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| 1 | Can trastuzumab emtansine be replaced by additional chemotherapy plus targeted therapy for HER2-overexpressing breast cancer patients with residual disease after neoadjuvant chemotherapy?显示文摘Human epidermal growth factor receptor 2(HER2)-overexpressing breast cancer is an aggressive phenotype with a poor prognosis,and can easily metastasize and recur.Currently,chemotherapy plus HER2-targeted therapy is the standard systemic treatment for most of these patients.Given that neoadjuvant chemotherapy(NAC)has an efficacy equivalent to that of adjuvant chemotherapy and some additional benefits,many patients,especially those with more advanced tumors,prefer NAC and generally will not receive additional chemotherapy after surgery,irrespective of the pathological response.However,achieving pathological complete response to NAC is strongly correlated with prognosis,especially in triple-negative and HER2-overexpressing breast cancer.Therefore,postoperative treatment of these patients with residual diseases should be optimized to achieve favorable outcomes.The CREATE-X study has confirmed that additional chemotherapy can improve the outcomes of patients with HER2-negative residual disease after NAC.In addition,chemotherapy plays an indispensable role in the treatment of patients who receive surgery directly or who have recurrent lesions.Therefore,can additional chemotherapy improve prognosis of patients with HER2-overexpressing residual breast cancer?At present,no studies have compared the efficacy of additional chemotherapy plus trastuzumab with that of anti-HER2 therapy alone in residual cancer.The KATHERINE study revealed that trastuzumab emtansine(T-DM1)can reduce the risk of recurrence or death by 50%compared with trastuzumab in patients with HER2-positive residual invasive breast cancer after neoadjuvant therapy.T-DM1 is an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine,and thus,to an extent,T-DM1 is equivalent to simultaneous application of chemotherapy and targeted therapy.However,high cost and low accessibility limit its use especially in low-and middle-income countries and regions.Hence,we proposed this perspective that additional chemotherapy plus trastuzumab should be given to HER2-overexpressing breast cancer patients with residual disease after NAC to improve their prognosis by discussing that the efficacy of additional chemotherapy plus trastuzumab is superior to that of anti-HER2 therapy alone and not inferior to T-DM1.Additional chemotherapy plus trastuzumab-based HER2-targeted therapy can be used as an alternative regimen to T-DM1 when T-DM1 is unavailable.However,further clinical research on the selection of chemotherapeutic agents is warranted. | Juan Wu Rong Kong Shen Tian Hao Li Kainan Wu Lingquan Kong | 2019 | Chinese Journal of Cancer Research2019，31，6： | 7 |
| 2 | Properties of coarse particles in suspended particulate matter of the North Yellow Sea during summer显示文摘Fine particles in seawater commonly form large porous aggregates. Aggregate density and settling velocity determine the behavior of this suspended particulate matter(SPM) within the water column.However, few studies of aggregate particles over a continental shelf have been undertaken. In our case study, properties of aggregate particles, including size and composition, over the continental shelf of the North Yellow Sea were investigated. During a scienti?c cruise in July 2016, in situ ef fective particle size distributions of SPM at 10 stations were measured, while temperature and turbidity measurements and samples of water were obtained from surface, middle, and bottom layers. Dispersed and inorganic particle size distributions were determined in the laboratory. The in situ SPM was divided into(1) small particles(<32 μm),(2) medium particles(32–256 μm) and(3) large particles(>256 μm). Large particles and medium particles dominated the total volume concentrations(VCs) of in situ SPM. After dispersion, the VCs of medium particles decreased to low values(<0.1 μL/L). The VCs of large particles in the surface and middle layers also decreased markedly, although they had higher peak values(0.1–1 μL/L). This suggests that almost all in situ medium particles and some large particles were aggregated, while other large particles were single particles. Correlation analysis showed that primary particles <32 μm in?uenced the formation of these aggregates. Microscopic examination revealed that these aggregates consisted of both organic and inorganic ?ne particles, while large particles were mucus-bound organic aggregates or individual plankton.The vertical distribution of coarser particles was clearly related to water strati?cation. Generally, medium aggregate particles were dominant in SPM of the bottom layer. A thermocline blocked resuspension of?ne material into upper layers, yielding low VCs of medium-sized aggregate particles in the surface layer.Abundant large biogenic particles were present in both surface and middle layers. | ZHANG Kainan WANG Zhenyan LI Wenjian YAN Jun | 2019 | Journal of Oceanology and Limnology2019，37，1： | 4 |
| 3 | A Bio-inspired Soft Robotic Arm: Kinematic Modeling and Hydrodynamic Experiments显示文摘 | Zheyuan Gong Jiahui Cheng Xingyu Chen Wenguang Sun Xi Fang Kainan Hu Zhexin Xie Tianmiao Wang Li Wen | 2018 | Journal of Bionic Engineering2018，15，2： | 3 |
| 4 | 乳腺癌患者携邛PICC化疗并发导管败血症的诊治探讨(英文)显示文摘Objective:The aim of our research was to study the incidence,clinical diagnosis and treatment of peripherally inserted central catheters(PICC)-related sepsis in breast cancer patients carrying PICC catheter for chemotherapy.Methods:The data of the incidence,diagnosis and treatment of PICC-related sepsis in 215 cases of breast cancer patients carrying PICC catheter for chemotherapy in our hospital from August,2009 to September,2011 were analyzed retrospectively.Results:216 PICCs had been successfully applied in 215 cases of breast cancer patients and followed for a total of 19,109 catheter days,(median catheterization duration,88.9 days,range 1-212 days).Among those,3(1.39%) PICCs were removed respectively as a result of PICC-related sepsis in 29,73 and 108 catheter-days(median 70 d),with a rate of 0.16 per 1000 catheter-days.Conclusion:Chemotherapeutic treatment via PICC for breast cancer patients is one of the most secure and effective measures but there exists small number of cases in which PICC catheter related sepsis is possible.Careful observation of relevant symptoms and signs,early diagnosis and treatment,not relying completely on blood culture tests and timely removal of PICC catheter can be very effective in treating PICC-related sepsis in these patients. | Lei Xing Vishnu Prasad Adhikari Lingquan Kong Hongyuan Li Guosheng Ren Feng Luo Kainan Wu | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 5 | On strong Markov property for Fleming-Viot processes显示文摘In this note,we prove that any Fleming-Viot process on a Polish space is strongly Markovian provided so is the mutation process. | LI QinFeng MA ChunHua XIANG KaiNan | 2013 | Science China Mathematics2013，56，10： | 2 |
| 6 | Analysis of transmitter-side control methods in wireless EV charging systems显示文摘The wireless electric vehicle(EV) charging system is highly safe and flexible. To reduce the weight and cost of EVs, the wireless charging system, which simplifies the structure inside an EV and utilizes the transmitter-side control method, has become popular. This study investigates the transmitter-side control methods in a wireless EV charging system. First, a universal wireless charging system is introduced, and the function of its transfer power is derived. It is observed that the transfer power can be controlled by regulating either the phase-shift angle or the DC-link voltage. Further, the influence of the control variables is studied using numerical analysis. Additionally, the corresponding control methods, namely the phase-shift angle and the DC-link voltage control, are compared by calculation and simulation. It is found that:(1) the system efficiency is low with the phase-shift control method because of the converter switching loss;(2) the dynamic response is slow with the DC-link voltage control method because of the large inertia of the inductor and capacitor;(3) both the control methods have limitations in their adjustable power range. Therefore, a combined control method is proposed, with the advantages of high system efficiency, fast dynamic response, and wide adjustable power range. Finally, experiments are performed to verify the validity of the theoretical analysis and the effectiveness of the proposed method. This study provides a detailed and comprehensive analysis of the transmitter-side control methods in the wireless charging system, considering the sensitivity of parameters, converter losses, system efficiency,and dynamic performance, with the dead-time effect taken into consideration. Moreover, the proposed control method can be used to realize the optimal combination of the phase-shift angle and the DC-link voltage with good dynamic performance, and it is useful for the optimal operation of the wireless charging system. | LIU Fang CHEN KaiNan ZHAO ZhengMing LI Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 2 |
| 7 | Proton radiography of magnetic fields generated with an open-ended coil driven by high power laser pulses显示文摘Recently generation of strong magnetic(B)fields has been demonstrated in capacitor coils heated by high power laser pulses[S.Fujioka et al.,Sci.Rep.3,1170(2013)].This paper will present a direct measurement of B field generated with an open-ended coil target driven by a nanosecond laser pulse using ultrafast proton radiography.The radiographs are analyzed with particle-tracing simulations.The B field at the coil center is inferred to be ~50 T at an irradiance of ~5×10^(14) W·cm^(-2).The B field generation is attributed to the background cold electron flow pointing to the laser focal spot,where a target potential is induced due to the escape of energetic electrons. | Guoqian Liao Yutong Li Baojun Zhu Yanfei Li Fang Li Mengchao Li Xuan Wang Zhe Zhang Shukai He Weiwu Wang Feng Lu Faqiang Zhang Lei Yang Kainan Zhou Na Xie Wei Hong Yuqiu Gu Zongqing Zhao Baohan Zhang Jie Zhang | 2016 | Matter and Radiation at Extremes2016，1，4： | 1 |
| 8 | Electron transfer in Cu/Cu_(2)O generated by disproportionation promoting efficient CO_(2)photoreduction显示文摘Constructing a high-efficiency composite material for CO_(2)photoreduction is a key step to the achievement of carbon neutralization,but a comprehensive understanding of the factors that dictate CO_(2)reduction activity remains elusive.Here,we constructed a series of Cu in situ combined on Cu_(2)O(Cu/Cu_(2)O-1,-2,-3)via an acid disproportionation method with various processing time.The optimal photocatalyst(Cu/Cu_(2)O-2)affords CO at a rate of 10.43μmol·g^(−1)·h^(−1),which is more than fourfold to that of pristine Cu_(2)O.Electron transfer in the samples was detected by X-ray absorption spectroscopy(XAS)as well as X-ray photoelectron spectroscopy(XPS).Interestingly,the best photoreduction performance was not achieved by the sample possessing the most electron transfer(Cu/Cu_(2)O-1)but by the one with moderate electron transfer(Cu/Cu_(2)O-2).By virtue of density functional theory(DFT)calculations,a linear relationship between Bader charge variation(Δq)of the active sites and adsorption energy of CO_(2)reduction intermediates was discovered,wherein the moderate charge transfer corresponds to appropriate adsorption energy,which benefits CO_(2)photoreduction activity substantially.This work provides guidance for the construction of composite catalysts for efficient CO_(2)photoreduction in a perspective of the quantity of electron transfer. | Qian Zhu Kainan Zhu Minmin Cai Yaowen Zhang Zhiyu Shao Mengpei Jiang Xiyang Wang Zhibin Geng Xiaofeng Wu Manrong Li Keke Huang Shouhua Feng | 2022 | Nano Research2022，15，8： | 0 |
| 9 | 妊娠乳腺癌患者2例终止妊娠前或后行首程化疗的疗效分析并文献复习(英文)显示文摘Pregnancy-associated breast cancer (PABC) is defined as breast cancer occurring anytime during gestation, lactation, or within 1 year after delivery. The incidence is between 1 in 3000 and 1 in 10,000 pregnancies and comprises about 0.2% to 3.8% of all breast cancers diagnosed in women under the age of 50 years. As women tend to delay childbearing into their third and fourth decades, the incidence of PABC is expected to increase. Here we reported two PABC patients with similar clinic and pathologic characters received chemotherapy before or after termination of pregnancy respectively, and found that the former got pathologic complete response. Based on the phenomena and the fact that endocrine hormones may have chemosensitization role in cancer chemotherapy, which is called hormonosensitizing chemotherapy (HSCT), endocrinosensitizing chemotherapy (ESCT) or neoendocrinochemotherapy (NECT), suggestion is proposed that chemotherapy should be taken before or immediately after termination for PABC, especially for the patients who prefer to artificial abortion, which may possibly acquire improved chemotherapeutic effect. | Lei Xing Guangyan Ji Liangbin Jin Jianbo Huang Shengchun Liu Hongyuan Li Guosheng Ren Kainan Wu Lingquan Kong | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，2： | 0 |
| 10 | Pulse repetition-rate effect on the intensity inside a femtosecond laser filament in air显示文摘As intense,ultrashort,kHz-repetition-rate laser systems become commercially available,pulse cumulative effects are critical for laser filament-based applications.In this work,the pulse repetition-rate effect on femtosecond laser filamentation in air was investigated both numerically and experimentally.The pulse repetition-rate effect has negligible influence at the leading edge of the filament.Clear intensity enhancement from a high-repetition pulse is observed at the peak and tailing edge of the laser filament.As the repetition rate of the laser pulses increases from 100 to 1000 Hz,the length of the filament extends and the intensity inside the filament increases.A physical picture based on the pulse repetition-rate dependent‘low-density hole’effect on filamentation is proposed to explain the obtained results well. | Fukang Yin Juan Long Yaoxiang Liu Yingxia Wei Bin Zhu Kainan Zhou Tie-Jun Wang Yuxin Leng Ruxin Li | 2023 | High Power Laser Science and Engineering2023，11，4： | 0 |
| 11 | Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study显示文摘Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. | Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 12 | Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability显示文摘The biodegradable substitution materials for bone tissue engineering have been a research hotspot.As is known to all,the biodegradability,biocompatibility,mechanical properties and plasticity of the substitution materials are the important indicators for the application of implantation materials.In this article,we reported a novel binary substitution material by blending the poly(lactic-acid)-co-(trimethylenecarbonate)and poly(glycolic-acid)-co-(trimethylene-carbonate),which are both biodegradable polymers with the same segment of flexible trimethylene-carbonate in order to accelerate the degradation rate of poly(lactic-acid)-co-(trimethylene carbonate)substrate and improve its mechanical properties.Besides,we further fabricate the porous poly(lactic-acid)-co-(trimethylene-carbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)scaffolds with uniform microstructure by the 3D extrusion printing technology in a mild printing condition.The physicochemical properties of the poly(lactic-acid)-co-(trimethylenecarbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate)and the 3D printing scaffolds were investigated by universal tensile dynamometer,fourier transform infrared reflection(FTIR),scanning electron microscope(SEM)and differential scanning calorimeter(DSC).Meanwhile,the degradability of the PLLATMC/GA-TMC was performed in vitro degradation assays.Compared with PLLA-TMC group,PLLA-TMC/GATMC groups maintained the decreasing Tg,higher degradation rate and initial mechanical performance.Furthermore,the PLLA-TMC/GA-TMC 3D printing scaffolds provided shape-memory ability at 37℃.In summary,the PLLA-TMC/GA-TMC can be regarded as an alternative substitution material for bone tissue engineering. | Xulin Hu Weiming Zhao Zhen Zhang Jianping Xie Jian He Jianfei Cao Qing Li Yajing Yan Chengdong Xiong Kainan Li | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 13 | Prevalence of hepatic steatosis and metabolic associated fatty liver disease among female breast cancer survivors显示文摘To the Editor:Non-alcoholic fatty liver disease(NAFLD)comes to prevail in Asia and,the prevalence in China is reported tobe24%to36%.lilThe prevalence ofNAFLD and its associated medical burden might be underestimated.The diagnosis of NAFLD led to the exclusion of other chronic liver diseases including“excess”alcohols,thus the population with alcoholic consumptions or other liver diseases might be neglected.In March 2020,the international expert consensus proposed a new concept,“metabolic associated fatty liver disease(MAFLD),”“and replaced the earlier term” of NAFLD.2As themost prevalent female malignancy,breast cancer(BC)shares similar risk factors to MAFLD.Higher levels of obesity and physical inactivity are closely correlated to BC and are significant drive for the increasing trends in the prevalence of BC.Some BC survivors may receive chemotherapy and endocrine therapy,both of which are reported to increase the risk of hepatic steatosis(HS),which is the fundamental criteria of the diagnosis of MAFLD. | Shen Tian Hao Li Renhua Li Liang Ran Shu Li Juan Wu Zhou Xu Xinyu Liang Yuling Chen Jun Xiao Jiaying Wei Chenyu Ma Jingyu Song Ruiling She Kainan Wu Lingquan Kong | 2022 | Chinese Medical Journal2022，135，19： | 0 |
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