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| 1 | Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection显示文摘AIM:To investigate the risk factors for postoperative liver insufficiency in patients with Child-Pugh class A liver function undergoing liver resection.METHODS:A total of 427 consecutive patients undergoing partial hepatectomy from October 2007 to April 2011 at a single center(Department of Hepatic SurgeryⅠ,Eastern Hepatobiliary Surgery Hospital,Shanghai,China) were included in the study.All the patients had preoperative liver function of Child-Pugh class A and were diagnosed as having primary liver cancer by postoperative histopathology.Surgery was performed by the same team and hepatic resection was carried out by a clamp crushing method.A clamp/unclamp time of 15 min/5 min was adopted for hepatic inflow occlusion.Patients' records of demographic variables,intraoperative parameters,pathological findings and laboratory test results were reviewed.Postoperative liver insufficiency and failure were defined as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,clinically apparent ascites,prolonged coagulopathy requiring frozen fresh plasma,and/or hepatic encephalopathy.The incidence of postoperative liver insufficiency or liver failure was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive factors.RESULTS:Among the 427 patients,there were 362 males and 65 females,with a mean age of 51.1 ± 10.4 years.Most patients(86.4%) had a background of viral hepatitis and 234(54.8%) patients had liver cirrhosis.Indications for partial hepatectomy included hepatocellular carcinoma(391 patients),intrahepatic cholangiocarcinoma(31 patients) and a combination of both(5 patients).Hepatic resections of ≤ 3 and ≥ 4 liver segments were performed in 358(83.8%) and 69(16.2%) patients,respectively.Seventeen(4.0%) patients developed liver insufficiency after hepatectomy,of whom 10 patients manifested as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,6 patients had clinically apparent ascites and prolonged coagulopathy,1 patient had hepatic encephalopathy and died on day 21 after surgery.On univariate analysis,age ≥ 60 years and prealbumin < 170 mg/dL were found to be significantly correlated with postoperative liver insufficiency(P = 0.045 and P = 0.009,respectively).There was no statistical difference in postoperative liver insufficiency between patients with or without hepatitis,liver cirrhosis and esophagogastric varices.Intraoperative parameters(type of resection,inflow blood occlusion time,blood loss and blood transfusion) and laboratory test results were not associated with postoperative liver insufficiency either.Age ≥ 60 years and prealbumin < 170 mg/dL were selected on multivariate analysis,and only prealbumin < 170 mg/dL remained predictive(hazard ratio,3.192;95%CI:1.185-8.601,P = 0.022).CONCLUSION:Prealbumin serum level is a predictive factor for postoperative liver insufficiency in patients with liver function of Child-Pugh class A undergoing hepatectomy.Since prealbumin is a good marker of nutritional status,the improved nutritional status may decrease the incidence of liver insufficiency. | Liang Huang Jing Li Jian-Jun Yan Cai-Feng Liu MengChao Wu Yi-Qun Yan | 2012 | World Journal of Gastroenterology2012，18，47： | 36 |
| 2 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 3 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 4 | Big Earth data analytics:a survey显示文摘Big Earth data are produced from satellite observations,Internet-ofThings,model simulations,and other sources.The data embed unprecedented insights and spatiotemporal stamps of relevant Earth phenomena for improving our understanding,responding,and addressing challenges of Earth sciences and applications.In the past years,new technologies(such as cloud computing,big data and artificial intelligence)have gained momentum in addressing the challenges of using big Earth data for scientific studies and geospatial applications historically intractable.This paper reviews the big Earth data analytics from several aspects to capture the latest advancements in this fast-growing domain.We first introduce the concepts of big Earth data.The architecture,various functionalities,and supporting modules are then reviewed from a generic methodology aspect.Analytical methods supporting the functionalities are surveyed and analyzed in the context of different tools.The driven questions are exemplified through cutting-edge Earth science researches and applications.A list of challenges and opportunities are proposed for different stakeholders to collaboratively advance big Earth data analytics in the near future. | Chaowei Yang Manzhu Yu Yun Li Fei Hu Yongyao Jiang Qian Liu Dexuan Sha Mengchao Xu Juan Gu | 2019 | Big Earth Data2019，3，2： | 3 |
| 5 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 6 | Cold-induced retrotransposition of fish LINEs显示文摘Classes of retrotransposons constitute a large portion of metazoan genome. There have been cases reported that genomic abundance of retrotransposons is correlated with the severity of low environmental temperatures. However, the molecular mechanisms underlying such correlation are unknown. We show here by cell transfection assays that retrotransposition(RTP) of a long interspersed nuclear element(LINE) from an Antarctic notothenioid fish Dissostichus mawsoni(dmLl) could be activated by low temperature exposure, causing increased dmL1 copies in the host cell genome. The cold-induced dmL1 propagation was demonstrated to be mediated by the mitogen-activated protein kinases(MAPK)/p38 signaling pathway, which is activated by accumulation of reactive oxygen species(ROS) in cold-stressed conditions. Surprisingly, dmL1 transfected cells showed an increase in the number of viable cells after prolonged cold exposures than non-transfected cells. Features of cold inducibility of dmL1 were recapitulated in LINEs of zebrafish origin both in cultured cell lines and tissues, suggesting existence of a common cold-induced LINE amplification in fishes. The findings reveal an important function of LINES in temperature adaptation and provid insights into the MAPK/p38 stress responsive pathway that shapes LINE composition in fishes facing cold stresses. | Shue Chen Mengchao Yu Xu Chu Wenhao Li Xiujuan Yin Liangbiao Chen | 2017 | Journal of Genetics and Genomics2017，44，8： | 2 |
| 7 | MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma显示文摘 | Shupeng Liu Weixing Guo Jie Shi Nan Li Xiya Yu Jie Xue Xiaohui Fu Kaijian Chu Chongde Lu Jiangsha Zhao Dong Xie Mengchao Wu Shuqun Cheng Shanrong Liu | 2011 | Journal of Hepatology2011，，2： | 2 |
| 8 | [Corrigendum] Cidan inhibits liver cancer cell growth by reducing COX-2and VEGF expression and cell cycle arrest显示文摘 | Nan Li Donghai Zheng Jie Xue Weixing Guo Jie Shi Juxian Sun Chongde Lu Weida Zheng Mengchao Wu Shuqun Cheng | 2015 | Experimental and Therapeutic Medicine2015，，4： | 1 |
| 9 | Scaling analysis ofcoolant spraying process in automatic depressurizedsystem显示文摘 | Xiangbin Li Mengchao Zhang | 2014 | Annals of Nuclear Energy2014，72，： | 1 |
| 10 | Proton radiography of magnetic fields generated with an open-ended coil driven by high power laser pulses显示文摘Recently generation of strong magnetic(B)fields has been demonstrated in capacitor coils heated by high power laser pulses[S.Fujioka et al.,Sci.Rep.3,1170(2013)].This paper will present a direct measurement of B field generated with an open-ended coil target driven by a nanosecond laser pulse using ultrafast proton radiography.The radiographs are analyzed with particle-tracing simulations.The B field at the coil center is inferred to be ~50 T at an irradiance of ~5×10^(14) W·cm^(-2).The B field generation is attributed to the background cold electron flow pointing to the laser focal spot,where a target potential is induced due to the escape of energetic electrons. | Guoqian Liao Yutong Li Baojun Zhu Yanfei Li Fang Li Mengchao Li Xuan Wang Zhe Zhang Shukai He Weiwu Wang Feng Lu Faqiang Zhang Lei Yang Kainan Zhou Na Xie Wei Hong Yuqiu Gu Zongqing Zhao Baohan Zhang Jie Zhang | 2016 | Matter and Radiation at Extremes2016，1，4： | 1 |
| 11 | Low glucose promotes CD133mAb-elicited cell death via inhibition of autophagy in hepatocarcinoma cells显示文摘 | Haiyang Chen Zaili Luo Wen Sun Cunzhen Zhang Huanlin Sun Nanjie Zhao Jin Ding Mengchao Wu Zhong Li Hongyang Wang | 2013 | Cancer Letters2013，，1： | 1 |
| 12 | The Mitochondrial Genome of Pseudocalotes microlepis (Squamata: Agamidae) and its Phylogenetic Position in Agamids显示文摘We describe the complete mitochondrial genome of a small-scaled forest agamid(Pseudocalotes microlepis), which is 17 873 bp in size, containing 13 PCGs, 2 r RNAs, 22 t RNAs and non-coding regions. The mitogenome has a typical gene order among squamates. 13 PCGs include 2 start codons(ATG and ATA), 3 stop codons(TAG, TAA and AGG), and an incomplete stop codon(T-). Codon usage analyses showed that CUA-Leu1 and CGG-Arg are the most frequently and rarely used codon, respectively. All 22 t RNAs were predicted to form canonical cloverleaf secondary structures, except for two t RNAs(t RNACys and t RNASer(AGY)) lacking the dihydorouridine(DHU) arm. The large noncoding region(control region) is 2 687 bp long(28.3% T, 18.2% C, 42.3% A, and 11.2% G), with four different types of repeating sequences. The phylogenetic tree resulting from BEAST analyses based on concatenated 2 r RNAs and 13 PCGs in sequence revealed that the newly sequenced P. microlepis, where the genus Acanthosaura were aggregated. Together with Calotes versicolor, they constitute the subfamily Draconinae. | Xiuli YU Yu DU Mengchao FANG Hong LI Longhui LIN | 2018 | Asian Herpetological Research2018，9，1： | 1 |
| 13 | Conversion of rat embryonic stem cells into neural precursors in chemical-defined medium显示文摘 | Xinrong Peng Haixia Gao Ying Wang Baotian Yang Tao Liu Yan Sun Huajun Jin Lihua Jiang Linfang Li Mengchao Wu Qijun Qian | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 14 | Adjuvant Therapy With Capecitabine Postpones Recurrence of Hepatocellular Carcinoma After Curative Resection: A Randomized Controlled Trial显示文摘 | Yong Xia MD Yinghe Qiu MD Jun Li MD Lehua Shi MD Kui Wang MD Tao Xi MD Feng Shen MD Zhenlin Yan MD Mengchao Wu MD | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 15 | Surgery for pregnancy-associated primary hepatocellular carcinoma: Report of four cases显示文摘 | Aijun Li Weiping Zhou Junhua Lu Longjiu Cui Xiaoyu Yang Lei Yin Mengchao Wu | 2014 | International Journal of Surgery Case Reports2014，，： | 1 |
| 16 | Tumor Necrosis Factor-alpha Promotes Tumor Growth by Inducing Vascular Endothelial Growth Factor显示文摘 | Yingying Jing Nannan Ma Tingting Fan Chenyang Wang Xinxin Bu Guocheng Jiang Rong Li Lu Gao Ding Li Mengchao Wu Lixin Wei | 2011 | Cancer Investigation2011，，7： | 1 |
| 17 | Simultaneous measurement of strain and temperature with a long-period fiber grating inscribed Sagnac interferometer 显示文摘 | KANG Juan DONC Xinyong ZHAO Chunliu QIAN Wenwen LI Mengchao | 2011 | Optics Communications2011，284，8： | 1 |
| 18 | Adjuvant Therapy With Capecitabine Postpones Recurrence of Hepatocellular Carcinoma After Curative Resection: A Randomized Controlled Trial显示文摘 | Yong Xia Yinghe Qiu Jun Li Lehua Shi Kui Wang Tao Xi Feng Shen Zhenlin Yan Mengchao Wu | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 19 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 20 | Performance enhancement of solution-processed InZnO thin-film transistors by Al doping and surface passivation显示文摘Solution-processed oxide semiconductors have been considered as a potential alternative to vacuum-based ones in printable electronics.However,despite spincoated InZnO(IZO)thin-film transistors(TFTs)have shown a relatively high mobil-ity,the lack of carrier suppressor and the high sensitivity to oxygen and water molecules in ambient air make them potentially suffer issues of poor stability.In this work,Al is used as the third cation doping element to study the effects on the electrical,optoelectronic,and physical properties of IZO TFTs.A hydrophobic self-assembled monolayer called octadecyltrimethoxysilane is introduced as the surface passivation layer,aiming to reduce the effects from air and understand the importance of top surface conditions in solution-processed,ultra-thin oxide TFTs.Owing to the reduced trap states within the film and at the top surface enabled by the doping and passivation,the optimized TFTs show an increased current on/off ratio,a reduced drain current hysteresis,and a significantly enhanced bias stress stability,compared with the untreated ones.By combining with high-capacitance AlO_(x),TFTs with a low operating voltage of 1.5 V,a current on/off ratio of>10^(4) and a mobility of 4.6 cm^(2)/(V·s)are demonstrated,suggesting the promising features for future low-cost,low-power electronics. | Wensi Cai Haiyun Li Mengchao Li Zhigang Zang | 2022 | Journal of Semiconductors2022，43，3： | 0 |
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