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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models显示文摘Objective: Triple-negative breast cancer(TNBC) is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu(TBM), the rhizome of Bolbostemma paniculatum(Maxim.) Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu(ETBM) on TNBC orthotopic mouse models and cell lines.Methods: We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis applied to explore the pathways influenced by ETBM.Moreover, quantitative real-time polymerase chain reactions(q RT-PCR) and Western blot were delivered to confirm the gene expression changes.Results: ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1(ITGβ1), integrin β8(ITGβ8) and Rho GTPase activating protein 5(ARHGAP5), which disabled the focal adhesion pathway and caused change in cell morphology.Conclusions: This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC. | Jingxiao Wang Xinjie Yang Haibo Han Limin Wang Weiqian Bao Shanshan Wang Robert M.Hoffman Meng Yang Hui Qi Chao An Kaiwen Hu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 8 |
| 3 | LA-ICP-MS U-Pb zircon dating of the Bozhushan granite in Southeast Yunnan显示文摘The LA-ICP-MS U-Pb zircon dating of eight typical samples from four units of the Bozhushan granite intrusion in southeastern Yunnan Province, constrains the age of acidic magmatic intrusion in this area. Both the oscillatory zoning and chondrite-normalized REE patterns characterized by LREE-depletion and HREE-enrichment with positive Ce anomaly and negative Eu anomaly indicate the magmatic genesis of these zircons. Eight zircon samples from the Bozhushan granite yielded a mean 206 Pb/ 238 U age of (85.58±1.0) Ma (MSWD=4.1) to (88.10±0.66) Ma (MSWD=1.8). These chronology data suggest an accurate isotopic age for the intrusion of the Bozhushan granite, and are different from the published age data of 48 to 111.5 Ma. The geochronology data of the Gejiu, Dulong and Dachang super-large deposits and related Yanshanian granites indicated that there occurred large-scale granitic magmatism and mineralization events in western Nanling region during the Late Cretaceous. | LI Kaiwen ZHANG Qian WANG Dapeng CAI Yi LIU Yuping | 2013 | Chinese Journal Of Geochemistry2013，32，2： | 5 |
| 4 | Interfacial Engineering of NiFeP/NiFe-LDH Heterojunction for Efficient Overall Water Splitting显示文摘In consideration of application prospect of non-noble metallic materials catalysts,the study of exploring more highly effective electrocatalysts has been focused on by researchers.Herein,a novel strategy is employed to construct a heterojunction consisting of metal phosphide Ni_(x)Fe_(y)P and layered double hydroxide(LDH)with graphene oxide(GO)as conductive support.By adjusting the molar ratio of Ni to Fe,a series of heterojunctions with mixed valence state Fe^(δ+)/Fe^(3+)and Ni^(δ+)/Ni^(2+)(δis likely close to 0)redox couples are achieved and strong synergistic effects towards overall water splitting performance are found.The optimized catalyst with a Ni/Fe molar ratio of 0.72:0.33,namely Ni_(0.7)Fe_(0.3)P/LDH/GO,delivers ultra-low overpotentials for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)of 79 and 198 mV at the current density of 10 mA·cm^(-2),respectively.Furthermore,for overall water-splitting practical application,it only requires 1.526 V at 10 mA·cm^(-2)with robust stability,which is superior to most reported electrocatalysts.Experimental results demonstrate the im-proved electronic conductivity,enlarged electrochemically active area and accelerated kinetics together account for the enhanced performance.This work supplies new prospects for the promotion and application of such heterojunction electrocatalysts in overall water splitting. | Xuanyu Long Jiazhi Meng Jiabao Gu Lanqing Ling Qianwen Li Nan Liu Kaiwen Wang Zequan Li | 2022 | Chinese Journal of Structural Chemistry2022，41，4： | 4 |
| 5 | Dry reforming of methane on active and coke resistant Ni/Y_2Zr_2O_7 catalysts treated by dielectric barrier discharge plasma显示文摘In this study, Ni/Y_2Zr_2O_7 catalysts prepared with impregnation method and treated by dielectric barrier discharge plasma(DBD) in different atmospheres have been investigated for methane dry reforming. It is revealed by H_2-TPR that plasma treatment can enhance the interaction between Ni O/Ni particles and the Y_2Zr_2O_7 pyrochlore support. Therefore, catalysts with smaller Ni O and Ni grains sizes, higher metallic Ni active surface areas can be achieved, as evidenced by XRD, TEM and H_2 adsorption-desorption measurements. As a consequence, the plasma-treated catalysts show significantly improved activity, stability and coke resistance, as testified by the TEM and TGA-DSC results. Plasma treatment in H_2/Ar gas mixture is found to be the best condition to prepare Ni/Y_2Zr_2O_7, which can be used to obtain a catalyst with the highest activity, stability and most potent coke resistance. It is believed that the smaller Ni grain size and higher metallic Ni active surface area induced by plasma treatment are the inherent reasons accounting for the promoted reaction performance of the Ni/Y_2Zr_2O_7 pyrochlore catalysts. | Xiuzhong Fang Jie Lian Kaiwen Nie Xianhua Zhang Yanfeng Dai Xianglan Xu Xiang Wang Wenming Liu Changqing Li Wufeng Zhou | 2016 | Journal of Energy Chemistry2016，25，5： | 3 |
| 6 | Sm-Nd dating and rare earth element geochemistry of the hydrothermal calcites from Guling carbonate-hosted talc mineralization in the central Guangxi province,South China显示文摘Many carbonate-hosted talc mineralization,which are widespread in South China,exclusively developed in Carboniferous dolomitic limestone with many siliceous bands and nodules,and cherts.One of those typical deposits is the Guling talc deposit in Mashan County,central Guangxi province,with a talc reserve of1.51 million tons.Mineral associations in the deposit are sample,mainly including talc and calcite.In this paper,Sm-Nd isotopic system and rare earth elements and yttrium(REE + Y) for the hydrothermal calcite intergrown with talc are used to constrain the age and origin of the talc mineralization.The hydrothermal calcite samples from the deposit display Sm and Nd concentrations ranging from 0.18 to 0.85 and 0.85 to 4.56 ppm,respectively,and variable Sm/Nd ratios of 0.21-0.24.These calcites further yield an Sm-Nd isochron age of 232 ±19 Ma(2a)(MSWD = 0.47) with an concordant initial ^(143)Nd-^(144)Nd ratios of 0.511967 ± 0.000017,which should be interpreted as the mineralization age of the Guling talc deposit.In addition,the calcite samples are enriched in REE with the variable SREE contents ranging from 4.82 to21.50 ppm and display relatively consistent chondritenormalized REE + Y patterns with the LREE enrichment(LREE/HREE=2.00-3.60)and the obvious negative Eu(δEu=0.52-0.68)and Ce(δCe=0.16-0.33)anomalies.The Y/Ho ratios of seven calcites varies from 43.30 to59.34,with a mean value of 49.73.The available mineral associations and REE parameters(i.e.,REE patterns and Y/Ho ratios) of those calcites indicate that the ore-forming fluids of the talc mineralization be probably derived from the meteoric waters,in particular evolved ones in the Karst areas and the ore-forming materials(e.g.,Si and Mg) are likely to be originated from the ore-bearing dolostone in the Yanguan Formation(C_1y) and underlying siliceous rocks in the Liujiang Formation(D_3l).Furthermore,the talc mineralization could take place within a hydrothermal system with relative oxidizing environment and middle temperature,due to the obvious negative Eu and Ce anomalies in the calcites in the Guling deposit. | Yi Cai Qian Zhang Yongbing Zhang Dapeng Wang Kaiwen Li | 2015 | Chinese Journal Of Geochemistry2015，34，2： | 3 |
| 7 | Multi-centric clinical study of the effect of intervention time on efficacy of gastroparesis external application prescription treatment of gastrointestinal tumor postsurgical gastroparesis显示文摘Objective:This intervention has been shown to be clinically efficacious and safe.The aim of this study was to determine the effect of different intervention times on the efficacy of gastroparesis external application prescription versus placebo for the treatment of gastrointestinal tumor postoperative,postsurgical gastroparesis.Methods:A multicenter,randomized,double-blind,placebo controlled phaseⅢclinical trial was designed to demonstrate superiority and conducted at four grade 3A hospitals in Beijing.Patients diagnosed with gastrointestinal tumor postsurgical gastroparesis and local cold syndrome in the abdomen were enrolled and received conventional treatment(nutritional support,gastrointestinal decompression,and prokinetic medication).Treatment and control groups respectively received gastroparesis external application prescription or placebo acupoint application over a treatment course of 14 days or until the primary efficacy endpoint(clinical efficiency)was achieved.Results:A total of 120 patients were enrolled in the treatment and control groups(n Z 60 per group),and 15 patients dropped out of the study because of skin allergies(n Z 7)or poor efficacy(nZ8).The efficacy among patients in Class B of Group A(treatment group)was marginally better than that of Group B(control group)(64.28%vs.55.56%)although the difference between the two groups was not significant.However,the efficacy among patients in Class C of Group A was significantly better than that of Group B(79.49%vs.43.33%).For Group A,the time for patients in the three classes to achieve the efficacy endpoint increased significantly with disease progression(3.00,6.78,and 8.29 days for Class A,B,and C,respectively).Conclusions:Gastroparesis external application prescription can effectively treat gastrointestinal tumor postsurgical gastroparesis and may be more efficacious in progressive disease compared placebo.Patients with gastrointestinal tumor postsurgical gastroparesis should therefore undergo intervention at an earlier stage. | Qin Zhou Minghuan Zuo Yantao Tian Yanbin Wang Yingjiang Ye Chao An Tian Zhou Chuanbo Liu Kaiwen Hu Quanwang Li | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 8 | Ultra-small hollow ternary alloy nanoparticles for efficient hydrogen evolution reaction显示文摘Hollow nanoparticles with large specific surface area and high atom utilization are promising catalysts for the hydrogen evolution reaction(HER). We describe herein the design and synthesis of a series of ultra-small hollow ternary alloy nanostructures using a simple one-pot strategy. The same technique was demonstrated for hollow PtNiCu nanoparticles, hollow PtCoCu nanoparticles and hollow CuNiCo nanoparticles. During synthesis, the displacement reaction and oxidative etching played important roles in the formation of hollow structures. Moreover, our hollow PtNiCu and PtCoCu nanoparticles were single crystalline, with an average diameter of 5 nm. Impressively, ultra-small hollow PtNiCu nanoparticles,containing only 10% Pt, exhibited greater electrocatalytic HER activity and stability than a commercial Pt/C catalyst. The overpotential of hollow Pt Ni Cu nanoparticles at 10 mA cm^(-2) was 28 mV versus reversible hydrogen electrode(RHE). The mass activity was 4.54 A mg Pt^(-1) at-70 mV versus RHE, which is 5.62-fold greater than that of a commercial Pt/C system(0.81 A mg Pt^(-1)). Through analyses of bonding and antibonding orbital filling, density functional theory calculations demonstrated that the bonding strength of different metals to the hydrogen intermediate(H*) was in the order of Pt > Co > Ni > Cu. The excellent HER performance of our hollow PtNiCu nanoparticles derives from moderately synergistic interactions between the three metals and H*. This work demonstrates a new strategy for the design of low-cost and high-activity HER catalysts. | Zhenxing Li Chengcheng Yu Yikun Kang Xin Zhang Yangyang Wen Zhao-Kui Wang Chang Ma Cong Wang Kaiwen Wang Xianlin Qu Miao He Ya-Wen Zhang Weiyu Song | 2021 | National Science Review2021，8，7： | 2 |
| 9 | Dynamic fragmentation of microwave irradiated rock显示文摘The microwave-assisted rock fragmentation has been proven to be a promising approach in reducing cutting tools wear and improving efficiency in rock crushing and excavation.Thus,understanding the influence of damage induced by microwave irradiation on rock fragmentation is necessary.In this context,cylindrical Fangshan granite(FG)specimens were exposed to microwave irradiation at a power of 6 kW for different durations up to 4.5 min.The damages of the specimens induced by irradiation were quantified by using both X-ray micro-CT scanning and ultrasonic wave measurement.The CT value and Pwave velocity decreased with increase of irradiation duration.The irradiated specimens were then tested using a split Hopkinson pressure bar(SHPB)system to simulate rock fragmentation.A momentum-trap technique was utilized to ensure single-pulse loading on the specimen in SHPB tests,enabling valid fragment size distribution(FSD)analysis.The dependence of dynamic uniaxial compressive strength(UCS)on the irradiation duration and loading rate was revealed.The dynamic UCS increased with increase of loading rate while decreased with increase of irradiation duration.Using the sieve analysis,three fragmentation types were proposed based on FSD,which were dictated by both loading rate and irradiation duration.In addition,an average fragment size was proposed to quantify FSD.The results showed that the average fragment size decreased with increase of loading rate.A loading rate range was identified,where a dramatic reduction of the average fragment size occurred.The dependence of fragmentation on the irradiation duration and loading rate was also discussed. | Shuai Wang Ying Xu Kaiwen Xia Tianyang Tong | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，2： | 2 |
| 10 | Isotype Heterojunction‑Boosted CO_(2) Photoreduction to CO显示文摘Photocatalytic conversion of CO_(2) to high-value products plays a crucial role in the global pursuit of carbon–neutral economy.Junction photocatalysts,such as the isotype heterojunctions,offer an ideal paradigm to navigate the photocatalytic CO_(2) reduction reaction(CRR).Herein,we elucidate the behaviors of isotype heterojunctions toward photocatalytic CRR over a representative photocatalyst,g-C_(3)N_(4).Impressively,the isotype heterojunctions possess a significantly higher efficiency for the spatial separation and transfer of photogenerated carriers than the single components.Along with the intrinsically outstanding stability,the isotype heterojunctions exhibit an exceptional and stable activity toward the CO_(2) photoreduction to CO.More importantly,by combining quantitative in situ technique with the first-principles modeling,we elucidate that the enhanced photoinduced charge dynamics promotes the production of key intermediates and thus the whole reaction kinetics. | Chaogang Ban Youyu Duan Yang Wang Jiangping Ma Kaiwen Wang Jiazhi Meng Xue Liu Cong Wang Xiaodong Han Guozhong Cao Liyong Gan Xiaoyuan Zhou | 2022 | Nano-Micro Letters2022，14，5： | 2 |
| 11 | The occurrence state of vanadium in the black shale-hosted vanadium deposits in Shangling of Guangxi Province, China显示文摘The Shangling vanadium deposit, which occurs in the Lower Devonian Tangding formation black rock series strata, has V2O5 reserves of more than 1.5 million tons and prospective reserves of more than 2 million tons. Preliminary studies on the occurrence state of vanadium(V) in this deposit have been conducted by artificial heavy minerals concentrates, leaching experiments, scanning and transmission electron microscopy and X-ray powder diffraction.These experiments have revealed no independent vanadium mineral occurrences in the Shangling vanadium deposit and the percentages of water-soluble vanadium, hydrochloric acid soluble vanadium and HF soluble vanadium were1.93 %, 21.42 % and 76.47 %, respectively. Based on our data and earlier research, we estimate that the valences state of V absorbed onto the surface of organic matter or clastic particles are +5 and +4, accounting for 10.00 % and13.35 % of the total amount of V, respectively and the valences state of V that exist in the octahedral crystal lattice of authigenic illite include +3 and +4, accounting for71.64 % and 4.83 % of the total amount of V, respectively.By calculating the correlation between the total organic carbon and V, we infer that after deposition and before entering the crystal lattice of illite, V occurs in the form of humate complex or is adsorbed by organic matter. About4.24 % of the Al is in the octahedral crystal lattice of illite,which was replaced by the vanadium under the metallogenic environments of Shanglin. | Yongbin Zhang Qian Zhang Yi Cai Dapeng Wang Kaiwen Li | 2015 | Chinese Journal Of Geochemistry2015，34，4： | 1 |
| 12 | Directional Analysis of Urban Expansion Based on Sub-pixel and Regional Scale: A Case Study of Main Districts in Guangzhou, China显示文摘Multi-scale data have had a wide-ranging level of performance in the area of urban change monitoring. Herein we investigate the correlation between the impervious surface fraction(ISF) and the Defense Meteorological Satellite Program/Operational Linescan System(DMSP/OLS) nighttime stable light(NTL) data with respect to the urban expansion in the main districts of Guangzhou. Landsat 5 Thematic Mapper and Landsat 8 Operational Land Image(OLI) data from 1988 to 2015 were used to extract the ISF using the linear spectral mixture analysis model and normal difference build-up index at the sub-pixel scale. DMSP/OLS NTL data from 1992 to 2013 were calibrated to illustrate the urban nighttime light conditions at the regional scale. Urban expansion directions were identified by statistics and kernel density analysis for the ISF study area at the sub-pixel scale. In addition, the correlation between the ISF and DMSP/OLS NTL data were illustrated by linear regression analysis. Furthermore, Profile Graph in ArcGIS was employed to illustrate the urban expansion from the differences in correlation in different directions. The conclusions are as follows: 1) The impervious surface(IS)in the study area has expanded to the northeast and the east, starting with the old urban zones, and the high-density IS area has increased by321.14 km^2. 2) The linear regression analysis reveals a positive correlation between the ISF and the DMSP/OLS NTL data. The multi-scale data changes are consistent with the actual urban planning of Guangzhou. 3) The DMSP/OLS NTL data overestimate the urban extent because of its saturation and blooming effects, causing its correlation with ISF to decrease. The pattern of urban expansion influences the saturation and blooming effects of the DMSP/OLS NTL data. | ZHAO Yi ZHONG Kaiwen XU Jianhui SUN Caige WANG Yunpeng | 2019 | Chinese Geographical Science2019，29，4： | 1 |
| 13 | Kinetic Performance of Oil-field Produced Water Treatment by Biological Aerated Filter 1 1 Supported by the National Natural Science Foundation of China (No.59978020).显示文摘 | Delin SU Jianlong WANG Kaiwen LIU Ding ZHOU | 2007 | Chinese Journal of Chemical Engineering2007，，4： | 1 |
| 14 | Engineering nanointerface of molybdenum-based heterostructures to boost the electrocatalytic hydrogen evolution reaction显示文摘Rational heterostructure-design in electrocatalysts represents a promising approach toward high performance in the electrocatalytic hydrogen evolution reaction(HER).In specific,optimizing the H adsorption behavior at the surface/interface of heterostructure is of key importance to improve the catalytic performance.Herein,we demonstrate the construction of a heterostructure from a well-defined oxygenbridged Co/Mo heterometallic zeolitic imidazolate framework(MOZ) as an efficient electrocatalyst for HER.The optimized hybrid exhibits high catalytic activity and stability in electrolytes with a wide pH range.Detailed XPS,XAS and theoretical studies reveal that the regulation of metal species can tailor the lattice of Mo_(2)C within the hybrid and induce the formation of defect sites,which could not only induce surface charge transfer between the atoms and provide an additional active site,but also affect the H adsorption behavior at the interface of a heterostructure.This work provides an effective strategy to design a heterostructure with tailored active sites for energy conversion. | Tong Liu Shuqing Zhou Jing Qi Kaiwen Wang Lirong Zheng Qingming Huang Tianhua Zhou Jian Zhang | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 15 | Dynamic ModeⅡfracture behavior of rocks under hydrostatic pressure using the short core in compression(SCC)method显示文摘The shear failure of rocks under both a static triaxial stress and a dynamic disturbance is common in deep underground engineering and it is therefore essential for the design of underground engineering to quantitively estimate the dynamic ModeⅡfracture toughness KⅡCof rocks under a triaxial stress state.However,the method for determining the dynamic KⅡCof rocks under a triaxial stress has not been developed yet.With an optimal sample preparation,the short core in compression(SCC)method was designed and verified in this study to measure the dynamic KⅡCof Fangshan marble(FM)subjected to different hydrostatic pressures through a triaxial dynamic testing system.The formula for calculating the dynamic KⅡCof the rock SCC specimen under hydrostatic pressures was obtained by using the finite element method in combination with secondary cracks.The experimental results indicate that the failure mode of the rock SCC specimen under a hydrostatic pressure is the shear fracture and the KⅡCof FM increases as the loading rate.In addition,at a given loading rate the dynamic rock KⅡCis barely affected by hydrostatic pressures.Another important observation is that the dynamic fracture energy of FM enhances with loading rates and hydrostatic pressures. | Wei Yao Ying XuChonglang Wang Kaiwen Xia Mikko Hokka | 2021 | International Journal of Mining Science and Technology2021，31，5： | 1 |
| 16 | The track of wheel contact points and the calculation of wheel/rail geometric contact parameters 显示文摘 | Wang Kaiwen | 1984 | Journal of Southwest Jiaotong University1984，1，10： | 1 |
| 17 | Current climate overrides past climate change in explaining multi-site beta diversity of Lauraceae species in China显示文摘Background:We aimed to characterise the geographical distribution of Sørensen-based multi-site dissimilarity(β_(sor))and its underlying true turnover(β_(sim))and nestedness(βsne)components for Chinese Lauraceae and to analyse their relationships to current climate and past climate change.Methods:We used ensembles of small models(ESMs)to map the current distributions of 353 Lauraceae species in China and calculated β_(sor) and its β_(sim) and β_(sne) components.We tested the relationship between β_(sor),β_(sne) and β_(sim) with current climate and past climate change related predictors using a series of simultaneous autoregressive(SAR_(err))models.Results:Spatial distribution of β_(sor)of Lauraceae is positively correlated with latitude,showing an inverse rela-tionship to the latitudinalα-diversity(species richness)gradient.High β_(sor) occurs at the boundaries of the warm temperate and subtropical zones and at the Qinghai-Tibet Plateau due to high β_(sne).The optimized SAR_(err) model explainsβ_(sor) andβ_(sne) well,but notβ_(sim).Current mean annual temperature determinesβ_(sor) and β_(sne) of Lauraceae more than anomalies and velocities of temperature or precipitation since the Last Glacial Maximum.Conclusions:Current low temperatures and high climatic heterogeneity are the main factors explaining the high multi-siteβ-diversity of Lauraceae.In contrast to analyses of the β-diversity of entire species assemblages,studies of single plant families can provide complementary insights into the drivers of β-diversity of evolutionarily more narrowly defined entities. | Ziyan Liao Youhua Chen Kaiwen Pan Mohammed A.Dakhil Kexin Lin Xianglin Tian Fengying Zhang Xiaogang Wu Bikram Pandey Bin Wang Niklaus E.Zimmermann Lin Zhang Michael P.Nobis | 2022 | Forest Ecosystems2022，9，2： | 1 |
| 18 | Time-dependent dilatancy for brittle rocks显示文摘This paper presents a theoretical study on time-dependent dilatancy behaviors for brittle rocks. The theory employs a well-accepted postulation that macroscopically observed dilatancy originates from the expansion of microcracks. The mechanism and dynamic process that microcracks initiate from local stress concentration and grow due to localized tensile stress are analyzed. Then, by generalizing the results from the analysis of single cracks, a parameter and associated equations for its evolution are developed to describe the behaviors of the microcracks. In this circumstance, the relationship between microcracking and dilatancy can be established, and the theoretical equations for characterizing the process of rock dilatancy behaviors are derived. Triaxial compression and creep tests are conducted to validate the developed theory. With properly chosen model parameters, the theory yields a satisfactory accuracy in comparison with the experimental results. | Jie Li Mingyang Wang Kaiwen Xia Ning Zhang Houxu Huang | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，6： | 1 |
| 19 | Flexible Large-Area Graphene Films of 50-600 nm Thickness with High Carrier Mobility显示文摘Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms. | Shiyu Luo Li Peng Yangsu Xie Xiaoxue Cao Xiao Wang Xiaoting Liu Tingting Chen Zhanpo Han Peidong Fan Haiyan Sun Ying Shen Fan Guo Yuxing Xia Kaiwen Li Xin Ming Chao Gao | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 20 | Understanding auditory neuropathy spectrum disorder: a system- atic review in transgenic mouse models显示文摘Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future. | Li Wang Jing Guan Hongyang Wang Lan Lan Qiujing Zhang Liang Zong Wan Du Wenping Xiong Fengjiao Li Kaiwen Wu Dayong Wang Qiuju Wang | 2016 | Science China(Life Sciences)2016，59，5： | 1 |
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