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| 1 | Towards developing Mg alloys with simultaneously improved strength and corrosion resistance via RE alloying显示文摘Magnesium(Mg)alloys have received an increasing interest in the past two decades for their tremendous application potential.The strength and corrosion resistance levels of common Mg alloys are still relativity low,and especially they are to be improved simultaneously.The addition of rare earth(RE)to Mg alloys is believed to be beneficial for both the strength and corrosion resistance,and some RE-modified traditional Mg alloys have been studied and some new RE-containing Mg alloys have been developed by now.However,further simultaneous improvements in both strength and anti-corrosion require a better understanding of the behavior and mechanism of RE in Mg alloys.In this review,the common influence mechanisms of RE on mechanical and anti-corrosion properties of Mg alloys are summarized,and the latest research progress of RE-containing Mg alloys with simultaneously improved strength and corrosion resistance are introduced.It is demonstrated that the research on high-strength and high corrosion resistant RE-containing Mg alloys is still immature,and some opinions and suggestions are put forward for the synergetic improvement of the strength and corrosion resistance of Mg alloys,so as to contribute to the further development of Mg alloys with higher performance. | Jinshu Xie Jinghuai Zhang Zihao You Shujuan Liu Kai Guan Ruizhi Wu Jun Wang Jing Feng | 2021 | Journal of Magnesium and Alloys2021，9，1： | 25 |
| 2 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 3 | Admission delay is associated with worse surgical outcomes for elderly hip fracture patients:A retrospective observational study显示文摘BACKGROUND:The influence of surgical delay on mortality and morbidity has been studied extensively among elderly hip fracture patients.However,most studies only focus on the timing of surgery when patients have already been hospitalized,without considering pre-admission waiting time.Therefore,the present study aims to explore the infl uence of admission delay on surgical outcomes.METHODS:In this retrospective study,we recorded admission timing and interval from admission to surgery for included patient.Other covariates were also collected to control confounding.The primary outcome was 1-year mortality.The secondary outcomes were 1-month mortality,3-month mortality,ICU admission and postoperative pneumonia.We mainly used multivariate logistic regression to determine the effect of admission timing on postoperative outcomes.An additional survival analysis was also performed to assess the impact of admission delay on survival status in the fi rst year after operation.RESULTS:The proportion of patients hospitalized on day 0,day 1,day 2 after injury was 25.4%,54.7%and 66.3%,respectively.And 12.6%patients visited hospital one week later after injury.Mean time from admission to surgery was 5.2 days(standard deviation 2.8 days).Hospitalization at one week after injury was a risk factor for 1-year mortality(OR 1.762,95%CI 1.026–3.379,P=0.041).CONCLUSION:Admission delay of more than one week is signifi cantly associated with higher 1-year mortality.As a supplement to the current guidelines which emphasizes early surgery after admission,we also advocate early admission once patients get injured. | Wei He Yue-yang You Kai Sun Chen Xie Yue Ming Li-na Yu Feng-jiang Zhang Min Yan | 2020 | World Journal of Emergency Medicine2020，11，1： | 11 |
| 4 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 5 | Effects of electroacupuncture at Guanyuan(CV 4)or Sanyinjiao(SP 6)on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice显示文摘OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8(SAMP8)were divided into three groups: the disease model,EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1(SAMR1)were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone(FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determinethe HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze(MWM) test.RESULTS:(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels(P < 0.01), and an increase in Gn RH, LH and FSH levels(P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group(P < 0.05). In contrast,Gn RH and LH and FSH levels were reduced(P <0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining Gn RH levels(P < 0.01).(b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day5 compared with the disease model group(P <0.05), whereas the EA-Guanyuan treatment group showed no significant difference.CONCLUSION: EA can regulate hormone(E2, FSH,LH, Gn RH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory. | Wang Jing Cheng Kai Qin Zhuo Wang Yanping Zhai Lijing You Min Wu Juanjiao | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 8 |
| 6 | Adaptive Gaussian sum squared-root cubature Kalman filter with split-merge scheme for state estimation显示文摘The paper deals with state estimation problem of nonlinear non-Gaussian discrete dynamic systems for improvement of accuracy and consistency. An efficient new algorithm called the adaptive Gaussian-sum square-root cubature Kalman filter(AGSSCKF) with a split-merge scheme is proposed. It is developed based on the squared-root extension of newly introduced cubature Kalman filter(SCKF) and is built within a Gaussian-sum framework. Based on the condition that the probability density functions of process noises and initial state are denoted by a Gaussian sum using optimization method, a bank of SCKF are used as the sub-filters to estimate state of system with the corresponding weights respectively, which is adaptively updated. The new algorithm consists of an adaptive splitting and merging procedure according to a proposed split-decision model based on the nonlinearity degree of measurement. The results of two simulation scenarios(one-dimensional state estimation and bearings-only tracking) show that the proposed filter demonstrates comparable performance to the particle filter with significantly reduced computational cost. | Liu Yu Dong Kai Wang Haipeng Liu Jun He You Pan Lina | 2014 | Chinese Journal of Aeronautics2014，27，5： | 5 |
| 7 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 8 | M13 Bacteriophage-Polymer Nanoassemblies as Drug Delivery Vehicles显示文摘Poly (caprolactone-b-2-vinylpyridine )(PCL-P2VP ) 与叶酸结合 M13 (FA-M13 ) 涂提供能够包含象 doxorubicin (纪录影片) 那样的恐水病的 antitumor 药的一个 nanosized 交货系统。装载纪录影片的 FA-M13-PCL-P2VP 集会有约 200 nm 的一条平均直径,他们的结构用传播电子显微镜学被描绘,扫描电子显微镜学,并且动态轻散布。粒子在生理的 pH 是稳定的,但是能在更低的 pH 被降级。从在酸的条件下面的 nanoassemblies 的纪录影片的版本比在生理的 pH 观察了的被显示显著地快。另外,装载纪录影片的 FA-M13-PCL-P2VP 粒子比 folate-receptor-negative 房间对 folate-receptor-positive 癌症房间显示出显然更大的细胞的举起和 cytotoxicity,显示受体便于经由调停受体的 endocytosis 的叶酸的举起。而且,装载纪录影片的粒子也与免费纪录影片相比有显著地更高的肿瘤举起和选择。这研究因此提供一个新方法制作 nanosized 药交货车辆。 | Nisaraporn Suthiwangcharoen Tao Li Kai Li Preston Thompson Shaojin You Qian Wang | 2011 | Nano Research2011，4，5： | 4 |
| 9 | Multi-dimensional overall regulatory modes and threshold values for water cycle of the Haihe River Basin显示文摘In this study, a multi-dimensional critical regulatory criteria and decision-making mechanism based on the scientific cognition of multi-dimensional attributes and characteristics of the water cycle was proposed. This system was functioned by deeply discriminating the nature-society binary characteristics of the five-dimensional characteristics of the water cycle system of the Haihe River Basin (water resources, economy, society, ecology, and environment) under the influence of high-intensity human activities and hydrological changes and by analyzing the organic interactive relationships between the five dimensions and their overall effect on the water cycle. A GDP calculation model was constructed in this study by adjusting the water environment for water resources, after which five-dimensional normalization objective functions were established for multi-objective analysis to carry out trade-off analysis of multi-dimensional regulatory indexes. In addition, synergetic theory, entropy theory and dissipation structure theory were introduced to construct an evaluation model for multi-dimensional regulatory schemes. A water cycle multi-dimensional critical overall regulatory model system was also established. This system consisted of a multi-objective macroeconomic model (DAMOS), water resource allocation model based on rules (ROWAS), evaluation model for WEDP (EMW) and multi-dimensional regulatory scheme evaluation model (SEAMUR) as the main body. To address the national demands faced by the Haihe River Basin as a result of combinatorial schemes for different hydrological series and water amounts diverted by the south-to-north water diversion project, this study adopted a hierarchy progression method to set up the technologies, investigated multi-dimensional overall regulatory methods, proposed an overall regulation threshold value for the water cycle of the Haihe River Basin, and recommended corresponding five-dimensional regulatory schemes. | GAN Hong WANG Lin CAO YinBai YOU JinJun GAN ZhiGuo QIN ChangHai HE Shan XU Kai | 2013 | Chinese Science Bulletin2013，58，27： | 4 |
| 10 | Characteristics of a Drainage Channel with Staggered Indented Sills for Controlling Debris Flows显示文摘The characteristics of a new type of drainage channel with staggered indented sills for controlling debris flows were studied. The intermediate fluid in the non-viscous debris flow exhibited a helical movement, whereas the fluid near the sidewall had a stop-start movement pattern; the viscous debris flow exhibited a stable structure between the indented sills. The experimental results indicate that the mean velocity of the debris flow increased with increasing channel gradients, and the debris flow velocity was slightly affected by the angle of the sills. The average velocity of the non-viscous debris flow increased in the range of(0.5–1.5) interval between the indented sills, whereas the average velocity of the viscous debris flow increased initially and then decreased in the range of(0.75–1.25) interval between the indented sills. The depth of the non-viscous debris flow tended to gradually increase as the channel gradients increased, whereas the depth of the viscous debris flow gradually decreased as the channel gradients increased. When the discharge of the debris flow was constant, the angle and the interval between the indented sills had a slight effect on the depth of the viscous debris flow, whereas the depth of the non-viscous debris flow exhibited a different trend, as the sill angles and intervals were varied. | CHEN Xiao-qing YOU Yong CHEN Jian-gang HUANG Kai LI De-ji | 2014 | Journal of Mountain Science2014，11，5： | 4 |
| 11 | New variables for measuring joint space width to evaluate knee osteoarthritis显示文摘估计膝骨关节炎( OA )的X光线照相术的特征的背景,特别联合的空间变窄,是重要的因为评估这研究的疾病 progression.The 目的到过由在X光检查电影上测量 2 新 variables:the 一般水准关节空间宽度( aJSW )和清晰角度( AA )变窄的份量上分析关节空间,并且到评估在 2 个变量之间的关系,用基于万维网的辐射学阅读器( Cedara I-ReachTM 4.1.1 )的膝函数和 OA symptoms.Methods ,我们 | AN Bing-chen FANG Kai WANG You ZENG Yi-ming DAI Ke-rong | 2011 | Chinese Medical Journal2011，，23： | 3 |
| 12 | Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma显示文摘Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs(linc RNAs) play in diverse cellular processes, our knowledge of how linc RNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of linc RNAs.Consistent with previous findings of co-expression between neighboring protein-coding genes, linc RNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of linc RNAs termed 'regulatory linc RNAs', representing their dominant roles in gene regulation. The number of regulatory linc RNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory linc RNA,GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory linc RNAs with inclusion of some cancer-associated linc RNAs. Our integrated analysis reveals enhanced regulatory effects of linc RNAs and provides a resource for the study of regulatory linc RNAs that play critical roles in lung adenocarcinoma. | You Zhou Kai Wu Jianping Jiang Jinfei Huang Peiwei Zhang Yufei Zhu Guohong Hu Jingyu Lang Yufang Shi Landian Hu Tao Huang Xiangyin Kong | 2015 | Journal of Genetics and Genomics2015，42，8： | 3 |
| 13 | Effect of electroacpuncture of Neiguan(PC 6)and Tianquan(PC 2)on skin temperature,blood perfusion,and adrenoceptor response in rats with acute myocardial ischemia显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) of acupoints Neiguan(PC 6) and Tianquan(PC 2) on the skin temperature, blood perfusion, and alpha1-and beta2-adrenoreceptor(α1-AR and β2-AR) protein and m RNA level in rats with acute myocardial ischemia.METHODS: Thirty male adult Wistar rats [(230 ±20) g] were randomly assigned into five groups(n = 6 each): a control group, sham operation group, model group, model group treated with EA at low frequency(L-EA, 2 Hz, 1 m A) and model group treated with EA at high frequency(H-EA, 100 Hz, 1 m A). The rat model was prepared by ligating the left anterior descending coronary artery. Electroacupuncture was performed at the left Neiguan(PC 6) for 20 min daily for 3 d. After the 3 rd time of the treatment, measurements of skin blood perfusion and temperature in Neiguan(PC 6) and Tianquan(PC 2) in all groups were made by laser speckle contrast imaging and infrared thermal image instrument. Real-time PCR and ELISA were used to measure m RNA level and protein level of α1-AR andβ2-AR in the skin tissues of Neiguan(PC 6) and Tianquan(PC 2), respectively. Serum levels of c Tn T and electrocardiogram were used to identify the state of myocardium.RESULTS: In the group receiving electroacupunture at Neiguan(PC 6), compared with control group,the skin temperature, blood perfusion, and β2-AR m RNA and protein level of model group significantly decreased(P < 0.05), α1-AR m RNA and protein level of model group significantly increased(P < 0.05);compared with model group, the skin temperature,blood perfusion, and β2-AR m RNA and protein level of L-EA significantly increased(P < 0.05), α1-AR m RNA and protein level of L-EA and H-EA significantly decreased(P < 0.05). The same trend has taken place in the former four groups of the Tianquan(PC 2).CONCLUSION: Low-or high-frequency electroacupuncture can improve the skin temperature and blood perfusion which may be induced by decreasingthelevelofα1-ARandincreasingthelevelofβ2-AR of the Neiguan(PC 6) and Tianquan(PC 2) in the rat with acute myocaidial ischemia. | Wang Dan Ji Bo Zhao Guozhen Yan Mingna Bai Hongxin Sun Xiaomin Dai Jian Lu Yawen Liu Yitian You Min Wu Jiaojuan Ge Yunpeng Su Hang Cheng Kai | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 14 | LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy显示文摘Stem cell marker LIN28,related closely with SOX2 and OCT4,has been studied as a biomarker for the maintainance of pluripotent cells in several malignancies.Our previous study showed that SOX2 and OCT4 were negative predictors for hepatocellular carcinoma(HCC).However,the predictive value of LIN28 in HCC outcome is still undetermined.We hypothesized that LIN28 may also play a role as a biomarker for HCC.To test this hypothesis,we examined the expression of LIN28 in 129 radically resected HCC tissues using reverse transcription-polymerase chain reaction and analyzed the association of LIN28 expression with clinicopathologic features and prognosis.Our study showed that LIN28 was expressed at a higher frequency in tumor tissues than in non-HCC tissues(45.0% vs.21.7%,P = 0.020).Moreover,LIN28 expression was significantly increased in cases with large tumor size(P = 0.010).Univariate analysis did not reveal a significant correlation between LIN28 expression and overall survival or recurrence-free survival.For HCC patients who met the Milan criteria,stratified analysis revealed shorter overall survival(P = 0.007) and recurrence-free survival(P < 0.001) in those with detectable LIN28 expression compared to those with no detectable LIN28 expression.Furthermore,multivariate analysis revealed that LIN28 was a negative independent predictor for both overall survival(hazard ratio= 7.093,P = 0.017) and recurrence-free survival(hazard ratio=5.518,P = 0.004) in patients who met the Milan criteria.Taken together,our results suggest that LIN28 identifies low-risk and high-risk subsets of HCC patients meeting the Milan criteria who undergo hepatectomy. | Ji-Liang Qiu Pin-Zhu Huang Jing-Hong You Ru-Hai Zou Li Wang Jian Hong Bin-Kui Li Kai Zhou Yun-Fei Yuan | 2012 | Chinese Journal of Cancer2012，31，5： | 3 |
| 15 | Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme显示文摘背景 Glioblastoma multiforme ( GBM )是在 adults.Magnetic 回声成像( MRI )的最普通、致命的主要大脑肿瘤习惯性地在诊断被使用,描述和 GBM.The 诊断的临床的管理和 GBM 的治疗被试图识别在磁性的回声特征和 43 个 glioblastoma 病人的 GBM.Methods MRI 图象的分子的病理之间的关系的组织病理学说和 immunohistochemistry.This 学习大部分指导是 collected.Four 成像特征, | LI Wen-bin TANG Kai ZHANG Wei YAN Wei YOU Gang LI Shao-wu ZHANG Long HUANG Yan-jie JIANG Tao | 2011 | Chinese Medical Journal2011，，17： | 3 |
| 16 | Fabrication and Evaluation of Porous Keratin/chitosan(KCS) Scaffolds for Effectively Accelerating Wound Healing显示文摘Objective To develop a dressing with desired antibacterial activity, good water maintaining ability and mechanical properties for wound healing and skin regeneration. Methods The chitosan with different concentrations were added in keratin solution to form porous keratin/chitosan(KCS) scaffolds. The morphological characteristics, chemical composition, wettability, porosity, swelling ratio and degradation of the scaffolds were evaluated. The antibacterial activity was tested by using S. aureus and E. coli suspension for 2 h. And L929 fibroblast cells culture was used to evaluate the cytotoxicity of the KCS scaffolds. Results The adding of chitosan could increase the hydrophobicity, decrease porosity, swelling ratio and degradation rate of the KCS porous scaffolds. Mechanical properties of KCS scaffolds could be enhanced and well adjusted by chitosan. KCS scaffolds could obviously decrease bacteria number. The proliferation of fibroblast cells in porous KCS patch increased firstly and then decreased with the increase of chitosan concentration. It was appropriate to add 400 μg/m L chitosan to form porous KCS scaffold for achieving best cell attachment and proliferation compared with other samples. Conclusion The porous KCS scaffold may be used as implanted scaffold materials for promoting wound healing and skin regeneration. | TAN Hong Bo WANG Fu You DING Wei ZHANG Ying DING Jing CAI Di Xin YU Kai Fu YANG Jun YANG Liu XU Yong Qing | 2015 | Biomedical and Environmental Sciences2015，28，3： | 2 |
| 17 | Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq显示文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species. | Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi | 2018 | Science China(Life Sciences)2018，61，9： | 2 |
| 18 | Wisdom, predicaments, and challengesof a millennium ancient weir—Dujiangyan Project显示文摘The Dujiangyan Project,located at the junction of the upstream of the Minjiang River and Chengdu Plain,Sichuan Province,China,is an irrigation system project as important as the Great Wall in the history of China.Without dam structures,this project has been continuously playing its crucial role in diverting water for irrigation,separating sediments,and controlling flood for 2275 years.In this study,the predicaments of the Dujiangyan Project under the background of rapid urbanization and social economic development were summarized by conducting the field research and using the Indicators of Hydrological alteration(IHA)method:excessive diversion of water,disruption of hydrological pulses,erosion and deposition imbalance and conflicts between power generation and water supply.These contradictions have led to the weakening of the function of automatic water diversion and sand removal in the Dujiangyan Project.Considering the influence of climate change and strong human activities,we pointed out the challenges faced by the millennium ancient weir in balancing human and environmental water usage and project operation and management based on the simulation results of the hydrological model.The corresponding suggestions about strengthening agricultural water saving,generating artificial flood peak were provided to protect and continue to maintain the function of the Dujiangyan Project. | HUANG Xiao-rong ZHOU Xing-yu YOU Jin-jun YANG Qing WANG Yan-jun MA Kai | 2021 | Journal of Mountain Science2021，18，11： | 1 |
| 19 | Experimental and numerical investigation ofconvective drying of single coarse lignite particles显示文摘 | Kai Zhang Changfu You | 2010 | Energy andFuels2010，24，： | 1 |
| 20 | Experimental and numerical investigation oflignite particle drying in a fixed bed显示文摘 | Kai Zhang Changfu You | 2011 | Energy and Fuels2011，25，： | 1 |
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