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| 1 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 2 | Effect of particle size on the microstructure and thermal conductivity of Al/diamond composites prepared by spark plasma sintering显示文摘Spark plasma sintering (SPS) was used to fabricate Al/diamond composites. The influence of diamond particle size on the microstructure and thermal conductivity (TC) of composites was investigated by combining experimental results with model prediction. The results show that both composites with 40 μm particles and 70 μm particles exhibit high density and good TC, and the composite with 70 μm particles indicates an excellent TC of 325 W·m-1·K-1. Their TCs lay between the theoretical estimated bounds. In contrast, the composite with 100 μm particles demonstrates low density as well as poor TC due to its high porosity and weak interfacial bonding. Its TC is even considerably less than the lower bound of the predicted value. Using larger diamond particles can further enhance thermal conductive performance only based on the premise that highly dense composites of strong interfacial bonding can be obtained. | CHU Ke JIA Chengchang LIANG Xuebing CHEN Hui GAO Wenji | 2009 | Rare Metals2009，28，6： | 22 |
| 3 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 4 | Effect of powder mixing process on the microstructure and thermal conductivity of Al/diamond composites fabricated by spark plasma sintering显示文摘Two powder mixing processes, mechanical mixing (MM) and mechanical alloying (MA), were used to prepare mixed Al/diamond powders, which were subsequently consolidated using spark plasma sintering (SPS) to produce bulk Al/diamond composites. The effects of the powder mixing process on the morphologies of the mixed powders, the microstructure and the thermal conductivity of the composites were investigated. The results show that the powder mixing process can significantly affect the microstructure and the thermal conductivity of the composites. Agglomerations of the particles occurred in mixed powders using MM for 30 min, which led to high pore content and weak interfacial bonding in the composites and resulted in low relative density and low thermal conductivity for the composites. Mixed powders of homogeneous distribution of diamond particles could be obtained using MA for 10 min and MM for 2 h. The composite prepared through MA indicated a high relative density but low thermal conductivity due to its defects, such as damaged particles, Fe impurity, and local interfacial debonding, which were mainly introduced in the MA process. In contrast, the composite made by MM for 2 h demonstrated high relative density and an excellent thermal conductivity of 325 W·m-1·K-1, owing to its having few defects and strong interfacial bonding. | CHU Ke, JIA Chengchang, LIANG Xuebing, and CHEN Hui School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China | 2010 | Rare Metals2010，29，1： | 17 |
| 5 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 6 | Combined application of virtual imaging techniques and three-dimensional computed tomographic angiography in diagnosing intracranial aneurysms显示文摘虚拟成像的诊断价值为 intracranial 动脉瘤与三维的计算 tomographic angiography (3D-CTA ) 相结合的背景还充分没被阐明。这研究试图在在尖锐阶段与动脉瘤的 subarachnoid 出血(SAH ) 诊断病人评估虚拟成像技术和 3D-CTA 的联合申请的价值。有非创伤的 SAH 的八十个病人收到了 3D-CTA 考试的方法。这些病人的未加工的 CT 数据被重建并且基于虚拟现实(VR ) 通过外科的计划系统转了进 3D 模式图象,和 3D 颅骨和大脑血容器的虚拟图象被获得。有邻近的纸巾的动脉瘤和他们的解剖关系的地点,尺寸和形状从许多观点被测量。结果 73 个动脉瘤在 80 个病人中的 68 个被检测,但是 2 个动脉瘤在以前没有动脉瘤被发现了并且一个月以后为第二次收到了 3D-CTA 考试的 5 个病人中的 2 个被检测。虚拟图象由虚拟成像系统生产了的 3D 清楚、生动,并且他们能直接揭示到父母动脉和颅骨的动脉瘤和它的关系的地点和尺寸。3D-CTA 的成像是在诊断方便、可靠、快的 intracranial 动脉瘤和罐头的结论为破裂的 intracranial 动脉瘤的诊断和治疗被认为是第一种选择。基于 VR 图象与外科的计划系统结合了, 3D-CTA 可以关于动脉瘤获得更多的成像信息。 | GUO Yan-wu KE Yi-quan ZHANG Shi-zhong WANG Qiu-jing DUAN Chuan-zhi JIA Hong-shun ZHOU Li XU Ru-xiang | 2008 | Chinese Medical Journal2008，，24： | 14 |
| 7 | A voltage resonance-based single-ended online fault location algorithm for DC distribution networks显示文摘A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision. | JIA Ke LI Meng BI Tian Shu YANG Qi Xun | 2016 | Science China(Technological Sciences)2016，59，5： | 13 |
| 8 | Low-temperature processed inorganic hole transport layer for efficient and stable mixed Pb-Sn low-bandgap perovskite solar cells显示文摘Metal halide perovskite solar cells(PSCs)have attracted tremendous attention as an emerging photovoltaic technology due to their high efficiency,low cost and ease of fabrication from earth-abundant materials[1,2].The power conversion efficiencies(PCEs)have been rapidly boosted from 3.8%in the pioneer’s work to a certified 24.2%nowadays in just ten years[3].The PCE breakthroughs in PSCs have mostly adopted full lead-based perovskites(APbX3)with bandgaps of 1.5–1.6 eV. | Qiaolei Han Ying Wei Renxing Lin Zhimin Fang Ke Xiao Xin Luo Shuai Gu Jia Zhu Liming Ding Hairen Tan | 2019 | Science Bulletin2019，64，19： | 13 |
| 9 | The microphysics of ice accretion on wires:Observations and simulations显示文摘The weather system, meteorological conditions, and microphysics of cloud, fog, and rain droplets are studied during the formation, growth, maintenance, and shedding periods of ice accretion on wires in Enshi, Hubei Province in China using 2008/2009 and 2009/2010 winter observations. The comprehensive observations include data of visibility, microphysics of fog and rain droplets, and ice thickness, as well as data from an automated weather station and other routinely recorded meteorological data. The results show that icing occurred during the passage of a cold front, with a high-pressure system and a cold temperature trough at 850 hPa, and a southeasterly at 500 hPa that provided abundant moisture. Ice formation usually started in the evening or early morning, and ice shed around noon the following day when the temperature was-1°C to 0°C. The averaged liquid water content of the fog droplet was distinctly greater during the growth period than during the other three periods, and there was precipitation during the growth period in each case of ice accretion. The growth rate of the ice thickness was clearly correlated with the liquid water content, with a correlation coefficient of 0.62. Simulations using empirical equations were carried out, and the simulated ice thickness agreed with observations fairly well. | NIU ShengJie ZHOU Yue JIA Ran YANG Jun LUE JingJing KE YiMing YANG ZhiBiao | 2012 | Science China Earth Sciences2012，55，3： | 12 |
| 10 | Temperature dependent expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis显示文摘p34cdc2 and Cyclin B1 are key components of cell cycle controlling machine and are believed to play a fundamental role in gametogenesis. It is also well known that, in scrotal mammals, spermatogenesis depends greatly on the maintenance of comparatively low temperature in the scrotum. To investigate whether the expression of cdc2 and Cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event, in situ hybridization, Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and Cyclin B1 in normal and cryptorchid testis. Results showed that the abdominal temperature had no significant influence on the transcription of cdc2 and Cyclin B1 in the spermatogonia and pachytene/diplotene primary spermatocytes, but it blocked the translation of them. Due to the deficiency of p34cdc2 and Cyclin B1, the spermatogonia and pachytene/diplotene primary spermatocytes were unable to form MPF, hence, they couldn’t undergo karyokinesis. The development of primary spermatocytes was arrested at the G2 to M phase transition. We also found that testosterone could regulate the Cyclin B1 expression in spermatogenic cells. Muscular injection of testosterone could recover spermatogenesis in the unilateral scrotal testis which was influenced by the contralateral cryptorchid testis, but it could not salvage the spermatogenesis block in the cryptorchid testis. | KONG WEI HUA ZHENG GU JI NING LU JIA KE TSO Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China College of Life Science, Shandong University, Jinan 250100, China | 2000 | Cell Research2000，10，4： | 12 |
| 11 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 12 | Phytochemistry,Metabolism, and Metabolomics of Ginseng显示文摘Ginseng, as a medicinal plant, has been used for thousands of years in China, Korea, and Japan, and the study on ginseng is a hotspot in the research field as evidenced by about 7000 scientific papers in PUBMED. In recent decades, many ginseng studies focused on the metabolism and metabolomics of ginseng or its active ingredients using modern bioanalytical technologies. To date, more than 200 ginsenosides and non-saponin constituents have been isolated and identified. In the past decades, rapid development of analytical technologies has facilitated the advancement of ginseng research in many ways. In this review, we focus on the advances of ginseng research in chemistry, pharmacology, and metabolomics. We also provide the comments on the significance as well as challenges of metabolomics-based ginseng studies. | Xiao-peng Chen Yan-ping Lin Yao-zhong Hu Chang-xiao Liu Ke Lan Wei Jia | 2015 | Chinese Herbal Medicines2015，7，2： | 10 |
| 13 | Investigating the Transport Mechanism of PM2.5 Pollution during January 2014 in Wuhan, Central China显示文摘Severe haze pollution that occurred in January 2014 in Wuhan was investigated. The factors leading to Wuhan’s PM2.5 pollution and the characteristics and formation mechanism were found to be significantly different from other megacities, like Beijing. Both the growth rates and decline rates of PM2.5 concentrations in Wuhan were lower than those in Beijing, but the monthly PM2.5 value was approximately twice that in Beijing. Furthermore, the sharp increases of PM2.5 concentrations were often accompanied by strong winds. A high-precision modeling system with an online source-tagged method was established to explore the formation mechanism of five haze episodes. The long-range transport of the polluted air masses from the North China Plain (NCP) was the main factor leading to the sharp increases of PM2.5 concentrations in Wuhan, which contributed 53.4% of the monthly PM2.5 concentrations and 38.5% of polluted days. Furthermore, the change in meteorological conditions such as weakened winds and stable weather conditions led to the accumulation of air pollutants in Wuhan after the long-range transport. The contribution from Wuhan and surrounding cities to the PM2.5 concentrations was determined to be 67.4% during this period. Under the complex regional transport of pollutants from surrounding cities, the NCP, East China, and South China, the five episodes resulted in 30 haze days in Wuhan. The findings reveal important roles played by transregional and intercity transport in haze formation in Wuhan. | Miaomiao LU Xiao TANG Zifa WANG Lin WU Xueshun CHEN Shengwen LIANG Hui ZHOU Huangjian WU Ke HU Longjiao SHEN Jia YU Jiang ZHU | 2019 | Advances in Atmospheric Sciences2019，36，11： | 10 |
| 14 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 15 | Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen显示文摘Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is limited.The current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic GBC.Methods:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were retrieved.This retrospective study evaluated the clinical characteristics,survival outcomes and adverse events.Results:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were included.There were no significant differences between groups in baseline characteristics.The median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX group.Conclusions:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies. | Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui Xiang-Song Wu Lu Zou Xiao-Ling Song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang Wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 10 |
| 16 | Effect of sintering temperature on the microstructure and thermal conductivity of Al/diamond composites prepared by spark plasma sintering显示文摘火花血浆 sintering 被用来在微观结构上制作 sintering 温度的 Al/diamond composites.The 效果, composites 的热 conductivityTC 与试验性的结果和理论 analysis.The 的联合被调查在 550shows 的合成 sintered 高相对的密度并且强壮的界面的结合,而在温度不显示界面的结合并且差的界面的结合的 lower520CC 和 higher580-600 的 composites sintered , respectively.High 亲戚 | Ke Chu Cheng-chang Jia Xue-bing Liang Hui Chen | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，2： | 10 |
| 17 | Buoyance-driven hydrocarbon accumulation depth and its implication for unconventional resource prediction显示文摘The discovery of unconventional hydrocarbon resources since the late 20th century changed geologists’understanding of hydrocarbon migration and accumulations and provides a solution to energy shortage.In 2016,unconventional oil production in the USA accounted for 41%of the total oil production;and unconventional natural gas production in China accounted for 35%of total gas production,showing strong growth momentum of unconventional hydrocarbons explorations.Unconventional hydrocarbons generally coexist with conventional petroleum resources;they sometimes distribute in a separate system,not coexisting with a conventional system.Identification and prediction of unconventional resources and their potentials are prominent challenges for geologists.This study analyzed the results of 12,237 drilling wells in six representative petroliferous basins in China and studied the correlations and differences between conventional and unconventional hydrocarbons by comparing their geological features.Migration and accumulation of conventional hydrocarbon are caused dominantly by buoyance.Wepropose a concept of buoyance-driven hydrocarbon accumulation depth to describe the deepest hydrocarbon accumulation depth driven dominantly by buoyance;beyond this depth the buoyance becomes unimportant for hydrocarbon accumulation.We found that the buoyance-driven hydrocarbon accumulation depth in petroliferous basins controls the different oil/gas reservoirs distribution and resource potentials.Hydrocarbon migration and accumulations above this depth is dominated by buoyancy,forming conventional reservoirs in traps with high porosity and permeability,while hydrocarbon migration and accumulation below this depth is dominated by non-buoyancy forces(mainly refers to capillary force,hydrocarbon volumeexpansion force,etc.),forming unconventional reservoirs in tight layers.The buoyance-driven hydrocarbon accumulation depths in six basins in China range from 1200mto 4200 m,which become shallowerwith increasing geothermal gradient,decreasing particle size of sandstone reservoir layers,or an uplift in the whole petroliferous basin.The predicted unconventional resource potential belowthe buoyance-driven hydrocarbon accumulation depth in six basins in China is more than 15.71×10^(9) t oil equivalent,among them 4.71×10^(9) t reserves have been proved.Worldwide,94%of 52,926 oil and gas reservoirs in 1186 basins are conventional reservoirs and only 6%of them are unconventional reservoirs.These 94%conventional reservoirs show promising exploration prospects in the deep area below buoyance-driven hydrocarbon accumulation depth. | Xiongqi Pang Chengzao Jia Wenyang Wang Zhangxin Chen Maowen Li Fujie Jiang Tao Hu Ke Wang Yingxun Wang | 2021 | Geoscience Frontiers2021，12，4： | 9 |
| 18 | Effects of Nitrogen Application Levels on Ammonia Volatilization and Nitrogen Utilization during Rice Growing Season显示文摘We conducted field trials of rice grown in sandy soil and clay soil to determine the effects of nitrogen application levels on the concentration of NH4+-N in surface water,loss of ammonia through volatilization from paddy fields,rice production,nitrogen-use efficiency,and nitrogen content in the soil profile.The concentration of NH4+-N in surface water and the amount of ammonia lost through volatilization increased with increasing nitrogen application level,and peaked at 1-3 d after nitrogen application.Less ammonia was lost via volatilization from clay soil than from sandy soil.The amounts of ammonia lost via volatilization after nitrogen application differed depending on the stage when it was applied,from the highest loss to the lowest:N application to promote tillering > the first N topdressing to promote panicle initiation(applied at the last 4-leaf stage) > basal fertilizer > the second N topdressing to promote panicle initiation(applied at the last 2-leaf stage).The total loss of ammonia via volatilization from clay soil was 10.49-87.06 kg/hm2,equivalent to 10.92%-21.76% of the nitrogen applied.The total loss of ammonia via volatilization from sandy soil was 11.32?102.43 kg/hm2,equivalent to 11.32%-25.61% of the nitrogen applied.The amount of ammonia lost via volatilization and the concentration of NH4+-N in surface water peaked simultaneously after nitrogen application;both showed maxima at the tillering stage with the ratio between them ranging from 23.76% to 33.65%.With the increase in nitrogen application level,rice production and nitrogen accumulation in plants increased,but nitrogen-use efficiency decreased.Rice production and nitrogen accumulation in plants were slightly higher in clay soil than in sandy soil.In the soil,the nitrogen content was the lowest at a depth of 40-50 cm.In any specific soil layer,the soil nitrogen content increased with increasing nitrogen application level,and the soil nitrogen content was higher in clay soil than in sandy soil.In terms of ammonia volatilization,the amount of ammonia lost via volatilization increased markedly when the nitrogen application level exceeded 250 kg/hm2 in the rice growing season.However,for rice production,a suitable nitrogen application level is approximately 300 kg/hm2.Therefore,taking the needs for high crop yields and environmental protection into account,the appropriate nitrogen application level was 250-300 kg/hm2 in these conditions. | LIN Zhong-cheng DAI Qi-gen YE Shi-chao WU Fu-guan JIA Yu-shu CHEN Jing-dou XU Lu-sheng ZHANG Hong-cheng Huo Zhong-yang Xu Ke WEt Hai-yan | 2012 | Rice science2012，19，2： | 9 |
| 19 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 20 | Antibodies against the C-terminal peptide of rabbit oviductin inhibit mouse early embryo development to pass 2-cell stage显示文摘A full-length rabbit oviductin cDNA(1909bp) was cloned. It consists of a 5’-UTR of 52bp, an open reading frame (ORF) of 1374bp and a 3’-UTR of 483bp and has more than 80% homology with that of other mammal oviductins. N-terminal peptide (NTP) (384 residues) and C-terminal peptide (CTP) (73 residues) of deduced protein precursor has about 80% and 50% identity with that of other mammals respectively. Fusion proteins GST-NTP 368(1R-368N)and GST-CTP73 (369F-441A) were expressed and purified. NH2-terminal of CTP sequencing reveals that the purified protein is consistent with the deduced one. In order to study the function of NTP and CTP the mouse anti-NTP and rabbit anti-CTP antisera were prepared. Tissue-specific (skeleton muscle, oviduct, uterus, ovary, liver, heart and brain) analysis indicated that rabbit oviductin was only found in oviduct. The conditioned medium derived from the rabbit oviduct mucosa epithelial cells has a function of overcoming the early embryonic development block of Kunming mous e cultured in vitro. Anti-CTP antiserum could totally inhibit the early embryo development at 2-cell stage cultured in the conditioned culture medium, but anti-NTP antiserum couldn’t. There was a positive relationship between the ratio of early embryos at development block and the dosage of anti-CTP antiserum added in the conditioned culture medium. These results suggest that oviductin has a function not only on fertilization, but also on the release of early embryonic development block, and the later function domain of rabbit oviductin may be situate in its C-terminal. | PAN YONG, ZHENG GU, JIN PING LUO, JUN Ru WANG, JIA KE TSO National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned Parenthood Research, 21.40 Xietu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，1： | 8 |
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