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| 1 | Analysis of serum cardiac biomarkers and treadmill exercise test-electrocardiogram for the diagnosis of coronary heart disease in suspected patients显示文摘浆液蛋白质肌酸 kinase isoenzyme MB ( CK-MB )和心脏的 troponin T 是在临床的实践的心脏的 ischemic 损坏的经典 biomarkers ,它能易感知地检测心肌的坏死另外的二浆液蛋白质,修改局部缺血的白朊和N终端 pro-B-type natriuretic 肽( NT-proBNP ),最近作为心肌的局部缺血的新奇 biomarkers 被识别了。在这研究,四 biomarkers 在踏车锻练测试( TET )前后与怀疑的冠的心疾病( CHD )从 44 个合格病人在 sera 被检测,心电图( ECG )在 TET ( TET-ECG )和冠的 angiography ( CAG )的侵略检查期间被测量,它是 CHD 诊断的标准答案,也被执行。为 CAG, 25 个病人是积极的,, 19 为数字是的 TET-ECG 是否定的 19 和 25 分别地。在这四 biomarkers 之中,在 CAG 积极的组的 NT-proBNP 水平在 TET 前后两个都比在 CAG 否定的组的那些高得多,与在 TET 前的统计意义(P = 0.008 ) 。根据操作特征(巨鸟) 曲线的接收装置,而且,浆液 biomarker NT-proBNP 证明 CHD 和它的截止价值的诊断效果是 67 pg/ml,因此,在这的 30 个病人学习是积极的 NT-proBNP, 14 是否定的。并且是否独自或在里面与 TET-ECG 分析了联合,被发现 NT-proBNP 显然提高了考试的敏感。更重要地,在 NT-proBNP 和 TET-ECG 测试否定的所有病人结果是 CAG 否定,它意味着这二非侵略的考试的联合可能为 CHD 代替 CAG 的侵略检查诊断。与更多的病人一起的进一步的研究被保证在这份报纸验证调查结果。 | Zhenhua Zhu Yan Yan Qibing Wang Juying Qian Junbo Ge | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 10 |
| 2 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 3 | Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation显示文摘Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. | Junbo Gao Xingjie Zhang Kun Shang Weimao Zhong Ruihan Zhang Xiaochang Dai Xiaoli Li Qi Wang Yan Zou Weilie Xiao | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 4 | Observation of arc discharging process of nanocomposite Ag–SnO 2 and La-doped Ag–SnO 2 contact with a high-speed camera显示文摘 | Wang Junbo Zhang Yan Yang Minge Ding Bingjun Yang Zhimao | 2006 | Materials Science & Engineering B2006，，： | 2 |
| 5 | Observation of arc discharging process of nanocomposite Ag-SnO2 and La-doped Ag-SnO2 contact with a high- speed camera显示文摘 | Wang Junbo Zhang Yan Yang Minge | 2006 | Materials Science and Engineering B2006，131，13： | 1 |
| 6 | Band -notched UWB Printed Antenna with an Inverted - L - Slotted Ground 显示文摘 | Jiang Junbo Song Yue Yan Zehong | 2009 | Microwave and Optical Technology Letters2009，51，3： | 1 |
| 7 | Synthesis of several MPP derivatives for ^(99m)Tc-labelling and evaluated as potential 5-HT_(1A) receptor imaging agents显示文摘The(2-methoxyphenyl) piperazine(MPP) was selected as the functional group and conjugated to dithiocarbamate through different spacers.A series of new MPP derivatives(MPPnDTC,n = 2-6) were synthesized and radiolabelled with 99mTc-nitrido core or 99mTc-tricarboxyl core as potential 5-HT1A receptor imaging agents.All the six 99mTc-labelled complexes were lipophilic and neutral.Biodistribution results showed that those radiotracers had moderate initial brain and hippocampus uptake.There have no significant relation was observed between the biological properties of these tracers with the length of its carbon chain.The radioactivity concentrations of hippocampus of 99mTcN-MPP2DTC,99mTcN-MPP3DTC,99mTcN-MPP4DTC,99mTcN-MPP5DTC,99mTcN-MPP6DTC and 99mTc(CO)3-MPP3DTC at 2 min post-injection time(p.i.) were 0.43,1.15,0.99,1.04,1.13 and 0.83 %ID/g,respectively. | YANG WenJiang LIN Yan ZHANG XianZhong ZHANG JunBo WANG XueBin | 2011 | Science China Chemistry2011，54，7： | 1 |
| 8 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 9 | Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/mTOR Signaling显示文摘 | Dayong Zhang Bingxi Yan Shanshan Yu Chong Zhang Baoming Wang Yayan Wang Junbo Wang Zhanggen Yuan Lihuang Zhang Jianping Pan Sidhartha D. Ray | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 10 | Dual band-notched ultra-wideband printed antenna with two different types of slots显示文摘 | Jiang Junbo Yan Zehong Zhang Jieyu | 2009 | Micro Opt Technol Lett2009，52，9： | 1 |
| 11 | Synthesis and biological evaluation of ^(99m)Tc-HEDTA/HYNIC-MPP4 complex for 5-HT1A receptor imaging显示文摘5-HT1A receptor is associated with a variety of pathophysiology of neuropsychiatric disorders. Accordingly, we have synthesized a new 5-HT1A receptor ligand (HYNIC-MPP4) and labeled it with 99mTc using N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) as coligand. 99mTc-HEDTA/HYNIC-MPP4 was prepared under pH 6 at room temperature. Biodistribution of 99mTc-HEDTA/HYNIC-MPP4 in normal mice showed that this complex had moderate brain uptake (0.60% ID·g-1 at 2 min p.i.) and good retention. The hippocampus had the highest radioactivity uptake at 2 min p.i. (1.84% ID·g-1). The ratio of Hipp/CB was 3.1 at 2 min p.i. and increased to 4.4 at 60 min p.i. After blocking with 8-hydroxy-2-(dipropylamino) tetralin, the uptake of hippocampus was decreased significantly from 1.84% ID·g-1 to 0.53% ID·g-1 at 2 min p.i., while the cerebellum had no significant decrease. This 99mTc complex could be a potent agent for 5-HT1A receptor imaging. | FAN WeiWei*, LIN Yan*, ZHANG XianZhong, PANG Yan, MA Cong, TANG ZhiGang, ZHANG JunBo & WANG XueBin Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China | 2009 | Science China Chemistry2009，52，5： | 1 |
| 12 | Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca 2+ influx in breast cancer cells显示文摘 | Jiajia Hu Kunhua Qin Yan Zhang Junbo Gong Na Li Dan Lv Rong Xiang Xiaoyue Tan | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 13 | Geographic Variation in Cardiovascular Health as Analyzed from the China Cardiovascular Health Index Study——31 PLADs,China,2017-2021显示文摘Summary What is already known about this topic?The prevalence of cardiovascular disease(CVD)in China is high,while effective prevention and proper management is lacking.No available indicators were found before 2016 that could comprehensively evaluate different aspects of CVD prevention and treatment. | Fan Mao Yingying Jiang Jing Liu Yan Zhang Yong Jiang Linhong Wang Dong Zhao Yong Huo Junbo Ge Maigeng Zhou | 2022 | China CDC weekly2022，4，13： | 1 |
| 14 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 15 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 16 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 17 | High-speed penetration of ogive-nose projectiles into thick concrete targets:Tests and a projectile nose evolution model显示文摘The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit. | Xu Li Yan Liu Junbo Yan Zhenqing Shi Hongfu Wang Yingliang Xu Fenglei Huang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 18 | Pathways toward wearable and high-performance sensors based on hydrogels:toughening networks and conductive networks显示文摘Wearable hydrogel sensors provide a user-friendly option for wearable electronics and align well with the existing manufacturing strategy for connecting and communicating with large numbers of Internet of Things devices.This is attributed to their components and structures,which exhibit exceptional adaptability,scalability,bio-compatibility,and self-healing properties,reminiscent of human skin.This review focuses on the recent research on principal structural elements of wearable hydrogels:toughening networks and conductive networks,highlighting the strategies for enhancing mechanical and electrical properties.Wearable hydrogel sensors are categorized for an extensive exploration of their composition,mechanism,and design approach.This review provides a comprehensive understanding of wearable hydrogels and offers guidance for the design of components and structures in order to develop high-performance wearable hydrogel sensors. | Junbo Zhu Jingchen Tao Wei Yan Weixing Song | 2023 | National Science Review2023，10，9： | 0 |
| 19 | Experimental and numerical analyses of the effect of fibre content on the close-in blast performance of a UHPFRC beam显示文摘Limited research has been conducted on the influences of fiber content on close-in blasting characteristics for ultrahigh-performance fiber-reinforced concrete(UHPFRC)beams.This paper aims to address this knowledge gap through experimental and mesoscale numerical methods.Experiments were conducted on ten UHPFRC beams built with varying steel fiber volumetric fractions subjected to close-in explosive conditions.Additionally,this study considered other parameters,such as the longitudinal reinforcement type and ratio.In the case of UHPFRC beams featuring normal-strength longitudinal reinforcement of diametersΦ12,Φ16,andΦ20,a reduction in maximum displacement by magnitudes of19.6%,19.5%,and 17.4%was observed,respectively,as the volumetric fractions of fiber increased from1.0%to 2.5%.In addition,increasing the longitudinal reinforcement ratio and using high-strength steel longitudinal reinforcement both significantly reduced the deformation characteristics and increase the blasting resistances of UHPFRC beams.However,the effects on the local crushing and spalling damage were not significant.A mesoscale finite element model,which considers the impacts of fiber parameters on UHPFRC beam behaviors,was also established and well correlated with the test findings.Nevertheless,parametric analyses were further conducted to examine the impacts of the steel fiber content and length and the hybrid effects of various types of microfibers and steel fibers on the blasting performance of UHPFRC beams. | Junbo Yan Qiyue Zhang Yan Liu Yingliang Xu Zhenqing Shi Fan Bai Fenglei Huang | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 20 | A forced alignment approach to detect Chinese repetitive stuttering显示文摘A forced alignment based algorithms to detect Chinese repetitive stuttering is studied. According to the features of repetitions in Chinese stuttered speech,improvement solutions are provided based on the previous research findings.First,a multi-span looping forced alignment decoding networks is designed to detect multi-syllable repetitions in Chinese stuttered speech.Second,branch penalty factor is added in the networks to adjust decoding trend using recursive search in order to reduce the error from the complexity of the decoding networks. Finally,we re-judge the detected stutters by calculating confidence to improve the reliability of the detection result.The experimental results show that compared to previous algorithm,the proposed algorithm can improve system performance significantly,about 18%average detection error rate relatively. | ZHANG Junbo YAN Qian GAO Xinglong PAN Fuping FENG Yongqiang XING Lili LIN Chunlan PAN Jielin | 2013 | Chinese Journal of Acoustics2013，32，3： | 0 |
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