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| 1 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 2 | Optimal Design of Multiple Stresses Accelerated Life Test Plan Based on Transforming the Multiple Stresses to Single Stress显示文摘For planning optimum multiple stresses accelerated life test plans, a commonly followed guiding principle is that all parameters of the life-stress relationship should be estimated, and the number of the stress level combinations must be no less than the number of parameters of the life-stress relationship. However, the general objective of an accelerated life test(ALT) is to assess the p-th quantile of the product life distribution under normal stress. For this objective, estimating all model parameters is not necessary, and this will increase the cost of test. Based on the theoretical conclusion that the stress level combinations of the optimum multiple stresses ALT plan locate on a straight line through the origin of coordinate, it is proposed that a design idea of planning the optimum multiple stresses ALT plan through transforming the problem of designing an optimum multiple stresses ALT plan to designing an optimum single stress ALT plan. Moreover, a method of planning the optimum multiple stresses ALT plan which can avoid estimating all model parameters is established. An example shows that, the proposed plan which only has two stress level combinations could achieve an accuracy no less than the traditional plan, and save the test time and cost on one stress level combination at least; when the actual product life is less than the design value, even the deviation of the model initial parameters value is up to 20%, the variance of the estimation of the p-th quantile of the proposed plan is still smaller than the traditional plans approximately 25%. A design method is provided for planning the optimum multiple stresses ALT which uses the statistical optimum degenerate test plan as the optimum multiple stresses accelerated life test plan. | GAO Liang CHEN Wenhua QIAN Ping PAN Jun HE Qingchuan | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 3 | Effects of microstructure on the torsional properties of biodegradable WE43 Mg alloy显示文摘Torsional properties are important performance parameters for bone screw applications,but they are seldom studied,especially for newly developed biodegradable Mg alloys.In this study,WE43 Mg alloy with different microstructures was achieved by equal channel angular pressing(ECAP)and heat treatment,and their torsional properties were studied.In addition,tensile properties were also tested as a comparison.The results indicated that grain refinement led to higher torsional strength and ductility,while the second phases improved the torsional strength but reduced the ductility.The texture was strengthened after ECAP,as a result the tensile strength increased,but the torsional strength did not increase and even decreased,especially for 2-pass ECAP sample with a typical basal fiber texture.The basal plane orientation deviation from the extrusion direction after 4-pass ECAP resulted in higher torsional strength and lower torsional ductility,but lower tensile strength and higher tensile ductility were obtained.This implied that a strong fiber texture would reduce the torsional strength but improve the torsional ductility,which was different from its effect on tensile properties. | Yi Zhang Lili Tan Qingchuan Wang Ming Gao Iniobong P.Etim Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，16： | 4 |
| 4 | Mandatory IFRS adoption and executive compensation:Evidence from China显示文摘This study investigates how the mandatory adoption of International Financial Reporting Standards(IFRS) affects the contractual benefits of using accounting information to determine executive compensation in China. After controlling for firm and corporate governance characteristics, we find strong evidence supporting the positive role of mandatory IFRS adoption on the accounting-based performance sensitivity of executive compensation. Subsample analysis suggests that improvements in accounting-based performance sensitivity after IFRS adoption differ across regions with various levels of institutional quality and across firms that are affected to a different extent by the adoption. Additional analysis supports the argument that the positive effects of IFRS adoption on the use of accounting performance in executive compensation are driven by the reduction in accounting conservatism associated with IFRS adoption. | Qingchuan Hou Qinglu Jin Lanfang Wang | 2014 | China Journal of Accounting Research2014，，1： | 4 |
| 5 | Influence of precipitation on the Portevin-Le Chatelier effect in Al-Mg alloys显示文摘In the alloy with solute content higher than the limiting solubility,the solute atoms that have failed to dissolve will precipitate from the solid solution and form precipitations.In this study, the Portevin-Le Chatelier(PLC) effects in annealed 5456 and 5052 aluminum alloys with different precipitation contents have been investigated under different applied strain rates.The results suggest that precipitations have significant effect on the PLC effect and the more the precipitations are, the greater the ... | Qi Hu,~(a))Qingchuan Zhang,~(b)) Shihua Fu,Pengtao Cao,and Ming Gong CAS Key Laboratory of Mechanical Behavior and Design of Materials,University of Science and Technology of China,Hefei 230027,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，1： | 3 |
| 6 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 3 |
| 7 | Bi/BiOCl Nanosheets Enriched with Oxygen Vacancies to Enhance Photocatalytic CO_(2)Reduction显示文摘BiOCl has been used in the photoreduction of CO_(2),but exhibits limited photocatalytic activity.In this study,Bi was in situ reduced and deposited on the surface of(001)-dominated BiOCl nanosheets by NaBH 4 to form Bi/BiOCl nanosheets enriched with oxygen vacancies.The as-prepared Bi/BiOCl nanosheets having low thickness(ca.10 nm)showed much higher concentration of oxygen vacancies compared to Bi/BiOCl nanoplates having high thickness(ca.100 nm).Subsequently,the photocatalytic activity of the Bi/BiOCl nanosheets enriched with oxygen vacancies for CO_(2)reduction was dramatically enhanced and much higher than that of BiOCl nanoplates,nanosheets,and Bi/BiOCl nanoplates.It showed that the improved photocatalytic activity in the reduction of CO_(2)can be attributed to the enhanced separation effi ciency of photogenerated electron–hole pairs of the oxygen vacancies on BiOCl nanosheets and Bi metals.This work demonstrated that the in situ reduction of non-noble metals on the surface of BiOCl nanosheets that are enriched with oxygen vacancies is favorable for increasing photocatalytic CO_(2)reduction. | Shuqi Wu Junbu Wang Qingchuan Li Zeai Huang Zhiqiang Rao Ying Zhou | 2021 | Transactions of Tianjin University2021，27，2： | 3 |
| 8 | A global alfalfa diversity panel reveals genomic selection signatures in Chinese varieties and genomic associations with root development显示文摘Alfalfa(Medicago sativa L.) is an important forage crop worldwide. However, little is known about the effects of breeding status and different geographical populations on alfalfa improvement. Here, we sequenced 220 alfalfa core germplasms and determined that Chinese alfalfa cultivars form an independent group, as evidenced by comparisons of FSTvalues between different subgroups, suggesting that geographical origin plays an important role in group differentiation. By tracing the influence of geographical regions on the genetic diversity of alfalfa varieties in China, we identified 350 common candidate genetic regions and 548 genes under selection. We also defined 165 loci associated with 24 important traits from genome-wide association studies. Of those, 17 genomic regions closely associated with a given phenotype were under selection, with the underlying haplotypes showing significant differences between subgroups of distinct geographical origins. Based on results from expression analysis and association mapping,we propose that 6-phosphogluconolactonase(MsPGL) and a gene encoding a protein with NHL domains(MsNHL) are critical candidate genes for root growth. In conclusion, our results provide valuable information for alfalfa improvement via molecular breeding. | Lin Chen Fei He Ruicai Long Fan Zhang Mingna Li Zhen Wang Junmei Kang Qingchuan Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 3 |
| 9 | Investigation of Portevin–Le Chatelier Band Strain and Elastic Shrinkage in Al-Based Alloys Associated with Mg Contents显示文摘The Portevin–Le Chatelier(PLC) effect in Al–2.30wt%Mg, Al–4.57wt%Mg and Al–6.91wt%Mg alloys has been investigated at various applied strain rates at room temperature in this study. Three-dimensional digital image correlation(3D-DIC) technique was applied to obtaining the further insight into the spatiotemporal characteristics, in particular the influence of Mg content on deformation behaviors. Mg content has a pronounced effect on serration characteristics, including the serration type and amplitude; Mg content tends to weaken the spatial correlation of the propagative bands. Additionally, the serration amplitude linearly increases with the maximum PLC band strain; high Mg content generates a higher PLC band strain at a given serration amplitude compared with low Mg content. Mg content is found to be effective to enhance the serration amplitude, the maximum PLC band strain and also the amount of elastic shrinkage outside PLC bands. | Yulong Cai Suli Yang Shihua Fu Di Zhang Qingchuan Zhang | 2017 | Journal of Materials Science & Technology2017，33，6： | 3 |
| 10 | Research progress in rehabilitation treatment of stroke patients A bibliometric analysis显示文摘BACKGROUND: Stroke presents as a transient or chronic brain dysfunction and is associated with high morbidity and high mortality. The doctors and scientists would like to argue how to enhance the validity of the rehabilitation treatment and how to further improve the level of treatment on stroke. OBJECTIVE: The aim of this study was to quantitatively analyze the current worldwide progress in research on stroke rehabilitation treatment based on Web of Science database and ClinicalTrial.gov in the past 10 years. METHODS: We conducted a quantitative analysis of clinical trial articles regarding stroke rehabilitation published in English from 2003 to 2013 and indexed in the National Institutes of Health Clinical Trials registry and Web of Science databases. Data were downloaded on March 15, 2013. RESULTS: (1) From 2003 to 2013, 2 654 clinical trials investigating stroke were indexed in ClinicalTrials.gov. There were only 58 clinical trials registered in 2003, and there was a marked increase from 2005. A total of 605 clinical trials on the rehabilitation of stroke were conducted in the past 10 years. (2) The analysis showed that most of the trials in the field were registered by North American institutions. With respect to the Asian countries, China and Taiwan Region of China also published a reasonable proportion of the trials, but comparatively speaking, the number of trials is really rare. Most of the interventions were drugs, followed by the devices, and behavioral interventions were ranked third. (3) In the past 10 years, there were 4 052 studies on stroke indexed by Web of Science database. CONCLUSION: From perspective of research progress, we found that the number of clinical trials and papers on stroke rehabilitation has increased significantly in the past 10 years, between them a remarkable positive correlation exists. | Xiaodong Feng Chengmei Liu Qingchuan Guo Yanjie Bai Yafeng Ren Binbin Ren Junmin Bai Lidian Chen | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 11 | Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the interactions显示文摘The mechanical force between cells and the extracellular microenvironment is crucial to many physiological processes such as cancer metastasis and stem cell differentiation. Mitosis plays an essential role in all these processes and thus an in-depth understanding of forces during mitosis gains insight into disease diagnosis and disease treatment. Here, we develop a traction force microscope method based on monolayer fluorescent beads for measuring the weak traction force (tens of Pa) of mitotic cells in three dimensions. We quantify traction forces of human ovarian granulosa (KGN) cells exerted on the extracellular matrix throughout the entire cell cycle in three dimensions. Our measurements reveal how forces vary during the cell cycle, especially during cell division. Furthermore, we study the effect of paclitaxel (PTX) and nocodazole (NDZ) on mitotic KGN cells through the measurement of traction forces. Our results show that mitotic cells with high concentrations of PTX exert a larger force than those with high concentrations of NDZ, which proved to be caused by changes in the structure and number of microtubules. These findings reveal the key functions of microtubule in generating traction forces during cell mitosis and explain how dividing cells regulate themselves in response to anti-mitosis drugs. This work provides a powerful tool for investigating cell-matrix interactions during mitosis and may offer a potential way to new therapies for cancer. | Yongman Liu Jianye Wang Yong Su Xiaohai Xu Hong Liu Kainan Mei Shihai Lan Shubo Zhang Xiaoping Wu Yunxia Cao Qingchuan Zhang Shangquan Wu | 2021 | Nano Research2021，14，11： | 3 |
| 12 | Precise 3D shape measurement of three-dimensional digital image correlation for complex surfaces显示文摘Three dimensional-digital image correlation(3 D-DIC) is a widely used optical metrology in the experimental mechanics community because of its reliability, practicality, and flexibility. Although the precision of digital image correlation(DIC) has been thoroughly studied theoretically and numerically, verification experiments have seldom been performed, especially for complex surfaces with a small field of view(FOV). In this work, the shape of a 1-yuan coin was measured using 3 D-DIC; the shape was complex due to the presence of many fine details, and the FOV was relatively small because the coin diameter was only 25 mm. During the experiment, a novel strategy for speckle production was developed: white paint was simply sprayed onto the surface. Black paint was not used; instead, taking advantage of the reflective nature of the coin surface, polarized light and a Polaroid filter were introduced, and the polarization direction was carefully adjusted, ensuring that the spray pattern was extremely thin and that high-quality speckle images with significant contrast were captured. The three-dimensional coin shape was also successfully determined for comparison using a stylus profiler. The results demonstrate that 3 D-DIC provides high precision in shape measurement even for complex surfaces with small FOV. The precision of 3 D-DIC can reach 1/7000 of the field of view, corresponding to about 6 μm in this experiment. | YAN TianHao SU Yong ZHANG QingChuan | 2018 | Science China(Technological Sciences)2018，61，1： | 3 |
| 13 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 14 | Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer显示文摘 | Liang He Dake Chu Xia Li Jianyong Zheng Shanhong Liu Jipeng Li Qingchuan Zhao Gang Ji | 2013 | Digestive Diseases and Sciences2013，，5： | 2 |
| 15 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 16 | Performance analysis of microcantilever array sensing显示文摘Array sensing is increasingly important in the development of microcantilever(MC) sensors, and response consistency is the foundation for MC array sensing. In the present work, we investigated the response consistency of MC array sensing. The responses of two types of commercially available MC arrays were studied under conditions of temperature change, solution replacement and biochemical molecular interaction. For the thermal response, the deflections of both arrays were found to be proportional to temperature, and the responses of the MCs in both arrays were consistent with each other. The thermal response sensitivity for each MC during temperature increase and decrease also showed good consistency. Moreover, the MC array showed good consistency for the response induced by solution replacement. Finally, we also demonstrated that the MC array had good consistency in biochemical detection, exemplified by aflatoxin antibody-anti gen binding. The good response consistency makes this technology reliable and accurate for biochemical sensing. | ZHOU XiaRong LIU Hong WU ShangQuan ZHANG QingChuan WU XiaoPing | 2017 | Science China(Technological Sciences)2017，60，11： | 2 |
| 17 | Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma显示文摘骨头形态基因的蛋白质(BMP ) 在肿瘤房间增长,转移,和侵略起重要作用。然而,在有 non-small-cell 肺癌症(NSCLC ) 和他们与 NSCLC 致病的关联的病人的 BMP 的表示模式还没被检验。在这研究,在 NSCLC 纸巾的 BMP 家庭成员的 mRNA 层次被分析,结果证明分别地, BMP5 和 BMP7 的 mRNA 层次与在相应 noncancerous 纸巾的那些相比在肿瘤纸巾显著地下面调整、起来调整。有趣地, BMP5 的 mRNA 水平在肺比那在肺腺癌纸巾是显著地更高的有鳞的房间癌纸巾。而且,从 immunohistochemistry 分析的结果比在肺在肺腺癌证实了 BMP5 蛋白质的更强壮的表示有鳞的房间癌。我们的调查结果建议 BMP5 可能为有 NSCLC 的病人是潜在的预示的 biomarker 或治疗学的目标。 | Taoran Deng Dandan Lin Man Zhang Qingchuan Zhao Weina Li Bo Zhong Yu Deng Xiangning Fu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 2 |
| 18 | Experimental investigation of a Portevin-Le Chatelier band in Ni–Co-based superalloys in relation toγ’precipitates at 500℃显示文摘The macroscopically localized deformation behaviors of Ni–Co-based superalloys with differentγ’precipitate content were investigated at 500?C and 1×10-4 s-1 via an in situ method namely,digital image correlation(DIC).The DIC results showed that the serrated flow of the stress–strain curves was accompanied by localized deformation of the specimens.The fracture morphology was characterized mainly by transgranular fracture with numerous dimples in the lowγ’content alloy,and intergranular fracture with large fracture section in the highγ’content alloy.The Portevin–Le Chatelier(PLC)effect occurred in the investigated Ni–Co-based superalloys.Furthermore,the localized deformation of the highγ’content alloy was more severe than that of the lowγ’content alloy,and the band width was slightly larger.Moreover,for the first-time ever,a special propagation feature,namely±60?zigzag bands characterized by head-to-tail connections,was observed in the highγ’content alloy. | Yanke Liu Yulong Cai Chenggang Tian Guoliang Zhang Guoming Han Shihua Fu Chuanyong Cui Qingchuan Zhang | 2020 | Journal of Materials Science & Technology2020，47，14： | 2 |
| 19 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 20 | Simultaneous determination of artifi- cial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography 显示文摘 | Qingchuan C Jing W | 2001 | J Chromatogr A2001，937，12： | 1 |
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