust image segmentation using fern with spatial information 显示文摘 | Wang Xiang-Yang Bu Juan | 2010 | Digital Signal Processing2010，20，4： | 1 |
| 10 | A fast and robust image seg- mentation using FCM with spatial information 显示文摘 | Wang Xiang-Yang Bu Juan | 2010 | Digital Signal Processing2010，20，4： | 1 |
| 11 | A Fast and Robust Image SegmentationUsing FCM with Spatial Information显示文摘 | Wang Xiangyang Bu Juan | 2009 | Digital Signal Processing2009，11，7： | 1 |
| 12 | A fast and robust image segmentation using FCM with spatial information 显示文摘 | WSNG Yang-xiang BU Juan | 2009 | Digital Signal Processing2009，11，7： | 1 |
| 13 | Traffic Engineering Based on Deep Reinforcement Learning in Hybrid IP/SR Network显示文摘Segment Routing(SR)is a new routing paradigm based on source routing and provide traffic engineering(TE)capabilities in IP network.By extending interior gateway protocol(IGP),SR can be easily applied to IP network.However,upgrading current IP network to a full SR one can be costly and difficult.Hybrid IP/SR network will last for some time.Aiming at the low flexibility problem of static TE policies in the current SR networks,this paper proposes a Deep Reinforcement Learning(DRL)based TE scheme.The proposed scheme employs multi-path transmission and use DRL to dynamically adjust the traffic splitting ratio among different paths based on the network traffic distribution.As a result,the network congestion can be mitigated and the performance of the network is improved.Simulation results show that our proposed scheme can improve the throughput of the network by up to 9%than existing schemes. | Bo Chen Penghao Sun Peng Zhang Julong Lan Youjun Bu Juan Shen | 2021 | China Communications2021，18，10： | 1 |
| 14 | A Fast and Robust Image Segmentation Using FCM with Spatial Information 显示文摘 | WANG Xiangyang BU Juan | 2010 | Digital Signal Processing2010，20，4： | 1 |
| 15 | A fast and robust image segmentation using FCM with spatial information显示文摘 | Wang Xiangyang Bu Juan | 2009 | Digital Signal Processing2009，11，7： | 1 |
| 16 | Ru/SBA-15 catalysts for partial hydrogenation of benzene to cyclohexene: Tuning the Ru crystallite size by Ba显示文摘 | BU Juan LIU Jian-liang CHEN Xue-ying | 2008 | Catalysis Communications2008，9，： | 1 |
| 17 | A fhst and robust image segmentation using FCM with spatial inffoalation显示文摘 | Xiang-Yang Wang Juan Bu | 2010 | Digitd Signal Processirtg2010，20，4： | 1 |
| 18 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，14： | 1 |
| 19 | Selective hydrogenation of benzene over Ru/SBA-15 catalyst prepared by the 'double solvents' impregnation method 显示文摘 | Bu Juan PeiYan Guo Pingjun | 2007 | Studies in Surface Science and Catalysis2007，165，： | 1 |
| 20 | A fast and robust image segmentation using FCM with spatial information显示文摘 | Wang Xiangyang Bu Juan | 2010 | Digital Signal Processing2010，20，4： | 1 |
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