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| 1 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 2 | Cloning and bioinformatics analysis of a full-length cDNA of porcine CRl-like gene显示文摘 | Jing Cheng Junbing Jiang Junxing Zhao Zhirui Wang Yaogui Sun Haili Ma Kuohai Fan Wei Yin Na Sun Zhiwei Wang Xin Zhao Hongquan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 7 |
| 3 | Light-driven artificial muscles based on electrospun microfiber yarns显示文摘Artificial muscles are widely potential in diverse fields including medical treatment, humanoid robotics and industrial automation. Soft materials due to bio-friendly interaction are suitable for those applications. Planar and fiber shape based artificial muscles that use the polymer as substrate materials can be triggered by various stimuli like electric, moisture and heat. Here,artificial muscles based on electrospun microfiber yarns are demonstrated, which can be remotely controlled. The carbon nanotubes embedded in polyurethane microfibers enable the yarns to efficiently absorb near-infrared light and radiate heat,which induces the fast temperature change that leads to the contraction/expansion motions along the axial direction. Microfiber mats are collected by a rotating cylinder that results in highly oriented alignment. The yarns from microfiber mats are highly twisted into the coiled structure, which generates maximum contractive actuation of 6.7% at 70°C. 1000 cycles were demonstrated without an obvious decline of actuating performances. The light-driven artificial muscles can be potentially applied in wireless control, bio-medical devices and so on. | MENG JunXing HOU ChengYi ZHANG QingHong LI YaoGang WANG HongZhi | 2019 | Science China(Technological Sciences)2019，62，6： | 3 |
| 4 | Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate显示文摘 | Huarong Nie Aihua He Wanling Wu Jianfen Zheng Shanshan Xu Junxing Li Charles C. Han | 2009 | Polymer2009，，20： | 2 |
| 5 | A high-quality sponge gourd(Luffa cylindrica)genome显示文摘Sponge gourd(Luffa cylindrica)is an important cultivated vegetable and medicinal plant in the family Cucurbitaceae.In this study,a draft genome sequence of the sponge gourd inbred line P93075 was analyzed.Using Illumina,PacBio,and 10×Genomics sequencing techniques as well as new assembly techniques such as FALCON and chromatin interaction mapping(Hi-C),a chromosome-scale genome of approximately 656.19 Mb,with an N50 scaffold length of 48.76 Mb,was generated.From this assembly,25,508 protein-coding gene loci were identified,and 63.81%of the whole-genome consisted of transposable elements,which are major contributors to the expansion of the sponge gourd genome.According to a phylogenetic analysis of conserved genes,the sponge gourd lineage diverged from the bitter gourd lineage approximately 41.6 million years ago.Additionally,many genes that respond to biotic and abiotic stresses were found to be lineage specific or expanded in the sponge gourd genome,as demonstrated by the presence of 462 NBS-LRR genes,a much greater number than are found in the genomes of other cucurbit species;these results are consistent with the high stress resistance of sponge gourd.Collectively,our study provides insights into genome evolution and serves as a valuable reference for the genetic improvement of sponge gourd. | Haibin Wu Gangjun Zhao Hao Gong Junxing Li Caixia Luo Xiaoli He Shaobo Luo Xiaoming Zheng Xiaoxi Liu Jinju Guo Junqiu Chen Jianning Luo | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | Transferring conjugated poly (γ-glutamic acid-maleimide-co-L-lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine copolymer nanoparticles for targeting drug delivery显示文摘 | Caiyan Zhao Xiaoguang Liu Junxing Liu Zhiwei Yang Xianghui Rong Mingjun Li Xingjie Liang Yan Wu | 2014 | Colloids and Surfaces B: Biointerfaces2014，，： | 1 |
| 7 | Comparing Intra-Arterial Chemotherapy Combined With Intravesical Chemotherapy Versus Intravesical Chemotherapy Alone: A Randomised Prospective Pilot Study for T1G3 Bladder Transitional Cell Carcinoma After Bladder-Preserving Surgery显示文摘 | Junxing Chen Zhijun Yao Shaopeng Qiu Lingwu Chen Yu Wang Jianyong Yang Jiaping Li | 2013 | CardioVascular and Interventional Radiology2013，，6： | 1 |
| 8 | Effects of rape straw and red mud on extractability and bioavailability of cadmium in a calcareous soil显示文摘划算的土壤修正案屏蔽是重要的在 situ 补习技术发展因为镉(Cd ) 污染了土壤。在这研究,不同土壤修正案包括红泥,氧化铝工业的一个副产品,并且酸处理,由 nanoparticle milling , nano 和酸处理的红 对待nano 泥,沸石,玉米稻草,和强奸稻草,被评估在二个增加的层次使 Cd 不能调动( 2 和 5 mg Cd 敲漠?業牣?汥'虪箾K獹獩爠慥瑣牯?桷捩?湩楤慣整?牧慥?潰整瑮慩?潦?桴?牰捡楴慣?灡汰捩瑡潩?景琠敨挠牥浡捩?湩琠敨映敩摬漠?捡畴污椠摮獵牴慩? | Junxing YANG Liqun WANG Jumei LI Dongpu WEI Shibao CHEN Qingjun GUO Yibing MA | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 1 |
| 9 | An Evaluation on Transfection Efficiency of pHRE-Egr1-EGFP in Hepatocellular Carcinoma Cells Bel-7402 Mediated by PEI-MZF-NPs显示文摘 | Mei Lin Dongsheng Zhang Junxing Huang Jia Zhang Li Wang Ting Guo Li Xiao Jun Ye Lixin Zhang Daxiang Cui | 2011 | Journal of Nanomaterials2011，，： | 1 |
| 10 | Interfacial-Strain-Induced Structural and Polarization Evolutions in Epitaxial Multiferroic BiFeO_3(001) Thin Films显示文摘Varying the film thickness is a precise route to tune the interfacial strain to manipulate the properties of the multiferroic materials.Here,to explore the effects of the interfacial strain on the properties of the multiferroic BiFeO_3films,we investigated thickness-dependent structural and polarization evolutions of the BiFeO_3 films.The epitaxial growth with an atomic stacking sequence of BiO/TiO_2 at the interface was confirmed by scanning transmission electron microscopy.Combining X-ray diffraction experiments and first-principles calculations,a thickness-dependent structural evolution was observed from a fully strained tetragonality to a partially relaxed one without any structural phase transition or rotated twins.The tetragonality(c/a) of the BiFeO_3 films increases as the film thickness decreases,while the polarization is in contrast with this trend,and the size effect including the depolarization field plays a crucial role in this contradiction in thinner films.These findings offer an alternative strategy to manipulate structural and polarization properties by tuning the interfacial strain in epitaxial multiferroic thin films. | 郭海中 Ruiqiang Zhao Kui-juan Jin Lin Gu Dongdong Xiao Zhenzhong Yang Xiaolong Li Le Wang Xu He Junxing Gu Qian Wan Can Wang Huibin Lu Chen Ge Meng He Guozhen Yang | 2015 | 功能材料信息2015，12，3： | 1 |
| 11 | Hybrid bound states in the continuum in terahertz metasurfaces显示文摘Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical switches.The most common strategy to apply BICs in a metasurface is by breaking symmetry of resonators in the uniform array that leaks the otherwise uncoupled mode to free space and exhibits an inverse quadratic relationship between quality factor(Q)and asymmetry.Here,we propose a scheme to further reduce scattering losses and improve the robustness of symmetry-protected BICs by decreasing the radiation density with a hybrid BIC lattice.We observe a significant increase of radiative Q in the hybrid lattice compared to the uniform lattice with a factor larger than 14.6.In the hybrid BIC lattice,modes are transferred toГpoint inherited from high symmetric X,Y,and M points in the Brillouin zone that reveal as multiple Fano resonances in the far field and would find applications in hyperspectral sensing.This work initiates a novel and generalized path toward reducing scattering losses and improving the robustness of BICs in terms of lattice engineering that would release the rigid requirements of fabrication accuracy and benefit applications of photonics and optoelectronic devices. | Junxing Fan Zuolong Li Zhanqiang Xue Hongyang Xing Dan Lu Guizhen Xu Jianqiang Gu Jiaguang Han Longqing Cong | 2023 | Opto-Electronic Science2023，2，4： | 1 |
| 12 | Multi-scale promoting effects of lead for palladium catalyzed aerobic oxidative coupling of methylacrolein with methanol显示文摘 | Han Junxing Zhang Suojiang Li Yuchao | 2015 | Catal Sci Technol2015，5，4： | 1 |
| 13 | Preparation of exfoliated isotactic polypropylene/alkyl-triphenylphosphonium-modified montmorillonite nanocomposites via in situ intercalative polymerization 显示文摘 | He Aihua Wang Limei Li Junxing | 2006 | Polymer2006，47，6： | 1 |
| 14 | Gelatin and gelatin- hyaluronic acid nanofibrous membranes produced by electrospinning of their aqueous solutions显示文摘 | Li Junxing He Aihua Zheng Jianfen | 2006 | Biomacromolecules2006，，7： | 1 |
| 15 | Studies on the controlled morphology and wettabihty of polystyrene surfaces by electrospinning or electrospraying显示文摘 | Zheng Jianfen He Aihua Li Junxing Han Charles C | 2006 | Polymer2006，47，： | 1 |
| 16 | Lessons learned from the Wenchuan earthquake显示文摘 | Ji Shen Junxing Kang Yingkang Shi Youping Li Yuanfeng Li Lin Su Jianlin Wu Shangwei Zheng Jie Jiang Weijian Hu Yong Yang Xuefeng Tang Jin Wen Ling Li Jiantong Shen Dake Zhong | 2012 | Journal of Evidence‐Based Medicine2012，，2： | 1 |
| 17 | Vitamin A injection at birth improves muscle growth in lambs显示文摘Vitamin A and its metabolite,retinoic acid(RA)play important roles in regulating skeletal muscle development.This study was conducted to investigate the effects of early intramuscular vitamin A injection on the muscle growth of lambs.A total of 16 newborn lambs were given weekly intramuscular injections of corn oil(control group,n=8)or 7,500 IU vitamin A palmitate(vitamin A group,n=8)from birth to 3 wk of age(4 shots in total).At 3 wk of age and weaning,biceps femoris muscle samples were taken to analyze the effects of vitamin A on the myogenic capacity of skeletal muscle cells.All lambs were slaughtered at 8 months of age.The results suggest that vitamin A treatment accelerated the growth rate of lambs and increased the loin eye area(P<0.05).Consistently,vitamin A increased the diameter of myofibers in longissimus thoracis muscle(P<0.01)and increased the final body weight of lambs(P<0.05).Vitamin A injection did not change the protein kinase B/mammalian target of rapamycin and myostatin signaling(P>0.05).Moreover,vitamin A upregulated the expression of PAX7(P<0.05)and the myogenic marker genes including MYOD and MYOG(P<0.01).The skeletal muscle-derived mononuclear cells from vitamin A-treated lambs showed higher expression of myogenic genes(P<0.05)and formed more myotubes(P<0.01)when myogenic differentiation was induced in vitro.In addition,in vitro analysis showed that RA promoted myogenic differentiation of the skeletal muscle-derived mononuclear cells in the first 3 d(P<0.05)but not at the later stage(P>0.05)as evidenced by myogenic gene expression and fusion index.Taken together,neonatal intramuscular vitamin A injection promotes lamb muscle growth by promoting the myogenic potential of satellite cells. | Pengkang Song Xiaoyou Chen Jiamin Zhao Qiang Li Xinrui Li Yu Wang Bo Wang Junxing Zhao | 2023 | Animal Nutrition2023，，3： | 0 |
| 18 | The role of DNA methylation in the maintenance of phenotypic variation induced by grafting chimerism in Brassica显示文摘Grafting facilitates the interaction between heterologous cells with different genomes,resulting in abundant phenotypic variation,which provides opportunities for crop improvement.However,how grafting-induced variation occurs and is transmitted to progeny remains elusive.A graft chimera,especially a periclinal chimera,which has genetically distinct cell layers throughout the plant,is an excellent model to probe the molecular mechanisms of grafting-induced variation maintenance.Here we regenerated a plant from the T-cell layer of a periclinal chimera,TCC(where the apical meristem was artificially divided into three cell layers–from outside to inside,L1,L2,and L3;T=Tuber mustard,C=red Cabbage),named rTTT0(r=regenerated).Compared with the control(rsTTT,s=self-grafted),rTTT0 had multiple phenotypic variations,especially leaf shape variation,which could be maintained in sexual progeny.Transcriptomes were analyzed and 58 phenotypic variation-associated genes were identified.Whole-genome bisulfite sequencing analyses revealed that the methylome of rTTT0 was changed,and the CG methylation level was significantly increased by 8.74%.In rTTT0,the coding gene bodies are hypermethylated in the CG context,while their promoter regions are hypomethylated in the non-CG context.DNA methylation changes in the leaf shape variation-associated coding genes,ARF10,IAA20,ROF1,and TPR2,were maintained for five generations of rTTT0.Interestingly,grafting chimerism also affected transcription of the microRNA gene(MIR),among which the DNA methylation levels of the promoters of three MIRs associated with leaf shape variation were changed in rTTT0,and the DNA methylation modification of MIR319 was maintained to the fifth generation of selfed progeny of rTTT0(rTTT5).These findings demonstrate that DNA methylation of coding and non-coding genes plays an important role in heterologous cell interaction-induced variation formation and its transgenerational inheritance. | Ke Liu Tingjin Wang Duohong Xiao Bin Liu Yang Yang Kexin Xu Zhenyu Qi Yan Wang Junxing Li Xun Xiang Lu Yuan Liping Chen | 2023 | Horticulture Research2023，10，3： | 0 |
| 19 | Establishment of Agrobacterium tumefaciens-mediated Genetic Transformation System for Aspergillus awamori显示文摘[Objective] This study aimed to establish Agrobacterium tumefaciens-mediated genetic transformation system for Aspergillus awamori and investigate the feasibility of expressing heterologous proteins in A.awamori.[Method] Appropriate A.awamori host strains were determined according to the secretory protein profile.Selectable marker was selected for genetic transformation by drug sensitivity analysis.The established A.awamori genetic transformation system was used for transformation and expression analysis of Rhizomucor miehei lipase(RML).The feasibility of using A.awamori to express heterologous proteins was investigated by identification of transformants and property analysis.[Result] Based on the analysis of secretory protein profile,A.awamori strains CBS115.52 and CICC2257 were determined as the host strains for heterologous protein expression;drug sensitivity analysis shows that hygromycin B resistance gene(HygBr) is an effective genetic selectable marker;by using Agrobacterium tumefaciens-mediated transformation(ATMT) method,the plasmid pHGW-amdS containing HygBr was successfully transformed into A.awamori strain CBS115.52 to establish the genetic transformation system of A.awamori with HygBr as selectable marker.RML was transformed into A.awamori and its expression was validated by substrate hydrolysis test,SDS-PAGE and Western blot.[Conclusion] This study demonstrates that the genetic transformation system of A.awamori mediated by Agrobacterium tumefaciens has potential feasibility for expression of heterologous proteins. | Feng CHEN Kun WANG Chao YIN Deming LI Nan REN Junxing LI | 2012 | Agricultural Biotechnology2012，1，3： | 0 |
| 20 | Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK‑PGC‑1α signaling pathway and alters the muscle fiber composition of sheep显示文摘Background Vitamin A(VA)and its metabolite,retinoic acid(RA),are of great interest for their wide range of physiological functions.However,the regulatory contribution of VA to mitochondrial and muscle fiber composition in sheep has not been reported.Method Lambs were injected with 0(control)or 7,500 IU VA palmitate into the biceps femoris muscle on d 2 after birth.At the age of 3 and 32 weeks,longissimus dorsi(LD)muscle samples were obtained to explore the effect of VA on myofiber type composition.In vitro,we investigated the effects of RA on myofiber type composition and intrinsic mechanisms.Results The proportion of type I myofiber was greatly increased in VA-treated sheep in LD muscle at harvest.VA greatly promoted mitochondrial biogenesis and function in LD muscle of sheep.Further exploration revealed that VA elevated PGC-1αmRNA and protein contents,and enhanced the level of p38 MAPK phosphorylation in LD muscle of sheep.In addition,the number of type I myofibers with RA treatment was significantly increased,and type IIx myofibers was significantly decreased in primary myoblasts.Consistent with in vivo experiment,RA significantly improved mitochondrial biogenesis and function in primary myoblasts of sheep.We then used si-PGC-1αto inhibit PGC-1αexpression and found that si-PGC-1αsignificantly abrogated RA-induced the formation of type I myofibers,mitochondrial biogenesis,MitoTracker staining intensity,UQCRC1 and ATP5A1 expression,SDH activity,and enhanced the level of type IIx muscle fibers.These data suggested that RA improved mitochondrial biogenesis and function by promoting PGC-1αexpression,and increased type I myofibers.In order to prove that the effect of RA on the level of PGC-1αis caused by p38 MAPK signaling,we inhibited the p38 MAPK signaling using a p38 MAPK inhibitor,which significantly reduced RA-induced PGC-1αand MyHC I levels.Conclusion VA promoted PGC-1αexpression through the p38 MAPK signaling pathway,improved mitochondrial biogenesis,and altered the composition of muscle fiber type. | Pengkang Song Jiamin Zhao Fanqinyu Li Xiaoyi Zhao Jinxin Feng Yuan Su Bo Wang Junxing Zhao | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
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